Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 174

1.

Reptiles as a Model System to Study Heart Development.

Jensen B, Christoffels VM.

Cold Spring Harb Perspect Biol. 2019 Nov 11. pii: a037226. doi: 10.1101/cshperspect.a037226. [Epub ahead of print]

PMID:
31712265
2.

An enhancer cluster controls gene activity and topology of the SCN5A-SCN10A locus in vivo.

Man JCK, Mohan RA, Boogaard MVD, Hilvering CRE, Jenkins C, Wakker V, Bianchi V, Laat W, Barnett P, Boukens BJ, Christoffels VM.

Nat Commun. 2019 Oct 30;10(1):4943. doi: 10.1038/s41467-019-12856-5.

3.

Identification of atrial fibrillation associated genes and functional non-coding variants.

van Ouwerkerk AF, Bosada FM, van Duijvenboden K, Hill MC, Montefiori LE, Scholman KT, Liu J, de Vries AAF, Boukens BJ, Ellinor PT, Goumans MJTH, Efimov IR, Nobrega MA, Barnett P, Martin JF, Christoffels VM.

Nat Commun. 2019 Oct 18;10(1):4755. doi: 10.1038/s41467-019-12721-5.

4.

Low incidence of atrial septal defects in nonmammalian vertebrates.

Jensen B, Joyce W, Gregorovicova M, Sedmera D, Wang T, Christoffels VM.

Evol Dev. 2019 Oct 9:e12322. doi: 10.1111/ede.12322. [Epub ahead of print]

PMID:
31597012
5.

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice.

Houweling AC, Beaman GM, Postma AV, Gainous TB, Lichtenbelt KD, Brancati F, Lopes FM, van der Made I, Polstra AM, Robinson ML, Wright KD, Ellingford JM, Jackson AR, Overwater E, Genesio R, Romano S, Camerota L, D'Angelo E, Meijers-Heijboer EJ, Christoffels VM, McHugh KM, Black BL, Newman WG, Woolf AS, Creemers EE.

J Clin Invest. 2019 Nov 4. pii: 128545. doi: 10.1172/JCI128545. [Epub ahead of print]

6.

Identification and Characterization of a Transcribed Distal Enhancer Involved in Cardiac Kcnh2 Regulation.

van den Boogaard M, van Weerd JH, Bawazeer AC, Hooijkaas IB, van de Werken HJG, Tessadori F, de Laat W, Barnett P, Bakkers J, Christoffels VM.

Cell Rep. 2019 Sep 3;28(10):2704-2714.e5. doi: 10.1016/j.celrep.2019.08.007.

7.

Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.

Vincentz JW, Firulli BA, Toolan KP, Arking DE, Sotoodehnia N, Wan J, Chen PS, de Gier-de Vries C, Christoffels VM, Rubart-von der Lohe M, Firulli AB.

Circ Res. 2019 Aug 30;125(6):575-589. doi: 10.1161/CIRCRESAHA.119.315313. Epub 2019 Aug 1.

PMID:
31366290
8.

Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression.

van Eif VWW, Stefanovic S, Mohan RA, Christoffels VM.

Biochim Biophys Acta Mol Cell Res. 2019 Jul 12. pii: S0167-4889(19)30001-1. doi: 10.1016/j.bbamcr.2019.07.004. [Epub ahead of print] Review.

PMID:
31306714
9.

Identification of the building blocks of ventricular septation in monitor lizards (Varanidae).

Hanemaaijer J, Gregorovicova M, Nielsen JM, Moorman AFM, Wang T, Planken RN, Christoffels VM, Sedmera D, Jensen B.

Development. 2019 Jul 29;146(14). pii: dev177121. doi: 10.1242/dev.177121.

PMID:
31285354
10.

Conserved NPPB+ Border Zone Switches From MEF2- to AP-1-Driven Gene Program.

van Duijvenboden K, de Bakker DEM, Man JCK, Janssen R, Günthel M, Hill MC, Hooijkaas IB, van der Made I, van der Kraak PH, Vink A, Creemers EE, Martin JF, Barnett P, Bakkers J, Christoffels VM.

Circulation. 2019 Sep 9;140(10):864-879. doi: 10.1161/CIRCULATIONAHA.118.038944. Epub 2019 Jul 1.

PMID:
31259610
11.

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic program.

van Eif VWW, Stefanovic S, van Duijvenboden K, Bakker M, Wakker V, de Gier-de Vries C, Zaffran S, Verkerk AO, Boukens BJ, Christoffels VM.

Development. 2019 Apr 25;146(8). pii: dev173161. doi: 10.1242/dev.173161.

12.

Sinus venosus incorporation: contentious issues and operational criteria for developmental and evolutionary studies.

Faber JW, Boukens BJ, Oostra RJ, Moorman AFM, Christoffels VM, Jensen B.

