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Respiratory Viral Infections in Exacerbation of Chronic Airway Inflammatory Diseases: Novel Mechanisms and Insights From the Upper Airway Epithelium.

Tan KS, Lim RL, Liu J, Ong HH, Tan VJ, Lim HF, Chung KF, Adcock IM, Chow VT, Wang Y.

Front Cell Dev Biol. 2020 Feb 25;8:99. doi: 10.3389/fcell.2020.00099. eCollection 2020. Review.


Molecular insights into evolution, mutations and receptor-binding specificity of influenza A and B viruses from outpatients and hospitalized patients in Singapore.

Ivan FX, Zhou X, Lau SH, Rashid S, Teo JSM, Lee HK, Koay ES, Chan KP, Leo YS, Chen MIC, Kwoh CK, Chow VT.

Int J Infect Dis. 2020 Jan;90:84-96. doi: 10.1016/j.ijid.2019.10.024. Epub 2019 Oct 25.


Reverse Genetic Analysis of Adaptive Mutations within the Capsid Proteins of Enterovirus 71 (EV-A71) Strains Necessary for Infection of CHO-K1 Cells.

Victorio CBL, Xu Y, Ng Q, Chow VTK, Chua KB.

Virol Sin. 2020 Feb;35(1):110-114. doi: 10.1007/s12250-019-00167-4. Epub 2019 Oct 21. No abstract available.


RNA Sequencing of H3N2 Influenza Virus-Infected Human Nasal Epithelial Cells from Multiple Subjects Reveals Molecular Pathways Associated with Tissue Injury and Complications.

Tan KS, Andiappan AK, Lee B, Yan Y, Liu J, Tang SA, Lum J, He TT, Ong YK, Thong M, Lim HF, Choi HW, Rotzschke O, Chow VT, Wang Y.

Cells. 2019 Aug 27;8(9). pii: E986. doi: 10.3390/cells8090986.


Insights into Early Recovery from Influenza Pneumonia by Spatial and Temporal Quantification of Putative Lung Regenerating Cells and by Lung Proteomics.

Ong JWJ, Tan KS, Ler SG, Gunaratne J, Choi H, Seet JE, Chow VT.

Cells. 2019 Aug 26;8(9). pii: E975. doi: 10.3390/cells8090975.


Upregulation of cell-surface mucin MUC15 in human nasal epithelial cells upon influenza A virus infection.

Chen ZG, Wang ZN, Yan Y, Liu J, He TT, Thong KT, Ong YK, Chow VTK, Tan KS, Wang Y.

BMC Infect Dis. 2019 Jul 15;19(1):622. doi: 10.1186/s12879-019-4213-y.


Combination Therapy Targeting Platelet Activation and Virus Replication Protects Mice against Lethal Influenza Pneumonia.

Pulavendran S, Rudd JM, Maram P, Thomas PG, Akhilesh R, Malayer JR, Chow VTK, Teluguakula N.

Am J Respir Cell Mol Biol. 2019 Dec;61(6):689-701. doi: 10.1165/rcmb.2018-0196OC.


Neutrophils Induce a Novel Chemokine Receptors Repertoire During Influenza Pneumonia.

Rudd JM, Pulavendran S, Ashar HK, Ritchey JW, Snider TA, Malayer JR, Marie M, Chow VTK, Narasaraju T.

Front Cell Infect Microbiol. 2019 Apr 16;9:108. doi: 10.3389/fcimb.2019.00108. eCollection 2019.


Successful Genetic Transfection of the Colonic Protistan Parasite Blastocystis for Reliable Expression of Ectopic Genes.

Li FJ, Tsaousis AD, Purton T, Chow VTK, He CY, Tan KSW.

Sci Rep. 2019 Feb 28;9(1):3159. doi: 10.1038/s41598-019-39094-5.


Comparative Transcriptomic and Metagenomic Analyses of Influenza Virus-Infected Nasal Epithelial Cells From Multiple Individuals Reveal Specific Nasal-Initiated Signatures.

Tan KS, Yan Y, Koh WLH, Li L, Choi H, Tran T, Sugrue R, Wang Y, Chow VT.

Front Microbiol. 2018 Nov 14;9:2685. doi: 10.3389/fmicb.2018.02685. eCollection 2018.


A Co-culture Model of PBMC and Stem Cell Derived Human Nasal Epithelium Reveals Rapid Activation of NK and Innate T Cells Upon Influenza A Virus Infection of the Nasal Epithelium.

Luukkainen A, Puan KJ, Yusof N, Lee B, Tan KS, Liu J, Yan Y, Toppila-Salmi S, Renkonen R, Chow VT, Rotzschke O, Wang Y.

