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Histone deacetylases, Mbd3/NuRD, and Tet2 hydroxylase are crucial regulators of epithelial-mesenchymal plasticity and tumor metastasis.

Nihan Kilinc A, Sugiyama N, Reddy Kalathur RK, Antoniadis H, Birogul H, Ishay-Ronen D, George JT, Levine H, Kumar Jolly M, Christofori G.

Oncogene. 2019 Oct 30. doi: 10.1038/s41388-019-1081-2. [Epub ahead of print]


Inferring signalling dynamics by integrating interventional with observational data.

Cardner M, Meyer-Schaller N, Christofori G, Beerenwinkel N.

Bioinformatics. 2019 Jul 15;35(14):i577-i585. doi: 10.1093/bioinformatics/btz325.


Targeting Cancer Cell Metastasis by Converting Cancer Cells into Fat.

Ishay-Ronen D, Christofori G.

Cancer Res. 2019 Nov 1;79(21):5471-5475. doi: 10.1158/0008-5472.CAN-19-1242. Epub 2019 Jul 22. Review.


Tenascin-C increases lung metastasis by impacting blood vessel invasions.

Sun Z, Velázquez-Quesada I, Murdamoothoo D, Ahowesso C, Yilmaz A, Spenlé C, Averous G, Erne W, Oberndorfer F, Oszwald A, Kain R, Bourdon C, Mangin P, Deligne C, Midwood K, Abou-Faycal C, Lefebvre O, Klein A, van der Heyden M, Chenard MP, Christofori G, Mathelin C, Loustau T, Hussenet T, Orend G.

Matrix Biol. 2019 Jul 6. pii: S0945-053X(19)30128-3. doi: 10.1016/j.matbio.2019.07.001. [Epub ahead of print]


Endothelial cell-derived nidogen-1 inhibits migration of SK-BR-3 breast cancer cells.

Ferraro DA, Patella F, Zanivan S, Donato C, Aceto N, Giannotta M, Dejana E, Diepenbruck M, Christofori G, Buess M.

BMC Cancer. 2019 Apr 4;19(1):312. doi: 10.1186/s12885-019-5521-8.


Correction: The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking.

Francavilla C, Cattaneo P, Berezin V, Bock E, Ami D, de Marco A, Christofori G, Cavallaro U.

J Cell Biol. 2019 Apr 1;218(4):1422. doi: 10.1083/jcb.20090303002222019c. Epub 2019 Feb 26. No abstract available.


A Hierarchical Regulatory Landscape during the Multiple Stages of EMT.

Meyer-Schaller N, Cardner M, Diepenbruck M, Saxena M, Tiede S, Lüönd F, Ivanek R, Beerenwinkel N, Christofori G.

Dev Cell. 2019 Feb 25;48(4):539-553.e6. doi: 10.1016/j.devcel.2018.12.023. Epub 2019 Jan 31.


Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis.

Ishay-Ronen D, Diepenbruck M, Kalathur RKR, Sugiyama N, Tiede S, Ivanek R, Bantug G, Morini MF, Wang J, Hess C, Christofori G.

Cancer Cell. 2019 Jan 14;35(1):17-32.e6. doi: 10.1016/j.ccell.2018.12.002.


Mutational interactions define novel cancer subgroups.

Kuipers J, Thurnherr T, Moffa G, Suter P, Behr J, Goosen R, Christofori G, Beerenwinkel N.

Nat Commun. 2018 Oct 19;9(1):4353. doi: 10.1038/s41467-018-06867-x.


Foxf2 plays a dual role during transforming growth factor beta-induced epithelial to mesenchymal transition by promoting apoptosis yet enabling cell junction dissolution and migration.

Meyer-Schaller N, Heck C, Tiede S, Yilmaz M, Christofori G.

Breast Cancer Res. 2018 Oct 1;20(1):118. doi: 10.1186/s13058-018-1043-6.


The FAK inhibitor BI 853520 exerts anti-tumor effects in breast cancer.

Tiede S, Meyer-Schaller N, Kalathur RKR, Ivanek R, Fagiani E, Schmassmann P, Stillhard P, Häfliger S, Kraut N, Schweifer N, Waizenegger IC, Bill R, Christofori G.

Oncogenesis. 2018 Sep 20;7(9):73. doi: 10.1038/s41389-018-0083-1.


A Transgenic MMTV-Flippase Mouse Line for Molecular Engineering in Mammary Gland and Breast Cancer Mouse Models.

