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Items: 1 to 50 of 54

1.

Potent, orally bioavailable delta opioid receptor agonists for the treatment of pain: discovery of N,N-diethyl-4-(5-hydroxyspiro[chromene-2,4'-piperidine]-4-yl)benzamide (ADL5859).

Le Bourdonnec B, Windh RT, Ajello CW, Leister LK, Gu M, Chu GH, Tuthill PA, Barker WM, Koblish M, Wiant DD, Graczyk TM, Belanger S, Cassel JA, Feschenko MS, Brogdon BL, Smith SA, Christ DD, Derelanko MJ, Kutz S, Little PJ, DeHaven RN, DeHaven-Hudkins DL, Dolle RE.

J Med Chem. 2008 Oct 9;51(19):5893-6. doi: 10.1021/jm8008986. Epub 2008 Sep 13.

PMID:
18788723
2.

Potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE): discovery of indole, benzofuran, imidazopyridine and pyrazolopyridine P1' substituents.

Lu Z, Ott GR, Anand R, Liu RQ, Covington MB, Vaddi K, Qian M, Newton RC, Christ DD, Trzaskos J, Duan JJ.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):1958-62. doi: 10.1016/j.bmcl.2008.01.120. Epub 2008 Feb 7.

PMID:
18282708
3.

Potent, exceptionally selective, orally bioavailable inhibitors of TNF-alpha Converting Enzyme (TACE): novel 2-substituted-1H-benzo[d]imidazol-1-yl)methyl)benzamide P1' substituents.

Ott GR, Asakawa N, Lu Z, Anand R, Liu RQ, Covington MB, Vaddi K, Qian M, Newton RC, Christ DD, Trzaskos JM, Duan JJ.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1577-82. doi: 10.1016/j.bmcl.2008.01.075. Epub 2008 Jan 26.

PMID:
18242982
4.

Alpha,Beta-cyclic-beta-benzamido hydroxamic acids: Novel oxaspiro[4.4]nonane templates for the discovery of potent, selective, orally bioavailable inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).

Ott GR, Asakawa N, Liu RQ, Covington MB, Qian M, Vaddi K, Newton RC, Trzaskos JM, Christ DD, Galya L, Scholz T, Marshall W, Duan JJ.

Bioorg Med Chem Lett. 2008 Feb 15;18(4):1288-92. doi: 10.1016/j.bmcl.2008.01.030. Epub 2008 Jan 11.

PMID:
18234496
5.

Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).

Ott GR, Asakawa N, Lu Z, Liu RQ, Covington MB, Vaddi K, Qian M, Newton RC, Christ DD, Traskos JM, Decicco CP, Duan JJ.

Bioorg Med Chem Lett. 2008 Jan 15;18(2):694-9. Epub 2007 Nov 21.

PMID:
18061445
6.

Discovery of beta-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors.

Duan JJ, Chen L, Lu Z, Xue CB, Liu RQ, Covington MB, Qian M, Wasserman ZR, Vaddi K, Christ DD, Trzaskos JM, Newton RC, Decicco CP.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):241-6. Epub 2007 Oct 30.

PMID:
18032037
7.

N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.

He K, Qian M, Wong H, Bai SA, He B, Brogdon B, Grace JE, Xin B, Wu J, Ren SX, Zeng H, Deng Y, Graden DM, Olah TV, Unger SE, Luettgen JM, Knabb RM, Pinto DJ, Lam PY, Duan J, Wexler RR, Decicco CP, Christ DD, Grossman SJ.

J Pharm Sci. 2008 Jul;97(7):2568-80.

PMID:
17914718
8.

Pharmacokinetics and pharmacodynamics of DPC 333 ((2R)-2-((3R)-3-amino-3{4-[2-methyl-4-quinolinyl) methoxy] phenyl}-2-oxopyrrolidinyl)-N-hydroxy-4-methylpentanamide)), a potent and selective inhibitor of tumor necrosis factor alpha-converting enzyme in rodents, dogs, chimpanzees, and humans.

Qian M, Bai SA, Brogdon B, Wu JT, Liu RQ, Covington MB, Vaddi K, Newton RC, Fossler MJ, Garner CE, Deng Y, Maduskuie T, Trzaskos J, Duan JJ, Decicco CP, Christ DD.

Drug Metab Dispos. 2007 Oct;35(10):1916-25. Epub 2007 Jul 26.

PMID:
17656469
9.

CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.

Pruitt JR, Batt DG, Wacker DA, Bostrom LL, Booker SK, McLaughlin E, Houghton GC, Varnes JG, Christ DD, Covington M, Das AM, Davies P, Graden D, Kariv I, Orlovsky Y, Stowell NC, Vaddi KG, Wadman EA, Welch PK, Yeleswaram S, Solomon KA, Newton RC, Decicco CP, Carter PH, Ko SS.

Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7. Epub 2007 Mar 24.

PMID:
17418570
10.

A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1' group for the beta-amino hydroxamic acid derived TACE inhibitors.

