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Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women.

Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL.

J Appl Physiol (1985). 2019 Mar 21. doi: 10.1152/japplphysiol.00819.2018. [Epub ahead of print]


Evaluation of Clinical and Safety Outcomes Following Uncontrolled Tacrolimus Conversion in Adult Transplant Recipients.

Lichvar A, Tremblay S, Naik D, Lipscomb J, King E, Vinks AA, Christians U, Alloway RR.

Pharmacotherapy. 2019 Mar 20. doi: 10.1002/phar.2260. [Epub ahead of print]


Improving Therapeutic Decisions: Pharmacodynamic Monitoring as an Integral Part of Therapeutic Drug Monitoring.

Shipkova M, Christians U.

Ther Drug Monit. 2019 Apr;41(2):111-114. doi: 10.1097/FTD.0000000000000627.


Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development.

Freedman R, Hunter SK, Law AJ, Wagner BD, D'Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC.

J Pediatr. 2019 Mar 12. pii: S0022-3476(18)31727-X. doi: 10.1016/j.jpeds.2018.12.010. [Epub ahead of print]


Biomarkers of Oxidative Stress, Inflammation, and Vascular Dysfunction in Inherited Cystathionine β-synthase Deficient Homocystinuria and the Impact of Taurine Treatment in a Phase 1/2 human Clinical Trial.

Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN.

J Inherit Metab Dis. 2019 Mar 14. doi: 10.1002/jimd.12085. [Epub ahead of print]


A Theoretical Physiologically-Based Pharmacokinetic Approach to Ascertain Covariates Explaining the Large Interpatient Variability in Tacrolimus Disposition.

Emoto C, Johnson TN, Hahn D, Christians U, Alloway RR, Vinks AA, Fukuda T.

CPT Pharmacometrics Syst Pharmacol. 2019 Mar 7. doi: 10.1002/psp4.12392. [Epub ahead of print]


Improving therapeutic decisions: Pharmacodynamic monitoring as an integral part of Therapeutic Drug Monitoring.

Shipkova M, Christians U.

Ther Drug Monit. 2019 Feb 26. doi: 10.1097/FTD.0000000000000627. [Epub ahead of print] No abstract available.


Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay.

Davidson JA, Pfeifer Z, Frank B, Tong S, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J.

J Am Heart Assoc. 2018 Dec 18;7(24):e010711. doi: 10.1161/JAHA.118.010711.


Assessment of tacrolimus intrapatient variability in stable adherent transplant recipients: Establishing baseline values.

Leino AD, King EC, Jiang W, Vinks AA, Klawitter J, Christians U, Woodle ES, Alloway RR, Rohan JM.

Am J Transplant. 2018 Dec 1. doi: 10.1111/ajt.15199. [Epub ahead of print]


A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction.

Pedroso AP, Dornellas APS, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMO, Klawitter J, Christians U, Tashima AK, Ribeiro EB.

Eur J Nutr. 2018 Nov 7. doi: 10.1007/s00394-018-1851-6. [Epub ahead of print]


In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons.

Turner E, Erwin M, Atigh M, Christians U, Saul JM, Yazdani SK.

Front Pharmacol. 2018 Jul 30;9:808. doi: 10.3389/fphar.2018.00808. eCollection 2018.


Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.

Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM.

J Am Heart Assoc. 2018 Jul 13;7(14). pii: e007818. doi: 10.1161/JAHA.117.007818.


Regulation of kynurenine metabolism by a ketogenic diet.

Heischmann S, Gano LB, Quinn K, Liang LP, Klepacki J, Christians U, Reisdorph N, Patel M.

J Lipid Res. 2018 Jun;59(6):958-966. doi: 10.1194/jlr.M079251. Epub 2018 Mar 31.


Morphine Pharmacokinetics in Children With Down Syndrome Following Cardiac Surgery.

Goot BH, Kaufman J, Pan Z, Bourne DWA, Hickey F, Twite M, Galinkin J, Christians U, Zuk J, da Cruz EM.

Pediatr Crit Care Med. 2018 May;19(5):459-467. doi: 10.1097/PCC.0000000000001537.


A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples.

Bittersohl H, Schniedewind B, Christians U, Luppa PB.

