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Epidemiology of Pediatric Tracheostomy and Risk Factors for Poor Outcomes: An 11-Year Single-Center Experience.

Chia AZH, Ng ZM, Pang YX, Ang AHC, Chow CCT, Teoh OH, Lee JH.

Otolaryngol Head Neck Surg. 2019 Nov 19:194599819887096. doi: 10.1177/0194599819887096. [Epub ahead of print]


Progression of glucose intolerance and cardiometabolic risk factors over a decade in Chinese women with polycystic ovary syndrome: A case-control study.

Ng NYH, Jiang G, Cheung LP, Zhang Y, Tam CHT, Luk AOY, Quan J, Lau ESH, Yau TTL, Chan MHM, Ho CS, Lim CKP, Ozaki R, Huang J, Liu KH, Tam WH, Sahota DS, Chu WCW, Goggins W, Woo J, Li TC, Chow CC, Chan JCN, Ma RCW.

PLoS Med. 2019 Oct 25;16(10):e1002953. doi: 10.1371/journal.pmed.1002953. eCollection 2019 Oct.


Dynamical modeling of multi-scale variability in neuronal competition.

Cohen BP, Chow CC, Vattikuti S.

Commun Biol. 2019 Aug 23;2:319. doi: 10.1038/s42003-019-0555-7. eCollection 2019.


Unintentional error in formula preparation and its simulated impact on infant weight and adiposity.

Altazan AD, Gilmore LA, Guo J, Rosenberg DM, Toupo D, Gowins A, Burton JH, Beyl RA, Chow CC, Hall KD, Redman LM.

Pediatr Obes. 2019 Dec;14(12):e12564. doi: 10.1111/ijpo.12564. Epub 2019 Jul 26.


The antimalarial drug mefloquine enhances TP53 premature termination codon readthrough by aminoglycoside G418.

Ferguson MW, Gerak CAN, Chow CCT, Rastelli EJ, Elmore KE, Stahl F, Hosseini-Farahabadi S, Baradaran-Heravi A, Coltart DM, Roberge M.

PLoS One. 2019 May 23;14(5):e0216423. doi: 10.1371/journal.pone.0216423. eCollection 2019.


Posttraumatic growth among burn survivors 2 years after the 2015 Formosa Fun Coast Water Park explosion in Taiwan.

Su YJ, Chow CC, Yen CI, Chuang SS.

Psychol Trauma. 2019 Apr 11. doi: 10.1037/tra0000458. [Epub ahead of print]


HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance.

Nagao A, Kobayashi M, Koyasu S, Chow CCT, Harada H.

Int J Mol Sci. 2019 Jan 9;20(2). pii: E238. doi: 10.3390/ijms20020238. Review.


Intrinsic Dynamics of a Human Gene Reveal the Basis of Expression Heterogeneity.

Rodriguez J, Ren G, Day CR, Zhao K, Chow CC, Larson DR.

Cell. 2019 Jan 10;176(1-2):213-226.e18. doi: 10.1016/j.cell.2018.11.026. Epub 2018 Dec 13.


Progression of diabetic kidney disease and trajectory of kidney function decline in Chinese patients with Type 2 diabetes.

Jiang G, Luk AOY, Tam CHT, Xie F, Carstensen B, Lau ESH, Lim CKP, Lee HM, Ng ACW, Ng MCY, Ozaki R, Kong APS, Chow CC, Yang X, Lan HY, Tsui SKW, Fan X, Szeto CC, So WY, Chan JCN, Ma RCW; Hong Kong Diabetes Register TRS Study Group.

Kidney Int. 2019 Jan;95(1):178-187. doi: 10.1016/j.kint.2018.08.026. Epub 2018 Nov 8.


Asymmetric cell division-dominant neutral drift model for normal intestinal stem cell homeostasis.

Sei Y, Feng J, Chow CC, Wank SA.

Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G64-G74. doi: 10.1152/ajpgi.00242.2018. Epub 2018 Oct 25.