Chen XT, Ghavimi B, Corbett RL, Xue CB, Liu RQ, Covington MB, Qian M, Vaddi KG, Christ DD, Hartman KD, Ribadeneira MD, Trzaskos JM, Newton RC, Decicco CP, Duan JJ.

Bioorg Med Chem Lett. 2007 Apr 1;17(7):1865-70. Epub 2007 Jan 24.

PMID:
17276676
11.

Glucuronidation in the chimpanzee (Pan troglodytes): studies with acetaminophen, oestradiol and morphine.

Wong H, Grace JE Jr, Wright MR, Browning MR, Grossman SJ, Bai SA, Christ DD.

Xenobiotica. 2006 Dec;36(12):1178-90.

PMID:
17162465
12.

The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.

Wong H, Grossman SJ, Bai SA, Diamond S, Wright MR, Grace JE Jr, Qian M, He K, Yeleswaram K, Christ DD.

Drug Metab Dispos. 2004 Dec;32(12):1359-69. Epub 2004 Aug 27.

PMID:
15333515
13.

Sultam hydroxamates as novel matrix metalloproteinase inhibitors.

Cherney RJ, Mo R, Meyer DT, Hardman KD, Liu RQ, Covington MB, Qian M, Wasserman ZR, Christ DD, Trzaskos JM, Newton RC, Decicco CP.

J Med Chem. 2004 Jun 3;47(12):2981-3.

PMID:
15163180
14.

Rational design, synthesis and structure-activity relationships of a cyclic succinate series of TNF-alpha converting enzyme inhibitors. Part 2: lead optimization.

Xue CB, He X, Roderick J, Corbett RL, Duan JJ, Liu RQ, Covington MB, Qian M, Ribadeneira MD, Vaddi K, Christ DD, Newton RC, Trzaskos JM, Magolda RL, Wexler RR, Decicco CP.

Bioorg Med Chem Lett. 2003 Dec 15;13(24):4299-304.

PMID:
14643313
15.
16.

Design, synthesis, and evaluation of benzothiadiazepine hydroxamates as selective tumor necrosis factor-alpha converting enzyme inhibitors.

Cherney RJ, Duan JJ, Voss ME, Chen L, Wang L, Meyer DT, Wasserman ZR, Hardman KD, Liu RQ, Covington MB, Qian M, Mandlekar S, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP.

J Med Chem. 2003 May 8;46(10):1811-23.

PMID:
12723945
17.

Potent and selective aggrecanase inhibitors containing cyclic P1 substituents.

Cherney RJ, Mo R, Meyer DT, Wang L, Yao W, Wasserman ZR, Liu RQ, Covington MB, Tortorella MD, Arner EC, Qian M, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Decicco CP.

Bioorg Med Chem Lett. 2003 Apr 7;13(7):1297-300.

PMID:
12657268
18.

Discovery of gamma-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor alpha converting enzyme: design, synthesis, and structure-activity relationships.

Duan JJ, Chen L, Wasserman ZR, Lu Z, Liu RQ, Covington MB, Qian M, Hardman KD, Magolda RL, Newton RC, Christ DD, Wexler RR, Decicco CP.

J Med Chem. 2002 Nov 7;45(23):4954-7.

PMID:
12408705
19.

Interaction of ritonavir on tissue distribution of a [(14)c]L-valinamide, a potent human immunodeficiency virus-1 protease inhibitor, in rats using quantitative whole-body autoradiography.

Solon EG, Balani SK, Luo G, Yang TJ, Haines PJ, Wang L, Demond T, Diamond S, Christ DD, Gan LS, Lee FW.

Drug Metab Dispos. 2002 Nov;30(11):1164-9.

PMID:
12386120
20.

Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo.

Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL, Wang L, Meyer DT, Kennedy K, DeGradodagger WF, Hardman KD, Teleha CA, Jaffee BD, Liu RQ, Copeland RA, Covington MB, Christ DD, Trzaskos JM, Newton RC, Magolda RL, Wexler RR, Decicco CP.

J Med Chem. 2001 Aug 2;44(16):2636-60.

PMID:
11472217
21.

Cassette dosing pharmacokinetics: valuable tool or flawed science?

Christ DD.

Drug Metab Dispos. 2001 Jul;29(7):935. No abstract available.

PMID:
11408356
22.

Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz.

Markwalder JA, Christ DD, Mutlib A, Cordova BC, Klabe RM, Seitz SP.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):619-22.

PMID:
11266155
23.

Mass spectrometric and NMR characterization of metabolites of roxifiban, a potent and selective antagonist of the platelet glycoprotein IIb/IIIa receptor.

Mutlib AE, Diamond S, Shockcor J, Way R, Nemeth G, Gan L, Christ DD.

Xenobiotica. 2000 Nov;30(11):1091-110.

PMID:
11197070
24.

The species-dependent metabolism of efavirenz produces a nephrotoxic glutathione conjugate in rats.

Mutlib AE, Gerson RJ, Meunier PC, Haley PJ, Chen H, Gan LS, Davies MH, Gemzik B, Christ DD, Krahn DF, Markwalder JA, Seitz SP, Robertson RT, Miwa GT.

