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An open-label phase 1 clinical trial of the anti-α4β7 monoclonal antibody vedolizumab in HIV-infected individuals.

Sneller MC, Clarridge KE, Seamon C, Shi V, Zorawski MD, Justement JS, Blazkova J, Huiting ED, Proschan MA, Mora JR, Shetzline M, Moir S, Lane HC, Chun TW, Fauci AS.

Sci Transl Med. 2019 Sep 11;11(509). pii: eaax3447. doi: 10.1126/scitranslmed.aax3447. Epub 2019 Sep 5.


Predicting the broadly neutralizing antibody susceptibility of the HIV reservoir.

Yu WH, Su D, Torabi J, Fennessey CM, Shiakolas A, Lynch R, Chun TW, Doria-Rose N, Alter G, Seaman MS, Keele BF, Lauffenburger DA, Julg B.

JCI Insight. 2019 Sep 5;4(17). pii: 130153. doi: 10.1172/jci.insight.130153.


Delayed GALT reconstitution in duodenum compared to rectum in hiv-infected patients initiating antiretroviral therapy.

Sainz T, Serrano-Villar S, Mann S, Ma ZM, Utay NS, Thompson CG, Chun TW, Kashuba AD, Siewe B, Albanese A, Troia-Cancio P, Sinclair E, Somasunderam A, Yotter T, Moreno S, Pollard RB, Landay A, Miller CJ, Asmuth DM.

AIDS. 2019 Sep 2. doi: 10.1097/QAD.0000000000002361. [Epub ahead of print]


Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression.

Bae J, Choi SP, Isono K, Lee JY, Park SW, Choi CY, Han J, Kim SH, Lee HH, Park K, Jin HY, Lee SJ, Park CG, Koseki H, Lee YS, Chun T.

Nat Commun. 2019 Aug 2;10(1):3496. doi: 10.1038/s41467-019-11386-4.


Predictive Validity of the CRAFFT for Substance Use Disorder.

Shenoi RP, Linakis JG, Bromberg JR, Casper TC, Richards R, Mello MJ, Chun TH, Spirito A; PEDIATRIC EMERGENCY CARE APPLIED RESEARCH NETWORK.

Pediatrics. 2019 Aug;144(2). pii: e20183415. doi: 10.1542/peds.2018-3415. Epub 2019 Jul 24.


Reverse total shoulder arthroplasty: an imaging overview.

Lee DH, Choi YS, Potter HG, Endo Y, Sivakumaran T, Lim TK, Chun TJ.

Skeletal Radiol. 2019 Jul 18. doi: 10.1007/s00256-019-03275-0. [Epub ahead of print] Review.


Durable Control of HIV Infection in the Absence of Antiretroviral Therapy: Opportunities and Obstacles.

Chun TW, Eisinger RW, Fauci AS.

JAMA. 2019 Jul 2;322(1):27-28. doi: 10.1001/jama.2019.5397. No abstract available.


The effect of exogenous melatonin on reducing scoliotic curvature and improving bone quality in melatonin-deficient C57BL/6J mice.

Liu H, Liu Z, Man CW, Guo J, Han X, Hu Z, Ng TB, Zhao Z, Li J, Wang W, Chun TC, Qiao J, Shi B, Xu L, Bao H, Jiang Q, Lam TP, Cheng JCY, Qiu Y, Zhu Z.

Sci Rep. 2019 Apr 17;9(1):6202. doi: 10.1038/s41598-019-42467-5.


Effect of Anti-CD4 Antibody UB-421 on HIV-1 Rebound after Treatment Interruption.

Wang CY, Wong WW, Tsai HC, Chen YH, Kuo BS, Lynn S, Blazkova J, Clarridge KE, Su HW, Lin CY, Tseng FC, Lai A, Yang FH, Lin CH, Tseng W, Lin HY, Finstad CL, Wong-Staal F, Hanson CV, Chun TW, Liao MJ.

