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Items: 1 to 50 of 114

1.

PET Measures of D1, D2, and DAT Binding Are Associated With Heightened Tactile Responsivity in Rhesus Macaques: Implications for Sensory Processing Disorder.

Schneider ML, Moore CF, Ahlers EO, Barnhart TE, Christian BT, DeJesus OT, Engle JW, Holden JE, Larson JA, Moirano JM, Murali D, Nickles RJ, Resch LM, Converse AK.

Front Integr Neurosci. 2019 Jul 17;13:29. doi: 10.3389/fnint.2019.00029. eCollection 2019.

2.

Neuropathological correlates of amyloid PET imaging in Down syndrome.

Abrahamson EE, Head E, Lott IT, Handen BL, Mufson EJ, Christian BT, Klunk WE, Ikonomovic MD.

Dev Neurobiol. 2019 Aug 4. doi: 10.1002/dneu.22713. [Epub ahead of print] Review.

PMID:
31379087
3.

Intellectual and developmental disabilities research centers: Fifty years of scientific accomplishments.

Walkley SU, Abbeduto L, Batshaw ML, Bhattacharyya A, Bookheimer SY, Christian BT, Constantino JN, de Vellis J, Doherty DA, Nelson DL, Piven J, Poduri A, Pomeroy SL, Samaco RC, Zoghbi HY, Guralnick MJ; Intellectual and Developmental Disabilities Research Centers Directors Committee.

Ann Neurol. 2019 Sep;86(3):332-343. doi: 10.1002/ana.25531. Epub 2019 Jul 27. Review.

PMID:
31206741
4.

Leisure Activity, Brain β-amyloid, and Episodic Memory in Adults with Down Syndrome.

Mihaila I, Handen BL, Christian BT, Lao PJ, Cody KA, Klunk WE, Tudorascu DL, Cohen AD, Okonkwo OC, Hartley SL.

Dev Neurobiol. 2019 Mar 26. doi: 10.1002/dneu.22677. [Epub ahead of print]

PMID:
30912871
5.

KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD.

Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC.

Neurology. 2019 Apr 16;92(16):e1878-e1889. doi: 10.1212/WNL.0000000000007323. Epub 2019 Mar 13.

PMID:
30867273
6.

Dopamine receptor density and white mater integrity: 18F-fallypride positron emission tomography and diffusion tensor imaging study in healthy and schizophrenia subjects.

Mitelman SA, Buchsbaum MS, Christian BT, Merrill BM, Buchsbaum BR, Mukherjee J, Lehrer DS.

Brain Imaging Behav. 2018 Dec 6. doi: 10.1007/s11682-018-0012-0. [Epub ahead of print]

PMID:
30523488
7.

Changes in Endogenous Dopamine Induced by Methylphenidate Predict Functional Connectivity in Nonhuman Primates.

Birn RM, Converse AK, Rajala AZ, Alexander AL, Block WF, McMillan AB, Christian BT, Filla CN, Murali D, Hurley SA, Jenison RL, Populin LC.

J Neurosci. 2019 Feb 20;39(8):1436-1444. doi: 10.1523/JNEUROSCI.2513-18.2018. Epub 2018 Dec 10.

8.

Hypertension and obesity moderate the relationship between β-amyloid and cognitive decline in midlife.

Clark LR, Koscik RL, Allison SL, Berman SE, Norton D, Carlsson CM, Betthauser TJ, Bendlin BB, Christian BT, Chin NA, Asthana S, Johnson SC.

Alzheimers Dement. 2019 Mar;15(3):418-428. doi: 10.1016/j.jalz.2018.09.008. Epub 2018 Oct 25.

PMID:
30367828
9.

Comparison of longitudinal Aβ in nondemented elderly and Down syndrome.

Tudorascu DL, Anderson SJ, Minhas DS, Yu Z, Comer D, Lao P, Hartley S, Laymon CM, Snitz BE, Lopresti BJ, Johnson S, Price JC, Mathis CA, Aizenstein HJ, Klunk WE, Handen BL, Christian BT, Cohen AD.

Neurobiol Aging. 2019 Jan;73:171-176. doi: 10.1016/j.neurobiolaging.2018.09.030. Epub 2018 Sep 27.

PMID:
30359879
10.

In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration.

