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Items: 1 to 50 of 274

1.

A proteomics-metabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult female rats submitted to intrauterine growth restriction.

Pedroso AP, Dornellas APS, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMO, Klawitter J, Christians U, Tashima AK, Ribeiro EB.

Eur J Nutr. 2018 Nov 7. doi: 10.1007/s00394-018-1851-6. [Epub ahead of print]

PMID:
30406389
2.

In vitro and in vivo Assessment of Keratose as a Novel Excipient of Paclitaxel Coated Balloons.

Turner E, Erwin M, Atigh M, Christians U, Saul JM, Yazdani SK.

Front Pharmacol. 2018 Jul 30;9:808. doi: 10.3389/fphar.2018.00808. eCollection 2018.

3.

Endothelial Microparticles and Systemic Complement Activation in Patients With Chronic Kidney Disease.

Jalal D, Renner B, Laskowski J, Stites E, Cooper J, Valente K, You Z, Perrenoud L, Le Quintrec M, Muhamed I, Christians U, Klawitter J, Lindorfer MA, Taylor RP, Holers VM, Thurman JM.

J Am Heart Assoc. 2018 Jul 13;7(14). pii: e007818. doi: 10.1161/JAHA.117.007818.

4.

Regulation of kynurenine metabolism by a ketogenic diet.

Heischmann S, Gano LB, Quinn K, Liang LP, Klepacki J, Christians U, Reisdorph N, Patel M.

J Lipid Res. 2018 Jun;59(6):958-966. doi: 10.1194/jlr.M079251. Epub 2018 Mar 31.

PMID:
29605816
5.

Morphine Pharmacokinetics in Children With Down Syndrome Following Cardiac Surgery.

Goot BH, Kaufman J, Pan Z, Bourne DWA, Hickey F, Twite M, Galinkin J, Christians U, Zuk J, da Cruz EM.

Pediatr Crit Care Med. 2018 May;19(5):459-467. doi: 10.1097/PCC.0000000000001537.

PMID:
29547456
6.

A simple and highly sensitive on-line column extraction liquid chromatography-tandem mass spectrometry method for the determination of protein-unbound tacrolimus in human plasma samples.

Bittersohl H, Schniedewind B, Christians U, Luppa PB.

J Chromatogr A. 2018 Apr 27;1547:45-52. doi: 10.1016/j.chroma.2018.03.010. Epub 2018 Mar 7.

PMID:
29544893
7.

Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons.

Turner EA, Atigh MK, Erwin MM, Christians U, Yazdani SK.

Cardiovasc Eng Technol. 2018 Jun;9(2):240-250. doi: 10.1007/s13239-018-0346-1. Epub 2018 Mar 1.

PMID:
29497966
8.

Complement factor H protects mice from ischemic acute kidney injury but is not critical for controlling complement activation by glomerular IgM.

Goetz L, Laskowski J, Renner B, Pickering MC, Kulik L, Klawitter J, Stites E, Christians U, van der Vlag J, Ravichandran K, Holers VM, Thurman JM.

Eur J Immunol. 2018 May;48(5):791-802. doi: 10.1002/eji.201747240. Epub 2018 Feb 22.

PMID:
29389016
9.

The pharmacokinetics of intravenous ketorolac in children aged 2 months to 16 years: A population analysis.

McLay JS, Engelhardt T, Mohammed BS, Cameron G, Cohen MN, Galinkin JL, Christians U, Avram MJ, Henthorn TK, Dsida RM, Anderson BJ.

Paediatr Anaesth. 2018 Feb;28(2):80-86. doi: 10.1111/pan.13302. Epub 2017 Dec 21.

PMID:
29266539
10.

Bioequivalence between innovator and generic tacrolimus in liver and kidney transplant recipients: A randomized, crossover clinical trial.

Alloway RR, Vinks AA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S, Klawitter J, Klawitter J, Christians U.

PLoS Med. 2017 Nov 14;14(11):e1002428. doi: 10.1371/journal.pmed.1002428. eCollection 2017 Nov.

11.

A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of the menopausal transition.

Klawitter J, Hildreth KL, Christians U, Kohrt WM, Moreau KL.

Physiol Rep. 2017 Sep;5(17). pii: e13409. doi: 10.14814/phy2.13409.

12.

Mitochondrial cyclophilin D ablation is associated with the activation of Akt/p70S6K pathway in the mouse kidney.

Klawitter J, Pennington A, Klawitter J, Thurman JM, Christians U.