J Chromatogr A. 2018 Apr 27;1547:45-52. doi: 10.1016/j.chroma.2018.03.010. Epub 2018 Mar 7.


Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons.

Turner EA, Atigh MK, Erwin MM, Christians U, Yazdani SK.

Cardiovasc Eng Technol. 2018 Jun;9(2):240-250. doi: 10.1007/s13239-018-0346-1. Epub 2018 Mar 1.


Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.

Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM.

Eur J Immunol. 2018 May;48(5):791-802. doi: 10.1002/eji.201747240. Epub 2018 Feb 22.


The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis.

McLay JS, Engelhardt T, Mohammed BS, Cameron G, Cohen MN, Galinkin JL, Christians U, Avram MJ, Henthorn TK, Dsida RM, Hawwa AF, Anderson BJ.

Paediatr Anaesth. 2018 Feb;28(2):80-86. doi: 10.1111/pan.13302. Epub 2017 Dec 21. Erratum in: Paediatr Anaesth. 2018 Dec;28(12):1159.


Targeted and global pharmacometabolomics in everolimus-based immunosuppression: association of co-medication and lysophosphatidylcholines with dose requirement.

Lesche D, Sigurdardottir V, Leichtle AB, Nakas CT, Christians U, Englberger L, Fiedler M, Largiadèr CR, Mohacsi P, Sistonen J.

Metabolomics. 2017 Nov 25;14(1):3. doi: 10.1007/s11306-017-1294-8.


Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial.

Alloway RR, Vinks AA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S, Klawitter J, Klawitter J, Christians U.

PLoS Med. 2017 Nov 14;14(11):e1002428. doi: 10.1371/journal.pmed.1002428. eCollection 2017 Nov.


A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition.

Klawitter J, Hildreth KL, Christians U, Kohrt WM, Moreau KL.

Physiol Rep. 2017 Sep;5(17). pii: e13409. doi: 10.14814/phy2.13409.


Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney.

Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U.

Sci Rep. 2017 Sep 5;7(1):10540. doi: 10.1038/s41598-017-10076-9.


Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia.

Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ.

Clin Pharmacol Ther. 2018 May;103(5):888-898. doi: 10.1002/cpt.860. Epub 2017 Oct 17.


Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation.

Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R.

Neuropsychopharmacology. 2018 Feb;43(3):583-589. doi: 10.1038/npp.2017.182. Epub 2017 Aug 21.


A High-throughput HPLC-MS/MS Assay for the Detection, Quantification and Simultaneous Structural Confirmation of 136 Drugs and Metabolites in Human Urine.

Klepacki J, Davari B, Boulet M, Lizarraga R, Christians U.

Ther Drug Monit. 2017 Oct;39(5):565-574. doi: 10.1097/FTD.0000000000000429.


An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine.

Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J.

Ther Drug Monit. 2017 Oct;39(5):556-564. doi: 10.1097/FTD.0000000000000427.


Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.

Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK.

J Clin Invest. 2017 Jun 1;127(6):2438. doi: 10.1172/JCI94890. Epub 2017 Jun 1. No abstract available.


Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid.

Heischmann S, Christians U.

Xenobiotica. 2018 May;48(5):433-441. doi: 10.1080/00498254.2017.1329567. Epub 2017 May 30.


The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.

Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T.

Can J Physiol Pharmacol. 2017 Sep;95(9):1009-1018. doi: 10.1139/cjpp-2016-0635. Epub 2017 May 3.


The use of an occlusion perfusion catheter to deliver paclitaxel to the arterial wall.

Atigh MK, Turner E, Christians U, Yazdani SK.

Cardiovasc Ther. 2017 Aug;35(4). doi: 10.1111/1755-5922.12269.


Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy.

Diwan TS, Lichvar AB, Leino AD, Vinks AA, Christians U, Shields AR, Cardi MA, Fukuda T, Mizuno T, Kaiser T, Woodle ES, Alloway RR.

Clin Transplant. 2017 Jun;31(6). doi: 10.1111/ctr.12975. Epub 2017 May 2.


The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model.

Heischmann S, Dzieciatkowska M, Hansen K, Leibfritz D, Christians U.

Sci Rep. 2017 Mar 22;7:45088. doi: 10.1038/srep45088.


Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data.

Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB.

