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Sex differences in the peripubertal response to short-term high fat diet intake.

Freire-Regatillo A, Fernández-Gómez MJ, Díaz F, Barrios V, Sánchez-Jabonero I, Frago LM, Argente J, García-Segura LM, Chowen JA.

J Neuroendocrinol. 2019 Jun 10:e12756. doi: 10.1111/jne.12756. [Epub ahead of print]


Heterozygous rare genetic variants in non-syndromic early-onset obesity.

Serra-Juhé C, Martos-Moreno GÁ, Bou de Pieri F, Flores R, Chowen JA, Pérez-Jurado LA, Argente J.

Int J Obes (Lond). 2019 Mar 29. doi: 10.1038/s41366-019-0357-5. [Epub ahead of print]


Perinatal free-choice of a high-calorie low-protein diet affects leptin signaling through IRS1 and AMPK dephosphorylation in the hypothalami of female rat offspring in adulthood.

Rivera P, Ramírez-López MT, Vargas A, Decara J, Vázquez M, Arco R, Gómez de Heras R, Argente J, Rodríguez de Fonseca F, Chowen JA, Suárez J.

Acta Physiol (Oxf). 2019 Jun;226(2):e13244. doi: 10.1111/apha.13244. Epub 2019 Jan 21.


Physiological and pathophysiological roles of hypothalamic astrocytes in metabolism.

Chowen JA, Frago LM, Fernández-Alfonso MS.

J Neuroendocrinol. 2019 May;31(5):e12671. doi: 10.1111/jne.12671. Epub 2019 Jan 21. Review.


Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism.

García-Cáceres C, Balland E, Prevot V, Luquet S, Woods SC, Koch M, Horvath TL, Yi CX, Chowen JA, Verkhratsky A, Araque A, Bechmann I, Tschöp MH.

Nat Neurosci. 2019 Jan;22(1):7-14. doi: 10.1038/s41593-018-0286-y. Epub 2018 Dec 10. Review.


Editorial: Hormones and Neural Aging: Lessons From Experimental Models.

Varela-Nieto I, Chowen JA, García-Segura LM.

Front Aging Neurosci. 2018 Nov 15;10:374. doi: 10.3389/fnagi.2018.00374. eCollection 2018. No abstract available.


A novel approach to childhood obesity: circulating chemokines and growth factors as biomarkers of insulin resistance.

Rivera P, Martos-Moreno GÁ, Barrios V, Suárez J, Pavón FJ, Chowen JA, Rodríguez de Fonseca F, Argente J.

Pediatr Obes. 2019 Mar;14(3):e12473. doi: 10.1111/ijpo.12473. Epub 2018 Oct 22.


Neurobiological characteristics underlying metabolic differences between males and females.

Chowen JA, Freire-Regatillo A, Argente J.

Prog Neurobiol. 2019 May;176:18-32. doi: 10.1016/j.pneurobio.2018.09.001. Epub 2018 Sep 5. Review.


Metabolomics changes in patients with PAPP-A2 deficiency in response to rhIGF1 treatment.

Mastrangelo A, Martos-Moreno GÁ, Rupérez FJ, Chowen JA, Barbas C, Argente J.

Growth Horm IGF Res. 2018 Oct - Dec;42-43:28-31. doi: 10.1016/j.ghir.2018.08.002. Epub 2018 Aug 12.


Response to growth hormone in patients with RNPC3 mutations.

Martos-Moreno GÁ, Travieso-Suárez L, Pozo-Román J, Muñoz-Calvo MT, Chowen JA, Frilander MJ, Pérez-Jurado LA, Hawkins FG, Argente J.

EMBO Mol Med. 2018 Jul;10(7). pii: e9143. doi: 10.15252/emmm.201809143. No abstract available.


Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone β-Subunit in Peripubertal Male Rats.

Argente-Arizón P, Castro-González D, Díaz F, Fernández-Gómez MJ, Sánchez-Garrido MA, Tena-Sempere M, Argente J, Chowen JA.

Front Endocrinol (Lausanne). 2018 Apr 13;9:168. doi: 10.3389/fendo.2018.00168. eCollection 2018.


rhIGF-1 Treatment Increases Bone Mineral Density and Trabecular Bone Structure in Children with PAPP-A2 Deficiency.

Hawkins-Carranza FG, Muñoz-Calvo MT, Martos-Moreno GÁ, Allo-Miguel G, Del Río L, Pozo J, Chowen JA, Pérez-Jurado LA, Argente J.

Horm Res Paediatr. 2018;89(3):200-204. doi: 10.1159/000486336. Epub 2018 Feb 16.


The Protective Effects of IGF-I against β-Amyloid-related Downregulation of Hippocampal Somatostatinergic System Involve Activation of Akt and Protein Kinase A.

