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β1-adrenergic receptors mediate plasma acyl-ghrelin elevation and depressive-like behavior induced by chronic psychosocial stress.

Gupta D, Chuang JC, Mani BK, Shankar K, Rodriguez JA, Osborne-Lawrence S, Metzger NP, Zigman JM.

Neuropsychopharmacology. 2019 Jun;44(7):1319-1327. doi: 10.1038/s41386-019-0334-7. Epub 2019 Feb 8.


The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS-9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis.

Trauner M, Gulamhusein A, Hameed B, Caldwell S, Shiffman ML, Landis C, Eksteen B, Agarwal K, Muir A, Rushbrook S, Lu X, Xu J, Chuang JC, Billin AN, Li G, Chung C, Subramanian GM, Myers RP, Bowlus CL, Kowdley KV.

Hepatology. 2019 Jan 19. doi: 10.1002/hep.30509. [Epub ahead of print]


Arid1a Loss Drives Nonalcoholic Steatohepatitis in Mice Through Epigenetic Dysregulation of Hepatic Lipogenesis and Fatty Acid Oxidation.

Moore A, Wu L, Chuang JC, Sun X, Luo X, Gopal P, Li L, Celen C, Zimmer M, Zhu H.

Hepatology. 2019 May;69(5):1931-1945. doi: 10.1002/hep.30487. Epub 2019 Mar 18.


SWI/SNF component ARID1A restrains pancreatic neoplasia formation.

Wang SC, Nassour I, Xiao S, Zhang S, Luo X, Lee J, Li L, Sun X, Nguyen LH, Chuang JC, Peng L, Daigle S, Shen J, Zhu H.

Gut. 2019 Jul;68(7):1259-1270. doi: 10.1136/gutjnl-2017-315490. Epub 2018 Oct 12.


1,25-Dihydroxyvitamin D3 enhances glucose-stimulated insulin secretion in mouse and human islets: a role for transcriptional regulation of voltage-gated calcium channels by the vitamin D receptor.

Kjalarsdottir L, Tersey SA, Vishwanath M, Chuang JC, Posner BA, Mirmira RG, Repa JJ.

J Steroid Biochem Mol Biol. 2019 Jan;185:17-26. doi: 10.1016/j.jsbmb.2018.07.004. Epub 2018 Jul 30.


Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2tm1.1Bird Mouse, a Model for Rett Syndrome.

Lütjohann D, Lopez AM, Chuang JC, Kerksiek A, Turley SD.

Lipids. 2018 Apr;53(4):363-373. doi: 10.1002/lipd.12041. Epub 2018 May 17.


A pooled analysis of advanced nonsquamous non-small cell lung cancer patients with stable treated brain metastases in two phase II trials receiving bevacizumab and pemetrexed as second-line therapy.

Gubens MA, Chuang JC, Akerley W, Langer CJ, Clément-Duchêne C, San Pedro-Salcedo M, Colevas AD, Dragnev K, Socinski MA, Wakelee HA.

J Thorac Dis. 2018 Jan;10(1):219-227. doi: 10.21037/jtd.2017.12.30.


Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.

Sun X, Wang SC, Wei Y, Luo X, Jia Y, Li L, Gopal P, Zhu M, Nassour I, Chuang JC, Maples T, Celen C, Nguyen LH, Wu L, Fu S, Li W, Hui L, Tian F, Ji Y, Zhang S, Sorouri M, Hwang TH, Letzig L, James L, Wang Z, Yopp AC, Singal AG, Zhu H.

Cancer Cell. 2018 Jan 8;33(1):151-152. doi: 10.1016/j.ccell.2017.12.011. No abstract available.


Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse.

Lopez AM, Chuang JC, Turley SD.

Steroids. 2018 Feb;130:7-14. doi: 10.1016/j.steroids.2017.11.015. Epub 2017 Dec 13.


Anaplastic Lymphoma Kinase Testing: IHC vs. FISH vs. NGS.

Niu X, Chuang JC, Berry GJ, Wakelee HA.

Curr Treat Options Oncol. 2017 Nov 16;18(12):71. doi: 10.1007/s11864-017-0513-x. Review.


Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer.

Sun X, Wang SC, Wei Y, Luo X, Jia Y, Li L, Gopal P, Zhu M, Nassour I, Chuang JC, Maples T, Celen C, Nguyen LH, Wu L, Fu S, Li W, Hui L, Tian F, Ji Y, Zhang S, Sorouri M, Hwang TH, Letzig L, James L, Wang Z, Yopp AC, Singal AG, Zhu H.

Cancer Cell. 2017 Nov 13;32(5):574-589.e6. doi: 10.1016/j.ccell.2017.10.007. Erratum in: Cancer Cell. 2018 Jan 8;33(1):151-152.


