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Items: 32


Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner.

Basagiannis D, Zografou S, Galanopoulou K, Christoforidis S.

Sci Rep. 2017 Mar 22;7:45035. doi: 10.1038/srep45035.


The AP-2 complex has a specialized clathrin-independent role in apical endocytosis and polar growth in fungi.

Martzoukou O, Amillis S, Zervakou A, Christoforidis S, Diallinas G.

Elife. 2017 Feb 21;6. pii: e20083. doi: 10.7554/eLife.20083.


Design and synthesis of novel 7-aminosubstituted pyrido[2,3-b]pyrazines exhibiting anti-breast cancer activity.

Argyros O, Lougiakis N, Kouvari E, Papafotika A, Raptopoulou CP, Psycharis V, Christoforidis S, Pouli N, Marakos P, Tamvakopoulos C.

Eur J Med Chem. 2017 Jan 27;126:954-968. doi: 10.1016/j.ejmech.2016.12.025. Epub 2016 Dec 12.


Discovery of New Aminosubstituted Pyrrolopyrimidines with Antiproliferative Activity Against Breast Cancer Cells and Investigation of their Effect Towards the PI3Kα Enzyme.

Daniilides K, Lougiakis N, Evangelidis T, Kostakis IK, Pouli N, Marakos P, Mikros E, Skaltsounis AL, Bach S, Baratte B, Ruchaud S, Karamani V, Papafotika A, Christoforidis S, Argyros O, Kouvari E, Tamvakopoulos C.

Anticancer Agents Med Chem. 2017;17(7):990-1002. doi: 10.2174/1871520616666161207143450.


VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation through macropinocytosis.

Basagiannis D, Zografou S, Murphy C, Fotsis T, Morbidelli L, Ziche M, Bleck C, Mercer J, Christoforidis S.

J Cell Sci. 2016 Nov 1;129(21):4091-4104. Epub 2016 Sep 21.


Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding.

Basagiannis D, Christoforidis S.

J Biol Chem. 2016 Aug 5;291(32):16892-903. doi: 10.1074/jbc.M116.730309. Epub 2016 Jun 13.


Proteome Changes during Transition from Human Embryonic to Vascular Progenitor Cells.

Tsolis KC, Bagli E, Kanaki K, Zografou S, Carpentier S, Bei ES, Christoforidis S, Zervakis M, Murphy C, Fotsis T, Economou A.

J Proteome Res. 2016 Jun 3;15(6):1995-2007. doi: 10.1021/acs.jproteome.6b00180. Epub 2016 May 13.


Effect of azithromycin on the LPS-induced production and secretion of phospholipase A2 in lung cells.

Kitsiouli E, Antoniou G, Gotzou H, Karagiannopoulos M, Basagiannis D, Christoforidis S, Nakos G, Lekka ME.

Biochim Biophys Acta. 2015 Jul;1852(7):1288-97. doi: 10.1016/j.bbadis.2015.03.008. Epub 2015 Mar 17.


Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant.

Gkeka P, Evangelidis T, Pavlaki M, Lazani V, Christoforidis S, Agianian B, Cournia Z.

PLoS Comput Biol. 2014 Oct 23;10(10):e1003895. doi: 10.1371/journal.pcbi.1003895. eCollection 2014 Oct.


Exploring a non-ATP pocket for potential allosteric modulation of PI3Kα.

Gkeka P, Papafotika A, Christoforidis S, Cournia Z.

J Phys Chem B. 2015 Jan 22;119(3):1002-16. doi: 10.1021/jp506423e. Epub 2014 Dec 3.


A complete Rab screening reveals novel insights in Weibel-Palade body exocytosis.

Zografou S, Basagiannis D, Papafotika A, Shirakawa R, Horiuchi H, Auerbach D, Fukuda M, Christoforidis S.

J Cell Sci. 2012 Oct 15;125(Pt 20):4780-90. doi: 10.1242/jcs.104174. Epub 2012 Aug 16.


The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage.

Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, Christoforidis S, Tzavaras T, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E.

Cell Signal. 2012 Nov;24(11):2007-23. doi: 10.1016/j.cellsig.2012.06.010. Epub 2012 Jun 29.


CD39 reveals novel insights into the role of transmembrane domains in protein processing, apical targeting and activity.

Papanikolaou A, Papafotika A, Christoforidis S.

Traffic. 2011 Sep;12(9):1148-65. doi: 10.1111/j.1600-0854.2011.01224.x. Epub 2011 Jun 29.


ER targeting and retention of the HCV NS4B protein relies on the concerted action of multiple structural features including its transmembrane domains.

