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Items: 23


Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.

Heroes E, Van der Hoeven G, Choy MS, Garcia JDP, Ferreira M, Nys M, Derua R, Beullens M, Ulens C, Peti W, Van Meervelt L, Page R, Bollen M.

Structure. 2019 Mar 5;27(3):507-518.e5. doi: 10.1016/j.str.2018.12.002. Epub 2019 Jan 17.


The structure of SDS22 provides insights into the mechanism of heterodimer formation with PP1.

Choy MS, Bolik-Coulon N, Archuleta TL, Peti W, Page R.

Acta Crystallogr F Struct Biol Commun. 2018 Dec 1;74(Pt 12):817-824. doi: 10.1107/S2053230X18016503. Epub 2018 Nov 30.


Identification of the substrate recruitment mechanism of the muscle glycogen protein phosphatase 1 holoenzyme.

Kumar GS, Choy MS, Koveal DM, Lorinsky MK, Lyons SP, Kettenbach AN, Page R, Peti W.

Sci Adv. 2018 Nov 14;4(11):eaau6044. doi: 10.1126/sciadv.aau6044. eCollection 2018 Nov.


A Quantitative Chemical Proteomic Strategy for Profiling Phosphoprotein Phosphatases from Yeast to Humans.

Lyons SP, Jenkins NP, Nasa I, Choy MS, Adamo ME, Page R, Peti W, Moorhead GB, Kettenbach AN.

Mol Cell Proteomics. 2018 Dec;17(12):2448-2461. doi: 10.1074/mcp.RA118.000822. Epub 2018 Sep 18.


Candida catenulata Candidaemia and Possible Endocarditis in a Cirrhotic Patient Successfully De-escalated to Oral Fluconazole.

Ha MV, Choy MS, McCoy D, Fernandez N, Suh JS.

J Clin Pharm Ther. 2018 Dec;43(6):910-913. doi: 10.1111/jcpt.12728. Epub 2018 Jun 28.


A Sephin1-insensitive tripartite holophosphatase dephosphorylates translation initiation factor 2α.

Crespillo-Casado A, Claes Z, Choy MS, Peti W, Bollen M, Ron D.

J Biol Chem. 2018 May 18;293(20):7766-7776. doi: 10.1074/jbc.RA118.002325. Epub 2018 Apr 4.


PP1:Tautomycetin Complex Reveals a Path toward the Development of PP1-Specific Inhibitors.

Choy MS, Swingle M, D'Arcy B, Abney K, Rusin SF, Kettenbach AN, Page R, Honkanen RE, Peti W.

J Am Chem Soc. 2017 Dec 13;139(49):17703-17706. doi: 10.1021/jacs.7b09368. Epub 2017 Nov 28.


Conformational Rigidity and Protein Dynamics at Distinct Timescales Regulate PTP1B Activity and Allostery.

Choy MS, Li Y, Machado LESF, Kunze MBA, Connors CR, Wei X, Lindorff-Larsen K, Page R, Peti W.

Mol Cell. 2017 Feb 16;65(4):644-658.e5. doi: 10.1016/j.molcel.2017.01.014.


Mepolizumab (Nucala) For Severe Eosinophilic Asthma.

Choy MS, Dixit D, Bridgeman MB.

P T. 2016 Oct;41(10):619-622.


Molecular Insights into the Fungus-Specific Serine/Threonine Protein Phosphatase Z1 in Candida albicans.

Chen E, Choy MS, Petrényi K, Kónya Z, Erdődi F, Dombrádi V, Peti W, Page R.

MBio. 2016 Aug 30;7(4). pii: e00872-16. doi: 10.1128/mBio.00872-16.


PTP1B inhibition suggests a therapeutic strategy for Rett syndrome.

Krishnan N, Krishnan K, Connors CR, Choy MS, Page R, Peti W, Van Aelst L, Shea SD, Tonks NK.

J Clin Invest. 2015 Aug 3;125(8):3163-77. doi: 10.1172/JCI80323. Epub 2015 Jul 27.


Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase.

Choy MS, Yusoff P, Lee IC, Newton JC, Goh CW, Page R, Shenolikar S, Peti W.

Cell Rep. 2015 Jun 30;11(12):1885-91. doi: 10.1016/j.celrep.2015.05.043. Epub 2015 Jun 18.


Understanding the antagonism of retinoblastoma protein dephosphorylation by PNUTS provides insights into the PP1 regulatory code.

Choy MS, Hieke M, Kumar GS, Lewis GR, Gonzalez-DeWhitt KR, Kessler RP, Stein BJ, Hessenberger M, Nairn AC, Peti W, Page R.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4097-102. doi: 10.1073/pnas.1317395111. Epub 2014 Mar 3.


Regulation of protein phosphatase 1 by intrinsically disordered proteins.

Choy MS, Page R, Peti W.

Biochem Soc Trans. 2012 Oct;40(5):969-74. Review.


Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein.

Zhou W, Brush MH, Choy MS, Shenolikar S.

J Biol Chem. 2011 Jun 17;286(24):21687-96. doi: 10.1074/jbc.M110.212787. Epub 2011 Apr 25.


Temporal transcriptomic profiling reveals cellular targets that govern survival in HOCl-mediated neuronal apoptosis.

Yap YW, Chen MJ, Choy MS, Peng ZF, Whiteman M, Manikandan J, Melendez AJ, Cheung NS.

Life Sci. 2010 Oct 9;87(15-16):457-67. doi: 10.1016/j.lfs.2010.08.011. Epub 2010 Sep 15.


Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin.

Choy MS, Chen MJ, Manikandan J, Peng ZF, Jenner AM, Melendez AJ, Cheung NS.

J Cell Physiol. 2011 Feb;226(2):494-510. doi: 10.1002/jcp.22359.


Proteasome inhibition: an early or late event in nitric oxide-induced neuronal death?

Peng ZF, Chen MJ, Yap YW, Manikandan J, Melendez AJ, Choy MS, Moore PK, Cheung NS.

Nitric Oxide. 2008 Mar;18(2):136-45. Epub 2007 Nov 22.


PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis.

Choy MS, Bay BH, Cheng HC, Cheung NS.

Neurosci Lett. 2006 Sep 11;405(1-2):120-5. Epub 2006 Jul 20.


Early induction of calpains in rotenone-mediated neuronal apoptosis.

Chen MJ, Yap YW, Choy MS, Koh CH, Seet SJ, Duan W, Whiteman M, Cheung NS.

Neurosci Lett. 2006 Apr 10-17;397(1-2):69-73. Epub 2006 Jan 10.


Proteasome inhibition by lactacystin in primary neuronal cells induces both potentially neuroprotective and pro-apoptotic transcriptional responses: a microarray analysis.

Yew EH, Cheung NS, Choy MS, Qi RZ, Lee AY, Peng ZF, Melendez AJ, Manikandan J, Koay ES, Chiu LL, Ng WL, Whiteman M, Kandiah J, Halliwell B.

J Neurochem. 2005 Aug;94(4):943-56. Epub 2005 Jun 30.


Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction.

Cheung NS, Choy MS, Halliwell B, Teo TS, Bay BH, Lee AY, Qi RZ, Koh VH, Whiteman M, Koay ES, Chiu LL, Zhu HJ, Wong KP, Beart PM, Cheng HC.

Cell Mol Life Sci. 2004 Aug;61(15):1926-34.


Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons.

Cheung NS, Koh CH, Bay BH, Qi RZ, Choy MS, Li QT, Wong KP, Whiteman M.

Biochem Biophys Res Commun. 2004 Mar 5;315(2):408-17.


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