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LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks.

Chatterjee S, Pietrofesa RA, Park K, Tao JQ, Carabe-Fernandez A, Berman AT, Koumenis C, Sielecki T, Christofidou-Solomidou M.

Int J Mol Sci. 2019 Jan 5;20(1). pii: E176. doi: 10.3390/ijms20010176.


Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy.

Kokkinaki D, Hoffman M, Kalliora C, Kyriazis ID, Maning J, Lucchese AM, Shanmughapriya S, Tomar D, Park JY, Wang H, Yang XF, Madesh M, Lymperopoulos A, Koch WJ, Christofidou-Solomidou M, Drosatos K.

J Mol Cell Cardiol. 2019 Feb;127:232-245. doi: 10.1016/j.yjmcc.2018.12.016. Epub 2019 Jan 3.


Spatially controlled assembly of affinity ligand and enzyme cargo enables targeting ferritin nanocarriers to caveolae.

Shuvaev VV, Khoshnejad M, Pulsipher KW, Kiseleva RY, Arguiri E, Cheung-Lau JC, LeFort KM, Christofidou-Solomidou M, Stan RV, Dmochowski IJ, Muzykantov VR.

Biomaterials. 2018 Dec;185:348-359. doi: 10.1016/j.biomaterials.2018.09.015. Epub 2018 Sep 12.


Applications of Out of Body Lung Perfusion.

Zhu B, Suzuki Y, DiSanto T, Rubin S, Penfil Z, Pietrofesa RA, Chatterjee S, Christofidou-Solomidou M, Cantu E.

Acad Radiol. 2019 Mar;26(3):404-411. doi: 10.1016/j.acra.2018.05.022. Epub 2018 Jul 24.


Oxidative Stress and Space Biology: An Organ-Based Approach.

Goodwin TJ, Christofidou-Solomidou M.

Int J Mol Sci. 2018 Mar 23;19(4). pii: E959. doi: 10.3390/ijms19040959.


Synthetic secoisolariciresinol diglucoside (LGM2605) inhibits myeloperoxidase activity in inflammatory cells.

Mishra OP, Popov AV, Pietrofesa RA, Nakamaru-Ogiso E, Andrake M, Christofidou-Solomidou M.

Biochim Biophys Acta Gen Subj. 2018 Jun;1862(6):1364-1375. doi: 10.1016/j.bbagen.2018.03.003. Epub 2018 Mar 7.


Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605) Reduces Asbestos-Induced Cytotoxicity in an Nrf2-Dependent and -Independent Manner.

Pietrofesa RA, Chatterjee S, Park K, Arguiri E, Albelda SM, Christofidou-Solomidou M.

Antioxidants (Basel). 2018 Mar 2;7(3). pii: E38. doi: 10.3390/antiox7030038.


Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation.

Rom S, Zuluaga-Ramirez V, Reichenbach NL, Erickson MA, Winfield M, Gajghate S, Christofidou-Solomidou M, Jordan-Sciutto KL, Persidsky Y.

J Neuroinflammation. 2018 Jan 27;15(1):25. doi: 10.1186/s12974-018-1065-0.


Targeting superoxide dismutase to endothelial caveolae profoundly alleviates inflammation caused by endotoxin.

Shuvaev VV, Kiseleva RY, Arguiri E, Villa CH, Muro S, Christofidou-Solomidou M, Stan RV, Muzykantov VR.

J Control Release. 2018 Feb 28;272:1-8. doi: 10.1016/j.jconrel.2017.12.025. Epub 2017 Dec 29.


Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage.

Velalopoulou A, Chatterjee S, Pietrofesa RA, Koziol-White C, Panettieri RA, Lin L, Tuttle S, Berman A, Koumenis C, Christofidou-Solomidou M.

Int J Mol Sci. 2017 Nov 25;18(12). pii: E2525. doi: 10.3390/ijms18122525.


The Synthetic Lignan Secoisolariciresinol Diglucoside Prevents Asbestos-Induced NLRP3 Inflammasome Activation in Murine Macrophages.

Pietrofesa RA, Woodruff P, Hwang WT, Patel P, Chatterjee S, Albelda SM, Christofidou-Solomidou M.

Oxid Med Cell Longev. 2017;2017:7395238. doi: 10.1155/2017/7395238. Epub 2017 Sep 13.


Flaxseed Consumption Inhibits Chemically Induced Lung Tumorigenesis and Modulates Expression of Phase II Enzymes and Inflammatory Cytokines in A/J Mice.

Chikara S, Mamidi S, Sreedasyam A, Chittem K, Pietrofesa R, Zuppa A, Moorthy G, Dyer N, Christofidou-Solomidou M, Reindl KM.

Cancer Prev Res (Phila). 2018 Jan;11(1):27-37. doi: 10.1158/1940-6207.CAPR-17-0119. Epub 2017 Oct 26.


