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Clonal redemption and clonal anergy as mechanisms to balance B cell tolerance and immunity.

Burnett DL, Reed JH, Christ D, Goodnow CC.

Immunol Rev. 2019 Sep 26. doi: 10.1111/imr.12808. [Epub ahead of print] Review.


Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.

Zammit NW, Siggs OM, Gray PE, Horikawa K, Langley DB, Walters SN, Daley SR, Loetsch C, Warren J, Yap JY, Cultrone D, Russell A, Malle EK, Villanueva JE, Cowley MJ, Gayevskiy V, Dinger ME, Brink R, Zahra D, Chaudhri G, Karupiah G, Whittle B, Roots C, Bertram E, Yamada M, Jeelall Y, Enders A, Clifton BE, Mabbitt PD, Jackson CJ, Watson SR, Jenne CN, Lanier LL, Wiltshire T, Spitzer MH, Nolan GP, Schmitz F, Aderem A, Porebski BT, Buckle AM, Abbott DW, Ziegler JB, Craig ME, Benitez-Aguirre P, Teo J, Tangye SG, King C, Wong M, Cox MP, Phung W, Tang J, Sandoval W, Wertz IE, Christ D, Goodnow CC, Grey ST.

Nat Immunol. 2019 Oct;20(10):1299-1310. doi: 10.1038/s41590-019-0492-0. Epub 2019 Sep 18.


CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan.

Vennin C, Mélénec P, Rouet R, Nobis M, Cazet AS, Murphy KJ, Herrmann D, Reed DA, Lucas MC, Warren SC, Elgundi Z, Pinese M, Kalna G, Roden D, Samuel M, Zaratzian A, Grey ST, Da Silva A, Leung W; Australian Pancreatic Genome Initiative (APGI), Mathivanan S, Wang Y, Braithwaite AW, Christ D, Benda A, Parkin A, Phillips PA, Whitelock JM, Gill AJ, Sansom OJ, Croucher DR, Parker BL, Pajic M, Morton JP, Cox TR, Timpson P.

Nat Commun. 2019 Aug 12;10(1):3637. doi: 10.1038/s41467-019-10968-6.


An evaluation of adaptive planning by assessing the dosimetric impact of weight loss throughout the course of radiotherapy in bilateral treatment of head and neck cancer patients.

Stauch Z, Zoller W, Tedrick K, Walston S, Christ D, Hunzeker A, Lenards N, Culp L, Gamez ME, Blakaj D.

Med Dosim. 2019 Jun 17. pii: S0958-3947(19)30062-7. doi: 10.1016/j.meddos.2019.05.003. [Epub ahead of print]


GDF15 mediates adiposity resistance through actions on GFRAL neurons in the hindbrain AP/NTS.

Tsai VW, Zhang HP, Manandhar R, Schofield P, Christ D, Lee-Ng KKM, Lebhar H, Marquis CP, Husaini Y, Brown DA, Breit SN.

Int J Obes (Lond). 2019 May 31. doi: 10.1038/s41366-019-0365-5. [Epub ahead of print]


Expression of Human VH Single Domains as Fc Fusions in Mammalian Cells.

Abdelatti M, Schofield P, Christ D.

Methods Mol Biol. 2019;1953:121-136. doi: 10.1007/978-1-4939-9145-7_8.


Human Antibody Bispecifics through Phage Display Selection.

Luthra A, Langley DB, Schofield P, Jackson J, Abdelatti M, Rouet R, Nevoltris D, Mazigi O, Crossett B, Christie M, Christ D.

Biochemistry. 2019 Apr 2;58(13):1701-1704. doi: 10.1021/acs.biochem.9b00037. Epub 2019 Mar 22.


Efficient Intracellular Delivery of CRISPR-Cas Ribonucleoproteins through Receptor Mediated Endocytosis.

Rouet R, Christ D.

ACS Chem Biol. 2019 Mar 15;14(3):554-561. doi: 10.1021/acschembio.9b00116. Epub 2019 Feb 21.


Anaerobic co-digestion of industrial landfill leachate and glycerin: methanogenic potential, organic matter removal and process optimization.

de Castro TM, Torres DGB, Arantes EJ, de Carvalho KQ, Passig FH, Christ D, Gotardo JT, Gomes SD.

Environ Technol. 2019 Jan 29:1-11. doi: 10.1080/09593330.2019.1575915. [Epub ahead of print]


Expression of IgG Monoclonals with Engineered Immune Effector Functions.