Aguado-Llera D, Canelles S, Frago LM, Chowen JA, Argente J, Arilla E, Barrios V.

Neuroscience. 2018 Mar 15;374:104-118. doi: 10.1016/j.neuroscience.2018.01.041. Epub 2018 Feb 3.


Cholecystokinin is involved in triglyceride fatty acid uptake by rat adipose tissue.

Plaza A, Merino B, Cano V, Domínguez G, Pérez-Castells J, Fernández-Alfonso MS, Sengenès C, Chowen JA, Ruiz-Gayo M.

J Endocrinol. 2018 Mar;236(3):137-150. doi: 10.1530/JOE-17-0580. Epub 2018 Jan 16.


Resveratrol Intake During Pregnancy and Lactation Modulates the Early Metabolic Effects of Maternal Nutrition Differently in Male and Female Offspring.

Ros P, Díaz F, Freire-Regatillo A, Argente-Arizón P, Barrios V, Argente J, Chowen JA.

Endocrinology. 2018 Feb 1;159(2):810-825. doi: 10.1210/en.2017-00610.


Sex differences in the phagocytic and migratory activity of microglia and their impairment by palmitic acid.

Yanguas-Casás N, Crespo-Castrillo A, de Ceballos ML, Chowen JA, Azcoitia I, Arevalo MA, Garcia-Segura LM.

Glia. 2018 Mar;66(3):522-537. doi: 10.1002/glia.23263. Epub 2017 Nov 15.


Estradiol Uses Different Mechanisms in Astrocytes from the Hippocampus of Male and Female Rats to Protect against Damage Induced by Palmitic Acid.

Frago LM, Canelles S, Freire-Regatillo A, Argente-Arizón P, Barrios V, Argente J, Garcia-Segura LM, Chowen JA.

Front Mol Neurosci. 2017 Oct 24;10:330. doi: 10.3389/fnmol.2017.00330. eCollection 2017.


The Hypothalamic Inflammatory/Gliosis Response to Neonatal Overnutrition Is Sex and Age Dependent.

Argente-Arizón P, Díaz F, Ros P, Barrios V, Tena-Sempere M, García-Segura LM, Argente J, Chowen JA.

Endocrinology. 2018 Jan 1;159(1):368-387. doi: 10.1210/en.2017-00539.


Evaluation of plasma cytokines in patients with cocaine use disorders in abstinence identifies transforming growth factor alpha (TGFα) as a potential biomarker of consumption and dual diagnosis.

Maza-Quiroga R, García-Marchena N, Romero-Sanchiz P, Barrios V, Pedraz M, Serrano A, Nogueira-Arjona R, Ruiz JJ, Soria M, Campos R, Chowen JA, Argente J, Torrens M, López-Gallardo M, Marco EM, Rodríguez de Fonseca F, Pavón FJ, Araos P.

PeerJ. 2017 Oct 12;5:e3926. doi: 10.7717/peerj.3926. eCollection 2017.


The increase in fiber size in male rat gastrocnemius after chronic central leptin infusion is related to activation of insulin signaling.

Burgos-Ramos E, Canelles S, Rodríguez A, Frago LM, Gómez-Ambrosi J, Chowen JA, Frühbeck G, Argente J, Barrios V.

Mol Cell Endocrinol. 2018 Jul 15;470:48-59. doi: 10.1016/j.mce.2017.09.029. Epub 2017 Sep 27.


Ghrelin: A Link Between Energy Homeostasis and the Immune System.

Chowen JA, Argente J.

Endocrinology. 2017 Jul 1;158(7):2077-2081. doi: 10.1210/en.2017-00350. No abstract available.


One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology.

Argente J, Chowen JA, Pérez-Jurado LA, Frystyk J, Oxvig C.

EMBO Mol Med. 2017 Oct;9(10):1338-1345. doi: 10.15252/emmm.201707950. Review.


Differential vulnerability to adverse nutritional conditions in male and female rats: Modulatory role of estradiol during development.

Pinos H, Carrillo B, Díaz F, Chowen JA, Collado P.

Front Neuroendocrinol. 2018 Jan;48:13-22. doi: 10.1016/j.yfrne.2017.07.009. Epub 2017 Jul 25. Review.


Physiological and brain alterations produced by high-fat diet in male and female rats can be modulated by increased levels of estradiol during critical periods of development.

Carrillo B, Collado P, Díaz F, Chowen JA, Pérez-Izquierdo MÁ, Pinos H.

Nutr Neurosci. 2019 Jan;22(1):29-39. doi: 10.1080/1028415X.2017.1349574. Epub 2017 Jul 11.


Administration of a leptin antagonist during the neonatal leptin surge induces alterations in the redox and inflammatory state in peripubertal /adolescent rats.

Mela V, Hernandez O, Hunsche C, Diaz F, Chowen JA, De la Fuente M.

