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Items: 1 to 50 of 301

1.

An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.

Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T.

Cell. 2019 Oct 3;179(2):417-431.e19. doi: 10.1016/j.cell.2019.09.009.

PMID:
31585081
2.

UNUSUAL CAUSE OF BRANCH RETINAL ARTERY OCCLUSION: POLYCYTHEMIA IN A TRANSGENDER MAN FROM UNREGULATED TESTOSTERONE USE.

Choy DMY, Voon LW, Teoh SCB.

Retin Cases Brief Rep. 2019 Aug 28. doi: 10.1097/ICB.0000000000000924. [Epub ahead of print]

PMID:
31464822
3.

Nasal gene expression changes with inhaled corticosteroid treatment in asthma.

Boudewijn IM, Lan A, Faiz A, Cox CA, Brouwer S, Schokker S, Vroegop SJ, Nawijn MC, Woodruff PG, Christenson SA, Hagedoorn P, Frijlink HW, Choy DF, Brouwer U, Wisman M, Postma DS, Fingleton J, Beasley R, van den Berge M, Guryev V.

Allergy. 2019 Jun 22. doi: 10.1111/all.13952. [Epub ahead of print] No abstract available.

PMID:
31230369
4.

Inhibition of urinary stone disease by a multi-species bacterial network ensures healthy oxalate homeostasis.

Miller AW, Choy D, Penniston KL, Lange D.

Kidney Int. 2019 Jul;96(1):180-188. doi: 10.1016/j.kint.2019.02.012. Epub 2019 Feb 28.

PMID:
31130222
5.
6.

Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

Siddiqui S, Shikotra A, Richardson M, Doran E, Choy D, Bell A, Austin CD, Eastham-Anderson J, Hargadon B, Arron JR, Wardlaw A, Brightling CE, Heaney LG, Bradding P.

J Allergy Clin Immunol. 2018 Nov;142(5):1457-1468. doi: 10.1016/j.jaci.2017.12.982. Epub 2018 Mar 14.

PMID:
29550052
7.

Understanding urban water performance at the city-region scale using an urban water metabolism evaluation framework.

Renouf MA, Kenway SJ, Lam KL, Weber T, Roux E, Serrao-Neumann S, Choy DL, Morgan EA.

Water Res. 2018 Jun 15;137:395-406. doi: 10.1016/j.watres.2018.01.070. Epub 2018 Feb 8.

PMID:
29544822
8.

A randomised pragmatic trial of corticosteroid optimization in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care: study protocol for a randomised trial.

Hanratty CE, Matthews JG, Arron JR, Choy DF, Pavord ID, Bradding P, Brightling CE, Chaudhuri R, Cowan DC, Djukanovic R, Gallagher N, Fowler SJ, Hardman TC, Harrison T, Holweg CT, Howarth PH, Lordan J, Mansur AH, Menzies-Gow A, Mosesova S, Niven RM, Robinson DS, Shaw DE, Walker S, Woodcock A, Heaney LG; RASP-UK (Refractory Asthma Stratification Programme) Consortium.

Trials. 2018 Jan 4;19(1):5. doi: 10.1186/s13063-017-2384-7.

9.

IFN-stimulated Gene Expression, Type 2 Inflammation, and Endoplasmic Reticulum Stress in Asthma.

Bhakta NR, Christenson SA, Nerella S, Solberg OD, Nguyen CP, Choy DF, Jung KL, Garudadri S, Bonser LR, Pollack JL, Zlock LT, Erle DJ, Langelier C, Derisi JL, Arron JR, Fahy JV, Woodruff PG.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):313-324. doi: 10.1164/rccm.201706-1070OC.

10.

A case for osteoporosis screening and treatment in older people to prevent hip fracture.

Kwok T, Choy D.

Hong Kong Med J. 2017 Aug;23(4):421. doi: 10.12809/hkmj176857. No abstract available.

PMID:
28775228
11.

High density lipoproteins and type 2 inflammatory biomarkers are negatively correlated in atopic asthmatics.

Barochia AV, Gordon EM, Kaler M, Cuento RA, Theard P, Figueroa DM, Yao X, Weir NA, Sampson ML, Stylianou M, Choy DF, Holweg CTJ, Remaley AT, Levine SJ.

