Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 79

1.

Antibodies and venom peptides: new modalities for ion channels.

Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V.

Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8. Review.

2.

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state.

Villa A, Klein B, Janssen B, Pedragosa J, Pepe G, Zinnhardt B, Vugts DJ, Gelosa P, Sironi L, Beaino W, Damont A, Dollé F, Jego B, Winkeler A, Ory D, Solin O, Vercouillie J, Funke U, Laner-Plamberger S, Blomster LV, Christophersen P, Vegeto E, Aigner L, Jacobs A, Planas AM, Maggi A, Windhorst AD.

Theranostics. 2018 Oct 27;8(19):5400-5418. doi: 10.7150/thno.25572. eCollection 2018.

3.

Evaluation of drug permeation under fed state conditions using mucus-covered Caco-2 cell epithelium.

Birch D, Diedrichsen RG, Christophersen PC, Mu H, Nielsen HM.

Eur J Pharm Sci. 2018 Jun 15;118:144-153. doi: 10.1016/j.ejps.2018.02.032. Epub 2018 Mar 7.

PMID:
29524592
4.

The impact of particle preparation methods and polymorphic stability of lipid excipients on protein distribution in microparticles.

Liu J, Christophersen PC, Yang M, Nielsen HM, Mu H.

Drug Dev Ind Pharm. 2017 Dec;43(12):2032-2042. doi: 10.1080/03639045.2017.1361967. Epub 2017 Aug 11.

PMID:
28756687
5.

Potassium channel expression and function in microglia: Plasticity and possible species variations.

Nguyen HM, Blomster LV, Christophersen P, Wulff H.

Channels (Austin). 2017 Jul 4;11(4):305-315. doi: 10.1080/19336950.2017.1300738. Epub 2017 Mar 1. Review.

6.

Quantification of the functional expression of the Ca2+ -activated K+ channel KCa 3.1 on microglia from adult human neocortical tissue.

Blomster LV, Strøbaek D, Hougaard C, Klein J, Pinborg LH, Mikkelsen JD, Christophersen P.

Glia. 2016 Dec;64(12):2065-2078. doi: 10.1002/glia.23040. Epub 2016 Jul 29.

PMID:
27470924
7.

Recent developments in ion channel pharmacology.

Wulff H, Christophersen P.

Channels (Austin). 2015;9(6):335. doi: 10.1080/19336950.2015.1077650. Epub 2015 Nov 17. No abstract available.

8.

Pharmacological gating modulation of small- and intermediate-conductance Ca(2+)-activated K(+) channels (KCa2.x and KCa3.1).

Christophersen P, Wulff H.

Channels (Austin). 2015;9(6):336-43. doi: 10.1080/19336950.2015.1071748. Epub 2015 Jul 28. Review.

9.

Characterization of particulate drug delivery systems for oral delivery of Peptide and protein drugs.

Christophersen PC, Fano M, Saaby L, Yang M, Nielsen HM, Mu H.

Curr Pharm Des. 2015;21(19):2611-28. Review.

PMID:
25876916
10.

Investigation of protein distribution in solid lipid particles and its impact on protein release using coherent anti-Stokes Raman scattering microscopy.

Christophersen PC, Birch D, Saarinen J, Isomäki A, Nielsen HM, Yang M, Strachan CJ, Mu H.

J Control Release. 2015 Jan 10;197:111-20. doi: 10.1016/j.jconrel.2014.10.023. Epub 2014 Nov 3.

PMID:
25449810
11.

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions.

Nausch B, Rode F, Jørgensen S, Nardi A, Korsgaard MP, Hougaard C, Bonev AD, Brown WD, Dyhring T, Strøbæk D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Rønn LC.

J Pharmacol Exp Ther. 2014 Sep;350(3):520-30. doi: 10.1124/jpet.113.212662. Epub 2014 Jun 20.

12.

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.

Christophersen PC, Vaghela D, Müllertz A, Yang M, Nielsen HM, Mu H.

AAPS J. 2014 Jul;16(4):875-83. doi: 10.1208/s12248-014-9619-2. Epub 2014 May 30.

13.

Solid lipid particles for oral delivery of peptide and protein drugs II--the digestion of trilaurin protects desmopressin from proteolytic degradation.