Radiation Mitigating Properties of Intranasally Administered KL4 Surfactant in a Murine Model of Radiation-Induced Lung Damage.

Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Koumenis C, Segal R.

Radiat Res. 2017 Nov;188(5):491-504. doi: 10.1667/RR14686.1. Epub 2017 Sep 6.


Siderophore-mediated iron removal from chrysotile: Implications for asbestos toxicity reduction and bioremediation.

Mohanty SK, Gonneau C, Salamatipour A, Pietrofesa RA, Casper B, Christofidou-Solomidou M, Willenbring JK.

J Hazard Mater. 2018 Jan 5;341:290-296. doi: 10.1016/j.jhazmat.2017.07.033. Epub 2017 Jul 22.


Enterolactone Induces G1-phase Cell Cycle Arrest in Nonsmall Cell Lung Cancer Cells by Downregulating Cyclins and Cyclin-dependent Kinases.

Chikara S, Lindsey K, Dhillon H, Mamidi S, Kittilson J, Christofidou-Solomidou M, Reindl KM.

Nutr Cancer. 2017 May-Jun;69(4):652-662. doi: 10.1080/01635581.2017.1296169. Epub 2017 Mar 21.


Enterolactone alters FAK-Src signaling and suppresses migration and invasion of lung cancer cell lines.

Chikara S, Lindsey K, Borowicz P, Christofidou-Solomidou M, Reindl KM.

BMC Complement Altern Med. 2017 Jan 9;17(1):30. doi: 10.1186/s12906-016-1512-3.


Asbestos Fiber Preparation Methods Affect Fiber Toxicity.

Salamatipour A, Mohanty SK, Pietrofesa RA, Vann DR, Christofidou-Solomidou M, Willenbring JK.

Environ Sci Technol Lett. 2016 Jul 12;3(7):270-274. Epub 2016 Jun 14.


Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel.

Pietrofesa RA, Velalopoulou A, Lehman SL, Arguiri E, Solomides P, Koch CJ, Mishra OP, Koumenis C, Goodwin TJ, Christofidou-Solomidou M.

Int J Mol Sci. 2016 Jun 16;17(6). pii: E953. doi: 10.3390/ijms17060953.


Gamma-irradiation produces active chlorine species (ACS) in physiological solutions: Secoisolariciresinol diglucoside (SDG) scavenges ACS - A novel mechanism of DNA radioprotection.

Mishra OP, Popov AV, Pietrofesa RA, Christofidou-Solomidou M.

Biochim Biophys Acta. 2016 Sep;1860(9):1884-97. doi: 10.1016/j.bbagen.2016.05.037. Epub 2016 May 31.


Size and targeting to PECAM vs ICAM control endothelial delivery, internalization and protective effect of multimolecular SOD conjugates.

Shuvaev VV, Muro S, Arguiri E, Khoshnejad M, Tliba S, Christofidou-Solomidou M, Muzykantov VR.

J Control Release. 2016 Jul 28;234:115-23. doi: 10.1016/j.jconrel.2016.05.040. Epub 2016 May 20.


Asbestos Induces Oxidative Stress and Activation of Nrf2 Signaling in Murine Macrophages: Chemopreventive Role of the Synthetic Lignan Secoisolariciresinol Diglucoside (LGM2605).

Pietrofesa RA, Velalopoulou A, Albelda SM, Christofidou-Solomidou M.

Int J Mol Sci. 2016 Mar 1;17(3):322. doi: 10.3390/ijms17030322.


Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma.

Kadariya Y, Menges CW, Talarchek J, Cai KQ, Klein-Szanto AJ, Pietrofesa RA, Christofidou-Solomidou M, Cheung M, Mossman BT, Shukla A, Testa JR.

Cancer Prev Res (Phila). 2016 May;9(5):406-414. doi: 10.1158/1940-6207.CAPR-15-0347. Epub 2016 Mar 2.


Vascular Accessibility of Endothelial Targeted Ferritin Nanoparticles.

Khoshnejad M, Shuvaev VV, Pulsipher KW, Dai C, Hood ED, Arguiri E, Christofidou-Solomidou M, Dmochowski IJ, Greineder CF, Muzykantov VR.

Bioconjug Chem. 2016 Mar 16;27(3):628-37. doi: 10.1021/acs.bioconjchem.5b00641. Epub 2016 Jan 15.


The Flaxseed-Derived Lignan Phenolic Secoisolariciresinol Diglucoside (SDG) Protects Non-Malignant Lung Cells from Radiation Damage.

Velalopoulou A, Tyagi S, Pietrofesa RA, Arguiri E, Christofidou-Solomidou M.

Int J Mol Sci. 2015 Dec 22;17(1). pii: E7. doi: 10.3390/ijms17010007.


