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Items: 44


Hematopoietic cells as site of first-pass catabolism after subcutaneous dosing and contributors to systemic clearance of a monoclonal antibody in mice.

Richter WF, Christianson GJ, Frances N, Grimm HP, Proetzel G, Roopenian DC.

MAbs. 2018 Jul;10(5):803-813. doi: 10.1080/19420862.2018.1458808. Epub 2018 May 9.


A human endothelial cell-based recycling assay for screening of FcRn targeted molecules.

Grevys A, Nilsen J, Sand KMK, Daba MB, Øynebråten I, Bern M, McAdam MB, Foss S, Schlothauer T, Michaelsen TE, Christianson GJ, Roopenian DC, Blumberg RS, Sandlie I, Andersen JT.

Nat Commun. 2018 Feb 12;9(1):621. doi: 10.1038/s41467-018-03061-x.


Precocious Interleukin 21 Expression in Naive Mice Identifies a Natural Helper Cell Population in Autoimmune Disease.

Marnik EA, Wang X, Sproule TJ, Park G, Christianson GJ, Lane-Reticker SK, Jain S, Duffy T, Wang H, Carter GW, Morse HC 3rd, Roopenian DC.

Cell Rep. 2017 Oct 3;21(1):208-221. doi: 10.1016/j.celrep.2017.09.036.


Albumin, in the Presence of Calcium, Elicits a Massive Increase in Extracellular Bordetella Adenylate Cyclase Toxin.

Gonyar LA, Gray MC, Christianson GJ, Mehrad B, Hewlett EL.

Infect Immun. 2017 May 23;85(6). pii: e00198-17. doi: 10.1128/IAI.00198-17. Print 2017 Jun.


Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies.

Roopenian DC, Christianson GJ, Proetzel G, Sproule TJ.

Methods Mol Biol. 2016;1438:103-14. doi: 10.1007/978-1-4939-3661-8_6.


Interleukin 6 Accelerates Mortality by Promoting the Progression of the Systemic Lupus Erythematosus-Like Disease of BXSB.Yaa Mice.

Jain S, Park G, Sproule TJ, Christianson GJ, Leeth CM, Wang H, Roopenian DC, Morse HC 3rd.

PLoS One. 2016 Apr 6;11(4):e0153059. doi: 10.1371/journal.pone.0153059. eCollection 2016.


Albumin-deficient mouse models for studying metabolism of human albumin and pharmacokinetics of albumin-based drugs.

Roopenian DC, Low BE, Christianson GJ, Proetzel G, Sproule TJ, Wiles MV.

MAbs. 2015;7(2):344-51. doi: 10.1080/19420862.2015.1008345.


Dissection of the neonatal Fc receptor (FcRn)-albumin interface using mutagenesis and anti-FcRn albumin-blocking antibodies.

Sand KM, Dalhus B, Christianson GJ, Bern M, Foss S, Cameron J, Sleep D, Bjørås M, Roopenian DC, Sandlie I, Andersen JT.

J Biol Chem. 2014 Jun 13;289(24):17228-39. doi: 10.1074/jbc.M113.522565. Epub 2014 Apr 24.


Expression of neonatal Fc receptor in the eye.

Powner MB, McKenzie JA, Christianson GJ, Roopenian DC, Fruttiger M.

Invest Ophthalmol Vis Sci. 2014 Mar 19;55(3):1607-15. doi: 10.1167/iovs.13-12574.


IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice.

McPhee CG, Bubier JA, Sproule TJ, Park G, Steinbuck MP, Schott WH, Christianson GJ, Morse HC 3rd, Roopenian DC.

J Immunol. 2013 Nov 1;191(9):4581-8. doi: 10.4049/jimmunol.1300439. Epub 2013 Sep 27.


Monoclonal antibodies directed against human FcRn and their applications.

Christianson GJ, Sun VZ, Akilesh S, Pesavento E, Proetzel G, Roopenian DC.

MAbs. 2012 Mar-Apr;4(2):208-16. doi: 10.4161/mabs.4.2.19397. Epub 2012 Mar 1.


Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigens.

Dragovic SM, Hill T, Christianson GJ, Kim S, Elliott T, Scott D, Roopenian DC, Van Kaer L, Joyce S.

J Immunol. 2011 Jun 15;186(12):6683-92. doi: 10.4049/jimmunol.1100525. Epub 2011 May 13.


Human FcRn transgenic mice for pharmacokinetic evaluation of therapeutic antibodies.

Roopenian DC, Christianson GJ, Sproule TJ.

Methods Mol Biol. 2010;602:93-104. doi: 10.1007/978-1-60761-058-8_6.


Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolism.

Akilesh S, Christianson GJ, Roopenian DC, Shaw AS.

J Immunol. 2007 Oct 1;179(7):4580-8.


NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences.

Liu X, Ye L, Christianson GJ, Yang JQ, Roopenian DC, Zhu X.

J Immunol. 2007 Sep 1;179(5):2999-3011.


Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.

Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC.

Int Immunol. 2006 Dec;18(12):1759-69. Epub 2006 Oct 31.


The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease.

Akilesh S, Petkova S, Sproule TJ, Shaffer DJ, Christianson GJ, Roopenian D.

J Clin Invest. 2004 May;113(9):1328-33.


The H4b minor histocompatibility antigen is caused by a combination of genetically determined and posttranslational modifications.

Yadav R, Yoshimura Y, Boesteanu A, Christianson GJ, Ajayi WU, Shashidharamurthy R, Stanic AK, Roopenian DC, Joyce S.

J Immunol. 2003 May 15;170(10):5133-42.


The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs.

Roopenian DC, Christianson GJ, Sproule TJ, Brown AC, Akilesh S, Jung N, Petkova S, Avanessian L, Choi EY, Shaffer DJ, Eden PA, Anderson CL.

