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A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor.

Dekan Z, Sianati S, Yousuf A, Sutcliffe KJ, Gillis A, Mallet C, Singh P, Jin AH, Wang AM, Mohammadi SA, Stewart M, Ratnayake R, Fontaine F, Lacey E, Piggott AM, Du YP, Canals M, Sessions RB, Kelly E, Capon RJ, Alewood PF, Christie MJ.

Proc Natl Acad Sci U S A. 2019 Oct 29;116(44):22353-22358. doi: 10.1073/pnas.1908662116. Epub 2019 Oct 14.


Correction to: Electrophysiological Actions of N/OFQ.

Winters BL, Christie MJ, Vaughan CW.

Handb Exp Pharmacol. 2019;254:417. doi: 10.1007/164_2019_240.


Electrophysiological Actions of N/OFQ.

Winters BL, Christie MJ, Vaughan CW.

Handb Exp Pharmacol. 2019;254:91-130. doi: 10.1007/164_2019_205.


Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.

Mostyn SN, Rawling T, Mohammadi S, Shimmon S, Frangos ZJ, Sarker S, Yousuf A, Vetter I, Ryan RM, Christie MJ, Vandenberg RJ.

J Med Chem. 2019 Mar 14;62(5):2466-2484. doi: 10.1021/acs.jmedchem.8b01775. Epub 2019 Feb 20.


Phosphorylation-deficient G-protein-biased μ-opioid receptors improve analgesia and diminish tolerance but worsen opioid side effects.

Kliewer A, Schmiedel F, Sianati S, Bailey A, Bateman JT, Levitt ES, Williams JT, Christie MJ, Schulz S.

Nat Commun. 2019 Jan 21;10(1):367. doi: 10.1038/s41467-018-08162-1.


Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides.

Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ.

Sci Rep. 2018 Sep 7;8(1):13397. doi: 10.1038/s41598-018-31245-4.


Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.

Miess E, Gondin AB, Yousuf A, Steinborn R, Mösslein N, Yang Y, Göldner M, Ruland JG, Bünemann M, Krasel C, Christie MJ, Halls ML, Schulz S, Canals M.

Sci Signal. 2018 Jul 17;11(539). pii: eaas9609. doi: 10.1126/scisignal.aas9609.


Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter.

Brust A, Wang CA, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5203. doi: 10.1002/anie.201803138. No abstract available.


Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord.

Winters BL, Rawling T, Vandenberg RJ, Christie MJ, Bhola RF, Imlach WL.

Br J Pharmacol. 2018 Jun;175(12):2337-2347. doi: 10.1111/bph.14189. Epub 2018 Apr 14.


Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.

Yarwood RE, Imlach WL, Lieu T, Veldhuis NA, Jensen DD, Klein Herenbrink C, Aurelio L, Cai Z, Christie MJ, Poole DP, Porter CJH, McLean P, Hicks GA, Geppetti P, Halls ML, Canals M, Bunnett NW.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):12309-12314. doi: 10.1073/pnas.1706656114. Epub 2017 Oct 30.


Substance P and dopamine interact to modulate the distribution of delta-opioid receptors on cholinergic interneurons in the striatum.

Heath E, Chieng B, Christie MJ, Balleine BW.

Eur J Neurosci. 2018 May;47(10):1159-1173. doi: 10.1111/ejn.13750. Epub 2017 Nov 14.


Midterm Survivorship After Revision Total Hip Arthroplasty With a Custom Triflange Acetabular Component.

Gladnick BP, Fehring KA, Odum SM, Christie MJ, DeBoer DK, Fehring TK.

J Arthroplasty. 2018 Feb;33(2):500-504. doi: 10.1016/j.arth.2017.09.026. Epub 2017 Sep 21.


Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.

Jensen DD, Lieu T, Halls ML, Veldhuis NA, Imlach WL, Mai QN, Poole DP, Quach T, Aurelio L, Conner J, Herenbrink CK, Barlow N, Simpson JS, Scanlon MJ, Graham B, McCluskey A, Robinson PJ, Escriou V, Nassini R, Materazzi S, Geppetti P, Hicks GA, Christie MJ, Porter CJH, Canals M, Bunnett NW.

Sci Transl Med. 2017 May 31;9(392). pii: eaal3447. doi: 10.1126/scitranslmed.aal3447.


Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.


The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD.

Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0.