Metzger JM, Moore CF, Boettcher CA, Brunner KG, Fleddermann RA, Matsoff HN, Resnikoff HA, Bondarenko V, Kamp TJ, Hacker TA, Barnhart TE, Lao PJ, Christian BT, Nickles RJ, Gallagher CL, Holden JE, Emborg ME.

NPJ Parkinsons Dis. 2018 Jul 13;4:22. doi: 10.1038/s41531-018-0057-1. eCollection 2018.

11.

The use of Centiloids for applying [11C]PiB classification cutoffs across region-of-interest delineation methods.

Tudorascu DL, Minhas DS, Lao PJ, Betthauser TJ, Yu Z, Laymon CM, Lopresti BJ, Mathis CA, Klunk WE, Handen BL, Christian BT, Cohen AD.

Alzheimers Dement (Amst). 2018 Apr 21;10:332-339. doi: 10.1016/j.dadm.2018.03.006. eCollection 2018.

12.

In Vivo Characterization and Quantification of Neurofibrillary Tau PET Radioligand 18F-MK-6240 in Humans from Alzheimer Disease Dementia to Young Controls.

Betthauser TJ, Cody KA, Zammit MD, Murali D, Converse AK, Barnhart TE, Stone CK, Rowley HA, Johnson SC, Christian BT.

J Nucl Med. 2019 Jan;60(1):93-99. doi: 10.2967/jnumed.118.209650. Epub 2018 May 18.

13.

Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation.

Lao PJ, Handen BL, Betthauser TJ, Cody KA, Cohen AD, Tudorascu DL, Stone CK, Price JC, Johnson SC, Klunk WE, Christian BT.

Brain Imaging Behav. 2019 Apr;13(2):345-353. doi: 10.1007/s11682-018-9888-y.

14.

Alzheimer-Like Pattern of Hypometabolism Emerges with Elevated Amyloid-β Burden in Down Syndrome.

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Hartley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Johnson SC, Klunk WE, Christian BT.

J Alzheimers Dis. 2018;61(2):631-644. doi: 10.3233/JAD-170720.

15.

Characterization of the radiosynthesis and purification of [18F]THK-5351, a PET ligand for neurofibrillary tau.

Betthauser TJ, Ellison PA, Murali D, Lao PJ, Barnhart TE, Furumoto S, Okamura N, Johnson SC, Engle JW, Nickles RJ, Christian BT.

Appl Radiat Isot. 2017 Dec;130:230-237. doi: 10.1016/j.apradiso.2017.10.002. Epub 2017 Oct 4.

16.

Human biodistribution and dosimetry of [18F]nifene, an α4β2* nicotinic acetylcholine receptor PET tracer.

Betthauser TJ, Hillmer AT, Lao PJ, Ehlerding E, Mukherjee J, Stone CK, Christian BT.

Nucl Med Biol. 2017 Dec;55:7-11. doi: 10.1016/j.nucmedbio.2017.08.001. Epub 2017 Aug 17.

17.

Human brain imaging of nicotinic acetylcholine α4β2* receptors using [18 F]Nifene: Selectivity, functional activity, toxicity, aging effects, gender effects, and extrathalamic pathways.

Mukherjee J, Lao PJ, Betthauser TJ, Samra GK, Pan ML, Patel IH, Liang C, Metherate R, Christian BT.

J Comp Neurol. 2018 Jan 1;526(1):80-95. doi: 10.1002/cne.24320. Epub 2017 Sep 19.

18.

Corrigendum to "Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress" [Brain Behav. Immun. 58 (2016) 18-30].

Rosenkranz MA, Esnault S, Christian BT, Crisafi G, Gresham LK, Higgins AT, Moore MN, Moore SM, Weng HY, Salk RH, Busse WW, Davidson RJ.

Brain Behav Immun. 2018 Jan;67:398-401. doi: 10.1016/j.bbi.2017.08.009. Epub 2017 Aug 20. No abstract available.

19.

Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome.

Hartley SL, Handen BL, Devenny D, Mihaila I, Hardison R, Lao PJ, Klunk WE, Bulova P, Johnson SC, Christian BT.

Neurobiol Aging. 2017 Oct;58:68-76. doi: 10.1016/j.neurobiolaging.2017.05.019. Epub 2017 Jun 2.

20.

Longitudinal changes in amyloid positron emission tomography and volumetric magnetic resonance imaging in the nondemented Down syndrome population.