Christophersen PC, Zhang L, Müllertz A, Nielsen HM, Yang M, Mu H.

Pharm Res. 2014 Sep;31(9):2420-8. doi: 10.1007/s11095-014-1337-z. Epub 2014 Mar 13.

PMID:
24623481
14.

Kv7 channels as targets for anti-epileptic and psychiatric drug-development.

Grunnet M, Strøbæk D, Hougaard C, Christophersen P.

Eur J Pharmacol. 2014 Mar 5;726:133-7. doi: 10.1016/j.ejphar.2014.01.017. Epub 2014 Jan 20. Review.

PMID:
24457124
15.

Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons.

Dolga AM, de Andrade A, Meissner L, Knaus HG, Höllerhage M, Christophersen P, Zischka H, Plesnila N, Höglinger GU, Culmsee C.

Cell Death Dis. 2014 Jan 16;5:e999. doi: 10.1038/cddis.2013.530.

16.

Fed and fasted state gastro-intestinal in vitro lipolysis: In vitro in vivo relations of a conventional tablet, a SNEDDS and a solidified SNEDDS.

Christophersen PC, Christiansen ML, Holm R, Kristensen J, Jacobsen J, Abrahamsson B, Müllertz A.

Eur J Pharm Sci. 2014 Jun 16;57:232-9. doi: 10.1016/j.ejps.2013.09.007. Epub 2013 Sep 18.

PMID:
24056027
17.

Solid lipid particles for oral delivery of peptide and protein drugs I--elucidating the release mechanism of lysozyme during lipolysis.

Christophersen PC, Zhang L, Yang M, Nielsen HM, Müllertz A, Mu H.

Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):473-80. doi: 10.1016/j.ejpb.2013.07.017. Epub 2013 Aug 2.

PMID:
23911434
18.

Characterization of a novel high-potency positive modulator of K(v)7 channels.

Dalby-Brown W, Jessen C, Hougaard C, Jensen ML, Jacobsen TA, Nielsen KS, Erichsen HK, Grunnet M, Ahring PK, Christophersen P, Strøbæk D, Jørgensen S.

Eur J Pharmacol. 2013 Jun 5;709(1-3):52-63. doi: 10.1016/j.ejphar.2013.03.039. Epub 2013 Apr 3.

PMID:
23562623
19.

A high-throughput screening campaign for detection of ca(2+)-activated k(+) channel activators and inhibitors using a fluorometric imaging plate reader-based tl(+)-influx assay.

Jørgensen S, Dyhring T, Brown DT, Strøbæk D, Christophersen P, Demnitz J.

Assay Drug Dev Technol. 2013 Apr;11(3):163-72. doi: 10.1089/adt.2012.479. Epub 2012 Nov 30.

PMID:
23198866
20.

Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2.

Kasumu AW, Hougaard C, Rode F, Jacobsen TA, Sabatier JM, Eriksen BL, Strøbæk D, Liang X, Egorova P, Vorontsova D, Christophersen P, Rønn LC, Bezprozvanny I.

Chem Biol. 2012 Oct 26;19(10):1340-53. doi: 10.1016/j.chembiol.2012.07.013.

21.

NS6180, a new K(Ca) 3.1 channel inhibitor prevents T-cell activation and inflammation in a rat model of inflammatory bowel disease.

Strøbæk D, Brown DT, Jenkins DP, Chen YJ, Coleman N, Ando Y, Chiu P, Jørgensen S, Demnitz J, Wulff H, Christophersen P.

Br J Pharmacol. 2013 Jan;168(2):432-44. doi: 10.1111/j.1476-5381.2012.02143.x.

22.

CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate.

Herrik KF, Redrobe JP, Holst D, Hougaard C, Sandager-Nielsen K, Nielsen AN, Ji H, Holst NM, Rasmussen HB, Nielsen EØ, Strøbæk D, Shepard PD, Christophersen P.

Front Pharmacol. 2012 Feb 13;3:11. doi: 10.3389/fphar.2012.00011. eCollection 2012.

23.

Evidence for a common pharmacological interaction site on K(Ca)2 channels providing both selective activation and selective inhibition of the human K(Ca)2.1 subtype.

Hougaard C, Hammami S, Eriksen BL, Sørensen US, Jensen ML, Strøbæk D, Christophersen P.