α9-nAChR knockout mice exhibit dysregulation of stress responses, affect and reward-related behaviour.

Mohammadi SA, Burton TJ, Christie MJ.

Behav Brain Res. 2017 Jun 15;328:105-114. doi: 10.1016/j.bbr.2017.04.005. Epub 2017 Apr 10.


Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.


Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic pain.

Imlach WL, Bhola RF, Mohammadi SA, Christie MJ.

Sci Rep. 2016 Nov 14;6:37104. doi: 10.1038/srep37104.


Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers.

Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF.

J Pept Sci. 2016 May;22(5):280-9. doi: 10.1002/psc.2857. Epub 2016 Feb 22.


Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition.

Munasinghe NR, Christie MJ.

Toxins (Basel). 2015 Dec 10;7(12):5386-407. doi: 10.3390/toxins7124890. Review.


Conotoxin Interactions with α9α10-nAChRs: Is the α9α10-Nicotinic Acetylcholine Receptor an Important Therapeutic Target for Pain Management?

Mohammadi SA, Christie MJ.

Toxins (Basel). 2015 Sep 28;7(10):3916-32. doi: 10.3390/toxins7103916. Review.


A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model.

Imlach WL, Bhola RF, May LT, Christopoulos A, Christie MJ.

Mol Pharmacol. 2015 Sep;88(3):460-8. doi: 10.1124/mol.115.099499. Epub 2015 Jun 23.


Chronic Morphine Reduces Surface Expression of δ-Opioid Receptors in Subregions of Rostral Striatum.

Leah PM, Heath EM, Balleine BW, Christie MJ.

Neurochem Res. 2016 Mar;41(3):500-9. doi: 10.1007/s11064-015-1638-6. Epub 2015 Jun 21.


Plasticity in striatopallidal projection neurons mediates the acquisition of habitual actions.

Shan Q, Christie MJ, Balleine BW.

Eur J Neurosci. 2015 Aug;42(4):2097-104. doi: 10.1111/ejn.12971. Epub 2015 Jun 30.


Role of Phosphorylation Sites in Desensitization of µ-Opioid Receptor.

Yousuf A, Miess E, Sianati S, Du YP, Schulz S, Christie MJ.

Mol Pharmacol. 2015 Oct;88(4):825-35. doi: 10.1124/mol.115.098244. Epub 2015 May 12.


Themed section.

Christie MJ, Connor M, Traynor JR.

Br J Pharmacol. 2015 Jan;172(2):247-50. doi: 10.1111/bph.13028. No abstract available.


High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury.

Murali SS, Napier IA, Mohammadi SA, Alewood PF, Lewis RJ, Christie MJ.

J Neurophysiol. 2015 Mar 1;113(5):1511-9. doi: 10.1152/jn.00608.2014. Epub 2014 Dec 10.


Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic.

Gori A, Wang CI, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A.

Angew Chem Int Ed Engl. 2015 Jan 19;54(4):1361-4. doi: 10.1002/anie.201409678. Epub 2014 Dec 5.


The acquisition of goal-directed actions generates opposing plasticity in direct and indirect pathways in dorsomedial striatum.

Shan Q, Ge M, Christie MJ, Balleine BW.

J Neurosci. 2014 Jul 9;34(28):9196-201. doi: 10.1523/JNEUROSCI.0313-14.2014.


Glycine transport inhibitors for the treatment of pain.

Vandenberg RJ, Ryan RM, Carland JE, Imlach WL, Christie MJ.

Trends Pharmacol Sci. 2014 Aug;35(8):423-30. doi: 10.1016/ Epub 2014 Jun 21. Review.


The light touch of delta opioid receptors.

Imlach W, Christie MJ.

Neuron. 2014 Mar 19;81(6):1220-1222. doi: 10.1016/j.neuron.2014.03.004.


β-Arrestin-2 knockout prevents development of cellular μ-opioid receptor tolerance but does not affect opioid-withdrawal-related adaptations in single PAG neurons.

Connor M, Bagley EE, Chieng BC, Christie MJ.

Br J Pharmacol. 2015 Jan;172(2):492-500. doi: 10.1111/bph.12673. Epub 2014 Jul 1.


Challenges for opioid receptor nomenclature: IUPHAR Review 9.

Cox BM, Christie MJ, Devi L, Toll L, Traynor JR.

