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Items: 36

1.

Strategies and Limitations Associated with In Vitro Characterization of Vitamin D Receptor Activators.

Bukuroshi P, Saitoh H, Magomedova L, Cummins CL, Chow EC, Li AP, Sandy Pang K.

Biochem Pharmacol. 2018 Jul 17. pii: S0006-2952(18)30283-1. doi: 10.1016/j.bcp.2018.07.015. [Epub ahead of print]

PMID:
30028992
2.

FDA's Approval of the First Biosimilar to Bevacizumab.

Casak SJ, Lemery SJ, Chung J, Fuchs C, Schrieber SJ, Chow ECY, Yuan W, Rodriguez L, Gwise T, Rowzee A, Lim S, Keegan P, McKee AE, Pazdur R.

Clin Cancer Res. 2018 May 9. doi: 10.1158/1078-0432.CCR-18-0566. [Epub ahead of print]

PMID:
29743182
3.

Investigating the Impact of Drug Crystallinity in Amorphous Tacrolimus Capsules on Pharmacokinetics and Bioequivalence Using Discriminatory In Vitro Dissolution Testing and Physiologically Based Pharmacokinetic Modeling and Simulation.

Purohit HS, Trasi NS, Sun DD, Chow ECY, Wen H, Zhang X, Gao Y, Taylor LS.

J Pharm Sci. 2018 May;107(5):1330-1341. doi: 10.1016/j.xphs.2017.12.024. Epub 2017 Dec 29.

PMID:
29289674
4.

Alterations in gene expression in vitamin D-deficiency: Down-regulation of liver Cyp7a1 and renal Oat3 in mice.

Quach HP, Noh K, Hoi SY, Bruinsma A, Groothuis GMM, Li AP, Chow ECY, Pang KS.

Biopharm Drug Dispos. 2018 Feb;39(2):99-115. doi: 10.1002/bdd.2118. Epub 2018 Jan 30.

PMID:
29243851
5.

Highlighting Vitamin D Receptor-Targeted Activities of 1α,25-Dihydroxyvitamin D3 in Mice via Physiologically Based Pharmacokinetic-Pharmacodynamic Modeling.

Yang QJ, Bukuroshi P, Quach HP, Chow ECY, Pang KS.

Drug Metab Dispos. 2018 Jan;46(1):75-87. doi: 10.1124/dmd.117.077271. Epub 2017 Oct 30.

PMID:
29084783
6.

Using Physiologically Based Pharmacokinetic (PBPK) Modeling to Evaluate the Impact of Pharmaceutical Excipients on Oral Drug Absorption: Sensitivity Analyses.

Chow EC, Talattof A, Tsakalozou E, Fan J, Zhao L, Zhang X.

AAPS J. 2016 Nov;18(6):1500-1511. Epub 2016 Aug 12.

PMID:
27520379
7.

Disrupted Murine Gut-to-Human Liver Signaling Alters Bile Acid Homeostasis in Humanized Mouse Liver Models.

Chow EC, Quach HP, Zhang Y, Wang JZ, Evans DC, Li AP, Silva J, Tirona RG, Lai Y, Pang KS.

J Pharmacol Exp Ther. 2017 Jan;360(1):174-191. Epub 2016 Oct 27.

8.

Functional Integrity of the Chimeric (Humanized) Mouse Liver: Enzyme Zonation, Physiologic Spaces, and Hepatic Enzymes and Transporters.

Chow EC, Wang JZ, Quach HP, Tang H, Evans DC, Li AP, Silva J, Pang KS.

Drug Metab Dispos. 2016 Sep;44(9):1524-35. doi: 10.1124/dmd.116.070060. Epub 2016 Jun 24.

9.

Physiologically-Based Pharmacokinetic-Pharmacodynamic Modeling of 1α,25-Dihydroxyvitamin D3 in Mice.

Ramakrishnan V, Yang QJ, Quach HP, Cao Y, Chow EC, Mager DE, Pang KS.

