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Items: 41

1.

Viral hijacking of cellular metabolism.

Thaker SK, Ch'ng J, Christofk HR.

BMC Biol. 2019 Jul 18;17(1):59. doi: 10.1186/s12915-019-0678-9. Review.

2.

Author Correction: Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin.

Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE.

Nat Commun. 2019 Mar 26;10(1):1449. doi: 10.1038/s41467-019-09435-z.

3.

Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells.

Thaker SK, Chapa T, Garcia G Jr, Gong D, Schmid EW, Arumugaswami V, Sun R, Christofk HR.

Cell Metab. 2019 May 7;29(5):1206-1216.e4. doi: 10.1016/j.cmet.2019.01.024. Epub 2019 Feb 28.

PMID:
30827860
4.

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin.

Flores A, Sandoval-Gonzalez S, Takahashi R, Krall A, Sathe L, Wei L, Radu C, Joly JH, Graham NA, Christofk HR, Lowry WE.

Nat Commun. 2019 Jan 9;10(1):91. doi: 10.1038/s41467-018-07857-9. Erratum in: Nat Commun. 2019 Mar 26;10(1):1449.

5.

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.

Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR.

Cell. 2018 Sep 20;175(1):117-132.e21. doi: 10.1016/j.cell.2018.08.017. Epub 2018 Sep 6.

6.

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue.

Jelinek D, Flores A, Uebelhoer M, Pasque V, Plath K, Iruela-Arispe ML, Christofk HR, Lowry WE, Coller HA.

J Vis Exp. 2018 Jun 21;(136). doi: 10.3791/57760.

7.

The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma.

Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Braas D, Go J, Graeber TG, Parlati F, Demo S, Li R, Walser TC, Gricowski M, Shuman R, Ibarra J, Fridman D, Phelps ME, Badran K, St John M, Bernthal NM, Federman N, Yanagawa J, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB.

Cancer Cell. 2018 May 14;33(5):905-921.e5. doi: 10.1016/j.ccell.2018.04.002.

8.

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J.

Nat Cell Biol. 2017 Sep;19(9):1027-1036. doi: 10.1038/ncb3593. Epub 2017 Aug 14.

9.

Lactate dehydrogenase activity drives hair follicle stem cell activation.

Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE.

Nat Cell Biol. 2017 Sep;19(9):1017-1026. doi: 10.1038/ncb3575. Epub 2017 Aug 14.

10.

mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT.

Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS.

Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22.

11.

Cell cycle: Division enzyme regulates metabolism.

Krall AS, Christofk HR.

Nature. 2017 Jun 15;546(7658):357-358. doi: 10.1038/nature22504. Epub 2017 Jun 7. No abstract available.

PMID:
28607481
12.

Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures.

Graham NA, Minasyan A, Lomova A, Cass A, Balanis NG, Friedman M, Chan S, Zhao S, Delgado A, Go J, Beck L, Hurtz C, Ng C, Qiao R, Ten Hoeve J, Palaskas N, Wu H, Müschen M, Multani AS, Port E, Larson SM, Schultz N, Braas D, Christofk HR, Mellinghoff IK, Graeber TG.

Mol Syst Biol. 2017 Feb 15;13(2):914. doi: 10.15252/msb.20167159.

13.

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer.

Momcilovic M, Bailey ST, Lee JT, Fishbein MC, Magyar C, Braas D, Graeber T, Jackson NJ, Czernin J, Emberley E, Gross M, Janes J, Mackinnon A, Pan A, Rodriguez M, Works M, Zhang W, Parlati F, Demo S, Garon E, Krysan K, Walser TC, Dubinett SM, Sadeghi S, Christofk HR, Shackelford DB.

Cell Rep. 2017 Jan 17;18(3):601-610. doi: 10.1016/j.celrep.2016.12.061.

14.

Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State.

Gu W, Gaeta X, Sahakyan A, Chan AB, Hong CS, Kim R, Braas D, Plath K, Lowry WE, Christofk HR.

Cell Stem Cell. 2016 Oct 6;19(4):476-490. doi: 10.1016/j.stem.2016.08.008. Epub 2016 Sep 8.

15.

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor.

Krall AS, Xu S, Graeber TG, Braas D, Christofk HR.