Lao PJ, Handen BL, Betthauser TJ, Mihaila I, Hartley SL, Cohen AD, Tudorascu DL, Bulova PD, Lopresti BJ, Tumuluru RV, Murali D, Mathis CA, Barnhart TE, Stone CK, Price JC, Devenny DA, Mailick MR, Klunk WE, Johnson SC, Christian BT.

Alzheimers Dement (Amst). 2017 May 23;9:1-9. doi: 10.1016/j.dadm.2017.05.001. eCollection 2017.

21.

D2/D3 dopamine receptor binding with [F-18]fallypride correlates of executive function in medication-naïve patients with schizophrenia.

Vyas NS, Buchsbaum MS, Lehrer DS, Merrill BM, DeCastro A, Doninger NA, Christian BT, Mukherjee J.

Schizophr Res. 2018 Feb;192:442-456. doi: 10.1016/j.schres.2017.05.017. Epub 2017 May 31.

PMID:
28576546
22.

Moderate Physical Activity is Associated with Cerebral Glucose Metabolism in Adults at Risk for Alzheimer's Disease.

Dougherty RJ, Schultz SA, Kirby TK, Boots EA, Oh JM, Edwards D, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Johnson SC, Cook DB, Okonkwo OC.

J Alzheimers Dis. 2017;58(4):1089-1097. doi: 10.3233/JAD-161067.

23.

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC.

Neurology. 2017 May 30;88(22):2098-2106. doi: 10.1212/WNL.0000000000003980. Epub 2017 May 3.

24.

[18 F]Nifene test-retest reproducibility in first-in-human imaging of α4β2* nicotinic acetylcholine receptors.

Lao PJ, Betthauser TJ, Tudorascu DL, Barnhart TE, Hillmer AT, Stone CK, Mukherjee J, Christian BT.

Synapse. 2017 Aug;71(8). doi: 10.1002/syn.21981. Epub 2017 Apr 26.

25.

Positive affect predicts cerebral glucose metabolism in late middle-aged adults.

Nicholas CR, Hoscheidt SM, Clark LR, Racine AM, Berman SE, Koscik RL, Maritza Dowling N, Asthana S, Christian BT, Sager MA, Johnson SC.

Soc Cogn Affect Neurosci. 2017 Jun 1;12(6):993-1000. doi: 10.1093/scan/nsx027.

26.

Leisure Activity and Caregiver Involvement in Middle-Aged and Older Adults With Down Syndrome.

Mihaila I, Hartley SL, Handen BL, Bulova PD, Tumuluru RV, Devenny DA, Johnson SC, Lao PJ, Christian BT.

Intellect Dev Disabil. 2017 Apr;55(2):97-109. doi: 10.1352/1934-9556-55.2.97.

27.

In Vivo Comparison of Tau Radioligands 18F-THK-5351 and 18F-THK-5317.

Betthauser TJ, Lao PJ, Murali D, Barnhart TE, Furumoto S, Okamura N, Stone CK, Johnson SC, Christian BT.

J Nucl Med. 2017 Jun;58(6):996-1002. doi: 10.2967/jnumed.116.182980. Epub 2016 Nov 10.

28.

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer's Disease.

Racine AM, Clark LR, Berman SE, Koscik RL, Mueller KD, Norton D, Nicholas CR, Blennow K, Zetterberg H, Jedynak B, Bilgel M, Carlsson CM, Christian BT, Asthana S, Johnson SC.

J Alzheimers Dis. 2016 Oct 18;54(4):1395-1408.

29.

Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD.

J Alzheimers Dis. 2017;55(2):473-484.

30.

Mind-body interactions in the regulation of airway inflammation in asthma: A PET study of acute and chronic stress.

Rosenkranz MA, Esnault S, Christian BT, Crisafi G, Gresham LK, Higgins AT, Moore MN, Moore SM, Weng HY, Salk RH, Busse WW, Davidson RJ.

Brain Behav Immun. 2016 Nov;58:18-30. doi: 10.1016/j.bbi.2016.03.024. Epub 2016 Mar 30. Erratum in: Brain Behav Immun. 2018 Jan;67:398-401.

31.

Cerebrospinal fluid ratios with Aβ42 predict preclinical brain β-amyloid accumulation.

Racine AM, Koscik RL, Nicholas CR, Clark LR, Okonkwo OC, Oh JM, Hillmer AT, Murali D, Barnhart TE, Betthauser TJ, Gallagher CL, Rowley HA, Dowling NM, Asthana S, Bendlin BB, Blennow K, Zetterberg H, Carlsson CM, Christian BT, Johnson SC.

