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Items: 1 to 50 of 164

1.

Development, Proliferation, and Growth of the Mammalian Heart.

Günthel M, Barnett P, Christoffels VM.

Mol Ther. 2018 Jul 5;26(7):1599-1609. doi: 10.1016/j.ymthe.2018.05.022. Epub 2018 Jun 19. Review.

PMID:
29929790
2.

Transcriptional regulation of the cardiac conduction system.

van Eif VWW, Devalla HD, Boink GJJ, Christoffels VM.

Nat Rev Cardiol. 2018 Jun 6. doi: 10.1038/s41569-018-0031-y. [Epub ahead of print] Review.

PMID:
29875439
3.

Regulation of Vertebrate Conduction System Development.

van Weerd JH, Christoffels VM.

In: Nakanishi T, Markwald RR, Baldwin HS, Keller BB, Srivastava D, Yamagishi H, editors. Etiology and Morphogenesis of Congenital Heart Disease: From Gene Function and Cellular Interaction to Morphology [Internet]. Tokyo: Springer; 2016. Chapter 38.
2016 Jun 25.

4.

Developmental Origin of the Cardiac Conduction System: Insight from Lineage Tracing.

Mohan RA, Boukens BJ, Christoffels VM.

Pediatr Cardiol. 2018 May 17. doi: 10.1007/s00246-018-1906-8. [Epub ahead of print]

PMID:
29774393
5.

Specialized impulse conduction pathway in the alligator heart.

Jensen B, Boukens BJ, Crossley DA 2nd, Conner J, Mohan RA, van Duijvenboden K, Postma AV, Gloschat CR, Elsey RM, Sedmera D, Efimov IR, Christoffels VM.

Elife. 2018 Mar 22;7. pii: e32120. doi: 10.7554/eLife.32120.

6.

An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R.

Genes Dev. 2018 Mar 1;32(5-6):373-388. doi: 10.1101/gad.307330.117. Epub 2018 Mar 19.

PMID:
29555651
7.

Lineages of the Cardiac Conduction System.

Mohan R, Boukens BJ, Christoffels VM.

J Cardiovasc Dev Dis. 2017 May 2;4(2). pii: E5. doi: 10.3390/jcdd4020005. Review.

8.

On the Evolution of the Cardiac Pacemaker.

Burkhard S, van Eif V, Garric L, Christoffels VM, Bakkers J.

J Cardiovasc Dev Dis. 2017 Apr 27;4(2). pii: E4. doi: 10.3390/jcdd4020004. Review.

9.

Structure and function of the Nppa-Nppb cluster locus during heart development and disease.

Man J, Barnett P, Christoffels VM.

Cell Mol Life Sci. 2018 Apr;75(8):1435-1444. doi: 10.1007/s00018-017-2737-0. Epub 2018 Jan 4. Review.

10.

Origins and consequences of congenital heart defects affecting the right ventricle.

Woudstra OI, Ahuja S, Bokma JP, Bouma BJ, Mulder BJM, Christoffels VM.

Cardiovasc Res. 2017 Oct 1;113(12):1509-1520. doi: 10.1093/cvr/cvx155. Review.

PMID:
28957538
11.

Morpho-functional characterization of the systemic venous pole of the reptile heart.

Jensen B, Vesterskov S, Boukens BJ, Nielsen JM, Moorman AFM, Christoffels VM, Wang T.

Sci Rep. 2017 Jul 27;7(1):6644. doi: 10.1038/s41598-017-06291-z.

12.

Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia.

Anas AA, Claushuis TAM, Mohan RA, Christoffels VM, Aidinis V, Florquin S, Van't Veer C, Hou B, de Vos AF, van der Poll T.

Am J Respir Cell Mol Biol. 2017 May;56(5):648-656. doi: 10.1165/rcmb.2016-0190OC.

PMID:
28187270
13.

An interactive three-dimensional digital atlas and quantitative database of human development.

de Bakker BS, de Jong KH, Hagoort J, de Bree K, Besselink CT, de Kanter FE, Veldhuis T, Bais B, Schildmeijer R, Ruijter JM, Oostra RJ, Christoffels VM, Moorman AF.

Science. 2016 Nov 25;354(6315). pii: aag0053.

PMID:
27884980
14.