Flaxseed lignans enriched in secoisolariciresinol diglucoside prevent acute asbestos-induced peritoneal inflammation in mice.

Pietrofesa RA, Velalopoulou A, Arguiri E, Menges CW, Testa JR, Hwang WT, Albelda SM, Christofidou-Solomidou M.

Carcinogenesis. 2016 Feb;37(2):177-87. doi: 10.1093/carcin/bgv174. Epub 2015 Dec 17.


Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice.

Fan MH, Zhu Q, Li HH, Ra HJ, Majumdar S, Gulick DL, Jerome JA, Madsen DH, Christofidou-Solomidou M, Speicher DW, Bachovchin WW, Feghali-Bostwick C, Puré E.

J Biol Chem. 2016 Apr 8;291(15):8070-89. doi: 10.1074/jbc.M115.701433. Epub 2015 Dec 9.


Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure.

Mesaros C, Worth AJ, Snyder NW, Christofidou-Solomidou M, Vachani A, Albelda SM, Blair IA.

Bioanalysis. 2015;7(9):1157-73. doi: 10.4155/bio.15.53. Review.


Flaxseed modulates inflammatory and oxidative stress biomarkers in cystic fibrosis: a pilot study.

Turowski JB, Pietrofesa RA, Lawson JA, Christofidou-Solomidou M, Hadjiliadis D.

BMC Complement Altern Med. 2015 May 13;15:148. doi: 10.1186/s12906-015-0651-2.


Space radiation-associated lung injury in a murine model.

Christofidou-Solomidou M, Pietrofesa RA, Arguiri E, Schweitzer KS, Berdyshev EV, McCarthy M, Corbitt A, Alwood JS, Yu Y, Globus RK, Solomides CC, Ullrich RL, Petrache I.

Am J Physiol Lung Cell Mol Physiol. 2015 Mar 1;308(5):L416-28. doi: 10.1152/ajplung.00260.2014. Epub 2014 Dec 19.


Novel synthetic (S,S) and (R,R)-secoisolariciresinol diglucosides (SDGs) protect naked plasmid and genomic DNA From gamma radiation damage.

Mishra OP, Pietrofesa R, Christofidou-Solomidou M.

Radiat Res. 2014 Jul;182(1):102-10. doi: 10.1667/RR13635.1. Epub 2014 Jun 19.


Dietary flaxseed modulates the miRNA profile in irradiated and non-irradiated murine lungs: a novel mechanism of tissue radioprotection by flaxseed.

Christofidou-Solomidou M, Pietrofesa R, Arguiri E, McAlexander MA, Witwer KW.

Cancer Biol Ther. 2014 Jul;15(7):930-7. doi: 10.4161/cbt.28905. Epub 2014 Apr 22.


Dietary Flaxseed in Non-Small Cell Lung Cancer Patients Receiving Chemoradiation.

Berman AT, Turowski J, Mick R, Cengel K, Farnese N, Basel-Brown L, Mesaros C, Blair I, Lawson J, Christofidou-Solomidou M, Lee J, Rengan R.

J Pulm Respir Med. 2013 Aug 30;3(4):154.


Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system.

Akay C, Cooper M, Odeleye A, Jensen BK, White MG, Vassoler F, Gannon PJ, Mankowski J, Dorsey JL, Buch AM, Cross SA, Cook DR, Peña MM, Andersen ES, Christofidou-Solomidou M, Lindl KA, Zink MC, Clements J, Pierce RC, Kolson DL, Jordan-Sciutto KL.

J Neurovirol. 2014 Feb;20(1):39-53. doi: 10.1007/s13365-013-0227-1. Epub 2014 Jan 14.


Oxidative Lung Damage Resulting from Repeated Exposure to Radiation and Hyperoxia Associated with Space Exploration.

Pietrofesa RA, Turowski JB, Arguiri E, Milovanova TN, Solomides CC, Thom SR, Christofidou-Solomidou M.

J Pulm Respir Med. 2013 Sep 30;3(5). pii: 1000158.


Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo.

Shuvaev VV, Han J, Tliba S, Arguiri E, Christofidou-Solomidou M, Ramirez SH, Dykstra H, Persidsky Y, Atochin DN, Huang PL, Muzykantov VR.

PLoS One. 2013 Oct 11;8(10):e77002. doi: 10.1371/journal.pone.0077002. eCollection 2013.


Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs).

Mishra OP, Simmons N, Tyagi S, Pietrofesa R, Shuvaev VV, Valiulin RA, Heretsch P, Nicolaou KC, Christofidou-Solomidou M.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5325-8. doi: 10.1016/j.bmcl.2013.07.062. Epub 2013 Aug 2.


Keratinocyte growth factor and glucocorticoid induction of human peroxiredoxin 6 gene expression occur by independent mechanisms that are synergistic.