Front Immunol. 2018 Nov 8;9:2514. doi: 10.3389/fimmu.2018.02514. eCollection 2018.


Computational analysis of the receptor binding specificity of novel influenza A/H7N9 viruses.

Zhou X, Zheng J, Ivan FX, Yin R, Ranganathan S, Chow VTK, Kwoh CK.

BMC Genomics. 2018 May 9;19(Suppl 2):88. doi: 10.1186/s12864-018-4461-z.


CD151, a novel host factor of nuclear export signaling in influenza virus infection.

Qiao Y, Yan Y, Tan KS, Tan SSL, Seet JE, Arumugam TV, Chow VTK, Wang Y, Tran T.

J Allergy Clin Immunol. 2018 May;141(5):1799-1817. doi: 10.1016/j.jaci.2017.11.032. Epub 2017 Dec 21.


In Vitro Model of Fully Differentiated Human Nasal Epithelial Cells Infected With Rhinovirus Reveals Epithelium-Initiated Immune Responses.

Tan KS, Ong HH, Yan Y, Liu J, Li C, Ong YK, Thong KT, Choi HW, Wang DY, Chow VT.

J Infect Dis. 2018 Mar 5;217(6):906-915. doi: 10.1093/infdis/jix640.


The Role of Extracellular Histones in Influenza Virus Pathogenesis.

Ashar HK, Mueller NC, Rudd JM, Snider TA, Achanta M, Prasanthi M, Pulavendran S, Thomas PG, Ramachandran A, Malayer JR, Ritchey JW, Rajasekhar R, Chow VTK, Esmon CT, Teluguakula N.

Am J Pathol. 2018 Jan;188(1):135-148. doi: 10.1016/j.ajpath.2017.09.014. Epub 2017 Oct 26.


Epidemiology and Relative Severity of Influenza Subtypes in Singapore in the Post-Pandemic Period from 2009 to 2010.

Goh EH, Jiang L, Hsu JP, Tan LWL, Lim WY, Phoon MC, Leo YS, Barr IG, Chow VTK, Lee VJ, Lin C, Lin R, Sadarangani SP, Young B, Chen MI.

Clin Infect Dis. 2017 Nov 13;65(11):1905-1913. doi: 10.1093/cid/cix694.


Cold Chain-Free Storable Hydrogel for Infant-Friendly Oral Delivery of Amoxicillin for the Treatment of Pneumococcal Pneumonia.

Xu K, Li L, Cui M, Han Y, Karahan HE, Chow VTK, Xu C.

ACS Appl Mater Interfaces. 2017 Jun 7;9(22):18440-18449. doi: 10.1021/acsami.7b01462. Epub 2017 May 30.


Effective in vivo therapeutic IgG antibody against VP3 of enterovirus 71 with receptor-competing activity.

Jia Q, Ng Q, Chin W, Meng T, Chow VTK, Wang CI, Kwang J, He F.

Sci Rep. 2017 Apr 19;7:46402. doi: 10.1038/srep46402.


Impact of Respiratory Virus Infections in Exacerbation of Acute and Chronic Rhinosinusitis.

Tan KS, Yan Y, Ong HH, Chow VTK, Shi L, Wang DY.

Curr Allergy Asthma Rep. 2017 Apr;17(4):24. doi: 10.1007/s11882-017-0693-2. Review.


MicroRNA-146a induction during influenza H3N2 virus infection targets and regulates TRAF6 levels in human nasal epithelial cells (hNECs).

Deng Y, Yan Y, Tan KS, Liu J, Chow VT, Tao ZZ, Wang DY.

Exp Cell Res. 2017 Mar 15;352(2):184-192. doi: 10.1016/j.yexcr.2017.01.011. Epub 2017 Jan 25.


Differentiation of Club Cells to Alveolar Epithelial Cells In Vitro.

Zheng D, Soh BS, Yin L, Hu G, Chen Q, Choi H, Han J, Chow VT, Chen J.

Sci Rep. 2017 Jan 27;7:41661. doi: 10.1038/srep41661.


Comparative seroepidemiology of genital human papillomavirus infections in the general population in Singapore.

Khoo NK, Tan L, Lim WY, Chen MI, Chow VT.

Public Health. 2017 Jan;142:1-3. doi: 10.1016/j.puhe.2016.10.004. Epub 2016 Nov 9. No abstract available.


Lethal Synergism between Influenza and Streptococcus pneumoniae.

Rudd JM, Ashar HK, Chow VT, Teluguakula N.

J Infect Pulm Dis. 2016 Oct;2(2). doi: 10.16966/2470-3176.114. Epub 2016 Apr 30.


Enterovirus 71 infection of motor neuron-like NSC-34 cells undergoes a non-lytic exit pathway.