Sci Rep. 2017 Sep 5;7(1):10540. doi: 10.1038/s41598-017-10076-9.

13.

Safety and Ergogenic Properties of Combined Aminophylline and Ambrisentan in Hypoxia.

Schroeder T, Piantadosi CA, Natoli MJ, Autmizguine J, Cohen-Wolkowieczs M, Hamilton KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ.

Clin Pharmacol Ther. 2018 May;103(5):888-898. doi: 10.1002/cpt.860. Epub 2017 Oct 17.

14.

Pharmacokinetic Limitations on Effects of an Alpha7-Nicotinic Receptor Agonist in Schizophrenia: Randomized Trial with an Extended-Release Formulation.

Kem WR, Olincy A, Johnson L, Harris J, Wagner BD, Buchanan RW, Christians U, Freedman R.

Neuropsychopharmacology. 2018 Feb;43(3):583-589. doi: 10.1038/npp.2017.182. Epub 2017 Aug 21.

PMID:
28825423
15.

A High-throughput HPLC-MS/MS Assay for the Detection, Quantification and Simultaneous Structural Confirmation of 136 Drugs and Metabolites in Human Urine.

Klepacki J, Davari B, Boulet M, Lizarraga R, Christians U.

Ther Drug Monit. 2017 Oct;39(5):565-574. doi: 10.1097/FTD.0000000000000429.

PMID:
28650900
16.

An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine.

Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J.

Ther Drug Monit. 2017 Oct;39(5):556-564. doi: 10.1097/FTD.0000000000000427.

17.

Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice.

Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK.

J Clin Invest. 2017 Jun 1;127(6):2438. doi: 10.1172/JCI94890. Epub 2017 Jun 1. No abstract available.

18.

Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid.

Heischmann S, Christians U.

Xenobiotica. 2018 May;48(5):433-441. doi: 10.1080/00498254.2017.1329567. Epub 2017 May 30.

PMID:
28489504
19.

The novel combination of theophylline and bambuterol as a potential treatment of hypoxemia in humans.

Strand TE, Khiabani HZ, Boico A, Radiloff D, Zhao Y, Hamilton KL, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Bell C, Irwin D, Schroeder T.

Can J Physiol Pharmacol. 2017 Sep;95(9):1009-1018. doi: 10.1139/cjpp-2016-0635. Epub 2017 May 3.

PMID:
28467859
20.

The use of an occlusion perfusion catheter to deliver paclitaxel to the arterial wall.

Atigh MK, Turner E, Christians U, Yazdani SK.

Cardiovasc Ther. 2017 Aug;35(4). doi: 10.1111/1755-5922.12269.

21.

Pharmacokinetic and pharmacogenetic analysis of immunosuppressive agents after laparoscopic sleeve gastrectomy.

Diwan TS, Lichvar AB, Leino AD, Vinks AA, Christians U, Shields AR, Cardi MA, Fukuda T, Mizuno T, Kaiser T, Woodle ES, Alloway RR.

Clin Transplant. 2017 Jun;31(6). doi: 10.1111/ctr.12975. Epub 2017 May 2.

PMID:
28342282
22.

The Immunosuppressant Mycophenolic Acid Alters Nucleotide and Lipid Metabolism in an Intestinal Cell Model.

Heischmann S, Dzieciatkowska M, Hansen K, Leibfritz D, Christians U.

Sci Rep. 2017 Mar 22;7:45088. doi: 10.1038/srep45088.

23.

Intrauterine Growth Restriction Programs the Hypothalamus of Adult Male Rats: Integrated Analysis of Proteomic and Metabolomic Data.

Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP, Klawitter J, Christians U, Tashima AK, Ribeiro EB.

J Proteome Res. 2017 Apr 7;16(4):1515-1525. doi: 10.1021/acs.jproteome.6b00923. Epub 2017 Mar 30.

PMID:
28314371
24.

Ablation of Cyclophilin D Results in an Activation of FAK, Akt, and ERK Pathways in the Mouse Heart.

Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U.

J Cell Biochem. 2017 Sep;118(9):2933-2940. doi: 10.1002/jcb.25947. Epub 2017 Apr 12.

PMID:
28230282
25.

Everolimus does not prevent Lafora body formation in murine Lafora disease.

Mishra N, Wang P, Goldsmith D, Zhao X, Xue Y, Christians U, Minassian BA.

Neurol Genet. 2017 Jan 9;3(1):e127. doi: 10.1212/NXG.0000000000000127. eCollection 2017 Feb. No abstract available.

26.