Excessive trabeculations in noncompaction do not have the embryonic identity.

Jensen B, van der Wal AC, Moorman AFM, Christoffels VM.

Int J Cardiol. 2017 Jan 15;227:325-330. doi: 10.1016/j.ijcard.2016.11.089. Epub 2016 Nov 9.

15.

Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung.

Lüdtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A.

Dev Cell. 2016 Oct 24;39(2):239-253. doi: 10.1016/j.devcel.2016.08.007. Epub 2016 Oct 6.

16.

52 Genetic Loci Influencing Myocardial Mass.

van der Harst P, van Setten J, Verweij N, Vogler G, Franke L, Maurano MT, Wang X, Mateo Leach I, Eijgelsheim M, Sotoodehnia N, Hayward C, Sorice R, Meirelles O, Lyytikäinen LP, Polašek O, Tanaka T, Arking DE, Ulivi S, Trompet S, Müller-Nurasyid M, Smith AV, Dörr M, Kerr KF, Magnani JW, Del Greco M F, Zhang W, Nolte IM, Silva CT, Padmanabhan S, Tragante V, Esko T, Abecasis GR, Adriaens ME, Andersen K, Barnett P, Bis JC, Bodmer R, Buckley BM, Campbell H, Cannon MV, Chakravarti A, Chen LY, Delitala A, Devereux RB, Doevendans PA, Dominiczak AF, Ferrucci L, Ford I, Gieger C, Harris TB, Haugen E, Heinig M, Hernandez DG, Hillege HL, Hirschhorn JN, Hofman A, Hubner N, Hwang SJ, Iorio A, Kähönen M, Kellis M, Kolcic I, Kooner IK, Kooner JS, Kors JA, Lakatta EG, Lage K, Launer LJ, Levy D, Lundby A, Macfarlane PW, May D, Meitinger T, Metspalu A, Nappo S, Naitza S, Neph S, Nord AS, Nutile T, Okin PM, Olsen JV, Oostra BA, Penninger JM, Pennacchio LA, Pers TH, Perz S, Peters A, Pinto YM, Pfeufer A, Pilia MG, Pramstaller PP, Prins BP, Raitakari OT, Raychaudhuri S, Rice KM, Rossin EJ, Rotter JI, Schafer S, Schlessinger D, Schmidt CO, Sehmi J, Silljé HHW, Sinagra G, Sinner MF, Slowikowski K, Soliman EZ, Spector TD, Spiering W, Stamatoyannopoulos JA, Stolk RP, Strauch K, Tan ST, Tarasov KV, Trinh B, Uitterlinden AG, van den Boogaard M, van Duijn CM, van Gilst WH, Viikari JS, Visscher PM, Vitart V, Völker U, Waldenberger M, Weichenberger CX, Westra HJ, Wijmenga C, Wolffenbuttel BH, Yang J, Bezzina CR, Munroe PB, Snieder H, Wright AF, Rudan I, Boyer LA, Asselbergs FW, van Veldhuisen DJ, Stricker BH, Psaty BM, Ciullo M, Sanna S, Lehtimäki T, Wilson JF, Bandinelli S, Alonso A, Gasparini P, Jukema JW, Kääb S, Gudnason V, Felix SB, Heckbert SR, de Boer RA, Newton-Cheh C, Hicks AA, Chambers JC, Jamshidi Y, Visel A, Christoffels VM, Isaacs A, Samani NJ, de Bakker PIW.

J Am Coll Cardiol. 2016 Sep 27;68(13):1435-1448. doi: 10.1016/j.jacc.2016.07.729.

17.

Pitx2 modulates a Tbx5-dependent gene regulatory network to maintain atrial rhythm.

Nadadur RD, Broman MT, Boukens B, Mazurek SR, Yang X, van den Boogaard M, Bekeny J, Gadek M, Ward T, Zhang M, Qiao Y, Martin JF, Seidman CE, Seidman J, Christoffels V, Efimov IR, McNally EM, Weber CR, Moskowitz IP.

Sci Transl Med. 2016 Aug 31;8(354):354ra115. doi: 10.1126/scitranslmed.aaf4891.

18.

Cardiac defects, nuchal edema and abnormal lymphatic development are not associated with morphological changes in the ductus venosus.