Too IH, Yeo H, Sessions OM, Yan B, Libau EA, Howe JL, Lim ZQ, Suku-Maran S, Ong WY, Chua KB, Wong BS, Chow VT, Alonso S.

Sci Rep. 2016 Nov 16;6:36983. doi: 10.1038/srep36983.


Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication.

Wu KX, Phuektes P, Kumar P, Goh GY, Moreau D, Chow VT, Bard F, Chu JJ.

Nat Commun. 2016 Oct 17;7:13150. doi: 10.1038/ncomms13150.


Effect of High-Fat Diet on the Formation of Pulmonary Neutrophil Extracellular Traps during Influenza Pneumonia in BALB/c Mice.

Moorthy AN, Tan KB, Wang S, Narasaraju T, Chow VT.

Front Immunol. 2016 Aug 2;7:289. doi: 10.3389/fimmu.2016.00289. eCollection 2016.


A clinically authentic mouse model of enterovirus 71 (EV-A71)-induced neurogenic pulmonary oedema.

Victorio CB, Xu Y, Ng Q, Chua BH, Alonso S, Chow VT, Chua KB.

Sci Rep. 2016 Jun 30;6:28876. doi: 10.1038/srep28876.


Cooperative effect of the VP1 amino acids 98E, 145A and 169F in the productive infection of mouse cell lines by enterovirus 71 (BS strain).

Victorio CB, Xu Y, Ng Q, Meng T, Chow VT, Chua KB.

Emerg Microbes Infect. 2016 Jun 22;5:e60. doi: 10.1038/emi.2016.56.


Cigarette Smoke-Induced Lung Disease Predisposes to More Severe Infection with Nontypeable Haemophilus influenzae: Protective Effects of Andrographolide.

Tan WS, Peh HY, Liao W, Pang CH, Chan TK, Lau SH, Chow VT, Wong WS.

J Nat Prod. 2016 May 27;79(5):1308-15. doi: 10.1021/acs.jnatprod.5b01006. Epub 2016 Apr 22.


Capsules of virulent pneumococcal serotypes enhance formation of neutrophil extracellular traps during in vivo pathogenesis of pneumonia.

Moorthy AN, Rai P, Jiao H, Wang S, Tan KB, Qin L, Watanabe H, Zhang Y, Teluguakula N, Chow VT.

Oncotarget. 2016 Apr 12;7(15):19327-40. doi: 10.18632/oncotarget.8451.


Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest.

Rai P, He F, Kwang J, Engelward BP, Chow VT.

Sci Rep. 2016 Mar 30;6:22972. doi: 10.1038/srep22972.


Evaluation of antiviral activities of Houttuynia cordata Thunb. extract, quercetin, quercetrin and cinanserin on murine coronavirus and dengue virus infection.

Chiow KH, Phoon MC, Putti T, Tan BK, Chow VT.

Asian Pac J Trop Med. 2016 Jan;9(1):1-7. doi: 10.1016/j.apjtm.2015.12.002. Epub 2015 Dec 19. Review.


Human nasal epithelial cells derived from multiple subjects exhibit differential responses to H3N2 influenza virus infection in vitro.

Yan Y, Tan KS, Li C, Tran T, Chao SS, Sugrue RJ, Shi L, Chow VT, Wang DY.

J Allergy Clin Immunol. 2016 Jul;138(1):276-281.e15. doi: 10.1016/j.jaci.2015.11.016. Epub 2016 Jan 21. No abstract available.


Gene Microarray Analyses of Daboia russelli russelli Daboiatoxin Treatment of THP-1 Human Macrophages Infected with Burkholderia pseudomallei.

Perumal Samy R, Manikandan J, Pachiappan A, Ooi EE, Aw LT, Stiles BG, Franco OL, Kandasamy M, Mathi KM, Rane G, Siveen KS, Arunachalam C, Zayed ME, Alharbi SA, Kumar AP, Sethi G, Lim LH, Chow VT.

Curr Mol Med. 2015;15(10):961-74.


Targeting vascular leakage in lung inflammation.

Li L, Chow VT, Tan NS.

Oncotarget. 2015 Aug 14;6(23):19338-9. No abstract available.


Streptococcus pneumoniae secretes hydrogen peroxide leading to DNA damage and apoptosis in lung cells.

Rai P, Parrish M, Tay IJ, Li N, Ackerman S, He F, Kwang J, Chow VT, Engelward BP.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):E3421-30. doi: 10.1073/pnas.1424144112. Epub 2015 Jun 15.


Seroepidemiology of Coxsackievirus A6, Coxsackievirus A16, and Enterovirus 71 Infections among Children and Adolescents in Singapore, 2008-2010.

Ang LW, Tay J, Phoon MC, Hsu JP, Cutter J, James L, Goh KT, Chow VT.

