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Items: 16

1.

Identification of gene products that control lipid droplet size in yeast using a high-throughput quantitative image analysis.

Lv X, Liu J, Qin Y, Liu Y, Jin M, Dai J, Chua BT, Yang H, Li P.

Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Nov 7. pii: S1388-1981(18)30356-1. doi: 10.1016/j.bbalip.2018.11.001. [Epub ahead of print]

PMID:
30414449
2.

Polybasic RKKR motif in the linker region of lipid droplet (LD)-associated protein CIDEC inhibits LD fusion by interacting with acidic phospholipids.

Wang J, Yan C, Xu C, Chua BT, Li P, Chen FJ.

J Biol Chem. 2018 Oct 25. pii: jbc.RA118.004892. doi: 10.1074/jbc.RA118.004892. [Epub ahead of print]

3.

Autophagy Governs Protumorigenic Effects of Mitotic Slippage-induced Senescence.

Jakhar R, Luijten MNH, Wong AXF, Cheng B, Guo K, Neo SP, Au B, Kulkarni M, Lim KJ, Maimaiti J, Chong HC, Lim EH, Tan TBK, Ong KW, Sim Y, Wong JSL, Khoo JBK, Ho JTS, Chua BT, Sinha I, Wang X, Connolly JE, Gunaratne J, Crasta KC.

Mol Cancer Res. 2018 Nov;16(11):1625-1640. doi: 10.1158/1541-7786.MCR-18-0024. Epub 2018 Jul 23.

PMID:
30037855
4.

Primary angle closure glaucoma (PACG) susceptibility gene PLEKHA7 encodes a novel Rac1/Cdc42 GAP that modulates cell migration and blood-aqueous barrier function.

Lee MC, Shei W, Chan AS, Chua BT, Goh SR, Chong YF, Hilmy MH, Nongpiur ME, Baskaran M, Khor CC, Aung T, Hunziker W, Vithana EN.

Hum Mol Genet. 2017 Oct 15;26(20):4011-4027. doi: 10.1093/hmg/ddx292.

PMID:
29016860
5.

Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma.

Tan DSW, Chong FT, Leong HS, Toh SY, Lau DP, Kwang XL, Zhang X, Sundaram GM, Tan GS, Chang MM, Chua BT, Lim WT, Tan EH, Ang MK, Lim TKH, Sampath P, Chowbay B, Skanderup AJ, DasGupta R, Iyer NG.

Nat Med. 2017 Oct;23(10):1167-1175. doi: 10.1038/nm.4401. Epub 2017 Sep 18.

PMID:
28920960
6.

Overexpression of Tyro3 and its implications on hepatocellular carcinoma progression.

Duan Y, Wong W, Chua SC, Wee HL, Lim SG, Chua BT, Ho HK.

Int J Oncol. 2016 Jan;48(1):358-66. doi: 10.3892/ijo.2015.3244. Epub 2015 Nov 13.

PMID:
26573872
7.

Benzylidene-indolinones are effective as multi-targeted kinase inhibitor therapeutics against hepatocellular carcinoma.

Ho HK, Chua BT, Wong W, Lim KS, Teo V, Ong HT, Chen X, Zhang W, Hui KM, Go ML, Ullrich A.

Mol Oncol. 2014 Oct;8(7):1266-77. doi: 10.1016/j.molonc.2014.04.008. Epub 2014 May 2.

8.

Bosutinib inhibits migration and invasion via ACK1 in KRAS mutant non-small cell lung cancer.

Tan DS, Haaland B, Gan JM, Tham SC, Sinha I, Tan EH, Lim KH, Takano A, Krisna SS, Thu MM, Liew HP, Ullrich A, Lim WT, Chua BT.

Mol Cancer. 2014 Jan 24;13:13. doi: 10.1186/1476-4598-13-13.

9.

Current strategies for inhibiting FGFR activities in clinical applications: opportunities, challenges and toxicological considerations.

Ho HK, Yeo AH, Kang TS, Chua BT.

Drug Discov Today. 2014 Jan;19(1):51-62. doi: 10.1016/j.drudis.2013.07.021. Epub 2013 Aug 6. Review.

PMID:
23932951
10.

Developing FGFR4 inhibitors as potential anti-cancer agents via in silico design, supported by in vitro and cell-based testing.

Ho HK, Németh G, Ng YR, Pang E, Szántai-Kis C, Zsákai L, Breza N, Greff Z, Horváth Z, Pató J, Szabadkai I, Szokol B, Baska F, Őrfî L, Ullrich A, Kéri G, Chua BT.

Curr Med Chem. 2013;20(10):1203-17.

PMID:
23409720
11.

Klotho-beta overexpression as a novel target for suppressing proliferation and fibroblast growth factor receptor-4 signaling in hepatocellular carcinoma.

Poh W, Wong W, Ong H, Aung MO, Lim SG, Chua BT, Ho HK.

Mol Cancer. 2012 Mar 23;11:14. doi: 10.1186/1476-4598-11-14.

12.

Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells.

Chua BT, Lim SJ, Tham SC, Poh WJ, Ullrich A.

Mol Oncol. 2010 Aug;4(4):323-34. doi: 10.1016/j.molonc.2010.03.001. Epub 2010 Mar 19.

13.

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.

Chua BT, Gallego-Ortega D, Ramirez de Molina A, Ullrich A, Lacal JC, Downward J.

Mol Cancer. 2009 Dec 31;8:131. doi: 10.1186/1476-4598-8-131.

14.

The critical role of calpain versus caspase activation in excitotoxic injury induced by nitric oxide.

Volbracht C, Chua BT, Ng CP, Bahr BA, Hong W, Li P.

J Neurochem. 2005 Jun;93(5):1280-92. Erratum in: J Neurochem. 2005 Sep;94(5):1471.

15.

Mitochondrial translocation of cofilin is an early step in apoptosis induction.

Chua BT, Volbracht C, Tan KO, Li R, Yu VC, Li P.

Nat Cell Biol. 2003 Dec;5(12):1083-9. Epub 2003 Nov 23.

PMID:
14634665
16.

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