Lüönd F, Bill R, Vettiger A, Oller H, Pelczar P, Christofori G.

J Mammary Gland Biol Neoplasia. 2019 Mar;24(1):39-45. doi: 10.1007/s10911-018-9412-4. Epub 2018 Sep 12. Review.


PyMT-1099, a versatile murine cell model for EMT in breast cancer.

Saxena M, Kalathur RKR, Neutzner M, Christofori G.

Sci Rep. 2018 Aug 14;8(1):12123. doi: 10.1038/s41598-018-30640-1.


A kinome-wide high-content siRNA screen identifies MEK5-ERK5 signaling as critical for breast cancer cell EMT and metastasis.

Pavan S, Meyer-Schaller N, Diepenbruck M, Kalathur RKR, Saxena M, Christofori G.

Oncogene. 2018 Aug;37(31):4197-4213. doi: 10.1038/s41388-018-0270-8. Epub 2018 May 1.


PGE2 mediates EGFR internalization and nuclear translocation via caveolin endocytosis promoting its transcriptional activity and proliferation in human NSCLC cells.

Bazzani L, Donnini S, Giachetti A, Christofori G, Ziche M.

Oncotarget. 2018 Feb 15;9(19):14939-14958. doi: 10.18632/oncotarget.24499. eCollection 2018 Mar 13.


Inflammatory Cytokines Induce Podoplanin Expression at the Tumor Invasive Front.

Kunita A, Baeriswyl V, Meda C, Cabuy E, Takeshita K, Giraudo E, Wicki A, Fukayama M, Christofori G.

Am J Pathol. 2018 May;188(5):1276-1288. doi: 10.1016/j.ajpath.2018.01.016. Epub 2018 Feb 17.


Reciprocal regulatory circuits coordinating EMT plasticity.

Diepenbruck M, Christofori G.

Cell Stress. 2017 Dec 1;1(3):139-140. doi: 10.15698/cst2017.12.117.


miR-1199-5p and Zeb1 function in a double-negative feedback loop potentially coordinating EMT and tumour metastasis.

Diepenbruck M, Tiede S, Saxena M, Ivanek R, Kalathur RKR, Lüönd F, Meyer-Schaller N, Christofori G.

Nat Commun. 2017 Oct 27;8(1):1168. doi: 10.1038/s41467-017-01197-w.


NGS-pipe: a flexible, easily extendable and highly configurable framework for NGS analysis.

Singer J, Ruscheweyh HJ, Hofmann AL, Thurnherr T, Singer F, Toussaint NC, Ng CKY, Piscuoglio S, Beisel C, Christofori G, Dummer R, Hall MN, Krek W, Levesque MP, Manz MG, Moch H, Papassotiropoulos A, Stekhoven DJ, Wild P, Wüst T, Rinn B, Beerenwinkel N.

Bioinformatics. 2018 Jan 1;34(1):107-108. doi: 10.1093/bioinformatics/btx540.


PGE2/EP3/SRC signaling induces EGFR nuclear translocation and growth through EGFR ligands release in lung adenocarcinoma cells.

Bazzani L, Donnini S, Finetti F, Christofori G, Ziche M.

Oncotarget. 2017 May 9;8(19):31270-31287. doi: 10.18632/oncotarget.16116.


TFAP2A is a component of the ZEB1/2 network that regulates TGFB1-induced epithelial to mesenchymal transition.

Dimitrova Y, Gruber AJ, Mittal N, Ghosh S, Dimitriades B, Mathow D, Grandy WA, Christofori G, Zavolan M.

Biol Direct. 2017 Apr 17;12(1):8. doi: 10.1186/s13062-017-0180-7.


The Rip1Tag2 Transgenic Mouse Model.

Bill R, Christofori G.

Methods Mol Biol. 2016;1464:151-161.


Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe?

Diepenbruck M, Christofori G.

Curr Opin Cell Biol. 2016 Dec;43:7-13. doi: 10.1016/ Epub 2016 Jun 29. Review.


Targeting Metabolic Symbiosis to Overcome Resistance to Anti-angiogenic Therapy.

Pisarsky L, Bill R, Fagiani E, Dimeloe S, Goosen RW, Hagmann J, Hess C, Christofori G.

Cell Rep. 2016 May 10;15(6):1161-74. doi: 10.1016/j.celrep.2016.04.028. Epub 2016 Apr 28.


VEGF receptor-2-specific signaling mediated by VEGF-E induces hemangioma-like lesions in normal and in malignant tissue.