Alzheimers Dement (Amst). 2016;2:27-38.

32.

Beta-amyloid and cognitive decline in late middle age: Findings from the Wisconsin Registry for Alzheimer's Prevention study.

Clark LR, Racine AM, Koscik RL, Okonkwo OC, Engelman CD, Carlsson CM, Asthana S, Bendlin BB, Chappell R, Nicholas CR, Rowley HA, Oh JM, Hermann BP, Sager MA, Christian BT, Johnson SC.

Alzheimers Dement. 2016 Jul;12(7):805-14. doi: 10.1016/j.jalz.2015.12.009. Epub 2016 Jan 21.

33.

Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition.

Schultz SA, Boots EA, Almeida RP, Oh JM, Einerson J, Korcarz CE, Edwards DF, Koscik RL, Dowling MN, Gallagher CL, Bendlin BB, Christian BT, Zetterberg H, Blennow K, Carlsson CM, Asthana S, Hermann BP, Sager MA, Johnson SC, Stein JH, Okonkwo OC.

J Int Neuropsychol Soc. 2015 Nov;21(10):841-50. doi: 10.1017/S1355617715000843.

34.

Comparative assessment of (18) F-Mefway as a serotonin 5-HT1A receptor PET imaging agent across species: Rodents, nonhuman primates, and humans.

Mukherjee J, Bajwa AK, Wooten DW, Hillmer AT, Pan ML, Pandey SK, Saigal N, Christian BT.

J Comp Neurol. 2016 May 1;524(7):1457-71. doi: 10.1002/cne.23919. Epub 2015 Nov 18.

35.

Differential dopamine function in fibromyalgia.

Albrecht DS, MacKie PJ, Kareken DA, Hutchins GD, Chumin EJ, Christian BT, Yoder KK.

Brain Imaging Behav. 2016 Sep;10(3):829-39. doi: 10.1007/s11682-015-9459-4.

36.

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease.

Willette AA, Bendlin BB, Starks EJ, Birdsill AC, Johnson SC, Christian BT, Okonkwo OC, La Rue A, Hermann BP, Koscik RL, Jonaitis EM, Sager MA, Asthana S.

JAMA Neurol. 2015 Sep;72(9):1013-20. doi: 10.1001/jamaneurol.2015.0613. Erratum in: JAMA Neurol. 2015 Dec;72(12):1537. Erratum in: JAMA Neurol. 2017 Jul 1;74(7):873.

37.

Amyloid burden, cortical thickness, and cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Doherty BM, Schultz SA, Oh JM, Koscik RL, Dowling NM, Barnhart TE, Murali D, Gallagher CL, Carlsson CM, Bendlin BB, LaRue A, Hermann BP, Rowley HA, Asthana S, Sager MA, Christian BT, Johnson SC, Okonkwo OC.

Alzheimers Dement (Amst). 2015 Jun 1;1(2):160-169.

38.

The effects of normal aging on amyloid-β deposition in nondemented adults with Down syndrome as imaged by carbon 11-labeled Pittsburgh compound B.

Lao PJ, Betthauser TJ, Hillmer AT, Price JC, Klunk WE, Mihaila I, Higgins AT, Bulova PD, Hartley SL, Hardison R, Tumuluru RV, Murali D, Mathis CA, Cohen AD, Barnhart TE, Devenny DA, Mailick MR, Johnson SC, Handen BL, Christian BT.

Alzheimers Dement. 2016 Apr;12(4):380-90. doi: 10.1016/j.jalz.2015.05.013. Epub 2015 Jun 13.

39.

Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults.

Sprecher KE, Bendlin BB, Racine AM, Okonkwo OC, Christian BT, Koscik RL, Sager MA, Asthana S, Johnson SC, Benca RM.

Neurobiol Aging. 2015 Sep;36(9):2568-76. doi: 10.1016/j.neurobiolaging.2015.05.004. Epub 2015 May 14.

40.

Synthesis and Evaluation of Mefway Analogs as Ligands for Serotonin 5HT1A Receptors.

Thio JP, Liang C, Bajwa AK, Wooten DW, Christian BT, Mukherjee J.

Med Chem Res. 2015 Apr;24(4):1480-1486.

41.