Population pharmacokinetics of temsirolimus and sirolimus in children with recurrent solid tumours: a report from the Children's Oncology Group.

Mizuno T, Fukuda T, Christians U, Perentesis JP, Fouladi M, Vinks AA.

Br J Clin Pharmacol. 2017 May;83(5):1097-1107. doi: 10.1111/bcp.13181. Epub 2016 Dec 20.

27.

Identifying biomarkers for asthma diagnosis using targeted metabolomics approaches.

Checkley W, Deza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN.

Respir Med. 2016 Dec;121:59-66. doi: 10.1016/j.rmed.2016.10.011. Epub 2016 Oct 21.

28.

Characterizing the Developmental Trajectory of Sirolimus Clearance in Neonates and Infants.

Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christians U, Adams DM, Vinks AA.

CPT Pharmacometrics Syst Pharmacol. 2016 Aug;5(8):411-7. doi: 10.1002/psp4.12096. Epub 2016 Aug 8.

29.

Amino acids in a targeted versus a non-targeted metabolomics LC-MS/MS assay. Are the results consistent?

Klepacki J, Klawitter J, Klawitter J, Karimpour-Fard A, Thurman J, Ingle G, Patel D, Christians U.

Clin Biochem. 2016 Sep;49(13-14):955-61. doi: 10.1016/j.clinbiochem.2016.06.002. Epub 2016 Jun 8.

30.

Remifentanil and propofol undergo separation and layering when mixed in the same syringe for total intravenous anesthesia.

O'Connor S, Zhang YL, Christians U, Morrison JE Jr, Friesen RH.

Paediatr Anaesth. 2016 Jul;26(7):703-9. doi: 10.1111/pan.12917. Epub 2016 May 5.

PMID:
27146802
31.

Assuring the Proper Analytical Performance of Measurement Procedures for Immunosuppressive Drug Concentrations in Clinical Practice: Recommendations of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology Immunosuppressive Drug Scientific Committee.

Seger C, Shipkova M, Christians U, Billaud EM, Wang P, Holt DW, Brunet M, Kunicki PK, Pawiński T, Langman LJ, Marquet P, Oellerich M, Wieland E, Wallemacq P.

Ther Drug Monit. 2016 Apr;38(2):170-89. doi: 10.1097/FTD.0000000000000269. Review.

PMID:
26982493
32.

Barcelona Consensus on Biomarker-Based Immunosuppressive Drugs Management in Solid Organ Transplantation.

Brunet M, Shipkova M, van Gelder T, Wieland E, Sommerer C, Budde K, Haufroid V, Christians U, López-Hoyos M, Barten MJ, Bergan S, Picard N, Millán López O, Marquet P, Hesselink DA, Noceti O, Pawinski T, Wallemacq P, Oellerich M.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S1-20. doi: 10.1097/FTD.0000000000000287. Review.

PMID:
26977997
33.

Inhalation of two putative Gulf War toxins by mice.

Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith DM.

J Environ Sci Health B. 2016;51(6):366-73. doi: 10.1080/03601234.2016.1142318. Epub 2016 Mar 7. Erratum in: J Environ Sci Health B. 2016 Sep;51(9):654.

PMID:
26950528
34.

Development of liquid chromatography-tandem mass spectrometry methods for the quantitation of Anisakis simplex proteins in fish.

Fæste CK, Moen A, Schniedewind B, Haug Anonsen J, Klawitter J, Christians U.

J Chromatogr A. 2016 Feb 5;1432:58-72. doi: 10.1016/j.chroma.2016.01.002. Epub 2016 Jan 6.

PMID:
26787163
35.

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS.

Shokati T, Bodenberger N, Gadpaille H, Schniedewind B, Vinks AA, Jiang W, Alloway RR, Christians U.

J Vis Exp. 2015 Nov 8;(105):e52424. doi: 10.3791/52424.

36.

Analytical Aspects of the Implementation of Biomarkers in Clinical Transplantation.

Shipkova M, López OM, Picard N, Noceti O, Sommerer C, Christians U, Wieland E.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S80-92. doi: 10.1097/FTD.0000000000000230. Review.

PMID:
26418704
37.

Biomarkers in Transplantation--Proteomics and Metabolomics.

Christians U, Klawitter J, Klawitter J.

Ther Drug Monit. 2016 Apr;38 Suppl 1:S70-4. doi: 10.1097/FTD.0000000000000243. Review.

38.

Memory-updating abrogates extinction of learned immunosuppression.