Fagiani E, Lorentz P, Bill R, Pavotbawan K, Kopfstein L, Christofori G.

Angiogenesis. 2016 Jul;19(3):339-58. doi: 10.1007/s10456-016-9508-7. Epub 2016 Apr 1.


A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptor.

Lotz-Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, Wirth M, Pavan S, Bill R, Regenass U, Christofori G, Meyer-Schaller N.

Oncotarget. 2016 May 3;7(18):25983-6002. doi: 10.18632/oncotarget.8418.


The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression.

Huang YT, Lan Q, Ponsonnet L, Blanquet M, Christofori G, Zaric J, Rüegg C.

Oncotarget. 2016 Jan 12;7(2):1663-74. doi: 10.18632/oncotarget.6411.


Nintedanib Is a Highly Effective Therapeutic for Neuroendocrine Carcinoma of the Pancreas (PNET) in the Rip1Tag2 Transgenic Mouse Model.

Bill R, Fagiani E, Zumsteg A, Antoniadis H, Johansson D, Haefliger S, Albrecht I, Hilberg F, Christofori G.

Clin Cancer Res. 2015 Nov 1;21(21):4856-67. doi: 10.1158/1078-0432.CCR-14-3036. Epub 2015 Jul 23.


Simultaneous targeting of VEGF-receptors 2 and 3 with immunoliposomes enhances therapeutic efficacy.

Orleth A, Mamot C, Rochlitz C, Ritschard R, Alitalo K, Christofori G, Wicki A.

J Drug Target. 2016;24(1):80-9. doi: 10.3109/1061186X.2015.1056189. Epub 2015 Jul 23.


An immature B cell population from peripheral blood serves as surrogate marker for monitoring tumor angiogenesis and anti-angiogenic therapy in mouse models.

Fagiani E, Bill R, Pisarsky L, Ivanek R, Rüegg C, Christofori G.

Angiogenesis. 2015 Jul;18(3):327-45. doi: 10.1007/s10456-015-9470-9. Epub 2015 May 29.


The relevance of EMT in breast cancer metastasis: Correlation or causality?

Bill R, Christofori G.

FEBS Lett. 2015 Jun 22;589(14):1577-87. doi: 10.1016/j.febslet.2015.05.002. Epub 2015 May 12. Review.


Reply to Gerlee and Altrock: Diffusion and population size in game theory models of cancer.

Archetti M, Ferraro DA, Christofori G.

Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2744. doi: 10.1073/pnas.1505648112. Epub 2015 May 4. No abstract available.


Junctional adhesion molecule B interferes with angiogenic VEGF/VEGFR2 signaling.

Meguenani M, Miljkovic-Licina M, Fagiani E, Ropraz P, Hammel P, Aurrand-Lions M, Adams RH, Christofori G, Imhof BA, Garrido-Urbani S.

FASEB J. 2015 Aug;29(8):3411-25. doi: 10.1096/fj.15-270223. Epub 2015 Apr 24.


Heterogeneity for IGF-II production maintained by public goods dynamics in neuroendocrine pancreatic cancer.

Archetti M, Ferraro DA, Christofori G.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1833-8. doi: 10.1073/pnas.1414653112. Epub 2015 Jan 26.


PI3K signalling is required for a TGFβ-induced epithelial-mesenchymal-like transition (EMT-like) in human melanoma cells.

Schlegel NC, von Planta A, Widmer DS, Dummer R, Christofori G.

Exp Dermatol. 2015 Jan;24(1):22-8. doi: 10.1111/exd.12580. Epub 2014 Nov 18.


Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition.

Diepenbruck M, Waldmeier L, Ivanek R, Berninger P, Arnold P, van Nimwegen E, Christofori G.

J Cell Sci. 2014 Apr 1;127(Pt 7):1523-36. doi: 10.1242/jcs.139865. Epub 2014 Feb 19.


Synergism of peptide receptor-targeted Auger electron radiation therapy with anti-angiogenic compounds in a mouse model of neuroendocrine tumors.

Wicki A, Wild D, Prêtre V, Mansi R, Orleth A, Reubi JC, Rochlitz C, Mamot C, Mäcke HR, Christofori G.

EJNMMI Res. 2014 Feb 16;4(1):9. doi: 10.1186/2191-219X-4-9.


LIM-homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF-B signaling.

Kuzmanov A, Hopfer U, Marti P, Meyer-Schaller N, Yilmaz M, Christofori G.