J Immunol. 2003 Apr 1;170(7):3528-33.


Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide.

Choi EY, Christianson GJ, Yoshimura Y, Sproule TJ, Jung N, Joyce S, Roopenian DC.

Immunity. 2002 Nov;17(5):593-603.


Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease.

Choi EY, Christianson GJ, Yoshimura Y, Jung N, Sproule TJ, Malarkannan S, Joyce S, Roopenian DC.

Blood. 2002 Dec 15;100(13):4259-65. Epub 2002 Aug 22.


How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination.

Ostrov DA, Roden MM, Shi W, Palmieri E, Christianson GJ, Mendoza L, Villaflor G, Tilley D, Shastri N, Grey H, Almo SC, Roopenian D, Nathenson SG.

J Immunol. 2002 Jan 1;168(1):283-9.


Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others.

Choi EY, Yoshimura Y, Christianson GJ, Sproule TJ, Malarkannan S, Shastri N, Joyce S, Roopenian DC.

J Immunol. 2001 Apr 1;166(7):4370-9.


Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions.

Graser RT, DiLorenzo TP, Wang F, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV.

J Immunol. 2000 Apr 1;164(7):3913-8.


A new MHC locus that influences class I peptide presentation.

Taurog JD, Lindahl KF, Hammer RE, Slaughter CA, Maika SD, Zhou M, Roopenian DC, Christianson GJ, Gaskell SJ, Jones RC, Bordoli R, Ploegh HL, Galocha B, Summerfield SG.

Immunity. 1999 Oct;11(4):following 506. No abstract available.


Biochemical and immunogenetic analysis of an immunodominant peptide (B6dom1) encoded by the classical H7 minor histocompatibility locus.

Eden PA, Christianson GJ, Fontaine P, Wettstein PJ, Perreault C, Roopenian DC.

J Immunol. 1999 Apr 15;162(8):4502-10.


A molecular basis for how a single TCR interfaces multiple ligands.

Boesteanu A, Brehm M, Mylin LM, Christianson GJ, Tevethia SS, Roopenian DC, Joyce S.

J Immunol. 1998 Nov 1;161(9):4719-27.


Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement.

DiLorenzo TP, Graser RT, Ono T, Christianson GJ, Chapman HD, Roopenian DC, Nathenson SG, Serreze DV.

Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12538-43.


Expression screening of a yeast artificial chromosome contig refines the location of the mouse H3a minor histocompatibility antigen gene.

Zuberi AR, Christianson GJ, Dave SB, Bradley JA, Roopenian DC.

J Immunol. 1998 Jul 15;161(2):821-8.


A new MHC locus that influences class I peptide presentation.

Simmons WA, Roopenian DC, Summerfield SG, Jones RC, Galocha B, Christianson GJ, Maika SD, Zhou M, Gaskell SJ, Bordoli RS, Ploegh HL, Slaughter CA, Lindahl KF, Hammer RE, Taurog JD.

Immunity. 1997 Nov;7(5):641-51. Retraction in: Taurog JD, Lindahl KF, Hammer RE, Slaughter CA, Maika SD, Zhou M, Roopenian DC, Christianson GJ, Gaskell SJ, Jones RC, Bordoli R, Ploegh HL, Galocha B, Summerfield SG. Immunity. 1999 Oct;11(4):following 506.


Beta 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism.

Christianson GJ, Brooks W, Vekasi S, Manolfi EA, Niles J, Roopenian SL, Roths JB, Rothlein R, Roopenian DC.

J Immunol. 1997 Nov 15;159(10):4781-92.


Beta2-microglobulin-deficient mice are resistant to bullous pemphigoid.

Liu Z, Roopenian DC, Zhou X, Christianson GJ, Diaz LA, Sedmak DD, Anderson CL.

J Exp Med. 1997 Aug 29;186(5):777-83.


MHC class I-mediated antigen presentation and induction of CD8+ cytotoxic T-cell responses in autoimmune diabetes-prone NOD mice.

Serreze DV, Gallichan WS, Snider DP, Croitoru K, Rosenthal KL, Leiter EH, Christianson GJ, Dudley ME, Roopenian DC.

Diabetes. 1996 Jul;45(7):902-8.


beta2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice.

Christianson GJ, Blankenburg RL, Duffy TM, Panka D, Roths JB, Marshak-Rothstein A, Roopenian DC.

J Immunol. 1996 Jun 15;156(12):4932-9.


Lack of GVHD across classical, single minor histocompatibiliTy (miH) locus barriers in mice.

Blazar BR, Roopenian DC, Taylor PA, Christianson GJ, Panoskaltsis-Mortari A, Vallera DA.

Transplantation. 1996 Feb 27;61(4):619-24.


Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus.

King TR, Christianson GJ, Mitchell MJ, Bishop CE, Scott D, Ehrmann I, Simpson E, Eicher EM, Roopenian DC.

Genomics. 1994 Nov 1;24(1):159-68.


Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistant.

Serreze DV, Leiter EH, Christianson GJ, Greiner D, Roopenian DC.

Diabetes. 1994 Mar;43(3):505-9.


Gene mapping in a murine cell line by immunoselection with cytotoxic T lymphocytes.

Zuberi AR, Dudley ME, Christianson GJ, Roopenian DC.

Genomics. 1994 Jan 15;19(2):273-9.


The functional basis of minor histocompatibility loci.

Roopenian DC, Davis AP, Christianson GJ, Mobraaten LE.

J Immunol. 1993 Nov 1;151(9):4595-605.


The genetic origin of minor histocompatibility antigens.

Roopenian DC, Christianson GJ, Davis AP, Zuberi AR, Mobraaten LE.

Immunogenetics. 1993;38(2):131-40.


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