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Items: 1 to 50 of 127

1.

Chemical synthesis rewriting of a bacterial genome to achieve design flexibility and biological functionality.

Venetz JE, Del Medico L, Wölfle A, Schächle P, Bucher Y, Appert D, Tschan F, Flores-Tinoco CE, van Kooten M, Guennoun R, Deutsch S, Christen M, Christen B.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):8070-8079. doi: 10.1073/pnas.1818259116. Epub 2019 Apr 1.

2.

Identification of Small-Molecule Modulators of Diguanylate Cyclase by FRET-Based High-Throughput Screening.

Christen M, Kamischke C, Kulasekara HD, Olivas KC, Kulasekara BR, Christen B, Kline T, Miller SI.

Chembiochem. 2019 Feb 1;20(3):394-407. doi: 10.1002/cbic.201800593. Epub 2018 Dec 27.

PMID:
30395379
3.

Digital Medicine, Cybersecurity, and Ethics: An Uneasy Relationship.

Weber K, Loi M, Christen M, Kleine N.

Am J Bioeth. 2018 Sep;18(9):52-53. doi: 10.1080/15265161.2018.1498935. No abstract available.

PMID:
30235094
4.

Metabolism of Anethole Dithiolethione by Rat and Human Liver Microsomes: Formation of Various Products Deriving from Its O-Demethylation and S-Oxidation. Involvement of Cytochromes P450 and Flavin Monooxygenases in These Pathways.

Dulac M, Sassi A, Nagarathinan C, Christen MO, Dansette PM, Mansuy D, Boucher JL.

Drug Metab Dispos. 2018 Oct;46(10):1390-1395. doi: 10.1124/dmd.118.082545. Epub 2018 Jul 17.

PMID:
30018103
5.

Transposon Sequencing of Brucella abortus Uncovers Essential Genes for Growth In Vitro and Inside Macrophages.

Sternon JF, Godessart P, Gonçalves de Freitas R, Van der Henst M, Poncin K, Francis N, Willemart K, Christen M, Christen B, Letesson JJ, De Bolle X.

Infect Immun. 2018 Jul 23;86(8). pii: e00312-18. doi: 10.1128/IAI.00312-18. Print 2018 Aug.

6.

Recommendations for volume augmentation and rejuvenation of the face and hands with the new generation polycaprolactone-based collagen stimulator (Ellansé®).

de Melo F, Nicolau P, Piovano L, Lin SL, Baptista-Fernandes T, King MI, Camporese A, Hong K, Khattar MM, Christen MO.

Clin Cosmet Investig Dermatol. 2017 Nov 8;10:431-440. doi: 10.2147/CCID.S145195. eCollection 2017. Review.

7.

Editorial: The Clinical and Ethical Practice of Neuromodulation - Deep Brain Stimulation and Beyond.

Christen M, Müller S.

Front Integr Neurosci. 2017 Nov 9;11:32. doi: 10.3389/fnint.2017.00032. eCollection 2017. No abstract available.

8.

Transposon Sequencing Uncovers an Essential Regulatory Function of Phosphoribulokinase for Methylotrophy.

Ochsner AM, Christen M, Hemmerle L, Peyraud R, Christen B, Vorholt JA.

Curr Biol. 2017 Sep 11;27(17):2579-2588.e6. doi: 10.1016/j.cub.2017.07.025. Epub 2017 Aug 17.

9.

Development and validation of a multi-dimensional measure of intellectual humility.

Alfano M, Iurino K, Stey P, Robinson B, Christen M, Yu F, Lapsley D.

PLoS One. 2017 Aug 16;12(8):e0182950. doi: 10.1371/journal.pone.0182950. eCollection 2017.

10.

A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase.

Kirby KA, Myshakina NA, Christen MT, Chen YL, Schmidt HA, Huber AD, Xi Z, Kim S, Rao RK, Kramer ST, Yang Q, Singh K, Parniak MA, Wang Z, Ishima R, Sarafianos SG.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17. doi: 10.1128/AAC.01351-17. Print 2017 Oct.

11.

Gene Transfer Agent Promotes Evolvability within the Fittest Subpopulation of a Bacterial Pathogen.

