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Items: 33


CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases.

Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB.

Cancer Res. 2018 Dec 1;78(23):6594-6606. doi: 10.1158/0008-5472.CAN-18-1583. Epub 2018 Sep 5.


Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.

Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K.

Oncogene. 2018 Aug;37(35):4792-4808. doi: 10.1038/s41388-018-0316-y. Epub 2018 May 21.


Inhibition of CDK8 mediator kinase suppresses estrogen dependent transcription and the growth of estrogen receptor positive breast cancer.

McDermott MS, Chumanevich AA, Lim CU, Liang J, Chen M, Altilia S, Oliver D, Rae JM, Shtutman M, Kiaris H, Győrffy B, Roninson IB, Broude EV.

Oncotarget. 2017 Feb 21;8(8):12558-12575. doi: 10.18632/oncotarget.14894.


Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds.

Chumanevich AA, Chaparala A, Witalison EE, Tashkandi H, Hofseth AB, Lane C, Pena E, Liu P, Pittman DL, Nagarkatti P, Nagarkatti M, Hofseth LJ, Chumanevich AA.

Oncotarget. 2017 Jan 3;8(1):228-237. doi: 10.18632/oncotarget.13894.


Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties.

Chumanevich AA, Witalison EE, Chaparala A, Chumanevich A, Nagarkatti P, Nagarkatti M, Hofseth LJ.

Oncotarget. 2016 Aug 16;7(33):52928-52939. doi: 10.18632/oncotarget.10608.


Expression of CDK8 and CDK8-interacting Genes as Potential Biomarkers in Breast Cancer.

Broude EV, Győrffy B, Chumanevich AA, Chen M, McDermott MS, Shtutman M, Catroppo JF, Roninson IB.

Curr Cancer Drug Targets. 2015;15(8):739-49. Review.


Novel complex MAD phasing and RNase H structural insights using selenium oligonucleotides.

Abdur R, Gerlits OO, Gan J, Jiang J, Salon J, Kovalevsky AY, Chumanevich AA, Weber IT, Huang Z.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):354-61. doi: 10.1107/S1399004713027922. Epub 2014 Jan 29.


D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.

Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR.

ACS Med Chem Lett. 2012 Oct 26;3(12):1081-1085.


The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest.

Cui X, Witalison EE, Chumanevich AP, Chumanevich AA, Poudyal D, Subramanian V, Schetter AJ, Harris CC, Thompson PR, Hofseth LJ.

PLoS One. 2013;8(1):e53791. doi: 10.1371/journal.pone.0053791. Epub 2013 Jan 7.


Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.

Bicker KL, Subramanian V, Chumanevich AA, Hofseth LJ, Thompson PR.

J Am Chem Soc. 2012 Oct 17;134(41):17015-8. doi: 10.1021/ja308871v. Epub 2012 Oct 3.


A limited role of p53 on the ability of a Hexane fraction of American ginseng to suppress mouse colitis.

Poudyal D, Cui X, Mai Le P, Davis T, Hofseth AB, Jin Y, Chumanevich AA, Wargovich MJ, Nagarkatti M, Nagarkatti PS, Windust A, Hofseth LJ.

J Biomed Biotechnol. 2012;2012:785739. doi: 10.1155/2012/785739. Epub 2012 Jul 30.


Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation.

Shaked H, Hofseth LJ, Chumanevich A, Chumanevich AA, Wang J, Wang Y, Taniguchi K, Guma M, Shenouda S, Clevers H, Harris CC, Karin M.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14007-12. doi: 10.1073/pnas.1211509109. Epub 2012 Aug 14.


Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: a randomized, double-blind, placebo-controlled trial.

Cui X, Jin Y, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Poudyal D, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ.

Mol Nutr Food Res. 2012 Apr;56(4):666-70. doi: 10.1002/mnfr.201100496. Epub 2012 Mar 1.


A hexane fraction of American ginseng suppresses mouse colitis and associated colon cancer: anti-inflammatory and proapoptotic mechanisms.

Poudyal D, Le PM, Davis T, Hofseth AB, Chumanevich A, Chumanevich AA, Wargovich MJ, Nagarkatti M, Nagarkatti PS, Windust A, Hofseth LJ.

Cancer Prev Res (Phila). 2012 Apr;5(4):685-96. doi: 10.1158/1940-6207.CAPR-11-0421. Epub 2012 Jan 31.


The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR.

J Med Chem. 2011 Oct 13;54(19):6919-35. doi: 10.1021/jm2008985. Epub 2011 Sep 16. Erratum in: J Med Chem. 2011 Nov 24;54(22):7942.


Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.

Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ.

Am J Physiol Gastrointest Liver Physiol. 2011 Jun;300(6):G929-38. doi: 10.1152/ajpgi.00435.2010. Epub 2011 Mar 17.


Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis.

Cui X, Jin Y, Poudyal D, Chumanevich AA, Davis T, Windust A, Hofseth A, Wu W, Habiger J, Pena E, Wood P, Nagarkatti M, Nagarkatti PS, Hofseth L.