Vazquez-Lombardi R, Nevoltris D, Rouet R, Christ D.

Methods Mol Biol. 2018;1827:313-334. doi: 10.1007/978-1-4939-8648-4_16.


Sequencing and Affinity Determination of Antigen-Specific B Lymphocytes from Peripheral Blood.

Schofield P, Vazquez-Lombardi R, Abdelatti M, Nevoltris D, Goodnow CC, Christ D, Reed JH.

Methods Mol Biol. 2018;1827:287-309. doi: 10.1007/978-1-4939-8648-4_15.


Selection of Antibody Fragments Against Structured DNA by Phage Display.

Zeraati M, Dinger ME, Christ D.

Methods Mol Biol. 2018;1827:197-209. doi: 10.1007/978-1-4939-8648-4_11.


Crystal structure of duck egg lysozyme isoform II (DEL-II).

Langley DB, Christ D.

BMC Struct Biol. 2018 Aug 22;18(1):10. doi: 10.1186/s12900-018-0090-7.


Fluorescent labelling of Beet necrotic yellow vein virus and Beet soil-borne mosaic virus for co- and superinfection experiments in Nicotiana benthamiana.

Laufer M, Mohammad H, Christ DS, Riedel D, Maiss E, Varrelmann M, Liebe S.

J Gen Virol. 2018 Jul 30. doi: 10.1099/jgv.0.001122. [Epub ahead of print]


I-motif DNA structures are formed in the nuclei of human cells.

Zeraati M, Langley DB, Schofield P, Moye AL, Rouet R, Hughes WE, Bryan TM, Dinger ME, Christ D.

Nat Chem. 2018 Jun;10(6):631-637. doi: 10.1038/s41557-018-0046-3. Epub 2018 Apr 23.


Germinal center antibody mutation trajectories are determined by rapid self/foreign discrimination.

Burnett DL, Langley DB, Schofield P, Hermes JR, Chan TD, Jackson J, Bourne K, Reed JH, Patterson K, Porebski BT, Brink R, Christ D, Goodnow CC.

Science. 2018 Apr 13;360(6385):223-226. doi: 10.1126/science.aao3859.


Next-Generation Sequencing of Antibody Display Repertoires.

Rouet R, Jackson KJL, Langley DB, Christ D.

Front Immunol. 2018 Feb 2;9:118. doi: 10.3389/fimmu.2018.00118. eCollection 2018. Review.


Transient expression of human antibodies in mammalian cells.

Vazquez-Lombardi R, Nevoltris D, Luthra A, Schofield P, Zimmermann C, Christ D.

Nat Protoc. 2018 Jan;13(1):99-117. doi: 10.1038/nprot.2017.126. Epub 2017 Dec 14.


Cytosolic Recognition of RNA Drives the Immune Response to Heterologous Erythrocytes.

Loetsch C, Warren J, Laskowski A, Vazquez-Lombardi R, Jandl C, Langley DB, Christ D, Thorburn DR, Ryugo DK, Sprent J, Batten M, King C.

Cell Rep. 2017 Nov 7;21(6):1624-1638. doi: 10.1016/j.celrep.2017.10.044.


Structural basis of antigen recognition: crystal structure of duck egg lysozyme.

Langley DB, Crossett B, Schofield P, Jackson J, Zeraati M, Maltby D, Christie M, Burnett D, Brink R, Goodnow C, Christ D.

Acta Crystallogr D Struct Biol. 2017 Nov 1;73(Pt 11):910-920. doi: 10.1107/S2059798317013730. Epub 2017 Oct 25.


IL-2 Shapes the Survival and Plasticity of IL-17-Producing γδ T Cells.

Corpuz TM, Vazquez-Lombardi R, Luong JK, Warren J, Stolp J, Christ D, King C, Brink R, Sprent J, Webster KE.

J Immunol. 2017 Oct 1;199(7):2366-2376. doi: 10.4049/jimmunol.1700335. Epub 2017 Aug 23.


The Fluorocycline TP-271 Is Efficacious in Models of Aerosolized Francisella tularensis SCHU S4 Infection in BALB/c Mice and Cynomolgus Macaques.

Grossman TH, Anderson MS, Christ D, Gooldy M, Henning LN, Heine HS, Kindt MV, Lin W, Siefkas-Patterson K, Radcliff AK, Tam VH, Sutcliffe JA.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00448-17. doi: 10.1128/AAC.00448-17. Print 2017 Aug.


Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells.