J Anat. 2019 May;234(5):583-591. doi: 10.1111/joa.12962. Epub 2019 Mar 12. Review.

13.

Comparative analysis of avian hearts provides little evidence for variation among species with acquired endothermy.

Kroneman JGH, Faber JW, Schouten JCM, Wolschrijn CF, Christoffels VM, Jensen B.

J Morphol. 2019 Mar;280(3):395-410. doi: 10.1002/jmor.20952. Epub 2019 Jan 22.

14.

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing.

Végh AMD, den Haan AD, Cócera Ortega L, Verkerk AO, Sluijter JPG, Bakker D, van Amersfoorth S, van Veen TAB, Klerk M, Seppen J, de Bakker JMT, Christoffels VM, Geerts D, Goumans MJTH, Tan HL, Boink GJJ.

Molecules. 2019 Jan 5;24(1). pii: E181. doi: 10.3390/molecules24010181.

15.

TBX2 and TBX3 act downstream of canonical WNT signaling in patterning and differentiation of the mouse ureteric mesenchyme.

Aydoğdu N, Rudat C, Trowe MO, Kaiser M, Lüdtke TH, Taketo MM, Christoffels VM, Moon A, Kispert A.

Development. 2018 Nov 26;145(23). pii: dev171827. doi: 10.1242/dev.171827.

16.

Embryonic Tbx3+ cardiomyocytes form the mature cardiac conduction system by progressive fate restriction.

Mohan RA, Mommersteeg MTM, Domínguez JN, Choquet C, Wakker V, de Gier-de Vries C, Boink GJJ, Boukens BJ, Miquerol L, Verkerk AO, Christoffels VM.

Development. 2018 Sep 3;145(17). pii: dev167361. doi: 10.1242/dev.167361.

17.

Development, Proliferation, and Growth of the Mammalian Heart.

Günthel M, Barnett P, Christoffels VM.

Mol Ther. 2018 Jul 5;26(7):1599-1609. doi: 10.1016/j.ymthe.2018.05.022. Epub 2018 Jun 19. Review.

18.

Transcriptional regulation of the cardiac conduction system.

van Eif VWW, Devalla HD, Boink GJJ, Christoffels VM.

Nat Rev Cardiol. 2018 Oct;15(10):617-630. doi: 10.1038/s41569-018-0031-y. Review.

PMID:
29875439
19.

Direct Reprograming to Regenerate Myocardium and Repair Its Pacemaker and Conduction System.

Adepu S, Oosterwerff EFJ, Christoffels VM, Boink GJJ.

Medicines (Basel). 2018 Jun 4;5(2). pii: E48. doi: 10.3390/medicines5020048. Review.

20.

Regulation of Vertebrate Conduction System Development.

van Weerd JH, Christoffels VM.

In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 38.
2016 Jun 25.

21.

Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing.

Mohan RA, Boukens BJ, Christoffels VM.

Pediatr Cardiol. 2018 Aug;39(6):1107-1114. doi: 10.1007/s00246-018-1906-8. Epub 2018 May 17. Review.

22.

Specialized impulse conduction pathway in the alligator heart.

Jensen B, Boukens BJ, Crossley DA 2nd, Conner J, Mohan RA, van Duijvenboden K, Postma AV, Gloschat CR, Elsey RM, Sedmera D, Efimov IR, Christoffels VM.

Elife. 2018 Mar 22;7. pii: e32120. doi: 10.7554/eLife.32120.

23.

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R.

Genes Dev. 2018 Mar 1;32(5-6):373-388. doi: 10.1101/gad.307330.117. Epub 2018 Mar 19.

24.

Lineages of the Cardiac Conduction System.

Mohan R, Boukens BJ, Christoffels VM.

J Cardiovasc Dev Dis. 2017 May 2;4(2). pii: E5. doi: 10.3390/jcdd4020005. Review.

25.

On the Evolution of the Cardiac Pacemaker.

Burkhard S, van Eif V, Garric L, Christoffels VM, Bakkers J.

J Cardiovasc Dev Dis. 2017 Apr 27;4(2). pii: E4. doi: 10.3390/jcdd4020004. Review.

26.

Structure and function of the Nppa-Nppb cluster locus during heart development and disease.

Man J, Barnett P, Christoffels VM.

Cell Mol Life Sci. 2018 Apr;75(8):1435-1444. doi: 10.1007/s00018-017-2737-0. Epub 2018 Jan 4. Review.

27.

Origins and consequences of congenital heart defects affecting the right ventricle.

Woudstra OI, Ahuja S, Bokma JP, Bouma BJ, Mulder BJM, Christoffels VM.

Cardiovasc Res. 2017 Oct 1;113(12):1509-1520. doi: 10.1093/cvr/cvx155. Review.

PMID:
28957538
28.

Morpho-functional characterization of the systemic venous pole of the reptile heart.