Mol Cell Endocrinol. 2017 Oct 15;454:125-134. doi: 10.1016/j.mce.2017.06.018. Epub 2017 Jun 19.


Metabolomics allows the discrimination of the pathophysiological relevance of hyperinsulinism in obese prepubertal children.

Martos-Moreno GÁ, Mastrangelo A, Barrios V, García A, Chowen JA, Rupérez FJ, Barbas C, Argente J.

Int J Obes (Lond). 2017 Oct;41(10):1473-1480. doi: 10.1038/ijo.2017.137. Epub 2017 Jun 7.


Sex differences in the neuroendocrine control of metabolism and the implication of astrocytes.

Chowen JA, Argente-Arizón P, Freire-Regatillo A, Argente J.

Front Neuroendocrinol. 2018 Jan;48:3-12. doi: 10.1016/j.yfrne.2017.05.003. Epub 2017 May 25. Review.


Non-Neuronal Cells in the Hypothalamic Adaptation to Metabolic Signals.

Freire-Regatillo A, Argente-Arizón P, Argente J, García-Segura LM, Chowen JA.

Front Endocrinol (Lausanne). 2017 Mar 21;8:51. doi: 10.3389/fendo.2017.00051. eCollection 2017. Review.


Microglial Proliferation in Obesity: When, Where, Why, and What Does It Mean?

Chowen JA, Horvath TL, Argente J.

Diabetes. 2017 Apr;66(4):804-805. doi: 10.2337/dbi16-0073. No abstract available.


Involvement of Astrocytes in Mediating the Central Effects of Ghrelin.

Frago LM, Chowen JA.

Int J Mol Sci. 2017 Mar 2;18(3). pii: E536. doi: 10.3390/ijms18030536. Review.


Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity.

García-Marchena N, Araos PF, Barrios V, Sánchez-Marín L, Chowen JA, Pedraz M, Castilla-Ortega E, Romero-Sanchiz P, Ponce G, Gavito AL, Decara J, Silva D, Torrens M, Argente J, Rubio G, Serrano A, de Fonseca FR, Pavón FJ.

Front Psychiatry. 2017 Jan 18;7:214. doi: 10.3389/fpsyt.2016.00214. eCollection 2016.


Glial cells and energy balance.

Argente-Arizón P, Guerra-Cantera S, Garcia-Segura LM, Argente J, Chowen JA.

J Mol Endocrinol. 2017 Jan;58(1):R59-R71. Epub 2016 Nov 18. Review.


Treatment With Recombinant Human Insulin-Like Growth Factor-1 Improves Growth in Patients With PAPP-A2 Deficiency.

Muñoz-Calvo MT, Barrios V, Pozo J, Chowen JA, Martos-Moreno GÁ, Hawkins F, Dauber A, Domené HM, Yakar S, Rosenfeld RG, Pérez-Jurado LA, Oxvig C, Frystyk J, Argente J.

J Clin Endocrinol Metab. 2016 Nov;101(11):3879-3883. Epub 2016 Sep 20.


Blockage of neonatal leptin signaling induces changes in the hypothalamus associated with delayed pubertal onset and modifications in neuropeptide expression during adulthood in male rats.

Mela V, Jimenez S, Freire-Regatillo A, Barrios V, Marco EM, Lopez-Rodriguez AB, Argente J, Viveros MP, Chowen JA.

Peptides. 2016 Dec;86:63-71. doi: 10.1016/j.peptides.2016.10.003. Epub 2016 Oct 14.


Age and sex dependent effects of early overnutrition on metabolic parameters and the role of neonatal androgens.

Argente-Arizón P, Ros P, Díaz F, Fuente-Martin E, Castro-González D, Sánchez-Garrido MÁ, Barrios V, Tena-Sempere M, Argente J, Chowen JA.

Biol Sex Differ. 2016 May 18;7:26. doi: 10.1186/s13293-016-0079-5. eCollection 2016.


Free-choice high-fat diet alters circadian oscillation of energy intake in adolescent mice: role of prefrontal cortex.

Del Rio D, Stucchi P, Hernández-Nuño F, Cano V, Morales L, Chowen JA, Del Olmo N, Ruiz-Gayo M.

Eur J Nutr. 2017 Aug;56(5):1833-1844. doi: 10.1007/s00394-016-1225-x. Epub 2016 May 14.


Insulin resistance in prepubertal obese children correlates with sex-dependent early onset metabolomic alterations.

Mastrangelo A, Martos-Moreno GÁ, García A, Barrios V, Rupérez FJ, Chowen JA, Barbas C, Argente J.

Int J Obes (Lond). 2016 Oct;40(10):1494-1502. doi: 10.1038/ijo.2016.92. Epub 2016 May 10.


Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes.