J Lipid Res. 2017 Aug;58(8):1713-1721. doi: 10.1194/jlr.P077776. Epub 2017 Jun 27.

12.

Increased Autophagy-Related 5 Gene Expression Is Associated with Collagen Expression in the Airways of Refractory Asthmatics.

Poon AH, Choy DF, Chouiali F, Ramakrishnan RK, Mahboub B, Audusseau S, Mogas A, Harris JM, Arron JR, Laprise C, Hamid Q.

Front Immunol. 2017 Mar 29;8:355. doi: 10.3389/fimmu.2017.00355. eCollection 2017.

13.

Accurately measuring and modeling Th2 and Th17 endotypes in severe asthma.

Hart KM, Choy DF, Bradding P, Wynn TA, Arron JR.

Ann Transl Med. 2017 Feb;5(4):91. doi: 10.21037/atm.2017.02.07. No abstract available.

14.

A CEACAM6-High Airway Neutrophil Phenotype and CEACAM6-High Epithelial Cells Are Features of Severe Asthma.

Shikotra A, Choy DF, Siddiqui S, Arthur G, Nagarkar DR, Jia G, Wright AK, Ohri CM, Doran E, Butler CA, Hargadon B, Abbas AR, Jackman J, Wu LC, Heaney LG, Arron JR, Bradding P.

J Immunol. 2017 Apr 15;198(8):3307-3317. doi: 10.4049/jimmunol.1600606. Epub 2017 Mar 8.

15.

Seasonal variability of severe asthma exacerbations and clinical benefit from lebrikizumab.

Staton TL, Arron JR, Olsson J, Holweg CTJ, Matthews JG, Choy DF.

J Allergy Clin Immunol. 2017 May;139(5):1682-1684.e3. doi: 10.1016/j.jaci.2017.01.028. Epub 2017 Feb 24. No abstract available.

PMID:
28238745
16.

Depletion of major pathogenic cells in asthma by targeting CRTh2.

Huang T, Hazen M, Shang Y, Zhou M, Wu X, Yan D, Lin Z, Solon M, Luis E, Ngu H, Shi Y, Katewa A, Choy DF, Ramamoorthi N, Castellanos ER, Balazs M, Xu M, Lee WP, Matsumoto ML, Payandeh J, Arron JR, Hongo JA, Wang J, Hötzel I, Austin CD, Reif K.

JCI Insight. 2016 May 19;1(7):e86689. doi: 10.1172/jci.insight.86689.

17.

Peripheral blood gene expression predicts clinical benefit from anti-IL-13 in asthma.

Choy DF, Jia G, Abbas AR, Morshead KB, Lewin-Koh N, Dua R, Rivera P, Moonsamy P, Fontecha M, Balasubramanyam A, Santini C, Bassett E, Ray JM, Cabanski CR, Bradley MS, Maciuca R, Mosesova S, Scheerens H, Arron JR.

J Allergy Clin Immunol. 2016 Oct;138(4):1230-1233.e8. doi: 10.1016/j.jaci.2016.06.008. Epub 2016 Jun 29. No abstract available.

PMID:
27474124
18.

Reduced epithelial suppressor of cytokine signalling 1 in severe eosinophilic asthma.

Doran E, Choy DF, Shikotra A, Butler CA, O'Rourke DM, Johnston JA, Kissenpfennig A, Bradding P, Arron JR, Heaney LG.

Eur Respir J. 2016 Sep;48(3):715-25. doi: 10.1183/13993003.00400-2015. Epub 2016 Jun 23.

19.

Biomarkers in the clinical development of asthma therapies.

Staton TL, Choy DF, Arron JR.

Biomark Med. 2016;10(2):165-76. doi: 10.2217/bmm.15.116. Epub 2016 Jan 14. Review.

PMID:
26764286
20.

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Sun Y, Peng I, Webster JD, Suto E, Lesch J, Wu X, Senger K, Francis G, Barrett K, Collier JL, Burch JD, Zhou M, Chen Y, Chan C, Eastham-Anderson J, Ngu H, Li O, Staton T, Havnar C, Jaochico A, Jackman J, Jeet S, Riol-Blanco L, Wu LC, Choy DF, Arron JR, McKenzie BS, Ghilardi N, Ismaili MH, Pei Z, DeVoss J, Austin CD, Lee WP, Zarrin AA.