Vazquez-Lombardi R, Loetsch C, Zinkl D, Jackson J, Schofield P, Deenick EK, King C, Phan TG, Webster KE, Sprent J, Christ D.

Nat Commun. 2017 May 12;8:15373. doi: 10.1038/ncomms15373.


Cancer-associated noncoding mutations affect RNA G-quadruplex-mediated regulation of gene expression.

Zeraati M, Moye AL, Wong JWH, Perera D, Cowley MJ, Christ DU, Bryan TM, Dinger ME.

Sci Rep. 2017 Apr 6;7(1):708. doi: 10.1038/s41598-017-00739-y.


Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells.

Kräutler NJ, Suan D, Butt D, Bourne K, Hermes JR, Chan TD, Sundling C, Kaplan W, Schofield P, Jackson J, Basten A, Christ D, Brink R.

J Exp Med. 2017 May 1;214(5):1259-1267. doi: 10.1084/jem.20161533. Epub 2017 Mar 31.


Structural reconstruction of protein ancestry.

Rouet R, Langley DB, Schofield P, Christie M, Roome B, Porebski BT, Buckle AM, Clifton BE, Jackson CJ, Stock D, Christ D.

Proc Natl Acad Sci U S A. 2017 Apr 11;114(15):3897-3902. doi: 10.1073/pnas.1613477114. Epub 2017 Mar 29.


Structure and Characterisation of a Key Epitope in the Conserved C-Terminal Domain of the Malaria Vaccine Candidate MSP2.

Seow J, Morales RA, MacRaild CA, Krishnarjuna B, McGowan S, Dingjan T, Jaipuria G, Rouet R, Wilde KL, Atreya HS, Richards JS, Anders RF, Christ D, Drinkwater N, Norton RS.

J Mol Biol. 2017 Mar 24;429(6):836-846. doi: 10.1016/j.jmb.2017.02.003. Epub 2017 Feb 8.


Circumventing the stability-function trade-off in an engineered FN3 domain.

Porebski BT, Conroy PJ, Drinkwater N, Schofield P, Vazquez-Lombardi R, Hunter MR, Hoke DE, Christ D, McGowan S, Buckle AM.

Protein Eng Des Sel. 2016 Nov 1;29(11):541-550. doi: 10.1093/protein/gzw046.


Clonal redemption of autoantibodies by somatic hypermutation away from self-reactivity during human immunization.

Reed JH, Jackson J, Christ D, Goodnow CC.

J Exp Med. 2016 Jun 27;213(7):1255-65. doi: 10.1084/jem.20151978. Epub 2016 Jun 13.


Development of a DNA Microarray-Based Assay for the Detection of Sugar Beet Root Rot Pathogens.

Liebe S, Christ DS, Ehricht R, Varrelmann M.

Phytopathology. 2016 Jan;106(1):76-86. doi: 10.1094/PHYTO-07-15-0171-R. Epub 2015 Dec 22.


Challenges and opportunities for non-antibody scaffold drugs.

Vazquez-Lombardi R, Phan TG, Zimmermann C, Lowe D, Jermutus L, Christ D.

Drug Discov Today. 2015 Oct;20(10):1271-83. doi: 10.1016/j.drudis.2015.09.004. Epub 2015 Sep 7. Review.


FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production.

Butt D, Chan TD, Bourne K, Hermes JR, Nguyen A, Statham A, O'Reilly LA, Strasser A, Price S, Schofield P, Christ D, Basten A, Ma CS, Tangye SG, Phan TG, Rao VK, Brink R.

Immunity. 2015 May 19;42(5):890-902. doi: 10.1016/j.immuni.2015.04.010. Epub 2015 May 12.


Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate.

Morales RAV, MacRaild CA, Seow J, Krishnarjuna B, Drinkwater N, Rouet R, Anders RF, Christ D, McGowan S, Norton RS.

Sci Rep. 2015 May 12;5:10103. doi: 10.1038/srep10103.


Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis.

Allen MD, Christie M, Jones P, Porebski BT, Roome B, Freund SM, Buckle AM, Bycroft M, Christ D.

Protein Eng Des Sel. 2015 Oct;28(10):445-50. doi: 10.1093/protein/gzv021. Epub 2015 Apr 15.


Fully Human VH Single Domains That Rival the Stability and Cleft Recognition of Camelid Antibodies.

Rouet R, Dudgeon K, Christie M, Langley D, Christ D.

J Biol Chem. 2015 May 8;290(19):11905-17. doi: 10.1074/jbc.M114.614842. Epub 2015 Mar 3.