N Engl J Med. 2019 Apr 18;380(16):1535-1545. doi: 10.1056/NEJMoa1802264.


Reliability and Validity of the Newton Screen for Alcohol and Cannabis Misuse in a Pediatric Emergency Department Sample.

Linakis JG, Bromberg JR, Casper TC, Chun TH, Mello MJ, Ingebretsen H, Spirito A; Pediatric Emergency Care Applied Research Network.

J Pediatr. 2019 Jul;210:154-160.e1. doi: 10.1016/j.jpeds.2019.02.038. Epub 2019 Apr 6.


Decreased tenofovir diphosphate concentrations in a transgender female cohort: Implications for HIV pre-exposure prophylaxis (PrEP).

Cottrell ML, Prince HMA, Schauer AP, Sykes C, Maffuid K, Poliseno A, Chun TW, Huiting E, Stanczyk FZ, Peery AF, Dellon ES, Adams JL, Gay C, Kashuba ADM.

Clin Infect Dis. 2019 Apr 9. pii: ciz290. doi: 10.1093/cid/ciz290. [Epub ahead of print]


Adolescent Substance Abuse Risk: A Comparison of Pediatric Emergency Care Applied Research Network Emergency Department Patients and 2 Nationally Representative Samples.

Chun TH, Chernick LS, Ahmad FA, Ranney ML, Shenoi RP, Casper TC, Fein JA, Grupp-Phelan J, McAninch B, Powell EC, Bromberg JR, Linakis JG, Spirito A; Pediatric Emergency Care Applied Research Network.

Pediatr Emerg Care. 2019 Mar 19. doi: 10.1097/PEC.0000000000001763. [Epub ahead of print]


The Increasing Burden of Psychiatric Emergencies: A Call to Action.

Chun TH, Duffy SJ, Grupp-Phelan J.

Pediatrics. 2019 Apr;143(4). pii: e20190251. doi: 10.1542/peds.2019-0251. Epub 2019 Mar 18. No abstract available.


Substance use screening, brief intervention, and referral to treatment training for emergency medicine trainees.

Mello MJ, Bromberg JR, Rougas S, Chun TH, Brown LL, Parnagian CS, Baird J.

Adv Med Educ Pract. 2019 Feb 14;10:71-76. doi: 10.2147/AMEP.S186502. eCollection 2019.


Impact of Treatment Interruption on HIV Reservoirs and Lymphocyte Subsets in Individuals Who Initiated Antiretroviral Therapy During the Early Phase of Infection.

Huiting ED, Gittens K, Justement JS, Shi V, Blazkova J, Benko E, Kovacs C, Wender PA, Moir S, Sneller MC, Fauci AS, Chun TW.

J Infect Dis. 2019 Jun 19;220(2):270-274. doi: 10.1093/infdis/jiz100.


Ly6G+ inflammatory cells enable the conversion of cancer cells to cancer stem cells in an irradiated glioblastoma model.

Jeon HY, Ham SW, Kim JK, Jin X, Lee SY, Shin YJ, Choi CY, Sa JK, Kim SH, Chun T, Jin X, Nam DH, Kim H.

Cell Death Differ. 2019 Oct;26(10):2139-2156. doi: 10.1038/s41418-019-0282-0. Epub 2019 Feb 25.


Predictive Validity of a 2-Question Alcohol Screen at 1-, 2-, and 3-Year Follow-up.

Linakis JG, Bromberg JR, Casper TC, Chun TH, Mello MJ, Richards R, Mull CC, Shenoi RP, Vance C, Ahmad F, Bajaj L, Brown KM, Chernick LS, Cohen DM, Fein J, Horeczko T, Levas MN, McAninch B, Monuteaux MC, Grupp-Phelan J, Powell EC, Rogers A, Suffoletto B, Dean JM, Spirito A; Pediatric Emergency Care Applied Research Network.