The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies.

Lee JJ, McGue M, Iacono WG, Chow CC.

Genet Epidemiol. 2018 Dec;42(8):783-795. doi: 10.1002/gepi.22161. Epub 2018 Sep 24.


Learning recurrent dynamics in spiking networks.

Kim CM, Chow CC.

Elife. 2018 Sep 20;7. pii: e37124. doi: 10.7554/eLife.37124.


Guidance on the management of familial hypercholesterolaemia in Hong Kong: an expert panel consensus viewpoin.

Tomlinson B, Chan JC, Chan WB, Chen WW, Chow FC, Li SK, Kong AP, Ma RC, Siu DC, Tan KC, Wong LK, Yeung VT, But BW, Cheung PT, Fu CC, Tung JY, Wong WC, Yau HC.

Hong Kong Med J. 2018 Aug;24(4):408-415. doi: 10.12809/hkmj187215.


An Approach to Greater Specificity for Glucocorticoids.

Chow CC, Simons SS Jr.

Front Endocrinol (Lausanne). 2018 Mar 13;9:76. doi: 10.3389/fendo.2018.00076. eCollection 2018. Review.


High risk of conversion to diabetes in first-degree relatives of individuals with young-onset type 2 diabetes: a 12-year follow-up analysis.

Zhang Y, Luk AOY, Chow E, Ko GTC, Chan MHM, Ng M, Kong APS, Ma RCW, Ozaki R, So WY, Chow CC, Chan JCN.

Diabet Med. 2017 Dec;34(12):1701-1709. doi: 10.1111/dme.13516. Epub 2017 Oct 14.


CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.

Tien JF, Mazloomian A, Cheng SG, Hughes CS, Chow CCT, Canapi LT, Oloumi A, Trigo-Gonzalez G, Bashashati A, Xu J, Chang VC, Shah SP, Aparicio S, Morin GB.

Nucleic Acids Res. 2017 Jun 20;45(11):6698-6716. doi: 10.1093/nar/gkx187.


Regular mailing of personalized feedback reports improves glycemic control in diabetes: A randomized controlled trial.

Yin J, Luk A, Wong R, Chung H, Kong A, Ozaki R, Ma R, Chow CC, So W, Chan J.

J Diabetes. 2017 May;9(5):536-538. doi: 10.1111/1753-0407.12527. Epub 2017 Mar 5. No abstract available.


Altered Brain Structure-Function Relationships Underlie Executive Dysfunction in 22q11.2 Deletion Syndrome.

Jonas RK, Jalbrzikowski M, Montojo CA, Patel A, Kushan L, Chow CC, Vesagas T, Bearden CE.

Mol Neuropsychiatry. 2015 Dec;1(4):235-46. doi: 10.1159/000441979. Epub 2015 Dec 4.


Impact of Masked Replacement of Sugar-Sweetened with Sugar-Free Beverages on Body Weight Increases with Initial BMI: Secondary Analysis of Data from an 18 Month Double-Blind Trial in Children.

Katan MB, de Ruyter JC, Kuijper LD, Chow CC, Hall KD, Olthof MR.

PLoS One. 2016 Jul 22;11(7):e0159771. doi: 10.1371/journal.pone.0159771. eCollection 2016.


Genetic Modification of Human Pancreatic Progenitor Cells Through Modified mRNA.

Lu S, Chow CC, Zhou J, Leung PS, Tsui SK, Lui KO.

Methods Mol Biol. 2016;1428:307-17. doi: 10.1007/978-1-4939-3625-0_21.


Canonical Cortical Circuit Model Explains Rivalry, Intermittent Rivalry, and Rivalry Memory.

Vattikuti S, Thangaraj P, Xie HW, Gotts SJ, Martin A, Chow CC.

PLoS Comput Biol. 2016 May 3;12(5):e1004903. doi: 10.1371/journal.pcbi.1004903. eCollection 2016 May.


Uncovering the Genetic Architectures of Quantitative Traits.