Québatte M, Christen M, Harms A, Körner J, Christen B, Dehio C.

Cell Syst. 2017 Jun 28;4(6):611-621.e6. doi: 10.1016/j.cels.2017.05.011. Epub 2017 Jun 14.

12.

Genome Partitioner: A web tool for multi-level partitioning of large-scale DNA constructs for synthetic biology applications.

Christen M, Del Medico L, Christen H, Christen B.

PLoS One. 2017 May 22;12(5):e0177234. doi: 10.1371/journal.pone.0177234. eCollection 2017.

13.

Rapid adaptation to microgravity in mammalian macrophage cells.

Thiel CS, de Zélicourt D, Tauber S, Adrian A, Franz M, Simmet DM, Schoppmann K, Hauschild S, Krammer S, Christen M, Bradacs G, Paulsen K, Wolf SA, Braun M, Hatton J, Kurtcuoglu V, Franke S, Tanner S, Cristoforetti S, Sick B, Hock B, Ullrich O.

Sci Rep. 2017 Feb 27;7(1):43. doi: 10.1038/s41598-017-00119-6.

14.

Measuring value sensitivity in medicine.

Ineichen C, Christen M, Tanner C.

BMC Med Ethics. 2017 Jan 28;18(1):5. doi: 10.1186/s12910-016-0164-7.

15.

Entire-Dataset Analysis of NMR Fast-Exchange Titration Spectra: A Mg2+ Titration Analysis for HIV-1 Ribonuclease H Domain.

Karki I, Christen MT, Spiriti J, Slack RL, Oda M, Kanaori K, Zuckerman DM, Ishima R.

J Phys Chem B. 2016 Dec 15;120(49):12420-12431. Epub 2016 Dec 5.

16.

Moral Sensitivity as a Precondition of Moral Distress.

Christen M, Katsarov J.

Am J Bioeth. 2016 Dec;16(12):19-21. No abstract available.

PMID:
27901441
17.

Limb amputation and other disability desires as a medical condition.

Brugger P, Christen M, Jellestad L, Hänggi J.

Lancet Psychiatry. 2016 Dec;3(12):1176-1186. doi: 10.1016/S2215-0366(16)30265-6. Review.

18.

Deep Brain Stimulation: In Search of Reliable Instruments for Assessing Complex Personality-Related Changes.

Ineichen C, Baumann-Vogel H, Christen M.

Brain Sci. 2016 Sep 7;6(3). pii: E40. doi: 10.3390/brainsci6030040.

19.

Ethics of emergent information and communication technology applications in humanitarian medical assistance.

Hunt M, Pringle J, Christen M, Eckenwiler L, Schwartz L, Davé A.

Int Health. 2016 Jul;8(4):239-45. doi: 10.1093/inthealth/ihw028. Review.

PMID:
27481835
20.

«Moralische Intelligenz» in der medizinischen Praxis.

Christen M, Ineichen C, Tanner C.

Praxis (Bern 1994). 2016;105(21):1261-1266. doi: 10.1024/1661-8157/a002494. German. No abstract available.

PMID:
28573953
21.

Quantitative Selection Analysis of Bacteriophage φCbK Susceptibility in Caulobacter crescentus.

Christen M, Beusch C, Bösch Y, Cerletti D, Flores-Tinoco CE, Del Medico L, Tschan F, Christen B.

J Mol Biol. 2016 Jan 29;428(2 Pt B):419-30. doi: 10.1016/j.jmb.2015.11.018. Epub 2015 Nov 22.

22.

Analyzing 7000 texts on deep brain stimulation: what do they tell us?

Ineichen C, Christen M.

Front Integr Neurosci. 2015 Oct 26;9:52. doi: 10.3389/fnint.2015.00052. eCollection 2015.

23.

Resolving Some, But Not All Informed Consent Issues in DCDD--the Swiss Experiences.

Christen M, Bastami S, Gloor M, Krones T.

Am J Bioeth. 2015;15(8):29-31. doi: 10.1080/15265161.2015.1045095. No abstract available.

PMID:
26225513
24.

Genome Calligrapher: A Web Tool for Refactoring Bacterial Genome Sequences for de Novo DNA Synthesis.

