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Items: 1 to 50 of 81


A Human Embryonic Stem Cell Reporter Line for Monitoring Chemical-induced Cardiotoxicity.

Tsai SY, Ghazizadeh Z, Wang HJ, Amin S, Ortega FA, Badieyan ZS, Hsu ZT, Gordillo M, Kumar R, Christini DJ, Evans T, Chen S.

Cardiovasc Res. 2019 Jun 7. pii: cvz148. doi: 10.1093/cvr/cvz148. [Epub ahead of print]


Light-Activated Dynamic Clamp Using iPSC-Derived Cardiomyocytes.

Quach B, Krogh-Madsen T, Entcheva E, Christini DJ.

Biophys J. 2018 Dec 4;115(11):2206-2217. doi: 10.1016/j.bpj.2018.10.018. Epub 2018 Oct 30.


Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing.

Ortega FA, Grandi E, Krogh-Madsen T, Christini DJ.

Front Physiol. 2018 Jan 4;8:1099. doi: 10.3389/fphys.2017.01099. eCollection 2017. Review.


Global Optimization of Ventricular Myocyte Model to Multi-Variable Objective Improves Predictions of Drug-Induced Torsades de Pointes.

Krogh-Madsen T, Jacobson AF, Ortega FA, Christini DJ.

Front Physiol. 2017 Dec 19;8:1059. doi: 10.3389/fphys.2017.01059. eCollection 2017.


Overexpression of Map3k7 activates sinoatrial node-like differentiation in mouse ES-derived cardiomyocytes.

Brown K, Legros S, Ortega FA, Dai Y, Doss MX, Christini DJ, Robinson RB, Foley AC.

PLoS One. 2017 Dec 27;12(12):e0189818. doi: 10.1371/journal.pone.0189818. eCollection 2017.


Slow [Na+]i dynamics impacts arrhythmogenesis and spiral wave reentry in cardiac myocyte ionic model.

Krogh-Madsen T, Christini DJ.

Chaos. 2017 Sep;27(9):093907. doi: 10.1063/1.4999475.


Hard real-time closed-loop electrophysiology with the Real-Time eXperiment Interface (RTXI).

Patel YA, George A, Dorval AD, White JA, Christini DJ, Butera RJ.

PLoS Comput Biol. 2017 May 30;13(5):e1005430. doi: 10.1371/journal.pcbi.1005430. eCollection 2017 May. Erratum in: PLoS Comput Biol. 2017 Jul 17;13(7):e1005656.


Differential roles of two delayed rectifier potassium currents in regulation of ventricular action potential duration and arrhythmia susceptibility.

Devenyi RA, Ortega FA, Groenendaal W, Krogh-Madsen T, Christini DJ, Sobie EA.

J Physiol. 2017 Apr 1;595(7):2301-2317. doi: 10.1113/JP273191. Epub 2016 Dec 28.


Illuminating Myocyte-Fibroblast Homotypic and Heterotypic Gap Junction Dynamics Using Dynamic Clamp.

Brown TR, Krogh-Madsen T, Christini DJ.

Biophys J. 2016 Aug 23;111(4):785-797. doi: 10.1016/j.bpj.2016.06.042.


Improving cardiomyocyte model fidelity and utility via dynamic electrophysiology protocols and optimization algorithms.

Krogh-Madsen T, Sobie EA, Christini DJ.

J Physiol. 2016 May 1;594(9):2525-36. doi: 10.1113/JP270618. Epub 2016 Feb 4. Review.


Computational Approaches to Understanding the Role of Fibroblast-Myocyte Interactions in Cardiac Arrhythmogenesis.

Brown TR, Krogh-Madsen T, Christini DJ.

Biomed Res Int. 2015;2015:465714. doi: 10.1155/2015/465714. Epub 2015 Oct 25. Review.


Cell-specific cardiac electrophysiology models.

Groenendaal W, Ortega FA, Kherlopian AR, Zygmunt AC, Krogh-Madsen T, Christini DJ.

PLoS Comput Biol. 2015 Apr 30;11(4):e1004242. doi: 10.1371/journal.pcbi.1004242. eCollection 2015 Apr.


Dynamic clamp in cardiac and neuronal systems using RTXI.

Ortega FA, Butera RJ, Christini DJ, White JA, Dorval AD 2nd.

Methods Mol Biol. 2014;1183:327-54. doi: 10.1007/978-1-4939-1096-0_21.


Voltage and calcium dynamics both underlie cellular alternans in cardiac myocytes.

Groenendaal W, Ortega FA, Krogh-Madsen T, Christini DJ.

Biophys J. 2014 May 20;106(10):2222-32. doi: 10.1016/j.bpj.2014.03.048.


Dependence of phase-2 reentry and repolarization dispersion on epicardial and transmural ionic heterogeneity: a simulation study.

Maoz A, Christini DJ, Krogh-Madsen T.