Nat Commun. 2016 Apr 29;7:11457. doi: 10.1038/ncomms11457.

16.

MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.

Hong CS, Graham NA, Gu W, Espindola Camacho C, Mah V, Maresh EL, Alavi M, Bagryanova L, Krotee PAL, Gardner BK, Behbahan IS, Horvath S, Chia D, Mellinghoff IK, Hurvitz SA, Dubinett SM, Critchlow SE, Kurdistani SK, Goodglick L, Braas D, Graeber TG, Christofk HR.

Cell Rep. 2016 Feb 23;14(7):1590-1601. doi: 10.1016/j.celrep.2016.01.057. Epub 2016 Feb 11.

17.

Rethinking glutamine addiction.

Krall AS, Christofk HR.

Nat Cell Biol. 2015 Dec;17(12):1515-7. doi: 10.1038/ncb3278.

PMID:
26612572
18.

MYC-induced reprogramming of glutamine catabolism supports optimal virus replication.

Thai M, Thaker SK, Feng J, Du Y, Hu H, Ting Wu T, Graeber TG, Braas D, Christofk HR.

Nat Commun. 2015 Nov 12;6:8873. doi: 10.1038/ncomms9873.

19.

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling.

Fu X, Chin RM, Vergnes L, Hwang H, Deng G, Xing Y, Pai MY, Li S, Ta L, Fazlollahi F, Chen C, Prins RM, Teitell MA, Nathanson DA, Lai A, Faull KF, Jiang M, Clarke SG, Cloughesy TF, Graeber TG, Braas D, Christofk HR, Jung ME, Reue K, Huang J.

Cell Metab. 2015 Sep 1;22(3):508-15. doi: 10.1016/j.cmet.2015.06.009. Epub 2015 Jul 16.

20.

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy.

Domigan CK, Warren CM, Antanesian V, Happel K, Ziyad S, Lee S, Krall A, Duan L, Torres-Collado AX, Castellani LW, Elashoff D, Christofk HR, van der Bliek AM, Potente M, Iruela-Arispe ML.

J Cell Sci. 2015 Jun 15;128(12):2236-48. doi: 10.1242/jcs.163774. Epub 2015 May 8.

21.

The metabolic milieu of metastases.

Sullivan WJ, Christofk HR.

Cell. 2015 Jan 29;160(3):363-4. doi: 10.1016/j.cell.2015.01.023.

22.

Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression.

Drew BG, Hamidi H, Zhou Z, Villanueva CJ, Krum SA, Calkin AC, Parks BW, Ribas V, Kalajian NY, Phun J, Daraei P, Christofk HR, Hewitt SC, Korach KS, Tontonoz P, Lusis AJ, Slamon DJ, Hurvitz SA, Hevener AL.

J Biol Chem. 2015 Feb 27;290(9):5566-81. doi: 10.1074/jbc.M114.606459. Epub 2014 Dec 2.

23.

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J.

Nature. 2014 Jun 19;510(7505):397-401. doi: 10.1038/nature13264. Epub 2014 May 14.

24.

Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication.

Thai M, Graham NA, Braas D, Nehil M, Komisopoulou E, Kurdistani SK, McCormick F, Graeber TG, Christofk HR.

Cell Metab. 2014 Apr 1;19(4):694-701. doi: 10.1016/j.cmet.2014.03.009.

25.

Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer.

Garon EB, Christofk HR, Hosmer W, Britten CD, Bahng A, Crabtree MJ, Hong CS, Kamranpour N, Pitts S, Kabbinavar F, Patel C, von Euw E, Black A, Michelakis ED, Dubinett SM, Slamon DJ.

J Cancer Res Clin Oncol. 2014 Mar;140(3):443-52. doi: 10.1007/s00432-014-1583-9. Epub 2014 Jan 18.

26.

Doxycycline alters metabolism and proliferation of human cell lines.

Ahler E, Sullivan WJ, Cass A, Braas D, York AG, Bensinger SJ, Graeber TG, Christofk HR.

PLoS One. 2013 May 31;8(5):e64561. doi: 10.1371/journal.pone.0064561. Print 2013.

27.

EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer.