Christen M, Deutsch S, Christen B.

ACS Synth Biol. 2015 Aug 21;4(8):927-34. doi: 10.1021/acssynbio.5b00087. Epub 2015 Jul 6.

25.

From control to cooperation - Plea for a new role of IRBs.

Christen M, Brugger P.

Cortex. 2015 Oct;71:415-6. doi: 10.1016/j.cortex.2015.05.004. Epub 2015 May 27. No abstract available.

26.

Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor.

Christen M, Marcaida MJ, Lamprakis C, Aeschimann W, Vaithilingam J, Schneider P, Hilbert M, Schneider G, Cascella M, Stocker A.

J Struct Biol. 2015 Jun;190(3):261-70. doi: 10.1016/j.jsb.2015.05.001. Epub 2015 May 16.

PMID:
25987292
27.

A combined NMR and computational approach to investigate peptide binding to a designed Armadillo repeat protein.

Ewald C, Christen MT, Watson RP, Mihajlovic M, Zhou T, Honegger A, Plückthun A, Caflisch A, Zerbe O.

J Mol Biol. 2015 May 22;427(10):1916-33. doi: 10.1016/j.jmb.2015.02.022. Epub 2015 Mar 24.

28.

Beyond a piece of paper: learning to hire with synergy.

Jeffery AD, Christen M, Moore L.

Nurs Manage. 2015 Jan;46(1):52-4. doi: 10.1097/01.NUMA.0000452008.64591.fb. No abstract available.

PMID:
25536357
29.

Short-term functional versus patient-reported outcome of the bicruciate stabilized total knee arthroplasty: prospective consecutive case series.

Christen M, Aghayev E, Christen B.

BMC Musculoskelet Disord. 2014 Dec 16;15:435. doi: 10.1186/1471-2474-15-435.

30.

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant.

Folcher M, Oesterle S, Zwicky K, Thekkottil T, Heymoz J, Hohmann M, Christen M, Daoud El-Baba M, Buchmann P, Fussenegger M.

Nat Commun. 2014 Nov 11;5:5392. doi: 10.1038/ncomms6392.

31.

Safety of poly-L-lactic acid (New-Fill®) in the treatment of facial lipoatrophy: a large observational study among HIV-positive patients.

Duracinsky M, Leclercq P, Herrmann S, Christen MO, Dolivo M, Goujard C, Chassany O.

BMC Infect Dis. 2014 Sep 1;14:474. doi: 10.1186/1471-2334-14-474.

32.

Effects of brain lesions on moral agency: ethical dilemmas in investigating moral behavior.

Christen M, Müller S.

Curr Top Behav Neurosci. 2015;19:159-88. doi: 10.1007/7854_2014_342. Review.

PMID:
25120025
33.

How "moral" are the principles of biomedical ethics?--a cross-domain evaluation of the common morality hypothesis.

Christen M, Ineichen C, Tanner C.

BMC Med Ethics. 2014 Jun 17;15:47. doi: 10.1186/1472-6939-15-47.

34.

Spontaneous self-assembly of engineered armadillo repeat protein fragments into a folded structure.

Watson RP, Christen MT, Ewald C, Bumbak F, Reichen C, Mihajlovic M, Schmidt E, Güntert P, Caflisch A, Plückthun A, Zerbe O.

Structure. 2014 Jul 8;22(7):985-95. doi: 10.1016/j.str.2014.05.002. Epub 2014 Jun 12.

35.

The p66 immature precursor of HIV-1 reverse transcriptase.

Sharaf NG, Poliner E, Slack RL, Christen MT, Byeon IJ, Parniak MA, Gronenborn AM, Ishima R.

Proteins. 2014 Oct;82(10):2343-52. doi: 10.1002/prot.24594. Epub 2014 May 12.

36.

Mapping collective behavior--beware of looping.

Christen M, Brugger P.

Behav Brain Sci. 2014 Feb;37(1):80-1. doi: 10.1017/S0140525X13001696.

37.

c-di-GMP heterogeneity is generated by the chemotaxis machinery to regulate flagellar motility.

Kulasekara BR, Kamischke C, Kulasekara HD, Christen M, Wiggins PA, Miller SI.