Sci Signal. 2015 Dec 1;8(405):ra122. doi: 10.1126/scisignal.aab0949.

PMID:
26628680
21.

TH2 and TH17 inflammatory pathways are reciprocally regulated in asthma.

Choy DF, Hart KM, Borthwick LA, Shikotra A, Nagarkar DR, Siddiqui S, Jia G, Ohri CM, Doran E, Vannella KM, Butler CA, Hargadon B, Sciurba JC, Gieseck RL, Thompson RW, White S, Abbas AR, Jackman J, Wu LC, Egen JG, Heaney LG, Ramalingam TR, Arron JR, Wynn TA, Bradding P.

Sci Transl Med. 2015 Aug 19;7(301):301ra129. doi: 10.1126/scitranslmed.aab3142.

PMID:
26290411
22.

The airway microbiome in patients with severe asthma: Associations with disease features and severity.

Huang YJ, Nariya S, Harris JM, Lynch SV, Choy DF, Arron JR, Boushey H.

J Allergy Clin Immunol. 2015 Oct;136(4):874-84. doi: 10.1016/j.jaci.2015.05.044. Epub 2015 Jul 26.

23.

Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Heaney LG, Djukanovic R, Woodcock A, Walker S, Matthews JG, Pavord ID, Bradding P, Niven R, Brightling CE, Chaudhuri R, Arron JR, Choy DF, Cowan D, Mansur A, Menzies-Gow A, Adcock I, Chung KF, Corrigan C, Coyle P, Harrison T, Johnston S, Howarth P, Lordan J, Sabroe I, Bigler J, Smith D, Catley M, May R, Pierre L, Stevenson C, Crater G, Keane F, Costello RW, Hudson V, Supple D, Hardman T.

Thorax. 2016 Feb;71(2):187-9. doi: 10.1136/thoraxjnl-2015-207326. Epub 2015 Jul 23. Review.

24.

IL-13 mediates IL-33-dependent mast cell and type 2 innate lymphoid cell effects on bronchial epithelial cells.

Nagarkar DR, Ramirez-Carrozzi V, Choy DF, Lee K, Soriano R, Jia G, Abbas AR, Modrusan Z, Pappu R, Arron JR.

J Allergy Clin Immunol. 2015 Jul;136(1):202-5. doi: 10.1016/j.jaci.2015.01.036. Epub 2015 Mar 14. No abstract available.

PMID:
25784274
25.

A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production.

Simpson LJ, Patel S, Bhakta NR, Choy DF, Brightbill HD, Ren X, Wang Y, Pua HH, Baumjohann D, Montoya MM, Panduro M, Remedios KA, Huang X, Fahy JV, Arron JR, Woodruff PG, Ansel KM.

Nat Immunol. 2014 Dec;15(12):1162-70. doi: 10.1038/ni.3026. Epub 2014 Nov 2.

26.

Managing health impacts of heat in South East Queensland, Australia.

Schuch G, Serrao-Neumann S, Choy DL.

Disaster Health. 2014 Oct 30;2(2):82-91. doi: 10.4161/2167549X.2014.960717. eCollection 2014 Apr-Jun.

27.

Effects of polycaprolactone-based scaffolds on the blood-brain barrier and cerebral inflammation.

Nga VD, Lim J, Choy DK, Nyein MA, Lu J, Chou N, Yeo TT, Teoh SH.

Tissue Eng Part A. 2015 Feb;21(3-4):647-53. doi: 10.1089/ten.TEA.2013.0779. Epub 2015 Jan 22.

28.

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics.

Dennis G Jr, Holweg CT, Kummerfeld SK, Choy DF, Setiadi AF, Hackney JA, Haverty PM, Gilbert H, Lin WY, Diehl L, Fischer S, Song A, Musselman D, Klearman M, Gabay C, Kavanaugh A, Endres J, Fox DA, Martin F, Townsend MJ.

Arthritis Res Ther. 2014;16(2):R90. Epub 2014 Apr 30.

29.

History of lasers in medicine.

