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Correction to Structural and Chemical Biology of Terpenoid Cyclases.

Christianson DW.

Chem Rev. 2018 Dec 12. doi: 10.1021/acs.chemrev.8b00682. [Epub ahead of print] No abstract available.


Foraging investment in a long-lived herbivore and vulnerability to coursing and stalking predators.

Christianson D, Becker MS, Brennan A, Creel S, Dröge E, M'soka J, Mukula T, Schuette P, Smit D, Watson F.

Ecol Evol. 2018 Sep 17;8(20):10147-10155. doi: 10.1002/ece3.4489. eCollection 2018 Oct.


Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor.

Bhatia S, Krieger V, Groll M, Osko JD, Reßing N, Ahlert H, Borkhardt A, Kurz T, Christianson DW, Hauer J, Hansen FK.

J Med Chem. 2018 Nov 21;61(22):10299-10309. doi: 10.1021/acs.jmedchem.8b01487. Epub 2018 Nov 8.


Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene.

Blank PN, Pemberton TA, Chow JY, Poulter CD, Christianson DW.

Biochemistry. 2018 Nov 6;57(44):6326-6335. doi: 10.1021/acs.biochem.8b00899. Epub 2018 Oct 22.


The Psychological Experience of Awaiting Breast Diagnosis.

Sweeny K, Christianson D, McNeill J.

Ann Behav Med. 2018 Sep 18. doi: 10.1093/abm/kay072. [Epub ahead of print]


Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity.

Porter NJ, Osko JD, Diedrich D, Kurz T, Hooker JM, Hansen FK, Christianson DW.

J Med Chem. 2018 Sep 13;61(17):8054-8060. doi: 10.1021/acs.jmedchem.8b01013. Epub 2018 Aug 17.


Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors.

Mackwitz MKW, Hamacher A, Osko JD, Held J, Schöler A, Christianson DW, Kassack MU, Hansen FK.

Org Lett. 2018 Jun 1;20(11):3255-3258. doi: 10.1021/acs.orglett.8b01118. Epub 2018 May 23.


Quantifying lion (Panthera leo) demographic response following a three-year moratorium on trophy hunting.

Mweetwa T, Christianson D, Becker M, Creel S, Rosenblatt E, Merkle J, Dröge E, Mwape H, Masonde J, Simpamba T.

PLoS One. 2018 May 21;13(5):e0197030. doi: 10.1371/journal.pone.0197030. eCollection 2018.


Entropy as a Driver of Selectivity for Inhibitor Binding to Histone Deacetylase 6.

Porter NJ, Wagner FF, Christianson DW.

Biochemistry. 2018 Jul 3;57(26):3916-3924. doi: 10.1021/acs.biochem.8b00367. Epub 2018 May 18.


Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients.

Turner AM, Stolk J, Bals R, Lickliter JD, Hamilton J, Christianson DR, Given BD, Burdon JG, Loomba R, Stoller JK, Teckman JH.

J Hepatol. 2018 Aug;69(2):378-384. doi: 10.1016/j.jhep.2018.03.012. Epub 2018 Mar 21.


Polyamine Deacetylase Structure and Catalysis: Prokaryotic Acetylpolyamine Amidohydrolase and Eukaryotic HDAC10.

Shinsky SA, Christianson DW.

Biochemistry. 2018 Jun 5;57(22):3105-3114. doi: 10.1021/acs.biochem.8b00079. Epub 2018 Mar 21. Review.


Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.

Porter NJ, Mahendran A, Breslow R, Christianson DW.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13459-13464. doi: 10.1073/pnas.1718823114. Epub 2017 Dec 4.


Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes.

Blank PN, Barrow GH, Chou WKW, Duan L, Cane DE, Christianson DW.

Biochemistry. 2017 Oct 31;56(43):5798-5811. doi: 10.1021/acs.biochem.7b00895. Epub 2017 Oct 17.


Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8.

Porter NJ, Christianson DW.

ACS Chem Biol. 2017 Sep 15;12(9):2281-2286. doi: 10.1021/acschembio.7b00330. Epub 2017 Aug 30.


Structural and Chemical Biology of Terpenoid Cyclases.

Christianson DW.