Burger NB, Haak MC, Kok E, de Groot CJ, Shou W, Scambler PJ, Lee Y, Cho E, Christoffels VM, Bekker MN.

Early Hum Dev. 2016 Oct;101:39-48. doi: 10.1016/j.earlhumdev.2016.05.017. Epub 2016 Jul 9.

PMID:
27405055
19.

Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development.

Greulich F, Rudat C, Farin HF, Christoffels VM, Kispert A.

PLoS One. 2016 Jun 2;11(6):e0156787. doi: 10.1371/journal.pone.0156787. eCollection 2016.

20.

Absence of an anatomical origin for altered ductus venosus flow velocity waveforms in first-trimester human fetuses with increased nuchal translucency.

Burger NB, Matias A, Kok E, de Groot CJ, Christoffels VM, Bekker MN, Haak MC.

Prenat Diagn. 2016 Jun;36(6):537-44. doi: 10.1002/pd.4820. Epub 2016 May 10.

PMID:
27060369
21.

Identification of a regulatory domain controlling the Nppa-Nppb gene cluster during heart development and stress.

Sergeeva IA, Hooijkaas IB, Ruijter JM, van der Made I, de Groot NE, van de Werken HJ, Creemers EE, Christoffels VM.

Development. 2016 Jun 15;143(12):2135-46. doi: 10.1242/dev.132019. Epub 2016 Apr 5.

22.

The formation and function of the cardiac conduction system.

van Weerd JH, Christoffels VM.

Development. 2016 Jan 15;143(2):197-210. doi: 10.1242/dev.124883. Review.

23.

Embryonic development of the right ventricular outflow tract and arrhythmias.

Boukens BJ, Coronel R, Christoffels VM.

Heart Rhythm. 2016 Feb;13(2):616-22. doi: 10.1016/j.hrthm.2015.11.014. Epub 2015 Nov 14. Review. No abstract available.

PMID:
26586454
24.

EMERGE: a flexible modelling framework to predict genomic regulatory elements from genomic signatures.

van Duijvenboden K, de Boer BA, Capon N, Ruijter JM, Christoffels VM.

Nucleic Acids Res. 2016 Mar 18;44(5):e42. doi: 10.1093/nar/gkv1144. Epub 2015 Nov 3.

25.

A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference.

Kirchhof P, Breithardt G, Bax J, Benninger G, Blomstrom-Lundqvist C, Boriani G, Brandes A, Brown H, Brueckmann M, Calkins H, Calvert M, Christoffels V, Crijns H, Dobrev D, Ellinor P, Fabritz L, Fetsch T, Freedman SB, Gerth A, Goette A, Guasch E, Hack G, Haegeli L, Hatem S, Haeusler KG, Heidbüchel H, Heinrich-Nols J, Hidden-Lucet F, Hindricks G, Juul-Möller S, Kääb S, Kappenberger L, Kespohl S, Kotecha D, Lane DA, Leute A, Lewalter T, Meyer R, Mont L, Münzel F, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Piccini JP, Pilmeyer A, Potpara T, Ravens U, Reinecke H, Rostock T, Rustige J, Savelieva I, Schnabel R, Schotten U, Schwichtenberg L, Sinner MF, Steinbeck G, Stoll M, Tavazzi L, Themistoclakis S, Tse HF, Van Gelder IC, Vardas PE, Varpula T, Vincent A, Werring D, Willems S, Ziegler A, Lip GY, Camm AJ.

Europace. 2016 Jan;18(1):37-50. doi: 10.1093/europace/euv304. Epub 2015 Oct 18. Review.

PMID:
26481149
26.

Increased nuchal translucency origins from abnormal lymphatic development and is independent of the presence of a cardiac defect.

Burger NB, Bekker MN, Kok E, De Groot CJ, Martin JF, Shou W, Scambler PJ, Lee Y, Christoffels VM, Haak MC.

Prenat Diagn. 2015 Dec;35(13):1278-86. doi: 10.1002/pd.4687. Epub 2015 Oct 30.

PMID:
26338284
27.

Genetics of congenital heart disease: the contribution of the noncoding regulatory genome.

Postma AV, Bezzina CR, Christoffels VM.

J Hum Genet. 2016 Jan;61(1):13-9. doi: 10.1038/jhg.2015.98. Epub 2015 Jul 30. Review.