Toxicol Appl Pharmacol. 2000 Nov 15;169(1):102-13.

PMID:
11076702
25.

Identification and characterization of efavirenz metabolites by liquid chromatography/mass spectrometry and high field NMR: species differences in the metabolism of efavirenz.

Mutlib AE, Chen H, Nemeth GA, Markwalder JA, Seitz SP, Gan LS, Christ DD.

Drug Metab Dispos. 1999 Nov;27(11):1319-33.

PMID:
10534318
27.

The discovery and development of angiotensin II antagonists.

Carini DJ, Christ DD, Duncia JV, Pierce ME.

Pharm Biotechnol. 1998;11:29-56. Review. No abstract available.

PMID:
9760675
29.

Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model.

Lankford SM, Plummer D, Hellyer P, Christ DD, Bai SA.

J Cardiovasc Pharmacol. 1997 Nov;30(5):583-90.

PMID:
9388040
30.

DuP 532, an angiotensin II receptor antagonist: first administration and comparison with losartan.

Goldberg MR, Lo MW, Christ DD, Chiou R, Furtek CI, Amit O, Carides A, Biollaz J, Piguet V, Nussberger J, Brunner HR.

Clin Pharmacol Ther. 1997 Jan;61(1):59-69.

PMID:
9024174
31.
32.
34.

Analysis of the thrombin inhibitor DuP 714 by an enzyme-linked immunosorbent assay.

Mitchell TJ, Knabb RM, Christ DD, Farmer AR, Reilly TM.

Blood Coagul Fibrinolysis. 1994 Aug;5(4):517-21.

PMID:
7841307
35.

The pharmacokinetics and pharmacodynamics of the angiotensin II receptor antagonist losartan potassium (DuP 753/MK 954) in the dog.

Christ DD, Wong PC, Wong YN, Hart SD, Quon CY, Lam GN.

J Pharmacol Exp Ther. 1994 Mar;268(3):1199-205.

PMID:
8138932
36.

Induction of cytochromes P-450 2B and 3A in mice following the dietary administration of the novel cognitive enhancer linopirdine.

Diamond S, Rakestraw D, O'Neil J, Lam GN, Christ DD.

Drug Metab Dispos. 1994 Jan-Feb;22(1):65-73.

PMID:
8149892
37.

Enhancement of losartan (DuP 753)-induced angiotensin II receptor antagonism by PD123177 in rats.

Wong PC, Christ DD, Timmermans PB.

Eur J Pharmacol. 1992 Sep 22;220(2-3):267-70.

PMID:
1425998
38.

Monoclonal antibodies to the nonpeptide angiotensin II receptor antagonist, losartan.

Reilly TM, Christ DD, Duncia JV, Pierce SK, Timmermans PB.

Eur J Pharmacol. 1992 Jun 5;226(2):179-82.

PMID:
1639114
39.

Pharmacokinetics and metabolism of the pharmacologically active 4'-hydroxylated metabolite of propranolol in the dog.

Christ DD, Walle UK, Oatis JE Jr, Walle T.

Drug Metab Dispos. 1990 Jan-Feb;18(1):1-4.

PMID:
1970766
40.
41.
42.

Enflurane metabolism produces covalently bound liver adducts recognized by antibodies from patients with halothane hepatitis.

Christ DD, Kenna JG, Kammerer W, Satoh H, Pohl LR.

Anesthesiology. 1988 Dec;69(6):833-8.

PMID:
3195754
44.

The immunologic and metabolic basis of drug hypersensitivities.

Pohl LR, Satoh H, Christ DD, Kenna JG.

Annu Rev Pharmacol Toxicol. 1988;28:367-87. Review. No abstract available.

PMID:
3289490
45.

Potential metabolic basis for enflurane hepatitis and the apparent cross-sensitization between enflurane and halothane.

Christ DD, Satoh H, Kenna JG, Pohl LR.

Drug Metab Dispos. 1988 Jan-Feb;16(1):135-40.

PMID:
2894942
46.

Separation of the enantiomers of intact sulfate conjugates of adrenergic drugs by high-performance liquid chromatography after chiral derivatization.

Walle T, Christ DD, Walle UK, Wilson MJ.

J Chromatogr. 1985 May 31;341(1):213-6. No abstract available.

PMID:
4019688
47.

Stereoselective sulfate conjugation of 4-hydroxypropranolol in vitro by different species.

Christ DD, Walle T.

Drug Metab Dispos. 1985 May-Jun;13(3):380-1. No abstract available.

PMID:
2862002
48.

Ganglionic blockade by procaine in the presence of pentobarbital and diethyl ether.

Christ DD, Watts DR.

Arch Int Pharmacodyn Ther. 1982 Jun;257(2):213-24.

PMID:
6126162
49.

Anomalous rectification of mammalian sympathetic ganglion cells.

Christ DD, Nishi S.

Exp Neurol. 1973 Sep;40(3):806-15. No abstract available.

PMID:
4723856
50.

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