Drug Metab Dispos. 2016 Feb;44(2):189-208. doi: 10.1124/dmd.115.067033. Epub 2015 Nov 19.

10.

PKPD modelling to predict altered disposition of 1α,25-dihydroxyvitamin D3 in mice due to dose-dependent regulation of CYP27B1 on synthesis and CYP24A1 on degradation.

Quach HP, Yang QJ, Chow EC, Mager DE, Hoi SY, Pang KS.

Br J Pharmacol. 2015 Jul;172(14):3611-26. doi: 10.1111/bph.13153. Epub 2015 May 15.

11.
12.

Digital ischaemia: a rare but severe complication of jellyfish sting.

Lam SC, Hung YW, Chow EC, Wong CW, Tse WL, Ho PC.

Hong Kong Med J. 2014 Oct;20(5):460-3. doi: 10.12809/hkmj134155.

13.

Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.

Kim YC, Kim IB, Noh CK, Quach HP, Yoon IS, Chow ECY, Kim M, Jin HE, Cho KH, Chung SJ, Pang KS, Maeng HJ.

J Pharm Sci. 2014 Nov;103(11):3793-3805. doi: 10.1002/jps.24195. Epub 2014 Sep 29.

PMID:
25266751
14.

1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.

Durk MR, Han K, Chow EC, Ahrens R, Henderson JT, Fraser PE, Pang KS.

J Neurosci. 2014 May 21;34(21):7091-101. doi: 10.1523/JNEUROSCI.2711-13.2014.

15.

Arthroscopic osteochondral grafting for radiocarpal joint defects.

Ho PC, Tse WI, Wong CW, Chow EC.

J Wrist Surg. 2013 Aug;2(3):212-9. doi: 10.1055/s-0033-1351788.

16.

Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS.

Gastroenterology. 2014 Apr;146(4):1048-59. doi: 10.1053/j.gastro.2013.12.027. Epub 2013 Dec 21.

PMID:
24365583
17.

Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice.

Chow EC, Durk MR, Maeng HJ, Pang KS.

Biopharm Drug Dispos. 2013 Oct;34(7):402-16. doi: 10.1002/bdd.1856. Epub 2013 Sep 16. Erratum in: Biopharm Drug Dispos. 2014 Mar;35(2):134.

PMID:
23897575
18.

Temporal changes in tissue 1α,25-dihydroxyvitamin D3, vitamin D receptor target genes, and calcium and PTH levels after 1,25(OH)2D3 treatment in mice.

Chow EC, Quach HP, Vieth R, Pang KS.

Am J Physiol Endocrinol Metab. 2013 May 1;304(9):E977-89. doi: 10.1152/ajpendo.00489.2012. Epub 2013 Mar 12.

19.

1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.

Durk MR, Chan GN, Campos CR, Peart JC, Chow EC, Lee E, Cannon RE, Bendayan R, Miller DS, Pang KS.

J Neurochem. 2012 Dec;123(6):944-53. doi: 10.1111/jnc.12041. Epub 2012 Nov 1.

20.

Why we need proper PBPK models to examine intestine and liver oral drug absorption.

Chow EC, Pang KS.

Curr Drug Metab. 2013 Jan;14(1):57-79. Review.

PMID:
22935069
22.

Metacarpophalangeal joint arthroscopy: indications revisited.

Choi AK, Chow EC, Ho PC, Chow YY.

Hand Clin. 2011 Aug;27(3):369-82. doi: 10.1016/j.hcl.2011.05.007.

PMID:
21871361
23.
24.

1α,25-dihydroxyvitamin D3 on intestinal transporter function: studies with the rat everted intestinal sac.

Maeng HJ, Durk MR, Chow EC, Ghoneim R, Pang KS.

Biopharm Drug Dispos. 2011 Mar;32(2):112-25. doi: 10.1002/bdd.742. Epub 2011 Jan 14.

PMID:
21341280
25.

PBPK modeling of intestinal and liver enzymes and transporters in drug absorption and sequential metabolism.