Moderate-level prenatal alcohol exposure induces sex differences in dopamine d1 receptor binding in adult rhesus monkeys.

Converse AK, Moore CF, Holden JE, Ahlers EO, Moirano JM, Larson JA, Resch LM, DeJesus OT, Barnhart TE, Nickles RJ, Murali D, Christian BT, Schneider ML.

Alcohol Clin Exp Res. 2014 Dec;38(12):2934-43. doi: 10.1111/acer.12575.

42.

Anterior cingulate dopamine turnover and behavior change in Parkinson's disease.

Gallagher CL, Bell B, Palotti M, Oh J, Christian BT, Okonkwo O, Sojkova J, Buyan-Dent L, Nickles RJ, Harding SJ, Stone CK, Johnson SC, Holden JE.

Brain Imaging Behav. 2015 Dec;9(4):821-7. doi: 10.1007/s11682-014-9338-4.

43.

First-in-human evaluation of 18F-mefway, a PET radioligand specific to serotonin-1A receptors.

Hillmer AT, Wooten DW, Bajwa AK, Higgins AT, Lao PJ, Betthauser TJ, Barnhart TE, Rowley HA, Stone CK, Johnson SC, Mukherjee J, Christian BT.

J Nucl Med. 2014 Dec;55(12):1973-9. doi: 10.2967/jnumed.114.145151. Epub 2014 Nov 13.

44.

Physical activity attenuates age-related biomarker alterations in preclinical AD.

Okonkwo OC, Schultz SA, Oh JM, Larson J, Edwards D, Cook D, Koscik R, Gallagher CL, Dowling NM, Carlsson CM, Bendlin BB, LaRue A, Rowley HA, Christian BT, Asthana S, Hermann BP, Johnson SC, Sager MA.

Neurology. 2014 Nov 4;83(19):1753-60. doi: 10.1212/WNL.0000000000000964. Epub 2014 Oct 8. Erratum in: Neurology. 2015 Mar 3;84(9):963.

45.

The effects of chronic alcohol self-administration on serotonin-1A receptor binding in nonhuman primates.

Hillmer AT, Wooten DW, Tudorascu DL, Barnhart TE, Ahlers EO, Resch LM, Larson JA, Converse AK, Moore CF, Schneider ML, Christian BT.

Drug Alcohol Depend. 2014 Nov 1;144:119-26. doi: 10.1016/j.drugalcdep.2014.08.015. Epub 2014 Aug 29.

46.

Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway.

Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT.

Am J Nucl Med Mol Imaging. 2014 Aug 15;4(5):483-9. eCollection 2014.

47.

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome.

Hartley SL, Handen BL, Devenny DA, Hardison R, Mihaila I, Price JC, Cohen AD, Klunk WE, Mailick MR, Johnson SC, Christian BT.

Brain. 2014 Sep;137(Pt 9):2556-63. doi: 10.1093/brain/awu173. Epub 2014 Jul 2.

48.

Synthesis and evaluation of 2-(18)F-fluoro-5-iodo-3-[2-(S)-3,4-dehydropyrrolinylmethoxy]pyridine ((18)F-Niofene) as a potential imaging agent for nicotinic α4β2 receptors.

Kuruvilla SA, Hillmer AT, Wooten DW, Patel A, Christian BT, Mukherjee J.

Am J Nucl Med Mol Imaging. 2014 Jun 7;4(4):354-64. eCollection 2014.

49.

Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation.

Racine AM, Adluru N, Alexander AL, Christian BT, Okonkwo OC, Oh J, Cleary CA, Birdsill A, Hillmer AT, Murali D, Barnhart TE, Gallagher CL, Carlsson CM, Rowley HA, Dowling NM, Asthana S, Sager MA, Bendlin BB, Johnson SC.

Neuroimage Clin. 2014 Feb 19;4:604-14. doi: 10.1016/j.nicl.2014.02.001. eCollection 2014.

50.

Deficient import of acetyl-CoA into the ER lumen causes neurodegeneration and propensity to infections, inflammation, and cancer.

Peng Y, Li M, Clarkson BD, Pehar M, Lao PJ, Hillmer AT, Barnhart TE, Christian BT, Mitchell HA, Bendlin BB, Sandor M, Puglielli L.

J Neurosci. 2014 May 14;34(20):6772-89. doi: 10.1523/JNEUROSCI.0077-14.2014.

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