Jensen B, Vesterskov S, Boukens BJ, Nielsen JM, Moorman AFM, Christoffels VM, Wang T.

Sci Rep. 2017 Jul 27;7(1):6644. doi: 10.1038/s41598-017-06291-z.

29.

Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia.

Anas AA, Claushuis TAM, Mohan RA, Christoffels VM, Aidinis V, Florquin S, Van't Veer C, Hou B, de Vos AF, van der Poll T.

Am J Respir Cell Mol Biol. 2017 May;56(5):648-656. doi: 10.1165/rcmb.2016-0190OC.

PMID:
28187270
30.

An interactive three-dimensional digital atlas and quantitative database of human development.

de Bakker BS, de Jong KH, Hagoort J, de Bree K, Besselink CT, de Kanter FE, Veldhuis T, Bais B, Schildmeijer R, Ruijter JM, Oostra RJ, Christoffels VM, Moorman AF.

Science. 2016 Nov 25;354(6315). pii: aag0053.

PMID:
27884980
31.

Excessive trabeculations in noncompaction do not have the embryonic identity.

Jensen B, van der Wal AC, Moorman AFM, Christoffels VM.

Int J Cardiol. 2017 Jan 15;227:325-330. doi: 10.1016/j.ijcard.2016.11.089. Epub 2016 Nov 9.

32.

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

Lüdtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A.

Dev Cell. 2016 Oct 24;39(2):239-253. doi: 10.1016/j.devcel.2016.08.007. Epub 2016 Oct 6.

33.

52 Genetic Loci Influencing Myocardial Mass.

van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I, Eijgelsheim M, Sotoodehnia N, Hayward C, Sorice R, Meirelles O, Lyytikäinen LP, Polašek O, Tanaka T, Arking DE, Ulivi S, Trompet S, Müller-Nurasyid M, Smith AV, Dörr M, Kerr KF, Magnani JW, Del Greco M F, Zhang W, Nolte IM, Silva CT, Padmanabhan S, Tragante V, Esko T, Abecasis GR, Adriaens ME, Andersen K, Barnett P, Bis JC, Bodmer R, Buckley BM, Campbell H, Cannon MV, Chakravarti A, Chen LY, Delitala A, Devereux RB, Doevendans PA, Dominiczak AF, Ferrucci L, Ford I, Gieger C, Harris TB, Haugen E, Heinig M, Hernandez DG, Hillege HL, Hirschhorn JN, Hofman A, Hubner N, Hwang SJ, Iorio A, Kähönen M, Kellis M, Kolcic I, Kooner IK, Kooner JS, Kors JA, Lakatta EG, Lage K, Launer LJ, Levy D, Lundby A, Macfarlane PW, May D, Meitinger T, Metspalu A, Nappo S, Naitza S, Neph S, Nord AS, Nutile T, Okin PM, Olsen JV, Oostra BA, Penninger JM, Pennacchio LA, Pers TH, Perz S, Peters A, Pinto YM, Pfeufer A, Pilia MG, Pramstaller PP, Prins BP, Raitakari OT, Raychaudhuri S, Rice KM, Rossin EJ, Rotter JI, Schafer S, Schlessinger D, Schmidt CO, Sehmi J, Silljé HHW, Sinagra G, Sinner MF, Slowikowski K, Soliman EZ, Spector TD, Spiering W, Stamatoyannopoulos JA, Stolk RP, Strauch K, Tan ST, Tarasov KV, Trinh B, Uitterlinden AG, van den Boogaard M, van Duijn CM, van Gilst WH, Viikari JS, Visscher PM, Vitart V, Völker U, Waldenberger M, Weichenberger CX, Westra HJ, Wijmenga C, Wolffenbuttel BH, Yang J, Bezzina CR, Munroe PB, Snieder H, Wright AF, Rudan I, Boyer LA, Asselbergs FW, van Veldhuisen DJ, Stricker BH, Psaty BM, Ciullo M, Sanna S, Lehtimäki T, Wilson JF, Bandinelli S, Alonso A, Gasparini P, Jukema JW, Kääb S, Gudnason V, Felix SB, Heckbert SR, de Boer RA, Newton-Cheh C, Hicks AA, Chambers JC, Jamshidi Y, Visel A, Christoffels VM, Isaacs A, Samani NJ, de Bakker PIW.

J Am Coll Cardiol. 2016 Sep 27;68(13):1435-1448. doi: 10.1016/j.jacc.2016.07.729.

34.

Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus.

Burger NB, Haak MC, Kok E, de Groot CJ, Shou W, Scambler PJ, Lee Y, Cho E, Christoffels VM, Bekker MN.

Early Hum Dev. 2016 Oct;101:39-48. doi: 10.1016/j.earlhumdev.2016.05.017. Epub 2016 Jul 9.

PMID:
27405055
35.