Europace. 2014 Mar;16(3):458-65. doi: 10.1093/europace/eut379.


Kcne2 deletion creates a multisystem syndrome predisposing to sudden cardiac death.

Hu Z, Kant R, Anand M, King EC, Krogh-Madsen T, Christini DJ, Abbott GW.

Circ Cardiovasc Genet. 2014 Feb;7(1):33-42. doi: 10.1161/CIRCGENETICS.113.000315. Epub 2014 Jan 8.


NHE isoform switching and KChIP2 upregulation in aging porcine atria.

Kant R, Hu Z, Malhotra JK, Krogh-Madsen T, Christini DJ, Heerdt PM, Abbott GW.

PLoS One. 2013 Dec 23;8(12):e82951. doi: 10.1371/journal.pone.0082951. eCollection 2013.


The relative influences of phosphometabolites and pH on action potential morphology during myocardial reperfusion: a simulation study.

Roberts BN, Christini DJ.

PLoS One. 2012;7(11):e47117. doi: 10.1371/journal.pone.0047117. Epub 2012 Nov 7.


Rapid genetic algorithm optimization of a mouse computational model: benefits for anthropomorphization of neonatal mouse cardiomyocytes.

Bot CT, Kherlopian AR, Ortega FA, Christini DJ, Krogh-Madsen T.

Front Physiol. 2012 Nov 5;3:421. doi: 10.3389/fphys.2012.00421. eCollection 2012.


Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmia.

Gaeta SA, Christini DJ.

Front Physiol. 2012 May 31;3:157. doi: 10.3389/fphys.2012.00157. eCollection 2012.


Transcriptomic analysis reveals atrial KCNE1 down-regulation following lung lobectomy.

Heerdt PM, Kant R, Hu Z, Kanda VA, Christini DJ, Malhotra JK, Abbott GW.

J Mol Cell Cardiol. 2012 Sep;53(3):350-3. doi: 10.1016/j.yjmcc.2012.05.010. Epub 2012 May 25.


Nonlinear dynamics in cardiology.

Krogh-Madsen T, Christini DJ.

Annu Rev Biomed Eng. 2012;14:179-203. doi: 10.1146/annurev-bioeng-071811-150106. Epub 2012 Apr 18. Review.


Exploiting mathematical models to illuminate electrophysiological variability between individuals.

Sarkar AX, Christini DJ, Sobie EA.

J Physiol. 2012 Jun 1;590(11):2555-67. doi: 10.1113/jphysiol.2011.223313. Epub 2012 Apr 10. Review.


A class of Monte-Carlo-based statistical algorithms for efficient detection of repolarization alternans.

Iravanian S, Kanu UB, Christini DJ.

IEEE Trans Biomed Eng. 2012 Jul;59(7):1882-91. doi: 10.1109/TBME.2012.2192733. Epub 2012 Apr 3.


Effects of electrical and structural remodeling on atrial fibrillation maintenance: a simulation study.

Krogh-Madsen T, Abbott GW, Christini DJ.

PLoS Comput Biol. 2012;8(2):e1002390. doi: 10.1371/journal.pcbi.1002390. Epub 2012 Feb 23.


NHE inhibition does not improve Na(+) or Ca(2+) overload during reperfusion: using modeling to illuminate the mechanisms underlying a therapeutic failure.

Roberts BN, Christini DJ.

PLoS Comput Biol. 2011 Oct;7(10):e1002241. doi: 10.1371/journal.pcbi.1002241. Epub 2011 Oct 20.


A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms.

Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE.

Sci Transl Med. 2011 Aug 31;3(98):98ra83. doi: 10.1126/scitranslmed.3002588.


Control of action potential duration alternans in canine ventricular tissue.

Kanu U, Iravanian S, Gilmour RF, Christini DJ.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:1997-2000. doi: 10.1109/IEMBS.2010.5627828.


Real-time experiment interface for biological control applications.

Lin RJ, Bettencourt J, Wha Ite J, Christini DJ, Butera RJ.

Conf Proc IEEE Eng Med Biol Soc. 2010;2010:4160-3. doi: 10.1109/IEMBS.2010.5627397.


Control of action potential duration alternans in canine cardiac ventricular tissue.

Kanu UB, Iravanian S, Gilmour RF Jr, Christini DJ.

IEEE Trans Biomed Eng. 2011 Apr;58(4):894-904. doi: 10.1109/TBME.2010.2089984. Epub 2010 Oct 28.


Feedback-control induced pattern formation in cardiac myocytes: a mathematical modeling study.

Gaeta SA, Krogh-Madsen T, Christini DJ.

J Theor Biol. 2010 Oct 7;266(3):408-18. doi: 10.1016/j.jtbi.2010.06.041. Epub 2010 Jul 8.


Action potential voltage alternans: an indicator of calcium handling dysfunction during heart failure?