Fuente-Martín E, García-Cáceres C, Argente-Arizón P, Díaz F, Granado M, Freire-Regatillo A, Castro-González D, Ceballos ML, Frago LM, Dickson SL, Argente J, Chowen JA.

Sci Rep. 2016 Mar 30;6:23673. doi: 10.1038/srep23673.


Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.

Baquedano E, Burgos-Ramos E, Canelles S, González-Rodríguez A, Chowen JA, Argente J, Barrios V, Valverde AM, Frago LM.

Dis Model Mech. 2016 May 1;9(5):573-83. doi: 10.1242/dmm.023515. Epub 2016 Mar 24.


The role of astrocytes in the hypothalamic response and adaptation to metabolic signals.

Chowen JA, Argente-Arizón P, Freire-Regatillo A, Frago LM, Horvath TL, Argente J.

Prog Neurobiol. 2016 Sep;144:68-87. doi: 10.1016/j.pneurobio.2016.03.001. Epub 2016 Mar 18. Review.


Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism.

Burgos-Ramos E, Canelles S, Frago LM, Chowen JA, Arilla-Ferreiro E, Argente J, Barrios V.

Nutr Metab (Lond). 2016 Mar 1;13:19. doi: 10.1186/s12986-016-0079-9. eCollection 2016.


Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability.

Dauber A, Muñoz-Calvo MT, Barrios V, Domené HM, Kloverpris S, Serra-Juhé C, Desikan V, Pozo J, Muzumdar R, Martos-Moreno GÁ, Hawkins F, Jasper HG, Conover CA, Frystyk J, Yakar S, Hwa V, Chowen JA, Oxvig C, Rosenfeld RG, Pérez-Jurado LA, Argente J.

EMBO Mol Med. 2016 Apr 1;8(4):363-74. doi: 10.15252/emmm.201506106.


Interaction between neonatal maternal deprivation and serum leptin levels on metabolism, pubertal development, and sexual behavior in male and female rats.

Mela V, Díaz F, Vázquez MJ, Argente J, Tena-Sempere M, Viveros MP, Chowen JA.

Biol Sex Differ. 2016 Jan 11;7:2. doi: 10.1186/s13293-015-0054-6. eCollection 2016.


Reduction in Aβ-induced cell death in the hippocampus of 17β-estradiol-treated female rats is associated with an increase in IGF-I signaling and somatostatinergic tone.

Perianes-Cachero A, Canelles S, Aguado-Llera D, Frago LM, Toledo-Lobo MV, Carrera I, Cacabelos R, Chowen JA, Argente J, Arilla-Ferreiro E, Barrios V.

J Neurochem. 2015 Dec;135(6):1257-71. doi: 10.1111/jnc.13381. Epub 2015 Nov 6.


Long Term Hippocampal and Cortical Changes Induced by Maternal Deprivation and Neonatal Leptin Treatment in Male and Female Rats.

Mela V, Díaz F, Borcel E, Argente J, Chowen JA, Viveros MP.

PLoS One. 2015 Sep 18;10(9):e0137283. doi: 10.1371/journal.pone.0137283. eCollection 2015.


Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism.

Burgos-Ramos E, Canelles S, Rodríguez A, Gómez-Ambrosi J, Frago LM, Chowen JA, Frühbeck G, Argente J, Barrios V.

Mol Cell Endocrinol. 2015 Nov 5;415:157-72. doi: 10.1016/j.mce.2015.08.014. Epub 2015 Aug 18.


Hypothalamic Leptin and Ghrelin Signaling as Targets for Improvement in Metabolic Control.

Frago LM, Chowen JA.

Curr Pharm Des. 2015;21(25):3596-605. Review.


A proteomic approach to obesity and type 2 diabetes.

López-Villar E, Martos-Moreno GÁ, Chowen JA, Okada S, Kopchick JJ, Argente J.

J Cell Mol Med. 2015 Jul;19(7):1455-70. doi: 10.1111/jcmm.12600. Epub 2015 May 9. Review.


Role of non-neuronal cells in body weight and appetite control.

Argente-Arizón P, Freire-Regatillo A, Argente J, Chowen JA.

Front Endocrinol (Lausanne). 2015 Mar 26;6:42. doi: 10.3389/fendo.2015.00042. eCollection 2015. Review.


Blockage of the Neonatal Leptin Surge Affects the Gene Expression of Growth Factors, Glial Proteins, and Neuropeptides Involved in the Control of Metabolism and Reproduction in Peripubertal Male and Female Rats.

Mela V, Díaz F, Lopez-Rodriguez AB, Vázquez MJ, Gertler A, Argente J, Tena-Sempere M, Viveros MP, Chowen JA.

Endocrinology. 2015 Jul;156(7):2571-81. doi: 10.1210/en.2014-1981. Epub 2015 Apr 9.


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