PMID:
26223183
28.

GATA-dependent transcriptional and epigenetic control of cardiac lineage specification and differentiation.

Stefanovic S, Christoffels VM.

Cell Mol Life Sci. 2015 Oct;72(20):3871-81. doi: 10.1007/s00018-015-1974-3. Epub 2015 Jul 1. Review.

29.

The past, present, and future of pacemaker therapies.

Boink GJ, Christoffels VM, Robinson RB, Tan HL.

Trends Cardiovasc Med. 2015 Nov;25(8):661-73. doi: 10.1016/j.tcm.2015.02.005. Epub 2015 Feb 20. Review.

PMID:
26001958
30.

Why increased nuchal translucency is associated with congenital heart disease: a systematic review on genetic mechanisms.

Burger NB, Bekker MN, de Groot CJ, Christoffels VM, Haak MC.

Prenat Diagn. 2015 Jun;35(6):517-28. doi: 10.1002/pd.4586. Epub 2015 May 19. Review.

PMID:
25728762
31.

Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties.

Gillers BS, Chiplunkar A, Aly H, Valenta T, Basler K, Christoffels VM, Efimov IR, Boukens BJ, Rentschler S.

Circ Res. 2015 Jan 30;116(3):398-406. doi: 10.1161/CIRCRESAHA.116.304731. Epub 2014 Nov 6.

32.

HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme.

Osterwalder M, Speziale D, Shoukry M, Mohan R, Ivanek R, Kohler M, Beisel C, Wen X, Scales SJ, Christoffels VM, Visel A, Lopez-Rios J, Zeller R.

Dev Cell. 2014 Nov 10;31(3):345-357. doi: 10.1016/j.devcel.2014.09.018. Epub 2014 Nov 10.

33.

Transcriptional repressor Tbx3 is required for the hormone-sensing cell lineage in mammary epithelium.

Kunasegaran K, Ho V, Chang TH, De Silva D, Bakker ML, Christoffels VM, Pietersen AM.

PLoS One. 2014 Oct 24;9(10):e110191. doi: 10.1371/journal.pone.0110191. eCollection 2014.

34.

Integrating multi-scale knowledge on cardiac development into a computational model of ventricular trabeculation.

de Boer BA, Le Garrec JF, Christoffels VM, Meilhac SM, Ruijter JM.

Wiley Interdiscip Rev Syst Biol Med. 2014 Nov-Dec;6(6):389-97. doi: 10.1002/wsbm.1285. Epub 2014 Oct 6.

PMID:
25286050
35.

Tbx1 coordinates addition of posterior second heart field progenitor cells to the arterial and venous poles of the heart.

Rana MS, Théveniau-Ruissy M, De Bono C, Mesbah K, Francou A, Rammah M, Domínguez JN, Roux M, Laforest B, Anderson RH, Mohun T, Zaffran S, Christoffels VM, Kelly RG.

Circ Res. 2014 Oct 10;115(9):790-9. doi: 10.1161/CIRCRESAHA.115.305020. Epub 2014 Sep 4.

36.

A mutation in the Kozak sequence of GATA4 hampers translation in a family with atrial septal defects.

Mohan RA, van Engelen K, Stefanovic S, Barnett P, Ilgun A, Baars MJ, Bouma BJ, Mulder BJ, Christoffels VM, Postma AV.

Am J Med Genet A. 2014 Nov;164A(11):2732-8. doi: 10.1002/ajmg.a.36703. Epub 2014 Aug 5.

PMID:
25099673
37.

Involvement of neurons and retinoic acid in lymphatic development: new insights in increased nuchal translucency.

Burger NB, Stuurman KE, Kok E, Konijn T, Schooneman D, Niederreither K, Coles M, Agace WW, Christoffels VM, Mebius RE, van de Pavert SA, Bekker MN.

Prenat Diagn. 2014 Dec;34(13):1312-9. doi: 10.1002/pd.4473. Epub 2014 Aug 22.

PMID:
25088217
38.

A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system.

van Weerd JH, Badi I, van den Boogaard M, Stefanovic S, van de Werken HJ, Gomez-Velazquez M, Badia-Careaga C, Manzanares M, de Laat W, Barnett P, Christoffels VM.