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.

Greulich F, Rudat C, Farin HF, Christoffels VM, Kispert A.

PLoS One. 2016 Jun 2;11(6):e0156787. doi: 10.1371/journal.pone.0156787. eCollection 2016.

36.

Absence of an anatomical origin for altered ductus venosus flow velocity waveforms in first-trimester human fetuses with increased nuchal translucency.

Burger NB, Matias A, Kok E, de Groot CJ, Christoffels VM, Bekker MN, Haak MC.

Prenat Diagn. 2016 Jun;36(6):537-44. doi: 10.1002/pd.4820. Epub 2016 May 10.

PMID:
27060369
37.

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress.

Sergeeva IA, Hooijkaas IB, Ruijter JM, van der Made I, de Groot NE, van de Werken HJ, Creemers EE, Christoffels VM.

Development. 2016 Jun 15;143(12):2135-46. doi: 10.1242/dev.132019. Epub 2016 Apr 5.

38.

The formation and function of the cardiac conduction system.

van Weerd JH, Christoffels VM.

Development. 2016 Jan 15;143(2):197-210. doi: 10.1242/dev.124883. Review.

39.

Embryonic development of the right ventricular outflow tract and arrhythmias.

Boukens BJ, Coronel R, Christoffels VM.

Heart Rhythm. 2016 Feb;13(2):616-22. doi: 10.1016/j.hrthm.2015.11.014. Epub 2015 Nov 14. Review. No abstract available.

PMID:
26586454
40.

EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.

van Duijvenboden K, de Boer BA, Capon N, Ruijter JM, Christoffels VM.

Nucleic Acids Res. 2016 Mar 18;44(5):e42. doi: 10.1093/nar/gkv1144. Epub 2015 Nov 3.

41.

Increased nuchal translucency origins from abnormal lymphatic development and is independent of the presence of a cardiac defect.

Burger NB, Bekker MN, Kok E, De Groot CJ, Martin JF, Shou W, Scambler PJ, Lee Y, Christoffels VM, Haak MC.

Prenat Diagn. 2015 Dec;35(13):1278-86. doi: 10.1002/pd.4687. Epub 2015 Oct 30.

PMID:
26338284
42.

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome.

Postma AV, Bezzina CR, Christoffels VM.

J Hum Genet. 2016 Jan;61(1):13-9. doi: 10.1038/jhg.2015.98. Epub 2015 Jul 30. Review.

PMID:
26223183
43.

GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation.

Stefanovic S, Christoffels VM.

Cell Mol Life Sci. 2015 Oct;72(20):3871-81. doi: 10.1007/s00018-015-1974-3. Epub 2015 Jul 1. Review.

44.

The past, present, and future of pacemaker therapies.

Boink GJ, Christoffels VM, Robinson RB, Tan HL.

Trends Cardiovasc Med. 2015 Nov;25(8):661-73. doi: 10.1016/j.tcm.2015.02.005. Epub 2015 Feb 20. Review.

PMID:
26001958
45.

Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms.

Burger NB, Bekker MN, de Groot CJ, Christoffels VM, Haak MC.

Prenat Diagn. 2015 Jun;35(6):517-28. doi: 10.1002/pd.4586. Epub 2015 May 19. Review.

PMID:
25728762
46.

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

Gillers BS, Chiplunkar A, Aly H, Valenta T, Basler K, Christoffels VM, Efimov IR, Boukens BJ, Rentschler S.

Circ Res. 2015 Jan 30;116(3):398-406. doi: 10.1161/CIRCRESAHA.116.304731. Epub 2014 Nov 6.

47.

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R.

Dev Cell. 2014 Nov 10;31(3):345-357. doi: 10.1016/j.devcel.2014.09.018. Epub 2014 Nov 10.

48.

Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.

Kunasegaran K, Ho V, Chang TH, De Silva D, Bakker ML, Christoffels VM, Pietersen AM.

PLoS One. 2014 Oct 24;9(10):e110191. doi: 10.1371/journal.pone.0110191. eCollection 2014.

49.

Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation.

de Boer BA, Le Garrec JF, Christoffels VM, Meilhac SM, Ruijter JM.

Wiley Interdiscip Rev Syst Biol Med. 2014 Nov-Dec;6(6):389-97. doi: 10.1002/wsbm.1285. Epub 2014 Oct 6.

PMID:
25286050
50.

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.

Rana MS, Théveniau-Ruissy M, De Bono C, Mesbah K, Francou A, Rammah M, Domínguez JN, Roux M, Laforest B, Anderson RH, Mohun T, Zaffran S, Christoffels VM, Kelly RG.

Circ Res. 2014 Oct 10;115(9):790-9. doi: 10.1161/CIRCRESAHA.115.305020. Epub 2014 Sep 4.

PMID:
25190705

Supplemental Content

Loading ...
Support Center