Chem Rev. 2017 Sep 13;117(17):11570-11648. doi: 10.1021/acs.chemrev.7b00287. Epub 2017 Aug 25. Review.


ARID1A-mutated ovarian cancers depend on HDAC6 activity.

Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher FJ III, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R.

Nat Cell Biol. 2017 Aug;19(8):962-973. doi: 10.1038/ncb3582. Epub 2017 Jul 24.


Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.

Hai Y, Shinsky SA, Porter NJ, Christianson DW.

Nat Commun. 2017 May 18;8:15368. doi: 10.1038/ncomms15368.


The relationship between direct predation and antipredator responses: a test with multiple predators and multiple prey.

Creel S, Dröge E, M'soka J, Smit D, Becker M, Christianson D, Schuette P.

Ecology. 2017 Aug;98(8):2081-2092. doi: 10.1002/ecy.1885. Epub 2017 Jun 22.


Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases.

Pemberton TA, Chen M, Harris GG, Chou WK, Duan L, Köksal M, Genshaft AS, Cane DE, Christianson DW.

Biochemistry. 2017 Apr 11;56(14):2010-2023. doi: 10.1021/acs.biochem.7b00137. Epub 2017 Mar 31.


Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.

Porter NJ, Christianson NH, Decroos C, Christianson DW.

Biochemistry. 2016 Dec 6;55(48):6718-6729. Epub 2016 Nov 28.


Structural aspects of HDAC8 mechanism and dysfunction in Cornelia de Lange syndrome spectrum disorders.

Deardorff MA, Porter NJ, Christianson DW.

Protein Sci. 2016 Nov;25(11):1965-1976. doi: 10.1002/pro.3030. Epub 2016 Sep 16. Review.


Editorial overview: Catalysis and regulation: enzyme structure, mechanism, and biosynthetic pathways.

Christianson DW, Scrutton NS.

Curr Opin Struct Biol. 2016 Dec;41:viii-x. doi: 10.1016/ Epub 2016 Sep 16. No abstract available.


Histone deacetylase 6 structure and molecular basis of catalysis and inhibition.

Hai Y, Christianson DW.

Nat Chem Biol. 2016 Sep;12(9):741-7. doi: 10.1038/nchembio.2134. Epub 2016 Jul 25.


Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis.

Chen M, Harris GG, Pemberton TA, Christianson DW.

Curr Opin Struct Biol. 2016 Dec;41:27-37. doi: 10.1016/ Epub 2016 Jun 7. Review.


Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase.

Chen M, Chou WK, Al-Lami N, Faraldos JA, Allemann RK, Cane DE, Christianson DW.

Biochemistry. 2016 May 24;55(20):2864-74. doi: 10.1021/acs.biochem.6b00343. Epub 2016 May 12.


General base-general acid catalysis by terpenoid cyclases.

Pemberton TA, Christianson DW.

J Antibiot (Tokyo). 2016 Jul;69(7):486-93. doi: 10.1038/ja.2016.39. Epub 2016 Apr 13. Review.


Crystal structures of Leishmania mexicana arginase complexed with α,α-disubstituted boronic amino-acid inhibitors.

Hai Y, Christianson DW.

Acta Crystallogr F Struct Biol Commun. 2016 Apr;72(Pt 4):300-6. doi: 10.1107/S2053230X16003630. Epub 2016 Mar 16.


Mechanism of Germacradien-4-ol Synthase-Controlled Water Capture.

Grundy DJ, Chen M, González V, Leoni S, Miller DJ, Christianson DW, Allemann RK.

Biochemistry. 2016 Apr 12;55(14):2112-21. doi: 10.1021/acs.biochem.6b00115. Epub 2016 Mar 30.


Estimating Sonoran pronghorn abundance and survival with fecal DNA and capture-recapture methods.

Woodruff SP, Lukacs PM, Christianson D, Waits LP.

Conserv Biol. 2016 Oct;30(5):1102-11. doi: 10.1111/cobi.12710. Epub 2016 Apr 26.


General Base-General Acid Catalysis in Human Histone Deacetylase 8.

Gantt SM, Decroos C, Lee MS, Gullett LE, Bowman CM, Christianson DW, Fierke CA.