Mol Oncol. 2014 Mar;8(2):401-16. doi: 10.1016/j.molonc.2013.12.009. Epub 2013 Dec 25.


VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation.

Fantozzi A, Gruber DC, Pisarsky L, Heck C, Kunita A, Yilmaz M, Meyer-Schaller N, Cornille K, Hopfer U, Bentires-Alj M, Christofori G.

Cancer Res. 2014 Mar 1;74(5):1566-75. doi: 10.1158/0008-5472.CAN-13-1641. Epub 2014 Jan 10.


Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model.

Saupe F, Schwenzer A, Jia Y, Gasser I, Spenlé C, Langlois B, Kammerer M, Lefebvre O, Hlushchuk R, Rupp T, Marko M, van der Heyden M, Cremel G, Arnold C, Klein A, Simon-Assmann P, Djonov V, Neuville-Méchine A, Esposito I, Slotta-Huspenina J, Janssen KP, de Wever O, Christofori G, Hussenet T, Orend G.

Cell Rep. 2013 Oct 31;5(2):482-92. doi: 10.1016/j.celrep.2013.09.014. Epub 2013 Oct 17.


Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogramming.

Tiwari N, Tiwari VK, Waldmeier L, Balwierz PJ, Arnold P, Pachkov M, Meyer-Schaller N, Schübeler D, van Nimwegen E, Christofori G.

Cancer Cell. 2013 Jun 10;23(6):768-83. doi: 10.1016/j.ccr.2013.04.020.


Paralemmin-1 is expressed in lymphatic endothelial cells and modulates cell migration, cell maturation and tumor lymphangiogenesis.

Albrecht I, Bieri R, Leu A, Granacher P, Hagmann J, Kilimann MW, Christofori G.

Angiogenesis. 2013 Oct;16(4):795-807. doi: 10.1007/s10456-013-9356-7. Epub 2013 May 26.


The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity.

Michaloglou C, Lehmann W, Martin T, Delaunay C, Hueber A, Barys L, Niu H, Billy E, Wartmann M, Ito M, Wilson CJ, Digan ME, Bauer A, Voshol H, Christofori G, Sellers WR, Hofmann F, Schmelzle T.

PLoS One. 2013 Apr 16;8(4):e61916. doi: 10.1371/journal.pone.0061916. Print 2013.


Rebuilding cancer metastasis in the mouse.

Saxena M, Christofori G.

Mol Oncol. 2013 Apr;7(2):283-96. doi: 10.1016/j.molonc.2013.02.009. Epub 2013 Feb 20. Review.


Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer.

Chatterjee S, Heukamp LC, Siobal M, Schöttle J, Wieczorek C, Peifer M, Frasca D, Koker M, König K, Meder L, Rauh D, Buettner R, Wolf J, Brekken RA, Neumaier B, Christofori G, Thomas RK, Ullrich RT.

J Clin Invest. 2013 Apr;123(4):1732-40. Erratum in: J Clin Invest. 2013 Jul 1;123(7):3183.


Klf4 is a transcriptional regulator of genes critical for EMT, including Jnk1 (Mapk8).

Tiwari N, Meyer-Schaller N, Arnold P, Antoniadis H, Pachkov M, van Nimwegen E, Christofori G.

PLoS One. 2013;8(2):e57329. doi: 10.1371/journal.pone.0057329. Epub 2013 Feb 25. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/121b04a1-0cbb-4e24-8a63-fc9cdd31ec76.


The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion.

Braeutigam C, Rago L, Rolke A, Waldmeier L, Christofori G, Winter J.

Oncogene. 2014 Feb 27;33(9):1082-92. doi: 10.1038/onc.2013.50. Epub 2013 Feb 25.


Sprouty2 expression controls endothelial monolayer integrity and quiescence.

Peier M, Walpen T, Christofori G, Battegay E, Humar R.

Angiogenesis. 2013 Apr;16(2):455-68. doi: 10.1007/s10456-012-9330-9. Epub 2012 Dec 12.


Py2T murine breast cancer cells, a versatile model of TGFβ-induced EMT in vitro and in vivo.

Waldmeier L, Meyer-Schaller N, Diepenbruck M, Christofori G.

PLoS One. 2012;7(11):e48651. doi: 10.1371/journal.pone.0048651. Epub 2012 Nov 7.


Angiopoietins in angiogenesis.

Fagiani E, Christofori G.

Cancer Lett. 2013 Jan 1;328(1):18-26. doi: 10.1016/j.canlet.2012.08.018. Epub 2012 Aug 23. Review.


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