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Classification systems for platelet-rich plasma.

Rossi LA, Murray IR, Chu CR, Muschler GF, Rodeo SA, Piuzzi NS.

Bone Joint J. 2019 Aug;101-B(8):891-896. doi: 10.1302/0301-620X.101B8.BJJ-2019-0037.R1.


IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis.

Wang Q, Lepus CM, Raghu H, Reber LL, Tsai MM, Wong HH, von Kaeppler E, Lingampalli N, Bloom MS, Hu N, Elliott EE, Oliviero F, Punzi L, Giori NJ, Goodman SB, Chu CR, Sokolove J, Fukuoka Y, Schwartz LB, Galli SJ, Robinson WH.

Elife. 2019 May 14;8. pii: e39905. doi: 10.7554/eLife.39905.


Adaptive Sports and the Warrior Athlete.

Chu CR, Diaz R, Syrop IP.

Sports Med Arthrosc Rev. 2019 Jun;27(2):41. doi: 10.1097/JSA.0000000000000245. No abstract available.


Platelet-Rich Plasma (PRP) From Older Males With Knee Osteoarthritis Depresses Chondrocyte Metabolism and Upregulates Inflammation.

O'Donnell C, Migliore E, Grandi FC, Koltsov J, Lingampalli N, Cisar C, Indelli PF, Sebastiano V, Robinson WH, Bhutani N, Chu CR.

J Orthop Res. 2019 May 1. doi: 10.1002/jor.24322. [Epub ahead of print]


Changes in stair ascent biomechanics two to eight years after ACL reconstruction are associated with patient-reported outcomes.

Fischer AG, Erhart-Hledik JC, Chu CR, Asay JL, Andriacchi TP.

Gait Posture. 2019 Mar;69:91-95. doi: 10.1016/j.gaitpost.2019.01.029. Epub 2019 Jan 22.


Activating the somatosensory system enhances net quadriceps moment during gait.

Fischer AG, Erhart-Hledik JC, Asay JL, Chu CR, Andriacchi TP.

J Biomech. 2019 Jan 3;82:149-155. doi: 10.1016/j.jbiomech.2018.10.026. Epub 2018 Oct 26.


Proceedings of the signature series symposium "cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies-promise, facts and fantasy," international society for cellular therapies, montreal, canada, may 2, 2018.

Piuzzi NS, Dominici M, Long M, Pascual-Garrido C, Rodeo S, Huard J, Guicheux J, McFarland R, Goodrich LR, Maddens S, Robey PG, Bauer TW, Barrett J, Barry F, Karli D, Chu CR, Weiss DJ, Martin I, Jorgensen C, Muschler GF.

Cytotherapy. 2018 Nov;20(11):1381-1400. doi: 10.1016/j.jcyt.2018.09.001. Epub 2018 Oct 10.


Optimizing Clinical Use of Biologics in Orthopaedic Surgery: Consensus Recommendations From the 2018 AAOS/NIH U-13 Conference.

Chu CR, Rodeo S, Bhutani N, Goodrich LR, Huard J, Irrgang J, LaPrade RF, Lattermann C, Lu Y, Mandelbaum B, Mao J, McIntyre L, Mishra A, Muschler GF, Piuzzi NS, Potter H, Spindler K, Tokish JM, Tuan R, Zaslav K, Maloney W.

J Am Acad Orthop Surg. 2019 Jan 15;27(2):e50-e63. doi: 10.5435/JAAOS-D-18-00305.


MRI UTE-T2* shows high incidence of cartilage subsurface matrix changes 2 years after ACL reconstruction.

Williams AA, Titchenal MR, Do BH, Guha A, Chu CR.

J Orthop Res. 2019 Feb;37(2):370-377. doi: 10.1002/jor.24110. Epub 2019 Jan 8.


MRI UTE-T2* profile characteristics correlate to walking mechanics and patient reported outcomes 2 years after ACL reconstruction.

Williams AA, Titchenal MR, Andriacchi TP, Chu CR.

Osteoarthritis Cartilage. 2018 Apr;26(4):569-579. doi: 10.1016/j.joca.2018.01.012. Epub 2018 Feb 7.


Minimally Manipulated Bone Marrow Concentrate Compared with Microfracture Treatment of Full-Thickness Chondral Defects: A One-Year Study in an Equine Model.