Pediatrics. 2019 Mar;143(3). pii: e20182001. doi: 10.1542/peds.2018-2001. Epub 2019 Feb 19.


Screening for Adolescent Alcohol Use in the Emergency Department: What Does It Tell Us About Cannabis, Tobacco, and Other Drug Use?

Spirito A, Bromberg JR, Casper TC, Chun T, Mello MJ, Mull CC, Shenoi RP, Vance C, Ahmad F, Bajaj L, Brown KM, Chernick LS, Cohen DM, Fein J, Horeczko T, Levas MN, McAninch B, Monuteaux MC, Grupp-Phelan J, Powell EC, Rogers A, Suffoletto B, Linakis JG; Pediatric Emergency Care Research Network (PECARN).

Subst Use Misuse. 2019;54(6):1007-1016. doi: 10.1080/10826084.2018.1558251. Epub 2019 Feb 6.


Anti-Inflammatory Role of TAM Family of Receptor Tyrosine Kinases Via Modulating Macrophage Function.

Lee CH, Chun T.

Mol Cells. 2019 Jan 31;42(1):1-7. doi: 10.14348/molcells.2018.0419. Epub 2019 Jan 2. Review.


Intact HIV-1 proviruses accumulate at distinct chromosomal positions during prolonged antiretroviral therapy.

Einkauf KB, Lee GQ, Gao C, Sharaf R, Sun X, Hua S, Chen SM, Jiang C, Lian X, Chowdhury FZ, Rosenberg ES, Chun TW, Li JZ, Yu XG, Lichterfeld M.

J Clin Invest. 2019 Mar 1;129(3):988-998. doi: 10.1172/JCI124291. Epub 2019 Jan 28.


A novel role for programmed cell death receptor ligand 2 in sepsis-induced hepatic dysfunction.

Rossi AL, Le M, Chung CS, Chen Y, Fallon EA, Matoso A, Xu S, Chun TT, Erickson CP, Ayala A.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G106-G114. doi: 10.1152/ajpgi.00204.2018. Epub 2018 Nov 15.


The ORF5 protein of porcine circovirus type 2 enhances viral replication by dampening type I interferon expression in porcine epithelial cells.

Choi CY, Choi YC, Park IB, Lee CH, Kang SJ, Chun T.

Vet Microbiol. 2018 Nov;226:50-58. doi: 10.1016/j.vetmic.2018.10.005. Epub 2018 Oct 11.


HIF2A-LOX Pathway Promotes Fibrotic Tissue Remodeling in Thyroid-Associated Orbitopathy.

Hikage F, Atkins S, Kahana A, Smith TJ, Chun TH.

Endocrinology. 2019 Jan 1;160(1):20-35. doi: 10.1210/en.2018-00272.


Fibro-Adipogenic Remodeling of the Diaphragm in Obesity-Associated Respiratory Dysfunction.

Buras ED, Converso-Baran K, Davis CS, Akama T, Hikage F, Michele DE, Brooks SV, Chun TH.

Diabetes. 2019 Jan;68(1):45-56. doi: 10.2337/db18-0209. Epub 2018 Oct 25.


Reprogramming mechanisms influence the maturation of hematopoietic progenitors from human pluripotent stem cells.

Heo HR, Song H, Kim HR, Lee JE, Chung YG, Kim WJ, Yang SR, Kim KS, Chun T, Lee DR, Hong SH.

Cell Death Dis. 2018 Oct 24;9(11):1090. doi: 10.1038/s41419-018-1124-6.


Impact of intermediate-dose prophylaxis on progression of haemarthropathy in patients with severe haemophilia A: A 10-year, single-centre experience in Korea.

Kim JY, Lee DJ, Chun TJ, You CW.

Haemophilia. 2018 Nov;24(6):e402-e409. doi: 10.1111/hae.13610. Epub 2018 Sep 24.