Circ Res. 2014 Aug 1;115(4):432-41. doi: 10.1161/CIRCRESAHA.115.303591. Epub 2014 Jun 24.

39.

OccuPeak: ChIP-Seq peak calling based on internal background modelling.

de Boer BA, van Duijvenboden K, van den Boogaard M, Christoffels VM, Barnett P, Ruijter JM.

PLoS One. 2014 Jun 17;9(6):e99844. doi: 10.1371/journal.pone.0099844. eCollection 2014.

40.

Genetic determinants of P wave duration and PR segment.

Verweij N, Mateo Leach I, van den Boogaard M, van Veldhuisen DJ, Christoffels VM; LifeLines Cohort Study, Hillege HL, van Gilst WH, Barnett P, de Boer RA, van der Harst P.

Circ Cardiovasc Genet. 2014 Aug;7(4):475-81. doi: 10.1161/CIRCGENETICS.113.000373. Epub 2014 May 21.

41.

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

Stefanovic S, Barnett P, van Duijvenboden K, Weber D, Gessler M, Christoffels VM.

Nat Commun. 2014 Apr 28;5:3680. doi: 10.1038/ncomms4680.

42.

Mkk4 is a negative regulator of the transforming growth factor beta 1 signaling associated with atrial remodeling and arrhythmogenesis with age.

Davies L, Jin J, Shen W, Tsui H, Shi Y, Wang Y, Zhang Y, Hao G, Wu J, Chen S, Fraser JA, Dong N, Christoffels V, Ravens U, Huang CL, Zhang H, Cartwright EJ, Wang X, Lei M.

J Am Heart Assoc. 2014 Apr 10;3(2):e000340. doi: 10.1161/JAHA.113.000340.

43.

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP.

J Clin Invest. 2014 Apr;124(4):1844-52. doi: 10.1172/JCI73140. Epub 2014 Mar 18.

44.

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

van den Boogaard M, Barnett P, Christoffels VM.

Trends Cardiovasc Med. 2014 Apr;24(3):99-104. doi: 10.1016/j.tcm.2013.09.001. Epub 2013 Dec 17. Review.

PMID:
24360055
45.

Comparative cardiovascular physiology: future trends, opportunities and challenges.

Burggren WW, Christoffels VM, Crossley DA 2nd, Enok S, Farrell AP, Hedrick MS, Hicks JW, Jensen B, Moorman AF, Mueller CA, Skovgaard N, Taylor EW, Wang T.

Acta Physiol (Oxf). 2014 Feb;210(2):257-76. doi: 10.1111/apha.12170. Epub 2013 Oct 23. Review.

PMID:
24119052
46.

A transgenic mouse model for the simultaneous monitoring of ANF and BNP gene activity during heart development and disease.

Sergeeva IA, Hooijkaas IB, Van Der Made I, Jong WM, Creemers EE, Christoffels VM.

Cardiovasc Res. 2014 Jan 1;101(1):78-86. doi: 10.1093/cvr/cvt228. Epub 2013 Oct 8.

PMID:
24104878
47.

Developing insights into cardiac regeneration.

Christoffels VM, Pu WT.

Development. 2013 Oct;140(19):3933-7. doi: 10.1242/dev.096867. Review.

48.

Systematic analysis of the development of the ductus venosus in wild type mouse and human embryos.

Burger NB, Haak MC, De Bakker BS, Al Shaibani Z, De Groot CJ, Christoffels VM, Bekker MN.

Early Hum Dev. 2013 Dec;89(12):1067-73. doi: 10.1016/j.earlhumdev.2013.07.029. Epub 2013 Aug 23.

PMID:
23978399
49.

Gene regulatory elements of the cardiac conduction system.

van Duijvenboden K, Ruijter JM, Christoffels VM.

Brief Funct Genomics. 2014 Jan;13(1):28-38. doi: 10.1093/bfgp/elt031. Epub 2013 Aug 22. Review.

PMID:
23969024
50.

Homeobox transcription factor Pitx2: The rise of an asymmetry gene in cardiogenesis and arrhythmogenesis.

Franco D, Christoffels VM, Campione M.

Trends Cardiovasc Med. 2014 Jan;24(1):23-31. doi: 10.1016/j.tcm.2013.06.001. Epub 2013 Aug 15. Review.

PMID:
23953978

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