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Items: 1 to 50 of 65

1.

Catalyst free hydrazone ligation for protein labeling and modification using electron-deficient benzaldehyde reagents.

Xu Y, Wang Y, Liu P, Chu GC, Xu H, Li YM, Wang J, Shi J.

Org Biomol Chem. 2018 Oct 3;16(38):7036-7040. doi: 10.1039/c8ob01810c.

PMID:
30238118
2.

R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc.

Lin TP, Li J, Li Q, Li X, Liu C, Zeng N, Huang JM, Chu GC, Lin CH, Zhau HE, Chung LWK, Wu BJ, Shih JC.

Mol Cancer Res. 2018 Jul 24. doi: 10.1158/1541-7786.MCR-16-0346. [Epub ahead of print]

PMID:
30042175
3.

Serum and blood based biomarkers for lung cancer screening: a systematic review.

Chu GCW, Lazare K, Sullivan F.

BMC Cancer. 2018 Feb 13;18(1):181. doi: 10.1186/s12885-018-4024-3. Review.

4.

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism.

Biancur DE, Paulo JA, Małachowska B, Quiles Del Rey M, Sousa CM, Wang X, Sohn ASW, Chu GC, Gygi SP, Harper JW, Fendler W, Mancias JD, Kimmelman AC.

Nat Commun. 2017 Jul 3;8:15965. doi: 10.1038/ncomms15965.

5.

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer.

Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, Wang YA, Kwong LN, DePinho RA.

Genes Dev. 2017 Feb 15;31(4):370-382. doi: 10.1101/gad.293449.116. Epub 2017 Mar 13.

6.

Keratin 13 expression reprograms bone and brain metastases of human prostate cancer cells.

Li Q, Yin L, Jones LW, Chu GC, Wu JB, Huang JM, Li Q, You S, Kim J, Lu YT, Mrdenovic S, Wang R, Freeman MR, Garraway I, Lewis MS, Chung LW, Zhau HE.

Oncotarget. 2016 Dec 20;7(51):84645-84657. doi: 10.18632/oncotarget.13175.

7.

Cultured circulating tumor cells and their derived xenografts for personalized oncology.

Wang R, Chu GCY, Mrdenovic S, Annamalai AA, Hendifar AE, Nissen NN, Tomlinson JS, Lewis M, Palanisamy N, Tseng HR, Posadas EM, Freeman MR, Pandol SJ, Zhau HE, Chung LWK.

Asian J Urol. 2016 Oct;3(4):240-253. doi: 10.1016/j.ajur.2016.08.005. Epub 2016 Aug 25. Review.

8.

Regulation of prostate cancer progression by the tumor microenvironment.

Shiao SL, Chu GC, Chung LW.

Cancer Lett. 2016 Sep 28;380(1):340-8. doi: 10.1016/j.canlet.2015.12.022. Epub 2016 Jan 28. Review.

9.

Prostate cancer metastasis: roles of recruitment and reprogramming, cell signal network and three-dimensional growth characteristics.

Ziaee S, Chu GC, Huang JM, Sieh S, Chung LW.

Transl Androl Urol. 2015 Aug;4(4):438-54. doi: 10.3978/j.issn.2223-4683.2015.04.10. Review.

10.

SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer.

Gururajan M, Cavassani KA, Sievert M, Duan P, Lichterman J, Huang JM, Smith B, You S, Nandana S, Chu GC, Mink S, Josson S, Liu C, Morello M, Jones LW, Kim J, Freeman MR, Bhowmick N, Zhau HE, Chung LW, Posadas EM.

Oncotarget. 2015 Dec 29;6(42):44072-83. doi: 10.18632/oncotarget.6398.

11.

Near-infrared fluorescence heptamethine carbocyanine dyes mediate imaging and targeted drug delivery for human brain tumor.

Wu JB, Shi C, Chu GC, Xu Q, Zhang Y, Li Q, Yu JS, Zhau HE, Chung LW.