Elife. 2013 Dec 17;2:e01402. doi: 10.7554/eLife.01402.

38.

When benefitting a patient increases the risk for harm for third persons - the case of treating pedophilic Parkinsonian patients with deep brain stimulation.

Müller S, Walter H, Christen M.

Int J Law Psychiatry. 2014 May-Jun;37(3):295-303. doi: 10.1016/j.ijlp.2013.11.015. Epub 2013 Nov 26.

PMID:
24289863
39.

Colorful brains: 14 years of display practice in functional neuroimaging.

Christen M, Vitacco DA, Huber L, Harboe J, Fabrikant SI, Brugger P.

Neuroimage. 2013 Jun;73:30-9. doi: 10.1016/j.neuroimage.2013.01.068. Epub 2013 Feb 9.

PMID:
23403183
40.

Pharmaceutically controlled designer circuit for the treatment of the metabolic syndrome.

Ye H, Charpin-El Hamri G, Zwicky K, Christen M, Folcher M, Fussenegger M.

Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):141-6. doi: 10.1073/pnas.1216801110. Epub 2012 Dec 17.

41.

The response threshold of Salmonella PilZ domain proteins is determined by their binding affinities for c-di-GMP.

Pultz IS, Christen M, Kulasekara HD, Kennard A, Kulasekara B, Miller SI.

Mol Microbiol. 2012 Dec;86(6):1424-40. doi: 10.1111/mmi.12066. Epub 2012 Nov 19.

42.

Structural basis of the allosteric inhibitor interaction on the HIV-1 reverse transcriptase RNase H domain.

Christen MT, Menon L, Myshakina NS, Ahn J, Parniak MA, Ishima R.

Chem Biol Drug Des. 2012 Nov;80(5):706-16. doi: 10.1111/cbdd.12010. Epub 2012 Aug 31.

43.

Current status and future challenges of deep brain stimulation in Switzerland.

Christen M, Müller S.

Swiss Med Wkly. 2012 Apr 5;142:w13570. doi: 10.4414/smw.2012.13570. eCollection 2012.

44.

Single Cases Promote Knowledge Transfer in the Field of DBS.

Christen M, Müller S.

Front Integr Neurosci. 2011 May 5;5:13. doi: 10.3389/fnint.2011.00013. eCollection 2011. No abstract available.

45.

The redesigned follitropin α pen injector for infertility treatment.

Christen M, Schertz JC, Arriagada P, Keitel J, Müller H.

Expert Opin Drug Deliv. 2011 Jun;8(6):833-9. doi: 10.1517/17425247.2011.581658. Epub 2011 May 8. Review.

PMID:
21548843
46.

'Sciencenet'--towards a global search and share engine for all scientific knowledge.

Lütjohann DS, Shah AH, Christen MP, Richter F, Knese K, Liebel U.

Bioinformatics. 2011 Jun 15;27(12):1734-5. doi: 10.1093/bioinformatics/btr181. Epub 2011 Apr 14.

47.

Human plasminogen kringle 3: solution structure, functional insights, phylogenetic landscape.

Christen MT, Frank P, Schaller J, Llinás M.

Biochemistry. 2010 Aug 24;49(33):7131-50. doi: 10.1021/bi100687f.

PMID:
20617841
48.

Asymmetrical distribution of the second messenger c-di-GMP upon bacterial cell division.

Christen M, Kulasekara HD, Christen B, Kulasekara BR, Hoffman LR, Miller SI.

Science. 2010 Jun 4;328(5983):1295-7. doi: 10.1126/science.1188658.

49.

Antiplasmodial lanostanes from the Ganoderma lucidum mushroom.

Adams M, Christen M, Plitzko I, Zimmermann S, Brun R, Kaiser M, Hamburger M.

J Nat Prod. 2010 May 28;73(5):897-900. doi: 10.1021/np100031c.

PMID:
20384295
50.

Activation of a bacterial virulence protein by the GTPase RhoA.

Christen M, Coye LH, Hontz JS, LaRock DL, Pfuetzner RA, Megha, Miller SI.

Sci Signal. 2009 Nov 3;2(95):ra71. doi: 10.1126/scisignal.2000430.

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