Conflicting evidence for HIV enrichment in CD32+ CD4 T cells.

Pérez L, Anderson J, Chipman J, Thorkelson A, Chun TW, Moir S, Haase AT, Douek DC, Schacker TW, Boritz EA.

Nature. 2018 Sep;561(7723):E9-E16. doi: 10.1038/s41586-018-0493-4. Epub 2018 Sep 19. No abstract available.


IgG3 regulates tissue-like memory B cells in HIV-infected individuals.

Kardava L, Sohn H, Youn C, Austin JW, Wang W, Buckner CM, Justement JS, Melson VA, Roth GE, Hand MA, Gittens KR, Kwan RW, Sneller MC, Li Y, Chun TW, Sun PD, Pierce SK, Moir S.

Nat Immunol. 2018 Sep;19(9):1001-1012. doi: 10.1038/s41590-018-0180-5. Epub 2018 Aug 13.


Monitoring mRNA transcription of genes involved in early pregnancy from endometrium and peripheral blood mononuclear cells of pregnant pigs with different parity.

Choi SP, Choi YC, Yang J, Choi CY, Lee CH, Kang SJ, Park IB, Chun T.

Reprod Domest Anim. 2018 Dec;53(6):1594-1599. doi: 10.1111/rda.13278. Epub 2018 Aug 9.


The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies.

Namazi G, Fajnzylber JM, Aga E, Bosch RJ, Acosta EP, Sharaf R, Hartogensis W, Jacobson JM, Connick E, Volberding P, Skiest D, Margolis D, Sneller MC, Little SJ, Gianella S, Smith DM, Kuritzkes DR, Gulick RM, Mellors JW, Mehraj V, Gandhi RT, Mitsuyasu R, Schooley RT, Henry K, Tebas P, Deeks SG, Chun TW, Collier AC, Routy JP, Hecht FM, Walker BD, Li JZ.

J Infect Dis. 2018 Nov 5;218(12):1954-1963. doi: 10.1093/infdis/jiy479.


HIV-1 targets L-selectin for adhesion and induces its shedding for viral release.

Kononchik J, Ireland J, Zou Z, Segura J, Holzapfel G, Chastain A, Wang R, Spencer M, He B, Stutzman N, Kano D, Arthos J, Fischer E, Chun TW, Moir S, Sun P.

Nat Commun. 2018 Jul 19;9(1):2825. doi: 10.1038/s41467-018-05197-2.


Group 2 Innate Lymphoid Cells (ILC2s) Are Key Mediators of the Inflammatory Response in Polymicrobial Sepsis.

Chun TT, Chung CS, Fallon EA, Hutchins NA, Clarke E, Rossi AL, Cioffi WG, Heffernan DS, Ayala A.

Am J Pathol. 2018 Sep;188(9):2097-2108. doi: 10.1016/j.ajpath.2018.05.009. Epub 2018 Jun 20.


Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells.

Kuo HH, Ahmad R, Lee GQ, Gao C, Chen HR, Ouyang Z, Szucs MJ, Kim D, Tsibris A, Chun TW, Battivelli E, Verdin E, Rosenberg ES, Carr SA, Yu XG, Lichterfeld M.

Immunity. 2018 Jun 19;48(6):1183-1194.e5. doi: 10.1016/j.immuni.2018.04.004. Epub 2018 May 22.


Transcription factor 21 (TCF21) promotes proinflammatory interleukin 6 expression and extracellular matrix remodeling in visceral adipose stem cells.

Akama T, Chun TH.

J Biol Chem. 2018 Apr 27;293(17):6603-6610. doi: 10.1074/jbc.RA117.000456. Epub 2018 Mar 14.


Problem Behaviors and Psychological Distress Among Teens Seen in a National Sample of Emergency Departments.

Ranney ML, Bromberg J, Hozey A, Casper TC, Mello MJ, Spirito A, Chun TH, Linakis JG; Pediatric Emergency Care Applied Research Network.