Biochemistry. 2016 Feb 9;55(5):820-32. doi: 10.1021/acs.biochem.5b01327. Epub 2016 Jan 25.


Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.

Chen M, Chou WK, Toyomasu T, Cane DE, Christianson DW.

ACS Chem Biol. 2016 Apr 15;11(4):889-99. doi: 10.1021/acschembio.5b00960. Epub 2016 Jan 6.


CONSERVATION POLICY. Questionable policy for large carnivore hunting.

Creel S, Becker M, Christianson D, Dröge E, Hammerschlag N, Hayward MW, Karanth U, Loveridge A, Macdonald DW, Matandiko W, M'soka J, Murray D, Rosenblatt E, Schuette P.

Science. 2015 Dec 18;350(6267):1473-5. doi: 10.1126/science.aac4768. No abstract available.


Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence.

Harris GG, Lombardi PM, Pemberton TA, Matsui T, Weiss TM, Cole KE, Köksal M, Murphy FV 4th, Vedula LS, Chou WK, Cane DE, Christianson DW.

Biochemistry. 2015 Dec 8;54(48):7142-55. doi: 10.1021/acs.biochem.5b01143. Epub 2015 Nov 24.


Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disorders.

Decroos C, Christianson NH, Gullett LE, Bowman CM, Christianson KE, Deardorff MA, Christianson DW.

Biochemistry. 2015 Oct 27;54(42):6501-13. doi: 10.1021/acs.biochem.5b00881. Epub 2015 Oct 14.


Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase.

Decroos C, Christianson DW.

Biochemistry. 2015 Aug 4;54(30):4692-703. doi: 10.1021/acs.biochem.5b00536. Epub 2015 Jul 22.


Targeting the interleukin-11 receptor α in metastatic prostate cancer: A first-in-man study.

Pasqualini R, Millikan RE, Christianson DR, Cardó-Vila M, Driessen WH, Giordano RJ, Hajitou A, Hoang AG, Wen S, Barnhart KF, Baze WB, Marcott VD, Hawke DH, Do KA, Navone NM, Efstathiou E, Troncoso P, Lobb RR, Logothetis CJ, Arap W.

Cancer. 2015 Jul 15;121(14):2411-21. doi: 10.1002/cncr.29344. Epub 2015 Apr 1.


Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8.

Decroos C, Clausen DJ, Haines BE, Wiest O, Williams RM, Christianson DW.

Biochemistry. 2015 Mar 31;54(12):2126-35. doi: 10.1021/acs.biochem.5b00010. Epub 2015 Mar 20.


Ligand-directed targeting of lymphatic vessels uncovers mechanistic insights in melanoma metastasis.

Christianson DR, Dobroff AS, Proneth B, Zurita AJ, Salameh A, Dondossola E, Makino J, Bologa CG, Smith TL, Yao VJ, Calderone TL, O'Connell DJ, Oprea TI, Kataoka K, Cahill DJ, Gershenwald JE, Sidman RL, Arap W, Pasqualini R.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):2521-6. doi: 10.1073/pnas.1424994112. Epub 2015 Feb 6.


Combinatorial materials research applied to the development of new surface coatings XVI: fouling-release properties of amphiphilic polysiloxane coatings.

Stafslien SJ, Christianson D, Daniels J, VanderWal L, Chernykh A, Chisholm BJ.

Biofouling. 2015;31(2):135-49. doi: 10.1080/08927014.2014.1003295.


Crystal structure of an arginase-like protein from Trypanosoma brucei that evolved without a binuclear manganese cluster.

Hai Y, Kerkhoven EJ, Barrett MP, Christianson DW.

Biochemistry. 2015 Jan 20;54(2):458-71. doi: 10.1021/bi501366a. Epub 2014 Dec 23.


Compromised structure and function of HDAC8 mutants identified in Cornelia de Lange Syndrome spectrum disorders.

Decroos C, Bowman CM, Moser JA, Christianson KE, Deardorff MA, Christianson DW.

ACS Chem Biol. 2014 Sep 19;9(9):2157-64. doi: 10.1021/cb5003762. Epub 2014 Jul 30.


Ecosystem scale declines in elk recruitment and population growth with wolf colonization: a before-after-control-impact approach.