J Proteome Res. 2017 Apr 7;16(4):1515-1525. doi: 10.1021/acs.jproteome.6b00923. Epub 2017 Mar 30.


Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart.

Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U.

J Cell Biochem. 2017 Sep;118(9):2933-2940. doi: 10.1002/jcb.25947. Epub 2017 Apr 12.


Everolimus does not prevent Lafora body formation in murine Lafora disease.

Mishra N, Wang P, Goldsmith D, Zhao X, Xue Y, Christians U, Minassian BA.

Neurol Genet. 2017 Jan 9;3(1):e127. doi: 10.1212/NXG.0000000000000127. eCollection 2017 Feb. No abstract available.


Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group.

Mizuno T, Fukuda T, Christians U, Perentesis JP, Fouladi M, Vinks AA.

Br J Clin Pharmacol. 2017 May;83(5):1097-1107. doi: 10.1111/bcp.13181. Epub 2016 Dec 20.


Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches.

Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN.

Respir Med. 2016 Dec;121:59-66. doi: 10.1016/j.rmed.2016.10.011. Epub 2016 Oct 21.


Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants.

Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christians U, Adams DM, Vinks AA.

CPT Pharmacometrics Syst Pharmacol. 2016 Aug;5(8):411-7. doi: 10.1002/psp4.12096. Epub 2016 Aug 8.


Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?

Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U.

Clin Biochem. 2016 Sep;49(13-14):955-61. doi: 10.1016/j.clinbiochem.2016.06.002. Epub 2016 Jun 8.


Remifentanil and propofol undergo separation and layering when mixed in the same syringe for total intravenous anesthesia.

O'Connor S, Zhang YL, Christians U, Morrison JE Jr, Friesen RH.

Paediatr Anaesth. 2016 Jul;26(7):703-9. doi: 10.1111/pan.12917. Epub 2016 May 5.


Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee.

Seger C, Shipkova M, Christians U, Billaud EM, Wang P, Holt DW, Brunet M, Kunicki PK, Pawiński T, Langman LJ, Marquet P, Oellerich M, Wieland E, Wallemacq P.

Ther Drug Monit. 2016 Apr;38(2):170-89. doi: 10.1097/FTD.0000000000000269. Review.


Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation.

Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, López-Hoyos M, Barten MJ, Bergan S, Picard N, Millán López O, Marquet P, Hesselink DA, Noceti O, Pawinski T, Wallemacq P, Oellerich M.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S1-20. doi: 10.1097/FTD.0000000000000287. Review.


Inhalation of two putative Gulf War toxins by mice.

Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM.

J Environ Sci Health B. 2016;51(6):366-73. doi: 10.1080/03601234.2016.1142318. Epub 2016 Mar 7. Erratum in: J Environ Sci Health B. 2016 Sep;51(9):654.


Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish.

Fæste CK, Moen A, Schniedewind B, Haug Anonsen J, Klawitter J, Christians U.

J Chromatogr A. 2016 Feb 5;1432:58-72. doi: 10.1016/j.chroma.2016.01.002. Epub 2016 Jan 6.


Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS.

Shokati T, Bodenberger N, Gadpaille H, Schniedewind B, Vinks AA, Jiang W, Alloway RR, Christians U.

J Vis Exp. 2015 Nov 8;(105):e52424. doi: 10.3791/52424.


Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation.

Shipkova M, López OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S80-92. doi: 10.1097/FTD.0000000000000230. Review.


Biomarkers in Transplantation--Proteomics and Metabolomics.

Christians U, Klawitter J, Klawitter J.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S70-4. doi: 10.1097/FTD.0000000000000243. Review.


Memory-updating abrogates extinction of learned immunosuppression.

Hadamitzky M, Bösche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Lückemann L, Güntürkün O, Engler H, Schedlowski M.

Brain Behav Immun. 2016 Feb;52:40-48. doi: 10.1016/j.bbi.2015.09.009. Epub 2015 Sep 18.


Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs.

Christians U, Vinks AA, Langman LJ, Clarke W, Wallemacq P, van Gelder T, Renjen V, Marquet P, Meyer EJ.

Ther Drug Monit. 2015 Dec;37(6):718-24. doi: 10.1097/FTD.0000000000000205.


Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease.

Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA.

Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1534-41. doi: 10.2215/CJN.11331114. Epub 2015 Jul 29.

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