Chu CR, Fortier LA, Williams A, Payne KA, McCarrel TM, Bowers ME, Jaramillo D.

J Bone Joint Surg Am. 2018 Jan 17;100(2):138-146. doi: 10.2106/JBJS.17.00132.


Cartilage Subsurface Changes to Magnetic Resonance Imaging UTE-T2* 2 Years After Anterior Cruciate Ligament Reconstruction Correlate With Walking Mechanics Associated With Knee Osteoarthritis.

Titchenal MR, Williams AA, Chehab EF, Asay JL, Dragoo JL, Gold GE, McAdams TR, Andriacchi TP, Chu CR.

Am J Sports Med. 2018 Mar;46(3):565-572. doi: 10.1177/0363546517743969. Epub 2018 Jan 2.


Men and Women Differ in the Biochemical Composition of Platelet-Rich Plasma.

Xiong G, Lingampalli N, Koltsov JCB, Leung LL, Bhutani N, Robinson WH, Chu CR.

Am J Sports Med. 2018 Feb;46(2):409-419. doi: 10.1177/0363546517740845. Epub 2017 Dec 6.


Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β.

Lee J, Smeriglio P, Chu CR, Bhutani N.

Stem Cell Res Ther. 2017 Nov 2;8(1):244. doi: 10.1186/s13287-017-0696-x.


Longitudinal changes in knee gait mechanics between 2 and 8 years after anterior cruciate ligament reconstruction.

Erhart-Hledik JC, Chu CR, Asay JL, Andriacchi TP.

J Orthop Res. 2018 May;36(5):1478-1486. doi: 10.1002/jor.23770. Epub 2017 Nov 22.


Mechanically stimulated biomarkers signal cartilage changes over 5 years consistent with disease progression in medial knee osteoarthritis patients.

Chu CR, Sheth S, Erhart-Hledik JC, Do B, Titchenal MR, Andriacchi TP.

J Orthop Res. 2018 Mar;36(3):891-897. doi: 10.1002/jor.23720. Epub 2017 Sep 27.


Effects of active feedback gait retraining to produce a medial weight transfer at the foot in subjects with symptomatic medial knee osteoarthritis.

Erhart-Hledik JC, Asay JL, Clancy C, Chu CR, Andriacchi TP.

J Orthop Res. 2017 Oct;35(10):2251-2259. doi: 10.1002/jor.23527. Epub 2017 Feb 9.


CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis.

Raghu H, Lepus CM, Wang Q, Wong HH, Lingampalli N, Oliviero F, Punzi L, Giori NJ, Goodman SB, Chu CR, Sokolove JB, Robinson WH.

Ann Rheum Dis. 2017 May;76(5):914-922. doi: 10.1136/annrheumdis-2016-210426. Epub 2016 Dec 13.


Early Changes in Knee Center of Rotation During Walking After Anterior Cruciate Ligament Reconstruction Correlate With Later Changes in Patient-Reported Outcomes.

Titchenal MR, Chu CR, Erhart-Hledik JC, Andriacchi TP.

Am J Sports Med. 2017 Mar;45(4):915-921. doi: 10.1177/0363546516673835. Epub 2016 Nov 25.


Early articular cartilage MRI T2 changes after anterior cruciate ligament reconstruction correlate with later changes in T2 and cartilage thickness.

Williams A, Winalski CS, Chu CR.

J Orthop Res. 2017 Mar;35(3):699-706. doi: 10.1002/jor.23358. Epub 2016 Jul 29.


Gait mechanics 2 years after anterior cruciate ligament reconstruction are associated with longer-term changes in patient-reported outcomes.

Erhart-Hledik JC, Chu CR, Asay JL, Andriacchi TP.

J Orthop Res. 2017 Mar;35(3):634-640. doi: 10.1002/jor.23317. Epub 2016 Jun 15.


AAOS Research Symposium Updates and Consensus: Biologic Treatment of Orthopaedic Injuries.

LaPrade RF, Dragoo JL, Koh JL, Murray IR, Geeslin AG, Chu CR.

J Am Acad Orthop Surg. 2016 Jul;24(7):e62-78. doi: 10.5435/JAAOS-D-16-00086. Review.


Defining Pre-Osteoarthritis Is Key to Prevention.