Arid1b haploinsufficient mice reveal neuropsychiatric phenotypes and reversible causes of growth impairment.

Celen C, Chuang JC, Luo X, Nijem N, Walker AK, Chen F, Zhang S, Chung AS, Nguyen LH, Nassour I, Budhipramono A, Sun X, Bok LA, McEntagart M, Gevers EF, Birnbaum SG, Eisch AJ, Powell CM, Ge WP, Santen GW, Chahrour M, Zhu H.

Elife. 2017 Jul 11;6. pii: e25730. doi: 10.7554/eLife.25730.


The persistent promise of combining HGF/MET and EGFR inhibition in non-small cell lung cancer.

Chuang JC, Neal JW.

Cancer. 2017 Aug 1;123(15):2798-2801. doi: 10.1002/cncr.30718. Epub 2017 May 4. No abstract available.


Quantitation of the rates of hepatic and intestinal cholesterol synthesis in lysosomal acid lipase-deficient mice before and during treatment with ezetimibe.

Chuang JC, Lopez AM, Turley SD.

Biochem Pharmacol. 2017 Jul 1;135:116-125. doi: 10.1016/j.bcp.2017.03.010. Epub 2017 Mar 18.


Measurement of Rates of Cholesterol and Fatty Acid Synthesis In Vivo Using Tritiated Water.

Lopez AM, Chuang JC, Turley SD.

Methods Mol Biol. 2017;1583:241-256. doi: 10.1007/978-1-4939-6875-6_18.


ERBB2-Mutated Metastatic Non-Small Cell Lung Cancer: Response and Resistance to Targeted Therapies.

Chuang JC, Stehr H, Liang Y, Das M, Huang J, Diehn M, Wakelee HA, Neal JW.

J Thorac Oncol. 2017 May;12(5):833-842. doi: 10.1016/j.jtho.2017.01.023. Epub 2017 Feb 4.


Genetic Variation in Choline-Metabolizing Enzymes Alters Choline Metabolism in Young Women Consuming Choline Intakes Meeting Current Recommendations.

Ganz AB, Cohen VV, Swersky CC, Stover J, Vitiello GA, Lovesky J, Chuang JC, Shields K, Fomin VG, Lopez YS, Mohan S, Ganti A, Carrier B, Malysheva OV, Caudill MA.

Int J Mol Sci. 2017 Jan 26;18(2). pii: E252. doi: 10.3390/ijms18020252.


'Corrigenda to "Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis" [Brain Res. 1654 (2017) 77-84]'.

Lopez AM, Chuang JC, Posey KS, Turley SD.

Brain Res. 2017 Feb 15;1657:383. doi: 10.1016/j.brainres.2016.12.016. Epub 2016 Dec 22. No abstract available.


Neoadjuvant and Adjuvant Therapy for Non-Small Cell Lung Cancer.

Chuang JC, Liang Y, Wakelee HA.

Hematol Oncol Clin North Am. 2017 Feb;31(1):31-44. doi: 10.1016/j.hoc.2016.08.011. Review.


Suppression of brain cholesterol synthesis in male Mecp2-deficient mice is age dependent and not accompanied by a concurrent change in the rate of fatty acid synthesis.

Lopez AM, Chuang JC, Posey KS, Turley SD.

Brain Res. 2017 Jan 1;1654(Pt A):77-84. doi: 10.1016/j.brainres.2016.10.021. Epub 2016 Oct 24. Erratum in: Brain Res. 2017 Feb 15;1657:383.


Concordant and Discordant EGFR Mutations in Patients With Multifocal Adenocarcinomas: Implications for EGFR-Targeted Therapy.

Chuang JC, Shrager JB, Wakelee HA, Neal JW.

Clin Ther. 2016 Jul;38(7):1567-76. doi: 10.1016/j.clinthera.2016.06.005. Epub 2016 Jun 29. Review.


Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.

Ganz AB, Shields K, Fomin VG, Lopez YS, Mohan S, Lovesky J, Chuang JC, Ganti A, Carrier B, Yan J, Taeswuan S, Cohen VV, Swersky CC, Stover JA, Vitiello GA, Malysheva OV, Mudrak E, Caudill MA.

FASEB J. 2016 Oct;30(10):3321-3333. Epub 2016 Jun 24.


Suppression of the SWI/SNF Component Arid1a Promotes Mammalian Regeneration.

Sun X, Chuang JC, Kanchwala M, Wu L, Celen C, Li L, Liang H, Zhang S, Maples T, Nguyen LH, Wang SC, Signer RA, Sorouri M, Nassour I, Liu X, Xu J, Wu M, Zhao Y, Kuo YC, Wang Z, Xing C, Zhu H.

Cell Stem Cell. 2016 Apr 7;18(4):456-66. doi: 10.1016/j.stem.2016.03.001. Epub 2016 Mar 24.