Biomaterials. 2015 Oct;67:1-10. doi: 10.1016/j.biomaterials.2015.07.028. Epub 2015 Jul 16.

12.

Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF-1α/OATPs signaling axis.

Shi C, Wu JB, Chu GC, Li Q, Wang R, Zhang C, Zhang Y, Kim HL, Wang J, Zhau HE, Pan D, Chung LW.

Oncotarget. 2014 Oct 30;5(20):10114-26.

13.

miR-154* and miR-379 in the DLK1-DIO3 microRNA mega-cluster regulate epithelial to mesenchymal transition and bone metastasis of prostate cancer.

Gururajan M, Josson S, Chu GC, Lu CL, Lu YT, Haga CL, Zhau HE, Liu C, Lichterman J, Duan P, Posadas EM, Chung LW.

Clin Cancer Res. 2014 Dec 15;20(24):6559-69. doi: 10.1158/1078-0432.CCR-14-1784. Epub 2014 Oct 16.

14.

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.

Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA.

Cell. 2014 Jul 3;158(1):185-197. doi: 10.1016/j.cell.2014.06.003. Epub 2014 Jun 19.

15.

Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations.

Yang A, Rajeshkumar NV, Wang X, Yabuuchi S, Alexander BM, Chu GC, Von Hoff DD, Maitra A, Kimmelman AC.

Cancer Discov. 2014 Aug;4(8):905-13. doi: 10.1158/2159-8290.CD-14-0362. Epub 2014 May 29.

16.

RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization.

Chu GC, Zhau HE, Wang R, Rogatko A, Feng X, Zayzafoon M, Liu Y, Farach-Carson MC, You S, Kim J, Freeman MR, Chung LW.

Endocr Relat Cancer. 2014 Mar 4;21(2):311-26. doi: 10.1530/ERC-13-0548. Print 2014 Apr.

17.

RANK-mediated signaling network and cancer metastasis.

Chu GC, Chung LW.

Cancer Metastasis Rev. 2014 Sep;33(2-3):497-509. doi: 10.1007/s10555-013-9488-7. Review.

18.

Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee.

Ittmann M, Huang J, Radaelli E, Martin P, Signoretti S, Sullivan R, Simons BW, Ward JM, Robinson BD, Chu GC, Loda M, Thomas G, Borowsky A, Cardiff RD.

Cancer Res. 2013 May 1;73(9):2718-36. doi: 10.1158/0008-5472.CAN-12-4213. Epub 2013 Apr 22.

19.

Assessment of acute myocarditis by cardiovascular MR: diagnostic performance of shortened protocols.

Chu GC, Flewitt JA, Mikami Y, Vermes E, Friedrich MG.

Int J Cardiovasc Imaging. 2013 Jun;29(5):1077-83. doi: 10.1007/s10554-013-0189-7. Epub 2013 Feb 13.

PMID:
23404383
20.

Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression.

Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM.

Cancer Discov. 2013 Mar;3(3):294-307. doi: 10.1158/2159-8290.CD-12-0198. Epub 2012 Dec 28.

21.

Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.

Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, Jakubosky D, Genovese G, Muller FL, Jeong JH, Bender RP, Chu GC, Flaherty KT, Wargo JA, Collins JJ, Chin L.

Nat Med. 2012 Oct;18(10):1503-10. doi: 10.1038/nm.2941. Epub 2012 Sep 16. Erratum in: Nat Med. 2012 Dec;18(12):1857.

22.

Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.

Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher-Sananikone E, Locasale JW, Son J, Zhang H, Coloff JL, Yan H, Wang W, Chen S, Viale A, Zheng H, Paik JH, Lim C, Guimaraes AR, Martin ES, Chang J, Hezel AF, Perry SR, Hu J, Gan B, Xiao Y, Asara JM, Weissleder R, Wang YA, Chin L, Cantley LC, DePinho RA.

Cell. 2012 Apr 27;149(3):656-70. doi: 10.1016/j.cell.2012.01.058.

23.

Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases.