Br J Pharmacol. 2015 Jan;172(2):317-23. doi: 10.1111/bph.12612. Epub 2014 Jul 1. Review.


μ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neurons.

Sadeghi M, Tzschentke TM, Christie MJ.

Br J Pharmacol. 2015 Jan;172(2):460-8. doi: 10.1111/bph.12566. Epub 2014 Jul 1.


MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors.

Jin AH, Vetter I, Dutertre S, Abraham N, Emidio NB, Inserra M, Murali SS, Christie MJ, Alewood PF, Lewis RJ.

Biochemistry. 2014 Jan 14;53(1):1-3. doi: 10.1021/bi400882s. Epub 2013 Dec 30.


Usefulness of intraoperative radiographs in reducing errors of cup placement and leg length during total hip arthroplasty.

Wind MA Jr, Morrison JC, Christie MJ.

Am J Orthop (Belle Mead NJ). 2013 Nov;42(11):E104-8.


Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration.

Sadeghi M, Murali SS, Lewis RJ, Alewood PF, Mohammadi S, Christie MJ.

Mol Pain. 2013 Oct 20;9:51. doi: 10.1186/1744-8069-9-51.


Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter.

Brust A, Wang CI, Daly NL, Kennerley J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF.

Angew Chem Int Ed Engl. 2013 Nov 11;52(46):12020-3. doi: 10.1002/anie.201304660. Epub 2013 Sep 24. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2018 May 4;57(19):5203.


Learning-related translocation of δ-opioid receptors on ventral striatal cholinergic interneurons mediates choice between goal-directed actions.

Bertran-Gonzalez J, Laurent V, Chieng BC, Christie MJ, Balleine BW.

J Neurosci. 2013 Oct 9;33(41):16060-71. doi: 10.1523/JNEUROSCI.1927-13.2013.


Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model.

Jayamanne A, Jeong HJ, Schroeder CI, Lewis RJ, Christie MJ, Vaughan CW.

Br J Pharmacol. 2013 Sep;170(2):245-54. doi: 10.1111/bph.12251.


Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance.

Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ.

Pharmacol Rev. 2013 Jan 15;65(1):223-54. doi: 10.1124/pr.112.005942. Print 2013 Jan. Review.


A continuous, fluorescence-based assay of μ-opioid receptor activation in AtT-20 cells.

Knapman A, Santiago M, Du YP, Bennallack PR, Christie MJ, Connor M.

J Biomol Screen. 2013 Mar;18(3):269-76. doi: 10.1177/1087057112461376. Epub 2012 Sep 26.


Prolonged stimulation of μ-opioid receptors produces β-arrestin-2-mediated heterologous desensitization of α(2)-adrenoceptor function in locus ceruleus neurons.

Dang VC, Chieng BC, Christie MJ.

Mol Pharmacol. 2012 Sep;82(3):473-80. doi: 10.1124/mol.112.079350. Epub 2012 Jun 11.


Are metal ion levels a useful trigger for surgical intervention?

Griffin WL, Fehring TK, Kudrna JC, Schmidt RH, Christie MJ, Odum SM, Dennos AC.

J Arthroplasty. 2012 Sep;27(8 Suppl):32-6. doi: 10.1016/j.arth.2012.03.020. Epub 2012 May 17.


Nucleus accumbens D2- and D1-receptor expressing medium spiny neurons are selectively activated by morphine withdrawal and acute morphine, respectively.

Enoksson T, Bertran-Gonzalez J, Christie MJ.

Neuropharmacology. 2012 Jun;62(8):2463-71. doi: 10.1016/j.neuropharm.2012.02.020. Epub 2012 Mar 3.


Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells.

Vetter I, Mozar CA, Durek T, Wingerd JS, Alewood PF, Christie MJ, Lewis RJ.

Biochem Pharmacol. 2012 Jun 1;83(11):1562-71. doi: 10.1016/j.bcp.2012.02.022. Epub 2012 Mar 3.


Conus venom peptide pharmacology.

Lewis RJ, Dutertre S, Vetter I, Christie MJ.

Pharmacol Rev. 2012 Apr;64(2):259-98. doi: 10.1124/pr.111.005322. Epub 2012 Mar 8. Review.


Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels.

Murali SS, Napier IA, Rycroft BK, Christie MJ.

J Physiol. 2012 Apr 1;590(7):1655-67. doi: 10.1113/jphysiol.2012.228429. Epub 2012 Feb 27.

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