Mol Pharmacol. 2012 Feb;81(2):210-9. doi: 10.1124/mol.111.074252. Epub 2011 Nov 1.

PMID:
22046005
24.

Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of K(Ca)2 channels.

Jenkins DP, Strøbæk D, Hougaard C, Jensen ML, Hummel R, Sørensen US, Christophersen P, Wulff H.

Mol Pharmacol. 2011 Jun;79(6):899-909. doi: 10.1124/mol.110.069807. Epub 2011 Mar 1.

25.

Pharmacological modulation of the gating properties of small conductance Ca2+-activated K+ channels alters the firing pattern of dopamine neurons in vivo.

Herrik KF, Christophersen P, Shepard PD.

J Neurophysiol. 2010 Sep;104(3):1726-35. doi: 10.1152/jn.01126.2009. Epub 2010 Jul 21.

26.

The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties.

Dyhring T, Nielsen EØ, Sonesson C, Pettersson F, Karlsson J, Svensson P, Christophersen P, Waters N.

Eur J Pharmacol. 2010 Feb 25;628(1-3):19-26. doi: 10.1016/j.ejphar.2009.11.025. Epub 2009 Nov 15.

PMID:
19919834
27.

Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment.

Hougaard C, Jensen ML, Dale TJ, Miller DD, Davies DJ, Eriksen BL, Strøbaek D, Trezise DJ, Christophersen P.

Mol Pharmacol. 2009 Sep;76(3):569-78. doi: 10.1124/mol.109.056663. Epub 2009 Jun 10.

PMID:
19515965
28.

Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels.

Ji H, Hougaard C, Herrik KF, Strøbaek D, Christophersen P, Shepard PD.

Eur J Neurosci. 2009 May;29(9):1883-95. doi: 10.1111/j.1460-9568.2009.06735.x. Epub 2009 Apr 20.

29.

Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells.

Kjaer K, Strøbaek D, Christophersen P, Rønn LC.

Brain Res. 2009 Jul 24;1281:15-24. doi: 10.1016/j.brainres.2009.05.015. Epub 2009 May 13. Erratum in: Brain Res. 2009 Sep 29;1291:153.

PMID:
19446535
30.
31.

Synthesis and structure-activity relationship studies of 2-(N-substituted)-aminobenzimidazoles as potent negative gating modulators ofsmall conductance Ca2+-activated K+ channels.

Sørensen US, Strøbaek D, Christophersen P, Hougaard C, Jensen ML, Nielsen EØ, Peters D, Teuber L.

J Med Chem. 2008 Dec 11;51(23):7625-34. doi: 10.1021/jm800809f.

PMID:
18998663
32.

SK3 K+ channel-deficient mice have enhanced dopamine and serotonin release and altered emotional behaviors.

Jacobsen JP, Weikop P, Hansen HH, Mikkelsen JD, Redrobe JP, Holst D, Bond CT, Adelman JP, Christophersen P, Mirza NR.

Genes Brain Behav. 2008 Nov;7(8):836-48. doi: 10.1111/j.1601-183X.2008.00416.x. Epub 2008 Jul 28.

34.

Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels.

Hougaard C, Eriksen BL, Jørgensen S, Johansen TH, Dyhring T, Madsen LS, Strøbaek D, Christophersen P.

Br J Pharmacol. 2007 Jul;151(5):655-65. Epub 2007 May 8.

35.

Cell cycle-dependent activity of the volume- and Ca2+-activated anion currents in Ehrlich lettre ascites cells.

Klausen TK, Bergdahl A, Hougaard C, Christophersen P, Pedersen SF, Hoffmann EK.

J Cell Physiol. 2007 Mar;210(3):831-42.

PMID:
17111356
36.

Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons.

Strøbaek D, Hougaard C, Johansen TH, Sørensen US, Nielsen EØ, Nielsen KS, Taylor RD, Pedarzani P, Christophersen P.

Mol Pharmacol. 2006 Nov;70(5):1771-82. Epub 2006 Aug 22.

PMID:
16926279
37.

The human red cell voltage-dependent cation channel. Part III: Distribution homogeneity and pH dependence.

Bennekou P, Barksmann TL, Christophersen P, Kristensen BI.