Ding Z, Wu CJ, Jaskelioff M, Ivanova E, Kost-Alimova M, Protopopov A, Chu GC, Wang G, Lu X, Labrot ES, Hu J, Wang W, Xiao Y, Zhang H, Zhang J, Zhang J, Gan B, Perry SR, Jiang S, Li L, Horner JW, Wang YA, Chin L, DePinho RA.

Cell. 2012 Mar 2;148(5):896-907. doi: 10.1016/j.cell.2012.01.039. Epub 2012 Feb 16.

24.

Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer.

Hu P, Chu GC, Zhu G, Yang H, Luthringer D, Prins G, Habib F, Wang Y, Wang R, Chung LW, Zhau HE.

PLoS One. 2011;6(12):e28670. doi: 10.1371/journal.pone.0028670. Epub 2011 Dec 21.

25.

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma.

Olson P, Chu GC, Perry SR, Nolan-Stevaux O, Hanahan D.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1275-84. doi: 10.1073/pnas.1111079108. Epub 2011 Nov 14.

26.

PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network.

Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, Fletcher-Sananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik JH, Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF, Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA.

Cancer Discov. 2011 Jul;1(2):158-69. doi: 10.1158/2159-8290.CD-11-0031. Epub 2011 May 23.

27.

Proinvasion metastasis drivers in early-stage melanoma are oncogenes.

Scott KL, Nogueira C, Heffernan TP, van Doorn R, Dhakal S, Hanna JA, Min C, Jaskelioff M, Xiao Y, Wu CJ, Cameron LA, Perry SR, Zeid R, Feinberg T, Kim M, Vande Woude G, Granter SR, Bosenberg M, Chu GC, DePinho RA, Rimm DL, Chin L.

Cancer Cell. 2011 Jul 12;20(1):92-103. doi: 10.1016/j.ccr.2011.05.025.

28.

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]

Moskowitz IP, Wang J, Peterson MA, Pu WT, Mackinnon AC, Oxburgh L, Chu GC, Sarkar M, Berul C, Smoot L, Robertson EJ, Schwartz R, Seidman JG, Seidman CE.

Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4006-11. doi: 10.1073/pnas.1019025108. Epub 2011 Feb 17. Erratum in: Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5921.

29.

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.

Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, Zhang J, Perry SR, Labrot ES, Wu X, Lis R, Hoshida Y, Hiller D, Hu B, Jiang S, Zheng H, Stegh AH, Scott KL, Signoretti S, Bardeesy N, Wang YA, Hill DE, Golub TR, Stampfer MJ, Wong WH, Loda M, Mucci L, Chin L, DePinho RA.

Nature. 2011 Feb 10;470(7333):269-73. doi: 10.1038/nature09677. Epub 2011 Feb 2.

30.

Identification of methionine sulfoxide diastereomers in immunoglobulin gamma antibodies using methionine sulfoxide reductase enzymes.

Khor HK, Jacoby ME, Squier TC, Chu GC, Chelius D.

MAbs. 2010 May-Jun;2(3):299-308. Epub 2010 May 11.

31.

Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras.

Gidekel Friedlander SY, Chu GC, Snyder EL, Girnius N, Dibelius G, Crowley D, Vasile E, DePinho RA, Jacks T.

Cancer Cell. 2009 Nov 6;16(5):379-89. doi: 10.1016/j.ccr.2009.09.027.

32.

Pten and p53 converge on c-Myc to control differentiation, self-renewal, and transformation of normal and neoplastic stem cells in glioblastoma.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, dePinho RA.

Cold Spring Harb Symp Quant Biol. 2008;73:427-37. doi: 10.1101/sqb.2008.73.047. Epub 2009 Jan 15.

PMID:
19150964
33.

GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation.

Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández-Zapico ME, Hanahan D.

Genes Dev. 2009 Jan 1;23(1):24-36. doi: 10.1101/gad.1753809.

34.

Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.

Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RA.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19372-7. doi: 10.1073/pnas.0809966105. Epub 2008 Dec 2.

35.

Ott1 (Rbm15) is essential for placental vascular branching morphogenesis and embryonic development of the heart and spleen.