Acad Pediatr. 2018 Aug;18(6):650-654. doi: 10.1016/j.acap.2018.02.016. Epub 2018 Mar 2.


Effect of analytical treatment interruption and reinitiation of antiretroviral therapy on HIV reservoirs and immunologic parameters in infected individuals.

Clarridge KE, Blazkova J, Einkauf K, Petrone M, Refsland EW, Justement JS, Shi V, Huiting ED, Seamon CA, Lee GQ, Yu XG, Moir S, Sneller MC, Lichterfeld M, Chun TW.

PLoS Pathog. 2018 Jan 11;14(1):e1006792. doi: 10.1371/journal.ppat.1006792. eCollection 2018 Jan.


A randomized controlled safety/efficacy trial of therapeutic vaccination in HIV-infected individuals who initiated antiretroviral therapy early in infection.

Sneller MC, Justement JS, Gittens KR, Petrone ME, Clarridge KE, Proschan MA, Kwan R, Shi V, Blazkova J, Refsland EW, Morris DE, Cohen KW, McElrath MJ, Xu R, Egan MA, Eldridge JH, Benko E, Kovacs C, Moir S, Chun TW, Fauci AS.

Sci Transl Med. 2017 Dec 6;9(419). pii: eaan8848. doi: 10.1126/scitranslmed.aan8848.


Program Cell Death Receptor-1-Mediated Invariant Natural Killer T-Cell Control of Peritoneal Macrophage Modulates Survival in Neonatal Sepsis.

Fallon EA, Chun TT, Young WA, Gray C, Ayala A, Heffernan DS.

Front Immunol. 2017 Nov 20;8:1469. doi: 10.3389/fimmu.2017.01469. eCollection 2017.


Extensive virologic and immunologic characterization in an HIV-infected individual following allogeneic stem cell transplant and analytic cessation of antiretroviral therapy: A case study.

Cummins NW, Rizza S, Litzow MR, Hua S, Lee GQ, Einkauf K, Chun TW, Rhame F, Baker JV, Busch MP, Chomont N, Dean PG, Fromentin R, Haase AT, Hampton D, Keating SM, Lada SM, Lee TH, Natesampillai S, Richman DD, Schacker TW, Wietgrefe S, Yu XG, Yao JD, Zeuli J, Lichterfeld M, Badley AD.

PLoS Med. 2017 Nov 28;14(11):e1002461. doi: 10.1371/journal.pmed.1002461. eCollection 2017 Nov.


Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen-induced allergic rhinitis in mice.

Choi SP, Oh HN, Choi CY, Ahn H, Yun HS, Chung YM, Kim B, Lee SJ, Chun T.

J Appl Microbiol. 2018 Mar;124(3):821-828. doi: 10.1111/jam.13635. Epub 2018 Jan 28.


Methodology and Demographics of a Brief Adolescent Alcohol Screen Validation Study.

Bromberg JR, Spirito A, Chun T, Mello MJ, Casper TC, Ahmad F, Bajaj L, Brown KM, Chernick LS, Cohen DM, Fein J, Horeczko T, Levas MN, McAninch B, Monuteaux M, Mull CC, Grupp-Phelan J, Powell EC, Rogers A, Shenoi RP, Suffoletto B, Vance C, Linakis JG; Pediatric Emergency Care Applied Research Network.

Pediatr Emerg Care. 2017 Jul 3. doi: 10.1097/PEC.0000000000001221. [Epub ahead of print]


Tissue Pharmacologic and Virologic Determinants of Duodenal and Rectal Gastrointestinal-Associated Lymphoid Tissue Immune Reconstitution in HIV-Infected Patients Initiating Antiretroviral Therapy.

Asmuth DM, Thompson CG, Chun TW, Ma ZM, Mann S, Sainz T, Serrano-Villar S, Utay NS, Garcia JC, Troia-Cancio P, Pollard RB, Miller CJ, Landay A, Kashuba AD.