Christini DJ.

Heart Rhythm. 2010 Aug;7(8):1102-3. doi: 10.1016/j.hrthm.2010.05.001. Epub 2010 May 7. No abstract available.


Off-site control of repolarization alternans in cardiac fibers.

Krogh-Madsen T, Karma A, Riccio ML, Jordan PN, Christini DJ, Gilmour RF Jr.

Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Jan;81(1 Pt 1):011915. Epub 2010 Jan 25.


Anthropomorphizing the mouse cardiac action potential via a novel dynamic clamp method.

Ahrens-Nicklas RC, Christini DJ.

Biophys J. 2009 Nov 18;97(10):2684-92. doi: 10.1016/j.bpj.2009.09.002.


Pacing-induced spatiotemporal dynamics can be exploited to improve reentry termination efficacy.

Krogh-Madsen T, Christini DJ.

Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug;80(2 Pt 1):021924. Epub 2009 Aug 21.


Improving the utility of T-wave alternans by quantifying its relationship to underlying action-potential duration alternans.

Christini DJ.

Heart Rhythm. 2009 Aug;6(8):1220-1. doi: 10.1016/j.hrthm.2009.04.022. Epub 2009 Apr 22. No abstract available.


Dynamical mechanism for subcellular alternans in cardiac myocytes.

Gaeta SA, Bub G, Abbott GW, Christini DJ.

Circ Res. 2009 Aug 14;105(4):335-42. doi: 10.1161/CIRCRESAHA.109.197590. Epub 2009 Jul 23.


Instability in action potential morphology underlies phase 2 reentry: a mathematical modeling study.

Maoz A, Krogh-Madsen T, Christini DJ.

Heart Rhythm. 2009 Jun;6(6):813-22. doi: 10.1016/j.hrthm.2009.02.043. Epub 2009 Mar 13. Erratum in: Heart Rhythm. 2009 Aug;6(8):1255.


Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.

Ahrens-Nicklas RC, Clancy CE, Christini DJ.

Cardiovasc Res. 2009 Jun 1;82(3):439-47. doi: 10.1093/cvr/cvp083. Epub 2009 Mar 5.


MinK-dependent internalization of the IKs potassium channel.

Xu X, Kanda VA, Choi E, Panaghie G, Roepke TK, Gaeta SA, Christini DJ, Lerner DJ, Abbott GW.

Cardiovasc Res. 2009 Jun 1;82(3):430-8. doi: 10.1093/cvr/cvp047. Epub 2009 Feb 7.


Targeted deletion of kcne2 impairs ventricular repolarization via disruption of I(K,slow1) and I(to,f).

Roepke TK, Kontogeorgis A, Ovanez C, Xu X, Young JB, Purtell K, Goldstein PA, Christini DJ, Peters NS, Akar FG, Gutstein DE, Lerner DJ, Abbott GW.

FASEB J. 2008 Oct;22(10):3648-60. doi: 10.1096/fj.08-110171. Epub 2008 Jul 4.


Resetting and termination of reentry in a loop-and-tail cardiac model.

Krogh-Madsen T, Christini DJ.

Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jan;77(1 Pt 1):011916. Epub 2008 Jan 23.


A KCNE2 mutation in a patient with cardiac arrhythmia induced by auditory stimuli and serum electrolyte imbalance.

Gordon E, Panaghie G, Deng L, Bee KJ, Roepke TK, Krogh-Madsen T, Christini DJ, Ostrer H, Basson CT, Chung W, Abbott GW.

Cardiovasc Res. 2008 Jan;77(1):98-106. Epub 2007 Oct 4.


Structural barrier increases QT-peak dispersion in swine left ventricle in vivo.

Lu S, Gong Y, Iwai S, Stein KM, Lerman BB, Christini DJ.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:4039-42.


Optical mapping system with real-time control capability.

Iravanian S, Christini DJ.

Am J Physiol Heart Circ Physiol. 2007 Oct;293(4):H2605-11. Epub 2007 Jul 20.


Mechanism underlying initiation of paroxysmal atrial flutter/atrial fibrillation by ectopic foci: a simulation study.

Gong Y, Xie F, Stein KM, Garfinkel A, Culianu CA, Lerman BB, Christini DJ.

Circulation. 2007 Apr 24;115(16):2094-102. Epub 2007 Apr 9.


Implantable cardioverter-defibrillator detection of repolarization alternans: uncovering a marker of electrical instability.

Christini DJ, Lerman BB.

Heart Rhythm. 2006 Jul;3(7):798-9. Epub 2006 Apr 5. No abstract available.


Control of electrical alternans in canine cardiac purkinje fibers.

Christini DJ, Riccio ML, Culianu CA, Fox JJ, Karma A, Gilmour RF Jr.

Phys Rev Lett. 2006 Mar 17;96(10):104101. Epub 2006 Mar 17.

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