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Items: 13

1.

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.

Douglas G, Mehta V, Zen AAH, Akoumianakis I, Goel A, Rashbrook VS, Trelfa L, Donovan L, Drydale E, Chuaiphichai S, Antoniades C, Watkins H, Kyriakou T, Tzima E, Channon KM.

Cardiovasc Res. 2019 Oct 4. pii: cvz263. doi: 10.1093/cvr/cvz263. [Epub ahead of print]

PMID:
31584065
2.

Adipose tissue-derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases.

Akoumianakis I, Sanna F, Margaritis M, Badi I, Akawi N, Herdman L, Coutinho P, Fagan H, Antonopoulos AS, Oikonomou EK, Thomas S, Chiu AP, Chuaiphichai S, Kotanidis CP, Christodoulides C, Petrou M, Krasopoulos G, Sayeed R, Lv L, Hale A, Naeimi Kararoudi M, McNeill E, Douglas G, George S, Tousoulis D, Channon KM, Antoniades C.

Sci Transl Med. 2019 Sep 18;11(510). pii: eaav5055. doi: 10.1126/scitranslmed.aav5055.

PMID:
31534019
3.

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation.

Bailey JD, Diotallevi M, Nicol T, McNeill E, Shaw A, Chuaiphichai S, Hale A, Starr A, Nandi M, Stylianou E, McShane H, Davis S, Fischer R, Kessler BM, McCullagh J, Channon KM, Crabtree MJ.

Cell Rep. 2019 Jul 2;28(1):218-230.e7. doi: 10.1016/j.celrep.2019.06.018.

4.

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II-Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm.

Chuaiphichai S, Rashbrook VS, Hale AB, Trelfa L, Patel J, McNeill E, Lygate CA, Channon KM, Douglas G.

Hypertension. 2018 Jul;72(1):128-138. doi: 10.1161/HYPERTENSIONAHA.118.11144. Epub 2018 May 29.

5.

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II-mediated blood pressure control.

Patel J, Chuaiphichai S, Douglas G, Gorvin CM, Channon KM.

Vascul Pharmacol. 2018 Sep;108:15-22. doi: 10.1016/j.vph.2018.04.002. Epub 2018 Apr 11.

6.

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.

Douglas G, Hale AB, Patel J, Chuaiphichai S, Al Haj Zen A, Rashbrook VS, Trelfa L, Crabtree MJ, McNeill E, Channon KM.

Cardiovasc Res. 2018 Aug 1;114(10):1385-1399. doi: 10.1093/cvr/cvy078.

7.

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice.

Chuaiphichai S, Crabtree MJ, Mcneill E, Hale AB, Trelfa L, Channon KM, Douglas G.

Br J Pharmacol. 2017 Apr;174(8):657-671. doi: 10.1111/bph.13728. Epub 2017 Mar 13.

8.

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension.

Chuaiphichai S, Starr A, Nandi M, Channon KM, McNeill E.

Vascul Pharmacol. 2016 Feb;77:69-79. doi: 10.1016/j.vph.2015.08.009. Epub 2015 Aug 11.

9.

Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway.

Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ.

Neuron. 2015 Jun 17;86(6):1393-406. doi: 10.1016/j.neuron.2015.05.033.

10.

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.

McNeill E, Crabtree MJ, Sahgal N, Patel J, Chuaiphichai S, Iqbal AJ, Hale AB, Greaves DR, Channon KM.

Free Radic Biol Med. 2015 Feb;79:206-16. doi: 10.1016/j.freeradbiomed.2014.10.575. Epub 2014 Nov 6.

11.

Crucial role for neuronal nitric oxide synthase in early microcirculatory derangement and recipient survival following murine pancreas transplantation.

Cardini B, Watschinger K, Hermann M, Obrist P, Oberhuber R, Brandacher G, Chuaiphichai S, Channon KM, Pratschke J, Maglione M, Werner ER.

PLoS One. 2014 Nov 12;9(11):e112570. doi: 10.1371/journal.pone.0112570. eCollection 2014.

12.

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

Chuaiphichai S, McNeill E, Douglas G, Crabtree MJ, Bendall JK, Hale AB, Alp NJ, Channon KM.

Hypertension. 2014 Sep;64(3):530-40. doi: 10.1161/HYPERTENSIONAHA.114.03089. Epub 2014 Apr 28.

13.

A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): effects on tetrahydrobiopterin-dependent catalysis and eNOS dimerization.

Benson MA, Batchelor H, Chuaiphichai S, Bailey J, Zhu H, Stuehr DJ, Bhattacharya S, Channon KM, Crabtree MJ.

J Biol Chem. 2013 Oct 11;288(41):29836-45. doi: 10.1074/jbc.M113.493023. Epub 2013 Aug 21.

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