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Nat Cell Biol. 2019 Jan;21(1):54-62. doi: 10.1038/s41556-018-0243-8. Epub 2019 Jan 2.

The diverse consequences of aneuploidy.

Author information

1
Department of Molecular Genetics, TU Kaiserslautern, Kaiserslautern, Germany.
2
Department of Molecular Genetics, TU Kaiserslautern, Kaiserslautern, Germany. storchova@bio.uni-kl.de.

Abstract

Aneuploidy, or imbalanced chromosome number, has profound effects on eukaryotic cells. In humans, aneuploidy is associated with various pathologies, including cancer, which suggests that it mediates a proliferative advantage under these conditions. Here, we discuss physiological changes triggered by aneuploidy, such as altered cell growth, transcriptional changes, proteotoxic stress, genomic instability and response to interferons, and how cancer cells adapt to the changing aneuploid genome.

PMID:
30602769
DOI:
10.1038/s41556-018-0243-8
[Indexed for MEDLINE]

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