Hadamitzky M, Bösche K, Wirth T, Buck B, Beetz O, Christians U, Schniedewind B, Lückemann L, Güntürkün O, Engler H, Schedlowski M.

Brain Behav Immun. 2016 Feb;52:40-48. doi: 10.1016/j.bbi.2015.09.009. Epub 2015 Sep 18.

PMID:
26386321
39.

Impact of Laboratory Practices on Interlaboratory Variability in Therapeutic Drug Monitoring of Immunosuppressive Drugs.

Christians U, Vinks AA, Langman LJ, Clarke W, Wallemacq P, van Gelder T, Renjen V, Marquet P, Meyer EJ.

Ther Drug Monit. 2015 Dec;37(6):718-24. doi: 10.1097/FTD.0000000000000205.

PMID:
26291980
40.

Pravastatin Therapy and Biomarker Changes in Children and Young Adults with Autosomal Dominant Polycystic Kidney Disease.

Klawitter J, McFann K, Pennington AT, Wang W, Klawitter J, Christians U, Schrier RW, Gitomer B, Cadnapaphornchai MA.

Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1534-41. doi: 10.2215/CJN.11331114. Epub 2015 Jul 29.

41.

Long-term cross-validation of everolimus therapeutic drug monitoring assays: the Zortracker study.

Schniedewind B, Niederlechner S, Galinkin JL, Johnson-Davis KL, Christians U, Meyer EJ.

Ther Drug Monit. 2015 Jun;37(3):296-303. doi: 10.1097/FTD.0000000000000191.

42.

Everolimus and sirolimus in transplantation-related but different.

Klawitter J, Nashan B, Christians U.

Expert Opin Drug Saf. 2015 Jul;14(7):1055-70. doi: 10.1517/14740338.2015.1040388. Epub 2015 Apr 26. Review.

43.

A high-performance liquid chromatography-tandem mass spectrometry-based targeted metabolomics kidney dysfunction marker panel in human urine.

Klepacki J, Klawitter J, Klawitter J, Thurman JM, Christians U.

Clin Chim Acta. 2015 Jun 15;446:43-53. doi: 10.1016/j.cca.2015.04.005. Epub 2015 Apr 11.

44.

Neurobehavioral consequences of small molecule-drug immunosuppression.

Bösche K, Weissenborn K, Christians U, Witzke O, Engler H, Schedlowski M, Hadamitzky M.

Neuropharmacology. 2015 Sep;96(Pt A):83-93. doi: 10.1016/j.neuropharm.2014.12.008. Epub 2014 Dec 19. Review.

PMID:
25529273
45.

Endothelial dysfunction and oxidative stress in polycystic kidney disease.

Klawitter J, Reed-Gitomer BY, McFann K, Pennington A, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol M, Christians U, Schrier RW.

Am J Physiol Renal Physiol. 2014 Dec 1;307(11):F1198-206. doi: 10.1152/ajprenal.00327.2014. Epub 2014 Sep 18.

46.

Characterisation of potential novel allergens in the fish parasite Anisakis simplex.

Fæste CK, Jonscher KR, Dooper MM, Egge-Jacobsen W, Moen A, Daschner A, Egaas E, Christians U.

EuPA Open Proteom. 2014 Sep;4:140-155.

47.

Age-dependent changes in sirolimus metabolite formation in patients with neurofibromatosis type 1.

Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vinks AA.

Ther Drug Monit. 2015 Jun;37(3):395-9. doi: 10.1097/FTD.0000000000000130.

PMID:
25162215
48.

Fatty acid desaturation index in human plasma: comparison of different analytical methodologies for the evaluation of diet effects.

Klawitter J, Bek S, Zakaria M, Zeng C, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boernsen KO.

Anal Bioanal Chem. 2014 Oct;406(25):6399-408. doi: 10.1007/s00216-014-8020-4. Epub 2014 Aug 13.

PMID:
25116600
49.

Inhibition of calcineurin combined with dasatinib has direct and indirect anti-leukemia effects against BCR-ABL1(+) leukemia.

Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Pollyea DA, Takebe N, Christians U, Gore L, DeGregori J, Porter CC.

Am J Hematol. 2014 Sep;89(9):896-903. doi: 10.1002/ajh.23776. Epub 2014 Jun 19.

50.

Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-response relationships, and clinical outcomes.

Shihab F, Christians U, Smith L, Wellen JR, Kaplan B.

Transpl Immunol. 2014 Jun;31(1):22-32. doi: 10.1016/j.trim.2014.05.002. Epub 2014 May 24. Review.

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