Fan J, Chen S, Chow EC, Pang KS.

Curr Drug Metab. 2010 Nov;11(9):743-61. Review.

PMID:
21189137
26.

Comparative effects of doxercalciferol (1α-hydroxyvitamin D₂) versus calcitriol (1α,25-dihydroxyvitamin D₃) on the expression of transporters and enzymes in the rat in vivo.

Chow EC, Sondervan M, Jin C, Groothuis GM, Pang KS.

J Pharm Sci. 2011 Apr;100(4):1594-604. doi: 10.1002/jps.22366. Epub 2010 Oct 21.

PMID:
20967888
27.

The role of lithocholic acid in the regulation of bile acid detoxication, synthesis, and transport proteins in rat and human intestine and liver slices.

Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM.

Toxicol In Vitro. 2011 Feb;25(1):80-90. doi: 10.1016/j.tiv.2010.09.011. Epub 2010 Oct 1.

PMID:
20888898
28.

Effects of 1alpha,25-dihydroxyvitamin D3 on transporters and enzymes of the rat intestine and kidney in vivo.

Chow EC, Sun H, Khan AA, Groothuis GM, Pang KS.

Biopharm Drug Dispos. 2010 Jan;31(1):91-108. doi: 10.1002/bdd.694.

PMID:
20013813
29.

1alpha,25-Dihydroxyvitamin D(3) triggered vitamin D receptor and farnesoid X receptor-like effects in rat intestine and liver in vivo.

Chow EC, Maeng HJ, Liu S, Khan AA, Groothuis GM, Pang KS.

Biopharm Drug Dispos. 2009 Nov;30(8):457-75. doi: 10.1002/bdd.682.

PMID:
19753549
30.

Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver.

Khan AA, Chow EC, Porte RJ, Pang KS, Groothuis GM.

Biopharm Drug Dispos. 2009 Jul;30(5):241-58. doi: 10.1002/bdd.663.

PMID:
19562681
31.

Comparison of effects of VDR versus PXR, FXR and GR ligands on the regulation of CYP3A isozymes in rat and human intestine and liver.

Khan AA, Chow EC, van Loenen-Weemaes AM, Porte RJ, Pang KS, Groothuis GM.

Eur J Pharm Sci. 2009 May 12;37(2):115-25. doi: 10.1016/j.ejps.2009.01.006. Epub 2009 Jan 30.

PMID:
19429418
32.

The Caco-2 cell monolayer: usefulness and limitations.

Sun H, Chow EC, Liu S, Du Y, Pang KS.

Expert Opin Drug Metab Toxicol. 2008 Apr;4(4):395-411. doi: 10.1517/17425255.4.4.395 . Review.

PMID:
18433344
33.

Liver failure associated with the use of black cohosh for menopausal symptoms.

Chow EC, Teo M, Ring JA, Chen JW.

Med J Aust. 2008 Apr 7;188(7):420-2. No abstract available.

PMID:
18393750
34.

A catenary model to study transport and conjugation of baicalein, a bioactive flavonoid, in the Caco-2 cell monolayer: demonstration of substrate inhibition.

Sun H, Zhang L, Chow EC, Lin G, Zuo Z, Pang KS.

J Pharmacol Exp Ther. 2008 Jul;326(1):117-26. doi: 10.1124/jpet.108.137463. Epub 2008 Apr 2.

35.

Role of haptoglobin on the uptake of native and beta-chain [trimesoyl-(Lys82)beta-(Lys82)beta] cross-linked human hemoglobins in isolated perfused rat livers.

Chow EC, Liu L, Ship N, Kluger RH, Pang KS.

Drug Metab Dispos. 2008 May;36(5):937-45. doi: 10.1124/dmd.107.019174. Epub 2008 Feb 14.

36.

Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.

Chen Y, Whetstone HC, Youn A, Nadesan P, Chow EC, Lin AC, Alman BA.

J Biol Chem. 2007 Jan 5;282(1):526-33. Epub 2006 Nov 3.

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