Characterization of Fusarium secorum, a new species causing Fusarium yellowing decline of sugar beet in north central USA.

Secor GA, Rivera-Varas V, Christ DS, Mathew FM, Khan MF, Varrelmann M, Bolton MD.

Fungal Biol. 2014 Sep-Oct;118(9-10):764-75. doi: 10.1016/j.funbio.2014.06.001. Epub 2014 Jun 26.


Identification of aggregation inhibitors of the human antibody light chain repertoire by phage display.

Swift J, Saing S, Rouet R, Dudgeon K, Schofield P, Sewell W, Christ D.

Protein Eng Des Sel. 2014 Oct;27(10):405-9. doi: 10.1093/protein/gzu026. Epub 2014 Jul 22.


Stimulation of breast cancer cell lines by post-surgical drainage fluids.

Ramolu L, Christ D, Abecassis J, Rodier JF.

Anticancer Res. 2014 Jul;34(7):3489-92.


Cofactor-dependent conformational heterogeneity of GAD65 and its role in autoimmunity and neurotransmitter homeostasis.

Kass I, Hoke DE, Costa MG, Reboul CF, Porebski BT, Cowieson NP, Leh H, Pennacchietti E, McCoey J, Kleifeld O, Borri Voltattorni C, Langley D, Roome B, Mackay IR, Christ D, Perahia D, Buckle M, Paiardini A, De Biase D, Buckle AM.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2524-9. doi: 10.1073/pnas.1403182111. Epub 2014 Jun 9.


Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.

Sabouri Z, Schofield P, Horikawa K, Spierings E, Kipling D, Randall KL, Langley D, Roome B, Vazquez-Lombardi R, Rouet R, Hermes J, Chan TD, Brink R, Dunn-Walters DK, Christ D, Goodnow CC.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):E2567-75. doi: 10.1073/pnas.1406974111. Epub 2014 May 12.


Bispecific antibodies with native chain structure.

Rouet R, Christ D.

Nat Biotechnol. 2014 Feb;32(2):136-7. doi: 10.1038/nbt.2812. No abstract available.


Stability engineering of the human antibody repertoire.

Rouet R, Lowe D, Christ D.

FEBS Lett. 2014 Jan 21;588(2):269-77. doi: 10.1016/j.febslet.2013.11.029. Epub 2013 Nov 28. Review.


[Social and esthetic care in oncology, a part of the patient's journey].

Christ D, Reaux M.

Soins. 2013 Oct;(779):23-6. French.


IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection.

Schmitz I, Schneider C, Fröhlich A, Frebel H, Christ D, Leonard WJ, Sparwasser T, Oxenius A, Freigang S, Kopf M.

PLoS Pathog. 2013;9(5):e1003362. doi: 10.1371/journal.ppat.1003362. Epub 2013 May 16.


Rapid prediction of expression and refolding yields using phage display.

Dudgeon K, Rouet R, Christ D.

Protein Eng Des Sel. 2013 Oct;26(10):671-4. doi: 10.1093/protein/gzt019. Epub 2013 May 19.


Purification of molecular machines and nanomotors using phage-derived monoclonal antibody fragments.

Esteban O, Christ D, Stock D.

Methods Mol Biol. 2013;996:203-17. doi: 10.1007/978-1-62703-354-1_12.


The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells.

Gatto D, Wood K, Caminschi I, Murphy-Durland D, Schofield P, Christ D, Karupiah G, Brink R.

Nat Immunol. 2013 May;14(5):446-53. doi: 10.1038/ni.2555. Epub 2013 Mar 17. Erratum in: Nat Immunol. 2013 Aug;14(8):876.


Generation of human single domain antibody repertoires by Kunkel mutagenesis.

Rouet R, Dudgeon K, Christ D.

Methods Mol Biol. 2012;907:195-209. doi: 10.1007/978-1-61779-974-7_10.


Selection of human VH single domains with improved biophysical properties by phage display.

Dudgeon K, Rouet R, Famm K, Christ D.

Methods Mol Biol. 2012;911:383-97. doi: 10.1007/978-1-61779-968-6_23.


General strategy for the generation of human antibody variable domains with increased aggregation resistance.

Dudgeon K, Rouet R, Kokmeijer I, Schofield P, Stolp J, Langley D, Stock D, Christ D.

Proc Natl Acad Sci U S A. 2012 Jul 3;109(27):10879-84. doi: 10.1073/pnas.1202866109. Epub 2012 Jun 27.

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