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BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.

Kim HS, Neugebauer J, McKnite A, Tilak A, Christian JL.

Elife. 2019 Sep 30;8. pii: e48872. doi: 10.7554/eLife.48872.


Proteolytic Activation of Bmps: Analysis of Cleavage in Xenopus Oocytes and Embryos.

Kim HS, McKnite A, Christian JL.

Methods Mol Biol. 2019;1891:115-133. doi: 10.1007/978-1-4939-8904-1_9.


Fibronectin type III and intracellular domains of Toll-like receptor 4 interactor with leucine-rich repeats (Tril) are required for developmental signaling.

Kim HS, McKnite A, Xie Y, Christian JL.

Mol Biol Cell. 2018 Mar 1;29(5):523-531. doi: 10.1091/mbc.E17-07-0446. Epub 2018 Jan 3.


The TGFβ superfamily in Lisbon: navigating through development and disease.

Christian JL, Heldin CH.

Development. 2017 Dec 15;144(24):4476-4480. doi: 10.1242/dev.159756.


Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain.

Huang WC, Ferris E, Cheng T, Hörndli CS, Gleason K, Tamminga C, Wagner JD, Boucher KM, Christian JL, Gregg C.

Neuron. 2017 Mar 8;93(5):1094-1109.e7. doi: 10.1016/j.neuron.2017.01.033. Epub 2017 Feb 23.


Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos.

Green YS, Kwon S, Mimoto MS, Xie Y, Christian JL.

Development. 2016 Nov 1;143(21):4016-4026. Epub 2016 Sep 15.


Expression pattern of bcar3, a downstream target of Gata2, and its binding partner, bcar1, during Xenopus development.

Green YS, Kwon S, Christian JL.

Gene Expr Patterns. 2016 Jan;20(1):55-62. doi: 10.1016/j.gep.2015.11.004. Epub 2015 Nov 26.


GATA2 regulates Wnt signaling to promote primitive red blood cell fate.

Mimoto MS, Kwon S, Green YS, Goldman D, Christian JL.

Dev Biol. 2015 Nov 1;407(1):1-11. doi: 10.1016/j.ydbio.2015.08.012. Epub 2015 Sep 10.


The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivo.

Neugebauer JM, Kwon S, Kim HS, Donley N, Tilak A, Sopory S, Christian JL.

Proc Natl Acad Sci U S A. 2015 May 5;112(18):E2307-16. doi: 10.1073/pnas.1501449112. Epub 2015 Apr 20.


Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice.

Tilak A, Nelsen SM, Kim HS, Donley N, McKnite A, Lee H, Christian JL.

Development. 2014 Aug;141(15):3062-71. doi: 10.1242/dev.110130. Epub 2014 Jul 3.


Exploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variation.

Boell L, Pallares LF, Brodski C, Chen Y, Christian JL, Kousa YA, Kuss P, Nelsen S, Novikov O, Schutte BC, Wang Y, Tautz D.

Dev Genes Evol. 2013 Sep;223(5):279-87. doi: 10.1007/s00427-013-0443-y. Epub 2013 Apr 6.


Morphogen gradients in development: from form to function.

Christian JL.

Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb;1(1):3-15. doi: 10.1002/wdev.2. Epub 2011 Nov 17.


Manipulation of gene function in Xenopus laevis.

Mimoto MS, Christian JL.

Methods Mol Biol. 2011;770:55-75. doi: 10.1007/978-1-61779-210-6_3.


Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.

Kwon S, Christian JL.

J Biol Chem. 2011 Jun 17;286(24):21876-85. doi: 10.1074/jbc.M111.228262. Epub 2011 Apr 26.


Regulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain.

Sopory S, Kwon S, Wehrli M, Christian JL.

Dev Biol. 2010 Oct 1;346(1):102-12. doi: 10.1016/j.ydbio.2010.07.019. Epub 2010 Jul 24.


The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors.

Pratt EB, Wentzell JS, Maxson JE, Courter L, Hazelett D, Christian JL.

Acta Histochem. 2011 May;113(3):248-55. doi: 10.1016/j.acthis.2010.01.006. Epub 2010 Feb 1. Review.


BMP4 regulates the hematopoietic stem cell niche.

Goldman DC, Bailey AS, Pfaffle DL, Al Masri A, Christian JL, Fleming WH.

Blood. 2009 Nov 12;114(20):4393-401. doi: 10.1182/blood-2009-02-206433. Epub 2009 Sep 16.


Site-specific cleavage of BMP4 by furin, PC6, and PC7.

Nelsen SM, Christian JL.

J Biol Chem. 2009 Oct 2;284(40):27157-66. doi: 10.1074/jbc.M109.028506. Epub 2009 Aug 3.


Genetic interaction between Bmp2 and Bmp4 reveals shared functions during multiple aspects of mouse organogenesis.

Goldman DC, Donley N, Christian JL.

Mech Dev. 2009 Mar-Apr;126(3-4):117-27. doi: 10.1016/j.mod.2008.11.008. Epub 2008 Dec 11.


GATA-2 functions downstream of BMPs and CaM KIV in ectodermal cells during primitive hematopoiesis.

Dalgin G, Goldman DC, Donley N, Ahmed R, Eide CA, Christian JL.

Dev Biol. 2007 Oct 15;310(2):454-69. Epub 2007 Aug 16.