Carcinogenesis. 2010 Oct;31(10):1734-41. doi: 10.1093/carcin/bgq163. Epub 2010 Aug 20.


Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.

Chumanevich AA, Poudyal D, Cui X, Davis T, Wood PA, Smith CD, Hofseth LJ.

Carcinogenesis. 2010 Oct;31(10):1787-93. doi: 10.1093/carcin/bgq158. Epub 2010 Aug 5.


Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate.

Jin Y, Cui X, Singh UP, Chumanevich AA, Harmon B, Cavicchia P, Hofseth AB, Kotakadi V, Stroud B, Volate SR, Hurley TG, Hebert JR, Hofseth LJ.

Mol Nutr Food Res. 2010 Oct;54(10):1506-14. doi: 10.1002/mnfr.200900579.


American ginseng suppresses colitis through p53-mediated apoptosis of inflammatory cells.

Jin Y, Hofseth AB, Cui X, Windust AJ, Poudyal D, Chumanevich AA, Matesic LE, Singh NP, Nagarkatti M, Nagarkatti PS, Hofseth LJ.

Cancer Prev Res (Phila). 2010 Mar;3(3):339-47. doi: 10.1158/1940-6207.CAPR-09-0116. Epub 2010 Feb 23.


Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance.

Ghosh AK, Kulkarni S, Anderson DD, Hong L, Baldridge A, Wang YF, Chumanevich AA, Kovalevsky AY, Tojo Y, Amano M, Koh Y, Tang J, Weber IT, Mitsuya H.

J Med Chem. 2009 Dec 10;52(23):7689-705. doi: 10.1021/jm900695w.


Structural basis for executioner caspase recognition of P5 position in substrates.

Fu G, Chumanevich AA, Agniswamy J, Fang B, Harrison RW, Weber IT.

Apoptosis. 2008 Nov;13(11):1291-302. doi: 10.1007/s10495-008-0259-9.


Biochemical and structural analysis of substrate promiscuity in plant Mg2+-dependent O-methyltransferases.

Kopycki JG, Rauh D, Chumanevich AA, Neumann P, Vogt T, Stubbs MT.

J Mol Biol. 2008 Apr 18;378(1):154-64. doi: 10.1016/j.jmb.2008.02.019. Epub 2008 Feb 20.


Caught in the Act: the 1.5 A resolution crystal structures of the HIV-1 protease and the I54V mutant reveal a tetrahedral reaction intermediate.

Kovalevsky AY, Chumanevich AA, Liu F, Louis JM, Weber IT.

Biochemistry. 2007 Dec 25;46(51):14854-64. Epub 2007 Dec 4.


Crystallization and preliminary X-ray diffraction analysis of recombinant hydrolase domain of 10-formyltetrahydrofolate dehydrogenase.

Chumanevich AA, Davies C, Krupenko SA.

Acta Crystallogr D Biol Crystallogr. 2002 Oct;58(Pt 10 Pt 2):1841-2. Epub 2002 Sep 28.


Antiferritin VL homodimer binds human spleen ferritin with high specificity.

Nymalm Y, Kravchuk Z, Salminen T, Chumanevich AA, Dubnovitsky AP, Kankare J, Pentikäinen O, Lehtonen J, Arosio P, Martsev S, Johnson MS.

J Struct Biol. 2002 Jun;138(3):171-86.


Partially structured state of the functional VH domain of the mouse anti-ferritin antibody F11.

Martsev SP, Dubnovitsky AP, Stremovsky OA, Chumanevich AA, Tsybovsky YI, Kravchuk ZI, Deyev SM.

FEBS Lett. 2002 May 8;518(1-3):177-82.


Expression, refolding, and ferritin-binding activity of the isolated VL-domain of monoclonal antibody F11.

Dubnovitsky AP, Kravchuk ZI, Chumanevich AA, Cozzi A, Arosio P, Martsev SP.

Biochemistry (Mosc). 2000 Sep;65(9):1011-8.


Antiferritin single-chain Fv fragment is a functional protein with properties of a partially structured state: comparison with the completely folded V(L) domain.

Martsev SP, Chumanevich AA, Vlasov AP, Dubnovitsky AP, Tsybovsky YI, Deyev SM, Cozzi A, Arosio P, Kravchuk ZI.

Biochemistry. 2000 Jul 11;39(27):8047-57.


Antiferritin single-chain antibody: a functional protein with incomplete folding?

Martsev SP, Kravchuk ZI, Chumanevich AA, Vlasov AP, Dubnovitsky AP, Bespalov IA, Arosio P, Deyev SM.

FEBS Lett. 1998 Dec 28;441(3):458-62.


Thermodynamic stability of immunoglobulins and allosteric interactions with ferritin and protein A: distinct properties of the two antibodies of IgG2a subclass.

Chumanevich AA, Kravchuk ZI, Vlasov AP, Zhorov OV, Martsev SP.

Biochemistry (Mosc). 1998 Apr;63(4):476-84.


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