Chowdhury I, Fisher AB, Christofidou-Solomidou M, Gao L, Tao JQ, Sorokina EM, Lien YC, Bates SR, Feinstein SI.

Antioxid Redox Signal. 2014 Jan 20;20(3):391-402. doi: 10.1089/ars.2012.4634. Epub 2013 Sep 5.


Erythrocytosis and pulmonary hypertension in a mouse model of human HIF2A gain of function mutation.

Tan Q, Kerestes H, Percy MJ, Pietrofesa R, Chen L, Khurana TS, Christofidou-Solomidou M, Lappin TR, Lee FS.

J Biol Chem. 2013 Jun 14;288(24):17134-44. doi: 10.1074/jbc.M112.444059. Epub 2013 May 2.


Radiation mitigating properties of the lignan component in flaxseed.

Pietrofesa R, Turowski J, Tyagi S, Dukes F, Arguiri E, Busch TM, Gallagher-Colombo SM, Solomides CC, Cengel KA, Christofidou-Solomidou M.

BMC Cancer. 2013 Apr 4;13:179. doi: 10.1186/1471-2407-13-179.


Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG).

Christofidou-Solomidou M, Tyagi S, Pietrofesa R, Dukes F, Arguiri E, Turowski J, Grieshaber PA, Solomides CC, Cengel KA.

Radiat Res. 2012 Dec;178(6):568-80. doi: 10.1667/RR2980.1. Epub 2012 Oct 29.


Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235.

Cerniglia GJ, Karar J, Tyagi S, Christofidou-Solomidou M, Rengan R, Koumenis C, Maity A.

Mol Pharmacol. 2012 Dec;82(6):1230-40. doi: 10.1124/mol.112.080408. Epub 2012 Sep 18.


Gene expression profiling of flaxseed in mouse lung tissues-modulation of toxicologically relevant genes.

Dukes F, Kanterakis S, Lee J, Pietrofesa R, Andersen ES, Arguiri E, Tyagi S, Showe L, Amrani Y, Christofidou-Solomidou M.

BMC Complement Altern Med. 2012 Apr 20;12:47. doi: 10.1186/1472-6882-12-47.


Dietary flaxseed protects against lung ischemia reperfusion injury via inhibition of apoptosis and inflammation in a murine model.

Razi SS, Latif MJ, Li X, Afthinos JN, Ippagunta N, Schwartz G, Sagalovich D, Belsley SJ, Connery CP, Jour G, Christofidou-Solomidou M, Bhora FY.

J Surg Res. 2011 Nov;171(1):e113-21. doi: 10.1016/j.jss.2011.06.017. Epub 2011 Jul 7.


Dietary flaxseed administered post thoracic radiation treatment improves survival and mitigates radiation-induced pneumonopathy in mice.

Christofidou-Solomidou M, Tyagi S, Tan KS, Hagan S, Pietrofesa R, Dukes F, Arguiri E, Heitjan DF, Solomides CC, Cengel KA.

BMC Cancer. 2011 Jun 24;11:269. doi: 10.1186/1471-2407-11-269.


Modulation of endothelial targeting by size of antibody-antioxidant enzyme conjugates.

Shuvaev VV, Tliba S, Pick J, Arguiri E, Christofidou-Solomidou M, Albelda SM, Muzykantov VR.

J Control Release. 2011 Feb 10;149(3):236-41. doi: 10.1016/j.jconrel.2010.10.026. Epub 2010 Oct 31.


Anticancer activity of botanical compounds in ancient fermented beverages (review).

McGovern PE, Christofidou-Solomidou M, Wang W, Dukes F, Davidson T, El-Deiry WS.

Int J Oncol. 2010 Jul;37(1):5-14. Review.


Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice.

Lee JC, Kinniry PA, Arguiri E, Serota M, Kanterakis S, Chatterjee S, Solomides CC, Javvadi P, Koumenis C, Cengel KA, Christofidou-Solomidou M.

Radiat Res. 2010 May;173(5):590-601. doi: 10.1667/RR1522.1.


The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice.

Hickey MM, Richardson T, Wang T, Mosqueira M, Arguiri E, Yu H, Yu QC, Solomides CC, Morrisey EE, Khurana TS, Christofidou-Solomidou M, Simon MC.

J Clin Invest. 2010 Mar;120(3):827-39. doi: 10.1172/JCI36362. Epub 2010 Feb 8.


Neutrophil alpha-defensins cause lung injury by disrupting the capillary-epithelial barrier.

Bdeir K, Higazi AA, Kulikovskaya I, Christofidou-Solomidou M, Vinogradov SA, Allen TC, Idell S, Linzmeier R, Ganz T, Cines DB.

Am J Respir Crit Care Med. 2010 May 1;181(9):935-46. doi: 10.1164/rccm.200907-1128OC. Epub 2010 Jan 21.

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