Regulation of bone morphogenetic protein-4 activity by sequence elements within the prodomain.

Sopory S, Nelsen SM, Degnin C, Wong C, Christian JL.

J Biol Chem. 2006 Nov 10;281(45):34021-31. Epub 2006 Sep 11.


Mutation of an upstream cleavage site in the BMP4 prodomain leads to tissue-specific loss of activity.

Goldman DC, Hackenmiller R, Nakayama T, Sopory S, Wong C, Kulessa H, Christian JL.

Development. 2006 May;133(10):1933-42. Epub 2006 Apr 19.


Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks.

Sobeck A, Stone S, Costanzo V, de Graaf B, Reuter T, de Winter J, Wallisch M, Akkari Y, Olson S, Wang W, Joenje H, Christian JL, Lupardus PJ, Cimprich KA, Gautier J, Hoatlin ME.

Mol Cell Biol. 2006 Jan;26(2):425-37.


Ectodermally derived steel/stem cell factor functions non-cell autonomously during primitive erythropoiesis in Xenopus.

Goldman DC, Berg LK, Heinrich MC, Christian JL.

Blood. 2006 Apr 15;107(8):3114-21. Epub 2005 Dec 15.


Proprotein convertase genes in Xenopus development.

Nelsen S, Berg L, Wong C, Christian JL.

Dev Dyn. 2005 Jul;233(3):1038-44.


XPACE4 is a localized pro-protein convertase required for mesoderm induction and the cleavage of specific TGFbeta proteins in Xenopus development.

Birsoy B, Berg L, Williams PH, Smith JC, Wylie CC, Christian JL, Heasman J.

Development. 2005 Feb;132(3):591-602. Epub 2005 Jan 5.


Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.

Degnin C, Jean F, Thomas G, Christian JL.

Mol Biol Cell. 2004 Nov;15(11):5012-20. Epub 2004 Sep 8.


Argosomes: intracellular transport vehicles for intercellular signals?

Christian JL.

Sci STKE. 2002 Mar 19;2002(124):pe13. Review.


Calmodulin-dependent protein kinase IV mediated antagonism of BMP signaling regulates lineage and survival of hematopoietic progenitors.

Walters MJ, Wayman GA, Notis JC, Goodman RH, Soderling TR, Christian JL.

Development. 2002 Mar;129(6):1455-66.


The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.

Cui Y, Hackenmiller R, Berg L, Jean F, Nakayama T, Thomas G, Christian JL.

Genes Dev. 2001 Nov 1;15(21):2797-802.


CaM kinase IV regulates lineage commitment and survival of erythroid progenitors in a non-cell-autonomous manner.

Wayman GA, Walters MJ, Kolibaba K, Soderling TR, Christian JL.

J Cell Biol. 2000 Nov 13;151(4):811-24.


Regulation of BMP/Dpp signaling during embryonic development.

Nakayama T, Cui Y, Christian JL.

Cell Mol Life Sci. 2000 Jun;57(6):943-56. Review.


BMP, Wnt and Hedgehog signals: how far can they go?

Christian JL.

Curr Opin Cell Biol. 2000 Apr;12(2):244-9. Review.


Misexpression of Polycomb-group proteins in Xenopus alters anterior neural development and represses neural target genes.

Yoshitake Y, Howard TL, Christian JL, Hollenberg SM.

Dev Biol. 1999 Nov 15;215(2):375-87.


Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals.

Christian JL, Nakayama T.

Bioessays. 1999 May;21(5):382-90. Review.


Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors.

Souchelnytskyi S, Nakayama T, Nakao A, Morén A, Heldin CH, Christian JL, ten Dijke P.

J Biol Chem. 1998 Sep 25;273(39):25364-70.


Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis.

Nakayama T, Gardner H, Berg LK, Christian JL.

Genes Cells. 1998 Jun;3(6):387-94.


BMP-4 is proteolytically activated by furin and/or PC6 during vertebrate embryonic development.

Cui Y, Jean F, Thomas G, Christian JL.

EMBO J. 1998 Aug 17;17(16):4735-43.


Xenopus Smad8 acts downstream of BMP-4 to modulate its activity during vertebrate embryonic patterning.

Nakayama T, Snyder MA, Grewal SS, Tsuneizumi K, Tabata T, Christian JL.

Development. 1998 Mar;125(5):857-67.


Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling.

Nakao A, Afrakhte M, Morén A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, ten Dijke P.

Nature. 1997 Oct 9;389(6651):631-5.


Daughters against dpp modulates dpp organizing activity in Drosophila wing development.

Tsuneizumi K, Nakayama T, Kamoshida Y, Kornberg TB, Christian JL, Tabata T.

Nature. 1997 Oct 9;389(6651):627-31.


Xwnt-8 and lithium can act upon either dorsal mesodermal or neurectodermal cells to cause a loss of forebrain in Xenopus embryos.

Fredieu JR, Cui Y, Maier D, Danilchik MV, Christian JL.

Dev Biol. 1997 Jun 1;186(1):100-14.


Xwnt-5A: a maternal Wnt that affects morphogenetic movements after overexpression in embryos of Xenopus laevis.

Moon RT, Campbell RM, Christian JL, McGrew LL, Shih J, Fraser S.

Development. 1993 Sep;119(1):97-111.

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