Raffel GD, Chu GC, Jesneck JL, Cullen DE, Bronson RT, Bernard OA, Gilliland DG.

Mol Cell Biol. 2009 Jan;29(2):333-41. doi: 10.1128/MCB.00370-08. Epub 2008 Nov 3.

36.

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z, Stommel JM, Dunn KL, Wiedemeyer R, You MJ, Brennan C, Wang YA, Ligon KL, Wong WH, Chin L, DePinho RA.

Nature. 2008 Oct 23;455(7216):1129-33. doi: 10.1038/nature07443.

37.

Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development.

Wiedemeyer R, Brennan C, Heffernan TP, Xiao Y, Mahoney J, Protopopov A, Zheng H, Bignell G, Furnari F, Cavenee WK, Hahn WC, Ichimura K, Collins VP, Chu GC, Stratton MR, Ligon KL, Futreal PA, Chin L.

Cancer Cell. 2008 Apr;13(4):355-64. doi: 10.1016/j.ccr.2008.02.010.

38.

Specific requirement of the chromatin modifier mSin3B in cell cycle exit and cellular differentiation.

David G, Grandinetti KB, Finnerty PM, Simpson N, Chu GC, Depinho RA.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4168-72. doi: 10.1073/pnas.0710285105. Epub 2008 Mar 10.

39.

Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.

Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA.

Mol Cell Biol. 2008 Apr;28(7):2414-25. doi: 10.1128/MCB.01621-07. Epub 2008 Jan 28.

40.

Optic disc measurements in myopia with optical coherence tomography and confocal scanning laser ophthalmoscopy.

Leung CK, Cheng AC, Chong KK, Leung KS, Mohamed S, Lau CS, Cheung CY, Chu GC, Lai RY, Pang CC, Lam DS.

Invest Ophthalmol Vis Sci. 2007 Jul;48(7):3178-83.

PMID:
17591887
41.

Accumulation of succinimide in a recombinant monoclonal antibody in mildly acidic buffers under elevated temperatures.

Chu GC, Chelius D, Xiao G, Khor HK, Coulibaly S, Bondarenko PV.

Pharm Res. 2007 Jun;24(6):1145-56. Epub 2007 Mar 24.

PMID:
17385019
42.

18O labeling method for identification and quantification of succinimide in proteins.

Xiao G, Bondarenko PV, Jacob J, Chu GC, Chelius D.

Anal Chem. 2007 Apr 1;79(7):2714-21. Epub 2007 Feb 22.

PMID:
17313184
43.

Stromal biology of pancreatic cancer.

Chu GC, Kimmelman AC, Hezel AF, DePinho RA.

J Cell Biochem. 2007 Jul 1;101(4):887-907. Review.

PMID:
17266048
44.

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer.

Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D, DePinho RA.

Genes Dev. 2006 Nov 15;20(22):3130-46.

45.

Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA.

Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52. Epub 2006 Apr 3.

46.

XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands.

Lee AH, Chu GC, Iwakoshi NN, Glimcher LH.

EMBO J. 2005 Dec 21;24(24):4368-80. Epub 2005 Dec 15.

47.

TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.

Oxburgh L, Chu GC, Michael SK, Robertson EJ.

Development. 2004 Sep;131(18):4593-605.

48.

Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.

Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ.

Development. 2004 Aug;131(15):3501-12. Epub 2004 Jun 23.

49.

Effect of alcohol on the efficacy of excimer laser power.

Cheng AC, Law RW, Young AL, Chu GC, Lam DS.

J Cataract Refract Surg. 2004 Jul;30(7):1545-8.

PMID:
15210236
50.

Crystal structure of the dioxygen-bound heme oxygenase from Corynebacterium diphtheriae: implications for heme oxygenase function.

Unno M, Matsui T, Chu GC, Couture M, Yoshida T, Rousseau DL, Olson JS, Ikeda-Saito M.

J Biol Chem. 2004 May 14;279(20):21055-61. Epub 2004 Feb 13.

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