Boleti H, Smirlis D, Dalagiorgou G, Meurs EF, Christoforidis S, Mavromara P.

Mol Membr Biol. 2010 Jan;27(1):45-62. doi: 10.3109/09687680903426208.


Bcl-2 blocks 2-methoxyestradiol induced leukemia cell apoptosis by a p27(Kip1)-dependent G1/S cell cycle arrest in conjunction with NF-kappaB activation.

Batsi C, Markopoulou S, Kontargiris E, Charalambous C, Thomas C, Christoforidis S, Kanavaros P, Constantinou AI, Marcu KB, Kolettas E.

Biochem Pharmacol. 2009 Jul 1;78(1):33-44. doi: 10.1016/j.bcp.2009.03.017. Epub 2009 Mar 27.


An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway.

Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M.

J Cell Biol. 2005 Aug 15;170(4):607-18.


Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39.

Papanikolaou A, Papafotika A, Murphy C, Papamarcaki T, Tsolas O, Drab M, Kurzchalia TV, Kasper M, Christoforidis S.

J Biol Chem. 2005 Jul 15;280(28):26406-14. Epub 2005 May 12.


Prothymosin alpha associates with the oncoprotein SET and is involved in chromatin decondensation.

Karetsou Z, Martic G, Tavoulari S, Christoforidis S, Wilm M, Gruss C, Papamarcaki T.

FEBS Lett. 2004 Nov 19;577(3):496-500.


The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms.

Schnatwinkel C, Christoforidis S, Lindsay MR, Uttenweiler-Joseph S, Wilm M, Parton RG, Zerial M.

PLoS Biol. 2004 Sep;2(9):E261. Epub 2004 Aug 24.


APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.

Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton RG, Zerial M.

Cell. 2004 Feb 6;116(3):445-56.


Automated de novo sequencing of proteins using the differential scanning technique.

Uttenweiler-Joseph S, Neubauer G, Christoforidis S, Zerial M, Wilm M.

Proteomics. 2001 May;1(5):668-82.


Purification of EEA1 from bovine brain cytosol using Rab5 affinity chromatography and activity assays.

Christoforidis S, Zerial M.

Methods Enzymol. 2001;329:120-32. No abstract available.


The Eps8 protein coordinates EGF receptor signalling through Rac and trafficking through Rab5.

Lanzetti L, Rybin V, Malabarba MG, Christoforidis S, Scita G, Zerial M, Di Fiore PP.

Nature. 2000 Nov 16;408(6810):374-7.


Rabenosyn-5, a novel Rab5 effector, is complexed with hVPS45 and recruited to endosomes through a FYVE finger domain.

Nielsen E, Christoforidis S, Uttenweiler-Joseph S, Miaczynska M, Dewitte F, Wilm M, Hoflack B, Zerial M.

J Cell Biol. 2000 Oct 30;151(3):601-12.


Purification and identification of novel Rab effectors using affinity chromatography.

Christoforidis S, Zerial M.

Methods. 2000 Apr;20(4):403-10.


Phosphatidylinositol-3-OH kinases are Rab5 effectors.

Christoforidis S, Miaczynska M, Ashman K, Wilm M, Zhao L, Yip SC, Waterfield MD, Backer JM, Zerial M.

Nat Cell Biol. 1999 Aug;1(4):249-52. No abstract available.


The Rab5 effector EEA1 is a core component of endosome docking.

Christoforidis S, McBride HM, Burgoyne RD, Zerial M.

Nature. 1999 Feb 18;397(6720):621-5.


EEA1 links PI(3)K function to Rab5 regulation of endosome fusion.

Simonsen A, Lippé R, Christoforidis S, Gaullier JM, Brech A, Callaghan J, Toh BH, Murphy C, Zerial M, Stenmark H.

Nature. 1998 Jul 30;394(6692):494-8.


Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5.

Vitale G, Rybin V, Christoforidis S, Thornqvist P, McCaffrey M, Stenmark H, Zerial M.

EMBO J. 1998 Apr 1;17(7):1941-51.


Human placental ATP diphosphohydrolase is a highly N-glycosylated plasma membrane enzyme.

Christoforidis S, Papamarcaki T, Tsolas O.

Biochim Biophys Acta. 1996 Jul 25;1282(2):257-62.


Purification and properties of human placental ATP diphosphohydrolase.

Christoforidis S, Papamarcaki T, Galaris D, Kellner R, Tsolas O.

Eur J Biochem. 1995 Nov 15;234(1):66-74.

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