Chu CR.

Cartilage. 2016 Apr;7(2):204. doi: 10.1177/1947603515618758. Epub 2015 Dec 13. No abstract available.


Addition of Mesenchymal Stem Cells to Autologous Platelet-Enhanced Fibrin Scaffolds in Chondral Defects: Does It Enhance Repair?

Goodrich LR, Chen AC, Werpy NM, Williams AA, Kisiday JD, Su AW, Cory E, Morley PS, McIlwraith CW, Sah RL, Chu CR.

J Bone Joint Surg Am. 2016 Jan 6;98(1):23-34. doi: 10.2106/JBJS.O.00407.


Short-term Analysis vs Long-term Data on Total Hip Replacement Survivorship.

Chu CR.

JAMA Surg. 2015 Oct;150(10):989. doi: 10.1001/jamasurg.2015.1337. No abstract available.


The Challenge and the Promise of Bone Marrow Cells for Human Cartilage Repair.

Chu CR.

Cartilage. 2015 Apr;6(2 Suppl):36S-45S. doi: 10.1177/1947603515574839. Epub 2015 Mar 24.


Dance between biology, mechanics, and structure: A systems-based approach to developing osteoarthritis prevention strategies.

Chu CR, Andriacchi TP.

J Orthop Res. 2015 Jul;33(7):939-47. doi: 10.1002/jor.22817. Epub 2015 Apr 24.


Effects of high heel wear and increased weight on the knee during walking.

Titchenal MR, Asay JL, Favre J, Andriacchi TP, Chu CR.

J Orthop Res. 2015 Mar;33(3):405-11. doi: 10.1002/jor.22775. Epub 2014 Dec 22.


Synovial Fluid Lubricant Properties are Transiently Deficient after Arthroscopic Articular Cartilage Defect Repair with Platelet-Enriched Fibrin Alone and with Mesenchymal Stem Cells.

Grissom MJ, Temple-Wong MM, Adams MS, Tom M, Schumacher BL, McIlwraith CW, Goodrich LR, Chu CR, Sah RL.

Orthop J Sports Med. 2014 Jul;2(7). doi: 10.1177/2325967114542580.


A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease.

Andriacchi TP, Favre J, Erhart-Hledik JC, Chu CR.

Ann Biomed Eng. 2015 Feb;43(2):376-87. doi: 10.1007/s10439-014-1117-2. Epub 2014 Sep 16. Review.


Osteoarthritis: From Palliation to Prevention: AOA Critical Issues.

Chu CR, Millis MB, Olson SA.

J Bone Joint Surg Am. 2014 Aug 6;96(15):e130.


Quantitative Magnetic Resonance Imaging UTE-T2* Mapping of Cartilage and Meniscus Healing After Anatomic Anterior Cruciate Ligament Reconstruction.

Chu CR, Williams AA, West RV, Qian Y, Fu FH, Do BH, Bruno S.

Am J Sports Med. 2014 Aug;42(8):1847-56. doi: 10.1177/0363546514532227. Epub 2014 May 8.


The effect of platelet-rich plasma formulations and blood products on human synoviocytes: implications for intra-articular injury and therapy.

Braun HJ, Kim HJ, Chu CR, Dragoo JL.

Am J Sports Med. 2014 May;42(5):1204-10. doi: 10.1177/0363546514525593. Epub 2014 Mar 14.


Brief report: carboxypeptidase B serves as a protective mediator in osteoarthritis.

Lepus CM, Song JJ, Wang Q, Wagner CA, Lindstrom TM, Chu CR, Sokolove J, Leung LL, Robinson WH.

Arthritis Rheumatol. 2014 Jan;66(1):101-106. doi: 10.1002/art.38213.


Articular cartilage changes in maturing athletes: new targets for joint rejuvenation.

Luria A, Chu CR.

Sports Health. 2014 Jan;6(1):18-30. doi: 10.1177/1941738113514369.


Serum CTXii Correlates With Articular Cartilage Degeneration After Anterior Cruciate Ligament Transection or Arthrotomy Followed by Standardized Exercise.

Coyle CH, Henry SE, Haleem AM, O'Malley MJ, Chu CR.

Sports Health. 2012 Nov;4(6):510-7. doi: 10.1177/1941738112451425.