PLoS One. 2015 May 26;10(5):e0127999. doi: 10.1371/journal.pone.0127999. eCollection 2015.


Influenza infection induces host DNA damage and dynamic DNA damage responses during tissue regeneration.

Li N, Parrish M, Chan TK, Yin L, Rai P, Yoshiyuki Y, Abolhassani N, Tan KB, Kiraly O, Chow VT, Engelward BP.

Cell Mol Life Sci. 2015 Aug;72(15):2973-88. doi: 10.1007/s00018-015-1879-1. Epub 2015 Mar 26.


Impedimetric cell-based biosensor for real-time monitoring of cytopathic effects induced by dengue viruses.

Cheng MS, Lau SH, Chan KP, Toh CS, Chow VT.

Biosens Bioelectron. 2015 Aug 15;70:74-80. doi: 10.1016/j.bios.2015.03.018. Epub 2015 Mar 10.


MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response.

James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VTK, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y.

Cell Rep. 2015 Mar 17;10(10):1722-1734. doi: 10.1016/j.celrep.2015.02.030. Epub 2015 Mar 12.


A monoclonal antibody binds to threonine 49 in the non-structural 1 protein of influenza A virus and interferes with its ability to modulate viral replication.

Barnwal B, Mok CK, Wu J, Diwakar MK, Gupta G, Zeng Q, Chow VT, Song J, Yuan YA, Tan YJ.

Antiviral Res. 2015 Apr;116:55-61. doi: 10.1016/j.antiviral.2015.01.015. Epub 2015 Feb 7.


Angiopoietin-like 4 Increases Pulmonary Tissue Leakiness and Damage during Influenza Pneumonia.

Li L, Chong HC, Ng SY, Kwok KW, Teo Z, Tan EHP, Choo CC, Seet JE, Choi HW, Buist ML, Chow VTK, Tan NS.

Cell Rep. 2015 Feb 10;10(5):654-663. doi: 10.1016/j.celrep.2015.01.011. Epub 2015 Feb 5.


Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia.

Yin L, Zheng D, Limmon GV, Leung NH, Xu S, Rajapakse JC, Yu H, Chow VT, Chen J.

Respir Res. 2014 Sep 30;15:116. doi: 10.1186/s12931-014-0116-z.


Rate of decline of antibody titers to pandemic influenza A (H1N1-2009) by hemagglutination inhibition and virus microneutralization assays in a cohort of seroconverting adults in Singapore.

Hsu JP, Zhao X, Chen MI, Cook AR, Lee V, Lim WY, Tan L, Barr IG, Jiang L, Tan CL, Phoon MC, Cui L, Lin R, Leo YS, Chow VT.

BMC Infect Dis. 2014 Jul 28;14:414. doi: 10.1186/1471-2334-14-414.


Micro-RNAs in regenerating lungs: an integrative systems biology analysis of murine influenza pneumonia.

Tan KS, Choi H, Jiang X, Yin L, Seet JE, Patzel V, Engelward BP, Chow VT.

BMC Genomics. 2014 Jul 11;15:587. doi: 10.1186/1471-2164-15-587.


Combination therapy with hepatocyte growth factor and oseltamivir confers enhanced protection against influenza viral pneumonia.

Narasaraju T, Yang E, Samy RP, Tan KS, Moorthy AN, Phoon MC, van Rooijen N, Choi HW, Chow VT.

Curr Mol Med. 2014;14(5):690-702.


A novel universal neutralizing monoclonal antibody against enterovirus 71 that targets the highly conserved "knob" region of VP3 protein.

Kiener TK, Jia Q, Meng T, Chow VT, Kwang J.

PLoS Negl Trop Dis. 2014 May 29;8(5):e2895. doi: 10.1371/journal.pntd.0002895. eCollection 2014.


Phenotypic and genotypic characteristics of novel mouse cell line (NIH/3T3)-adapted human enterovirus 71 strains (EV71:TLLm and EV71:TLLmv).

Victorio CB, Xu Y, Ng Q, Chow VT, Chua KB.

PLoS One. 2014 Mar 26;9(3):e92719. doi: 10.1371/journal.pone.0092719. eCollection 2014. Erratum in: PLoS One. 2014;9(10):e112334.


Wound healing activity and mechanisms of action of an antibacterial protein from the venom of the eastern diamondback rattlesnake (Crotalus adamanteus).

Samy RP, Kandasamy M, Gopalakrishnakone P, Stiles BG, Rowan EG, Becker D, Shanmugam MK, Sethi G, Chow VT.

PLoS One. 2014 Feb 14;9(2):e80199. doi: 10.1371/journal.pone.0080199. eCollection 2014.

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