Rociletinib, a third generation EGFR tyrosine kinase inhibitor: current data and future directions.

Chuang JC, Salahudeen AA, Wakelee HA.

Expert Opin Pharmacother. 2016;17(7):989-93. doi: 10.1517/14656566.2016.1162786. Epub 2016 Apr 4. Review.


Crizotinib as first line therapy for advanced ALK-positive non-small cell lung cancers.

Chuang JC, Neal JW.

Transl Lung Cancer Res. 2015 Oct;4(5):639-41. doi: 10.3978/j.issn.2218-6751.2015.03.06. No abstract available.


Adult perceptions of dental fluorosis and select dental conditions-an Asian perspective.

Nair R, Chuang JC, Lee PS, Leo SJ, Yang NQ, Yee R, Tong HJ.

Community Dent Oral Epidemiol. 2016 Apr;44(2):135-44. doi: 10.1111/cdoe.12197. Epub 2015 Nov 12.


Pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimp.

Lai HC, Ng TH, Ando M, Lee CT, Chen IT, Chuang JC, Mavichak R, Chang SH, Yeh MD, Chiang YA, Takeyama H, Hamaguchi HO, Lo CF, Aoki T, Wang HC.

Fish Shellfish Immunol. 2015 Dec;47(2):1006-14. doi: 10.1016/j.fsi.2015.11.008. Epub 2015 Nov 6.


PRD125, a potent and selective inhibitor of sterol O-acyltransferase 2 markedly reduces hepatic cholesteryl ester accumulation and improves liver function in lysosomal acid lipase-deficient mice.

Lopez AM, Chuang JC, Posey KS, Ohshiro T, Tomoda H, Rudel LL, Turley SD.

J Pharmacol Exp Ther. 2015 Nov;355(2):159-67. doi: 10.1124/jpet.115.227207. Epub 2015 Aug 17.


Adjuvant therapy for EGFR mutant and ALK positive NSCLC: Current data and future prospects.

Chuang JC, Neal JW, Niu XM, Wakelee HA.

Lung Cancer. 2015 Oct;90(1):1-7. doi: 10.1016/j.lungcan.2015.07.016. Epub 2015 Jul 30. Review.


Lower Barthel Index Is Associated with Higher Risk of Hospitalization-Requiring Pneumonia in Long-Term Care Facilities.

Shiao CC, Hsu HC, Chen IL, Weng CY, Chuang JC, Lin SC, Tsai FF, Chen ZY.

Tohoku J Exp Med. 2015 Aug;236(4):281-8. doi: 10.1620/tjem.236.281.


Using urinary biomarkers to evaluate polycyclic aromatic hydrocarbon exposure in 126 preschool children in Ohio.

Morgan MK, Jones PA, Sobus JR, Chuang JC, Wilson NK.

Int J Environ Health Res. 2015;25(6):628-39. doi: 10.1080/09603123.2014.1003039. Epub 2015 Jan 23.


Comparison of True and Smoothed Puff Profile Replication on Smoking Behavior and Mainstream Smoke Emissions.

Brinkman MC, Kim H, Chuang JC, Kroeger RR, Deojay D, Clark PI, Gordon SM.

Chem Res Toxicol. 2015 Feb 16;28(2):182-90. doi: 10.1021/tx500318h. Epub 2015 Jan 13.


Impact of physiological levels of chenodeoxycholic acid supplementation on intestinal and hepatic bile acid and cholesterol metabolism in Cyp7a1-deficient mice.

Jones RD, Lopez AM, Tong EY, Posey KS, Chuang JC, Repa JJ, Turley SD.

Steroids. 2015 Jan;93:87-95. doi: 10.1016/j.steroids.2014.11.002. Epub 2014 Nov 28.


The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.

Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM.

Mol Psychiatry. 2015 Apr;20(4):500-8. doi: 10.1038/mp.2014.34. Epub 2014 Apr 22.


Impact of the loss of caveolin-1 on lung mass and cholesterol metabolism in mice with and without the lysosomal cholesterol transporter, Niemann-Pick type C1.

Mundy DI, Lopez AM, Posey KS, Chuang JC, Ramirez CM, Scherer PE, Turley SD.

Biochim Biophys Acta. 2014 Jul;1841(7):995-1002. doi: 10.1016/j.bbalip.2014.04.002. Epub 2014 Apr 18.


Exposures of 129 preschool children to organochlorines, organophosphates, pyrethroids, and acid herbicides at their homes and daycares in North Carolina.

Morgan MK, Wilson NK, Chuang JC.

Int J Environ Res Public Health. 2014 Apr 3;11(4):3743-64. doi: 10.3390/ijerph110403743.


Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin.