Registration of Magnetic Resonance Image Series for Knee Articular Cartilage Analysis: Data from the Osteoarthritis Initiative.

Urish KL, Williams AA, Durkin JR, Chu CR; the OAI Investigators Group.

Cartilage. 2013 Jan;4(1):20-27.


T2 texture index of cartilage can predict early symptomatic OA progression: data from the osteoarthritis initiative.

Urish KL, Keffalas MG, Durkin JR, Miller DJ, Chu CR, Mosher TJ.

Osteoarthritis Cartilage. 2013 Oct;21(10):1550-7. doi: 10.1016/j.joca.2013.06.007. Epub 2013 Jun 15.


Persistence, localization, and external control of transgene expression after single injection of adeno-associated virus into injured joints.

Lee HH, O'Malley MJ, Friel NA, Payne KA, Qiao C, Xiao X, Chu CR.

Hum Gene Ther. 2013 Apr;24(4):457-66. doi: 10.1089/hum.2012.118.


Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair.

Lee HH, O'Malley MJ, Friel NA, Chu CR.

Osteoarthritis Cartilage. 2013 Feb;21(2):385-393. doi: 10.1016/j.joca.2012.11.010. Epub 2012 Nov 24.


The role of ACL injury in the development of posttraumatic knee osteoarthritis.

Friel NA, Chu CR.

Clin Sports Med. 2013 Jan;32(1):1-12. doi: 10.1016/j.csm.2012.08.017. Review.


The feasibility of randomized controlled trials for early arthritis therapies (Earth) involving acute anterior cruciate ligament tear cohorts.

Chu CR, Beynnon BD, Dragoo JL, Fleisig GS, Hart JM, Khazzam M, Marberry KM, Nelson BJ; EARTH Group.

Am J Sports Med. 2012 Nov;40(11):2648-52. doi: 10.1177/0363546512465409.


Repeatability of ultrashort echo time-based two-component T2* measurements on cartilages in human knee at 3 T.

Qian Y, Williams AA, Chu CR, Boada FE.

Magn Reson Med. 2013 Jun;69(6):1564-72. doi: 10.1002/mrm.24392. Epub 2012 Oct 3.


Calibration and deployment of a fiber-optic sensing system for monitoring debris flows.

Huang CJ, Chu CR, Tien TM, Yin HY, Chen PS.

Sensors (Basel). 2012;12(5):5835-49. doi: 10.3390/s120505835. Epub 2012 May 7.


Early diagnosis to enable early treatment of pre-osteoarthritis.

Chu CR, Williams AA, Coyle CH, Bowers ME.

Arthritis Res Ther. 2012 Jun 7;14(3):212. doi: 10.1186/ar3845. Review.


UTE-T2∗ mapping detects sub-clinical meniscus injury after anterior cruciate ligament tear.

Williams A, Qian Y, Golla S, Chu CR.

Osteoarthritis Cartilage. 2012 Jun;20(6):486-94. doi: 10.1016/j.joca.2012.01.009. Epub 2012 Jan 18.


Clinical and Basic Science of Cartilage Injury and Arthritis in the Football (Soccer) Athlete.

Lee HH, Chu CR.

Cartilage. 2012 Jan;3(1 Suppl):63S-8S. doi: 10.1177/1947603511426882.


Arthroscopic optical coherence tomography in diagnosis of early arthritis.

O'Malley MJ, Chu CR.

Minim Invasive Surg. 2011;2011:671308. doi: 10.1155/2011/671308. Epub 2011 Apr 3.


High-resolution ultrashort echo time (UTE) imaging on human knee with AWSOS sequence at 3.0 T.

Qian Y, Williams AA, Chu CR, Boada FE.

J Magn Reson Imaging. 2012 Jan;35(1):204-10. doi: 10.1002/jmri.22639. Epub 2011 Oct 14.


Closing the gap between bench and bedside research for early arthritis therapies (EARTH): report from the AOSSM/NIH U-13 Post-Joint Injury Osteoarthritis Conference II.

Chu CR, Beynnon BD, Buckwalter JA, Garrett WE Jr, Katz JN, Rodeo SA, Spindler KP, Stanton RA.

Am J Sports Med. 2011 Jul;39(7):1569-78. doi: 10.1177/0363546511411654.

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