Choy DS.

Photomed Laser Surg. 2014 Mar;32(3):119-20. doi: 10.1089/pho.2014.9864. No abstract available.

PMID:
24621395
30.

Zonal rate model for axial and radial flow membrane chromatography, part II: model-based scale-up.

Ghosh P, Lin M, Vogel JH, Choy D, Haynes C, von Lieres E.

Biotechnol Bioeng. 2014 Aug;111(8):1587-94. doi: 10.1002/bit.25217. Epub 2014 May 13.

PMID:
24554490
31.

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF.

Shen J, Choy DF, Yoshida T, Iwase T, Hafiz G, Xie B, Hackett SF, Arron JR, Campochiaro PA.

J Cell Physiol. 2014 Aug;229(8):974-83. doi: 10.1002/jcp.24575.

32.

A new mixed-mode model for interpreting and predicting protein elution during isoelectric chromatofocusing.

Choy DY, Creagh AL, von Lieres E, Haynes C.

Biotechnol Bioeng. 2014 May;111(5):925-36. doi: 10.1002/bit.25166. Epub 2014 Jan 17.

PMID:
24293057
33.

Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma.

Arron JR, Choy DF, Scheerens H, Matthews JG.

Ann Am Thorac Soc. 2013 Dec;10 Suppl:S206-13. doi: 10.1513/AnnalsATS.201303-047AW. Review.

PMID:
24313774
34.

Increased expression of bronchial epithelial transient receptor potential vanilloid 1 channels in patients with severe asthma.

McGarvey LP, Butler CA, Stokesberry S, Polley L, McQuaid S, Abdullah H, Ashraf S, McGahon MK, Curtis TM, Arron J, Choy D, Warke TJ, Bradding P, Ennis M, Zholos A, Costello RW, Heaney LG.

J Allergy Clin Immunol. 2014 Mar;133(3):704-12.e4. doi: 10.1016/j.jaci.2013.09.016. Epub 2013 Nov 8.

PMID:
24210884
35.

Disconnect between sputum neutrophils and other measures of airway inflammation in asthma.

Arron JR, Choy DF, Laviolette M, Kelsen SG, Hatab A, Leigh R, Thomson NC, Bleecker ER, Olivenstein R, Avila PC, Jarjour NN, Castro M, Gauvreau GM, Good JT, Kline JN, Mansur A, Mayers I, Heaney LG, Hamid Q, Harris JM.

Eur Respir J. 2014 Feb;43(2):627-9. doi: 10.1183/09031936.00117013. Epub 2013 Oct 31. No abstract available.

36.

Improved isoelectric focusing chromatography on strong anion exchange media via a new model that custom designs mobile phases using simple buffers.

Choy DY, Creagh AL, Haynes C.

Biotechnol Bioeng. 2014 Mar;111(3):552-64. doi: 10.1002/bit.25122. Epub 2013 Oct 25.

PMID:
24166014
37.

The effects of lebrikizumab in patients with mild asthma following whole lung allergen challenge.

Scheerens H, Arron JR, Zheng Y, Putnam WS, Erickson RW, Choy DF, Harris JM, Lee J, Jarjour NN, Matthews JG.

Clin Exp Allergy. 2014 Jan;44(1):38-46. doi: 10.1111/cea.12220.

38.

A retrospective analysis and review of an institution's experience with the complications of cranioplasty.

Lee L, Ker J, Quah BL, Chou N, Choy D, Yeo TT.

Br J Neurosurg. 2013 Oct;27(5):629-35. doi: 10.3109/02688697.2013.815313. Epub 2013 Jul 24.

PMID:
23879443
39.

Brain tissue interaction with three-dimensional, honeycomb polycaprolactone-based scaffolds designed for cranial reconstruction following traumatic brain injury.

Choy DK, Nga VD, Lim J, Lu J, Chou N, Yeo TT, Teoh SH.

Tissue Eng Part A. 2013 Nov;19(21-22):2382-9. doi: 10.1089/ten.TEA.2012.0733. Epub 2013 Jul 25.

40.

Exploring the effects of omalizumab in allergic asthma: an analysis of biomarkers in the EXTRA study.