Wang Q, Liu C, Uchida A, Chuang JC, Walker A, Liu T, Osborne-Lawrence S, Mason BL, Mosher C, Berglund ED, Elmquist JK, Zigman JM.

Mol Metab. 2013 Oct 17;3(1):64-72. doi: 10.1016/j.molmet.2013.10.001. eCollection 2014 Feb.


Sustained and selective suppression of intestinal cholesterol synthesis by Ro 48-8071, an inhibitor of 2,3-oxidosqualene:lanosterol cyclase, in the BALB/c mouse.

Chuang JC, Valasek MA, Lopez AM, Posey KS, Repa JJ, Turley SD.

Biochem Pharmacol. 2014 Apr 1;88(3):351-63. doi: 10.1016/j.bcp.2014.01.031. Epub 2014 Jan 31.


Ezetimibe markedly attenuates hepatic cholesterol accumulation and improves liver function in the lysosomal acid lipase-deficient mouse, a model for cholesteryl ester storage disease.

Chuang JC, Lopez AM, Posey KS, Turley SD.

Biochem Biophys Res Commun. 2014 Jan 17;443(3):1073-7. doi: 10.1016/j.bbrc.2013.12.096. Epub 2013 Dec 25.


NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells.

Chuang AY, Chuang JC, Zhai Z, Wu F, Kwon JH.

Inflamm Bowel Dis. 2014 Jan;20(1):126-35. doi: 10.1097/01.MIB.0000436954.70596.9b.


Role of calcium and EPAC in norepinephrine-induced ghrelin secretion.

Mani BK, Chuang JC, Kjalarsdottir L, Sakata I, Walker AK, Kuperman A, Osborne-Lawrence S, Repa JJ, Zigman JM.

Endocrinology. 2014 Jan;155(1):98-107. doi: 10.1210/en.2013-1691. Epub 2013 Dec 20.


Determination of polychlorinated biphenyls in soil and sediment by selective pressurized liquid extraction with immunochemical detection.

Van Emon JM, Chuang JC, Bronshtein A, Altstein M.

Sci Total Environ. 2013 Oct 1;463-464:326-33. doi: 10.1016/j.scitotenv.2013.05.020. Epub 2013 Jul 2.


Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.

Chin M, Lee CY, Chuang JC, Bumeister R, Wigley WC, Sonis ST, Ward KW, Meyer C.

Am J Physiol Renal Physiol. 2013 Jun 15;304(12):F1438-46. doi: 10.1152/ajprenal.00387.2012. Epub 2013 Apr 17.


Characterization of gastric and neuronal histaminergic populations using a transgenic mouse model.

Walker AK, Park WM, Chuang JC, Perello M, Sakata I, Osborne-Lawrence S, Zigman JM.

PLoS One. 2013;8(3):e60276. doi: 10.1371/journal.pone.0060276. Epub 2013 Mar 29.


Differential effects of chronic social stress and fluoxetine on meal patterns in mice.

Kumar J, Chuang JC, Na ES, Kuperman A, Gillman AG, Mukherjee S, Zigman JM, McClung CA, Lutter M.

Appetite. 2013 May;64:81-8. doi: 10.1016/j.appet.2012.12.023. Epub 2013 Jan 11.


Hindbrain ghrelin receptor signaling is sufficient to maintain fasting glucose.

Scott MM, Perello M, Chuang JC, Sakata I, Gautron L, Lee CE, Lauzon D, Elmquist JK, Zigman JM.

PLoS One. 2012;7(8):e44089. doi: 10.1371/journal.pone.0044089. Epub 2012 Aug 31.


Development of a simultaneous extraction and cleanup method for pyrethroid pesticides from indoor house dust samples.

Van Emon JM, Chuang JC.

Anal Chim Acta. 2012 Oct 1;745:38-44. doi: 10.1016/j.aca.2012.07.031. Epub 2012 Jul 27.


Development and application of immunoaffinity chromatography for coplanar PCBs in soil and sediment.

Van Emon JM, Chuang JC.

Chemosphere. 2013 Jan;90(1):1-6. doi: 10.1016/j.chemosphere.2012.06.053. Epub 2012 Aug 18.


Feeding hermit crabs to shrimp broodstock increases their risk of WSSV infection.

Chang YS, Liu WJ, Chen TC, Chan TY, Liu KF, Chuang JC, Kou GH, Lo CF, Wang HC.

Dis Aquat Organ. 2012 Apr 26;98(3):193-9. doi: 10.3354/dao02447.


Exposure to and deposition of fine and ultrafine particles in smokers of menthol and nonmenthol cigarettes.

Brinkman MC, Chuang JC, Gordon SM, Kim H, Kroeger RR, Polzin GM, Richter PA.

Inhal Toxicol. 2012 Apr;24(5):255-69. doi: 10.3109/08958378.2012.667218.


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