J Infect Dis. 2017 Oct 17;216(7):813-818. doi: 10.1093/infdis/jix418.


Randomised controlled trial of Lactobacillus rhamnosus (LGG) versus placebo in children presenting to the emergency department with acute gastroenteritis: the PECARN probiotic study protocol.

Schnadower D, Tarr PI, Casper TC, Gorelick MH, Dean MJ, O'Connell KJ, Mahajan P, Chun TH, Bhatt SR, Roskind CG, Powell EC, Rogers AJ, Vance C, Sapien RE, Gao F, Freedman SB.

BMJ Open. 2017 Sep 24;7(9):e018115. doi: 10.1136/bmjopen-2017-018115.


In vivo activation of latent HIV with a synthetic bryostatin analog effects both latent cell "kick" and "kill" in strategy for virus eradication.

Marsden MD, Loy BA, Wu X, Ramirez CM, Schrier AJ, Murray D, Shimizu A, Ryckbosch SM, Near KE, Chun TW, Wender PA, Zack JA.

PLoS Pathog. 2017 Sep 21;13(9):e1006575. doi: 10.1371/journal.ppat.1006575. eCollection 2017 Sep.


A Combined Ultrasonographic and Conventional Radiographic Assessment of Hemophilic Arthropathy.

Chung SW, Seo YJ, You CW, Chun TJ, Jung KJ, Kim JH.

Indian J Hematol Blood Transfus. 2017 Sep;33(3):380-388. doi: 10.1007/s12288-016-0717-4. Epub 2016 Aug 18.


Long-term Treatment with Anti-platelet Agents for Collagen-induced Arthritis Improves Radiological Findings.

Kim C, Kim T, Yoo J, Sheen DH, Lee SK, Choi EH, Chun TJ, Kang SW, Shim SC, Lim MK.

Osong Public Health Res Perspect. 2017 Jun;8(3):179-184. doi: 10.24171/j.phrp.2017.8.3.04. Epub 2017 Jun 30.


Pig tissue factor pathway inhibitor α fusion immunoglobulin inhibits pig tissue factor activity in human plasma moderately more efficiently than the human counterpart.

Choi CY, Kim YH, Bae J, Lee SJ, Kim HK, Park CG, Chun T.

Biotechnol Lett. 2017 Nov;39(11):1631-1638. doi: 10.1007/s10529-017-2405-3. Epub 2017 Jul 26.


Membrane-Tethered Metalloproteinase Expressed by Vascular Smooth Muscle Cells Limits the Progression of Proliferative Atherosclerotic Lesions.

Barnes RH 2nd, Akama T, Öhman MK, Woo MS, Bahr J, Weiss SJ, Eitzman DT, Chun TH.

J Am Heart Assoc. 2017 Jul 22;6(7). pii: e003693. doi: 10.1161/JAHA.116.003693.


Anti-inflammatory potential of a heat-killed Lactobacillus strain isolated from Kimchi on house dust mite-induced atopic dermatitis in NC/Nga mice.

Choi CY, Kim YH, Oh S, Lee HJ, Kim JH, Park SH, Kim HJ, Lee SJ, Chun T.

J Appl Microbiol. 2017 Aug;123(2):535-543. doi: 10.1111/jam.13515. Epub 2017 Jul 12.


Early antibody therapy can induce long-lasting immunity to SHIV.

Nishimura Y, Gautam R, Chun TW, Sadjadpour R, Foulds KE, Shingai M, Klein F, Gazumyan A, Golijanin J, Donaldson M, Donau OK, Plishka RJ, Buckler-White A, Seaman MS, Lifson JD, Koup RA, Fauci AS, Nussenzweig MC, Martin MA.

Nature. 2017 Mar 23;543(7646):559-563. doi: 10.1038/nature21435. Epub 2017 Mar 13.

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