Hanania NA, Wenzel S, Rosén K, Hsieh HJ, Mosesova S, Choy DF, Lal P, Arron JR, Harris JM, Busse W.

Am J Respir Crit Care Med. 2013 Apr 15;187(8):804-11. doi: 10.1164/rccm.201208-1414OC.

PMID:
23471469
41.

Cerebral hyperperfusion syndrome after superficial temporal artery-middle cerebral artery bypass for severe intracranial steno-occlusive disease: a case control study.

Teo K, Choy DK, Lwin S, Ning C, Yeo TT, Shen L, Chong VF, Teoh HL, Seet RC, Chan BP, Sharma AK, Sharma VK.

Neurosurgery. 2013 Jun;72(6):936-42; discussion 942-3. doi: 10.1227/NEU.0b013e31828bb8b3.

PMID:
23407293
42.

Comparative transcriptomic analyses of atopic dermatitis and psoriasis reveal shared neutrophilic inflammation.

Choy DF, Hsu DK, Seshasayee D, Fung MA, Modrusan Z, Martin F, Liu FT, Arron JR.

J Allergy Clin Immunol. 2012 Dec;130(6):1335-43.e5. doi: 10.1016/j.jaci.2012.06.044. Epub 2012 Aug 22.

43.

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.

Jia G, Erickson RW, Choy DF, Mosesova S, Wu LC, Solberg OD, Shikotra A, Carter R, Audusseau S, Hamid Q, Bradding P, Fahy JV, Woodruff PG, Harris JM, Arron JR; Bronchoscopic Exploratory Research Study of Biomarkers in Corticosteroid-refractory Asthma (BOBCAT) Study Group.

J Allergy Clin Immunol. 2012 Sep;130(3):647-654.e10. doi: 10.1016/j.jaci.2012.06.025. Epub 2012 Aug 1.

44.

Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab.

Hogan VE, Holweg CT, Choy DF, Kummerfeld SK, Hackney JA, Teng YK, Townsend MJ, van Laar JM.

Ann Rheum Dis. 2012 Nov;71(11):1888-94. doi: 10.1136/annrheumdis-2011-201115. Epub 2012 Jun 26.

PMID:
22736099
45.

A confirmatory factor analytic approach on perceptions of knowledge and skills in teaching (PKST).

Choy D, Lim KM, Chong S, Wong AF.

Psychol Rep. 2012 Apr;110(2):589-97.

PMID:
22662412
46.

External ventricular drain infections: successful implementation of strategies to reduce infection rate.

Lwin S, Low SW, Choy DK, Yeo TT, Chou N.

Singapore Med J. 2012 Apr;53(4):255-9.

47.

Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma.

Butler CA, McQuaid S, Taggart CC, Weldon S, Carter R, Skibinski G, Warke TJ, Choy DF, McGarvey LP, Bradding P, Arron JR, Heaney LG.

Thorax. 2012 May;67(5):392-8. doi: 10.1136/thoraxjnl-2011-200760. Epub 2011 Dec 8.

PMID:
22156779
48.

Association between life events and change in depressive symptoms in Hong Kong Chinese elderly.

Chan D, Kwok A, Leung J, Yuen K, Choy D, Leung PC.

J Affect Disord. 2012 Feb;136(3):963-70. doi: 10.1016/j.jad.2011.08.031. Epub 2011 Nov 4.

PMID:
22055424
49.

Increased expression of immunoreactive thymic stromal lymphopoietin in patients with severe asthma.

Shikotra A, Choy DF, Ohri CM, Doran E, Butler C, Hargadon B, Shelley M, Abbas AR, Austin CD, Jackman J, Wu LC, Heaney LG, Arron JR, Bradding P.

J Allergy Clin Immunol. 2012 Jan;129(1):104-11.e1-9. doi: 10.1016/j.jaci.2011.08.031. Epub 2011 Oct 5.

PMID:
21975173
50.

Visual functioning and quality of life among the older people in Hong Kong.

Leung JC, Kwok TC, Chan DC, Yuen KW, Kwok AW, Choy DT, Lau EM, Leung PC.

Int J Geriatr Psychiatry. 2012 Aug;27(8):807-15. doi: 10.1002/gps.2789. Epub 2011 Sep 15.

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