Christianson D, Creel S.

PLoS One. 2014 Jul 16;9(7):e102330. doi: 10.1371/journal.pone.0102330. eCollection 2014.


Crystal structure of Schistosoma mansoni arginase, a potential drug target for the treatment of schistosomiasis.

Hai Y, Edwards JE, Van Zandt MC, Hoffmann KF, Christianson DW.

Biochemistry. 2014 Jul 22;53(28):4671-84. doi: 10.1021/bi5004519. Epub 2014 Jul 9.


Reprogramming the chemodiversity of terpenoid cyclization by remolding the active site contour of epi-isozizaene synthase.

Li R, Chou WK, Himmelberger JA, Litwin KM, Harris GG, Cane DE, Christianson DW.

Biochemistry. 2014 Feb 25;53(7):1155-68. doi: 10.1021/bi401643u. Epub 2014 Feb 11.


Underestimating the frequency, strength and cost of antipredator responses with data from GPS collars: an example with wolves and elk.

Creel S, Winnie JA Jr, Christianson D.

Ecol Evol. 2013 Dec;3(16):5189-200. doi: 10.1002/ece3.896. Epub 2013 Nov 26.


Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance.

Kaiser FJ, Ansari M, Braunholz D, Concepción Gil-Rodríguez M, Decroos C, Wilde JJ, Fincher CT, Kaur M, Bando M, Amor DJ, Atwal PS, Bahlo M, Bowman CM, Bradley JJ, Brunner HG, Clark D, Del Campo M, Di Donato N, Diakumis P, Dubbs H, Dyment DA, Eckhold J, Ernst S, Ferreira JC, Francey LJ, Gehlken U, Guillén-Navarro E, Gyftodimou Y, Hall BD, Hennekam R, Hudgins L, Hullings M, Hunter JM, Yntema H, Innes AM, Kline AD, Krumina Z, Lee H, Leppig K, Lynch SA, Mallozzi MB, Mannini L, McKee S, Mehta SG, Micule I; Care4Rare Canada Consortium, Mohammed S, Moran E, Mortier GR, Moser JA, Noon SE, Nozaki N, Nunes L, Pappas JG, Penney LS, Pérez-Aytés A, Petersen MB, Puisac B, Revencu N, Roeder E, Saitta S, Scheuerle AE, Schindeler KL, Siu VM, Stark Z, Strom SP, Thiese H, Vater I, Willems P, Williamson K, Wilson LC; University of Washington Center for Mendelian Genomics, Hakonarson H, Quintero-Rivera F, Wierzba J, Musio A, Gillessen-Kaesbach G, Ramos FJ, Jackson LG, Shirahige K, Pié J, Christianson DW, Krantz ID, Fitzpatrick DR, Deardorff MA.

Hum Mol Genet. 2014 Jun 1;23(11):2888-900. doi: 10.1093/hmg/ddu002. Epub 2014 Jan 8.


Formiminoglutamase from Trypanosoma cruzi is an arginase-like manganese metalloenzyme.

Hai Y, Dugery RJ, Healy D, Christianson DW.

Biochemistry. 2013 Dec 23;52(51):9294-309. doi: 10.1021/bi401352h. Epub 2013 Nov 21.


1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis.

Köksal M, Potter K, Peters RJ, Christianson DW.

Biochim Biophys Acta. 2014 Jan;1840(1):184-90. doi: 10.1016/j.bbagen.2013.09.004. Epub 2013 Sep 12.


Mechanistic insights from the binding of substrate and carbocation intermediate analogues to aristolochene synthase.

Chen M, Al-lami N, Janvier M, D'Antonio EL, Faraldos JA, Cane DE, Allemann RK, Christianson DW.

Biochemistry. 2013 Aug 13;52(32):5441-53. doi: 10.1021/bi400691v. Epub 2013 Aug 1.


Unexpected reactivity of 2-fluorolinalyl diphosphate in the active site of crystalline 2-methylisoborneol synthase.

Köksal M, Chou WK, Cane DE, Christianson DW.

Biochemistry. 2013 Aug 6;52(31):5247-55. doi: 10.1021/bi400797c. Epub 2013 Jul 22.

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