Babic I, Anderson ES, Tanaka K, Guo D, Masui K, Li B, Zhu S, Gu Y, Villa GR, Akhavan D, Nathanson D, Gini B, Mareninov S, Li R, Camacho CE, Kurdistani SK, Eskin A, Nelson SF, Yong WH, Cavenee WK, Cloughesy TF, Christofk HR, Black DL, Mischel PS.

Cell Metab. 2013 Jun 4;17(6):1000-8. doi: 10.1016/j.cmet.2013.04.013. Epub 2013 May 23.

28.

Cancer: A metabolic metamorphosis.

Krall AS, Christofk HR.

Nature. 2013 Apr 4;496(7443):38-40. doi: 10.1038/496038a. No abstract available.

PMID:
23552939
29.

An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.

Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN, Komisopoulou E, Henkin AH, Soto H, Chamberlain BT, Vergnes L, Jung ME, Torres JZ, Liau LM, Christofk HR, Prins RM, Mischel PS, Reue K, Graeber TG, Bensinger SJ.

Cancer Res. 2013 May 1;73(9):2850-62. doi: 10.1158/0008-5472.CAN-13-0382-T. Epub 2013 Feb 25.

30.

Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition.

Smith KB, Tran LM, Tam BM, Shurell EM, Li Y, Braas D, Tap WD, Christofk HR, Dry SM, Eilber FC, Wu H.

Am J Pathol. 2013 Apr;182(4):1400-11. doi: 10.1016/j.ajpath.2013.01.002. Epub 2013 Feb 12.

31.

Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment.

Braas D, Ahler E, Tam B, Nathanson D, Riedinger M, Benz MR, Smith KB, Eilber FC, Witte ON, Tap WD, Wu H, Christofk HR.

Cancer Discov. 2012 Dec;2(12):1109-17. doi: 10.1158/2159-8290.CD-12-0197.

32.

Histone acetylation regulates intracellular pH.

McBrian MA, Behbahan IS, Ferrari R, Su T, Huang TW, Li K, Hong CS, Christofk HR, Vogelauer M, Seligson DB, Kurdistani SK.

Mol Cell. 2013 Jan 24;49(2):310-21. doi: 10.1016/j.molcel.2012.10.025. Epub 2012 Nov 29.

33.

Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.

Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ, Vander Heiden MG.

Nat Chem Biol. 2012 Oct;8(10):839-47. Erratum in: Nat Chem Biol. 2012 Dec;8(12):1008.

34.

New aspects of the Warburg effect in cancer cell biology.

Bensinger SJ, Christofk HR.

Semin Cell Dev Biol. 2012 Jun;23(4):352-61. doi: 10.1016/j.semcdb.2012.02.003. Epub 2012 Mar 8. Review.

PMID:
22406683
35.

Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries.

Christofk HR, Wu N, Cantley LC, Asara JM.

J Proteome Res. 2011 Sep 2;10(9):4158-64. doi: 10.1021/pr200578n. Epub 2011 Aug 2.

36.

Evidence for an alternative glycolytic pathway in rapidly proliferating cells.

Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC.

Science. 2010 Sep 17;329(5998):1492-9. doi: 10.1126/science.1188015.

37.

Identification of small molecule inhibitors of pyruvate kinase M2.

Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC.

Biochem Pharmacol. 2010 Apr 15;79(8):1118-24. doi: 10.1016/j.bcp.2009.12.003. Epub 2009 Dec 11.

38.

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth.

Christofk HR, Vander Heiden MG, Harris MH, Ramanathan A, Gerszten RE, Wei R, Fleming MD, Schreiber SL, Cantley LC.

Nature. 2008 Mar 13;452(7184):230-3. doi: 10.1038/nature06734.

PMID:
18337823
39.

Pyruvate kinase M2 is a phosphotyrosine-binding protein.

Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC.

Nature. 2008 Mar 13;452(7184):181-6. doi: 10.1038/nature06667.

PMID:
18337815
40.

A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen.

Asara JM, Christofk HR, Freimark LM, Cantley LC.

Proteomics. 2008 Mar;8(5):994-9. doi: 10.1002/pmic.200700426.

PMID:
18324724
41.

In-gel stable isotope labeling for relative quantification using mass spectrometry.

Asara JM, Zhang X, Zheng B, Maroney LA, Christofk HR, Wu N, Cantley LC.

Nat Protoc. 2006;1(1):46-51.

PMID:
17406210

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