Blood Cells Mol Dis. 2006 Jan-Feb;36(1):10-4. Epub 2005 Dec 22.

PMID:
16376587
38.

Avulsion of primary teeth and sequelae on the permanent successors.

Christophersen P, Freund M, Harild L.

Dent Traumatol. 2005 Dec;21(6):320-3.

PMID:
16262616
39.

Specific enhancement of SK channel activity selectively potentiates the afterhyperpolarizing current I(AHP) and modulates the firing properties of hippocampal pyramidal neurons.

Pedarzani P, McCutcheon JE, Rogge G, Jensen BS, Christophersen P, Hougaard C, Strøbaek D, Stocker M.

J Biol Chem. 2005 Dec 16;280(50):41404-11. Epub 2005 Oct 20.

40.

Blockade of Ca2+-activated K+ channels in T cells: an option for the treatment of multiple sclerosis?

Madsen LS, Christophersen P, Olesen SP.

Eur J Immunol. 2005 Apr;35(4):1023-6.

41.

Acidification of the osteoclastic resorption compartment provides insight into the coupling of bone formation to bone resorption.

Karsdal MA, Henriksen K, Sørensen MG, Gram J, Schaller S, Dziegiel MH, Heegaard AM, Christophersen P, Martin TJ, Christiansen C, Bollerslev J.

Am J Pathol. 2005 Feb;166(2):467-76.

42.

Pharmacology of the human red cell voltage-dependent cation channel. Part II: inactivation and blocking.

Bennekou P, Barksmann TL, Kristensen BI, Jensen LR, Christophersen P.

Blood Cells Mol Dis. 2004 Nov-Dec;33(3):356-61.

PMID:
15528157
43.

Activation of human IK and SK Ca2+ -activated K+ channels by NS309 (6,7-dichloro-1H-indole-2,3-dione 3-oxime).

Strøbaek D, Teuber L, Jørgensen TD, Ahring PK, Kjaer K, Hansen RS, Olesen SP, Christophersen P, Skaaning-Jensen B.

Biochim Biophys Acta. 2004 Oct 11;1665(1-2):1-5.

44.

The chloride channel inhibitor NS3736 [corrected] prevents bone resorption in ovariectomized rats without changing bone formation.

Schaller S, Henriksen K, Sveigaard C, Heegaard AM, Hélix N, Stahlhut M, Ovejero MC, Johansen JV, Solberg H, Andersen TL, Hougaard D, Berryman M, Shiødt CB, Sørensen BH, Lichtenberg J, Christophersen P, Foged NT, Delaissé JM, Engsig MT, Karsdal MA.

J Bone Miner Res. 2004 Jul;19(7):1144-53. Epub 2004 Mar 1. Erratum in: J Bone Miner Res. 2004 Aug;19(8):1378.

45.

Pharmacology of the human red cell voltage-dependent cation channel; Part I. Activation by clotrimazole and analogues.

Barksmann TL, Kristensen BI, Christophersen P, Bennekou P.

Blood Cells Mol Dis. 2004 May-Jun;32(3):384-8.

PMID:
15121096
46.

Voltage activation and hysteresis of the non-selective voltage-dependent channel in the intact human red cell.

Bennekou P, Barksmann TL, Jensen LR, Kristensen BI, Christophersen P.

Bioelectrochemistry. 2004 May;62(2):181-5.

PMID:
15039024
47.

Inhibition of the endogenous volume-regulated anion channel (VRAC) in HEK293 cells by acidic di-aryl-ureas.

Hélix N, Strøbaek D, Dahl BH, Christophersen P.

J Membr Biol. 2003 Nov 15;196(2):83-94.

PMID:
14724745
48.
49.

Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352.

Schrøder RL, Strøbaek D, Olesen SP, Christophersen P.

Pflugers Arch. 2003 Aug;446(5):607-16. Epub 2003 Jul 8.

PMID:
12851819
50.

High throughput electrophysiology: new perspectives for ion channel drug discovery.

Willumsen NJ, Bech M, Olesen SP, Jensen BS, Korsgaard MP, Christophersen P.

Receptors Channels. 2003;9(1):3-12. Review.

PMID:
12825293

Supplemental Content

Loading ...
Support Center