Lee JJ, Vattikuti S, Chow CC.

Comput Struct Biotechnol J. 2015 Nov 23;14:28-34. doi: 10.1016/j.csbj.2015.10.002. eCollection 2016. Review.


Cross-Sectional Analysis of Neurocognitive Function, Retinopathy, and Retinal Thinning by Spectral-Domain Optical Coherence Tomography in Sickle Cell Patients.

Oltra EZ, Chow CC, Wubben T, Lim JI, Chau FY, Moss HE.

Middle East Afr J Ophthalmol. 2016 Jan-Mar;23(1):79-83. doi: 10.4103/0974-9233.150632.


Modeling glucose and free fatty acid kinetics in glucose and meal tolerance test.

Li Y, Chow CC, Courville AB, Sumner AE, Periwal V.

Theor Biol Med Model. 2016 Mar 2;13:8. doi: 10.1186/s12976-016-0036-3.


Practical considerations for the use of sodium-glucose co-transporter type 2 inhibitors in treating hyperglycemia in type 2 diabetes.

Lam KS, Chow CC, Tan KC, Ma RC, Kong AP, Tong PC, Tsang MW, Chan TM, Tang SC, Lee KK, So WY, Tomlinson B.

Curr Med Res Opin. 2016 Jun;32(6):1097-108. doi: 10.1185/03007995.2016.1161608. Epub 2016 Apr 4.


Progression to treatment failure among Chinese patients with type 2 diabetes initiated on metformin versus sulphonylurea monotherapy--The Hong Kong Diabetes Registry.

Jiang G, Luk AO, Yang X, Wang Y, Tam CHT, Lau SH, Ozaki R, Kong APS, Tong PC, Chow CC, Chan JCN, So WY, Ma RCW.

Diabetes Res Clin Pract. 2016 Feb;112:57-64. doi: 10.1016/j.diabres.2015.11.003. Epub 2015 Nov 23.


Single-Molecule Imaging Reveals a Switch between Spurious and Functional ncRNA Transcription.

Lenstra TL, Coulon A, Chow CC, Larson DR.

Mol Cell. 2015 Nov 19;60(4):597-610. doi: 10.1016/j.molcel.2015.09.028. Epub 2015 Nov 5.


Quality of care in patients with diabetic kidney disease in Asia: The Joint Asia Diabetes Evaluation (JADE) Registry.

Luk AO, Li X, Zhang Y, Guo X, Jia W, Li W, Weng J, Yang W, Chan WB, Ozaki R, Tsang CC, Mukhopadhyay M, Ojha AK, Hong EG, Yoon KH, Sobrepena L, Toledo RM, Duran M, Sheu W, Q Do T, Nguyen TK, Ma RC, Kong AP, Chow CC, Tong PC, So WY, Chan JC; JADE Study Group.

Diabet Med. 2016 Sep;33(9):1230-9. doi: 10.1111/dme.13014. Epub 2015 Dec 6.


Kinetically Defined Mechanisms and Positions of Action of Two New Modulators of Glucocorticoid Receptor-regulated Gene Induction.

Pradhan MA, Blackford JA Jr, Devaiah BN, Thompson PS, Chow CC, Singer DS, Simons SS Jr.

J Biol Chem. 2016 Jan 1;291(1):342-54. doi: 10.1074/jbc.M115.683722. Epub 2015 Oct 26.


Increased food energy supply as a major driver of the obesity epidemic: a global analysis.

Vandevijvere S, Chow CC, Hall KD, Umali E, Swinburn BA.

Bull World Health Organ. 2015 Jul 1;93(7):446-56. doi: 10.2471/BLT.14.150565.


Theory of partial agonist activity of steroid hormones.

Chow CC, Ong KM, Kagan B, Simons SS Jr.

AIMS Mol Sci. 2015;2(2):101-123.


Impact of a low-glucose peritoneal dialysis regimen on fibrosis and inflammation biomarkers.

Yung S, Lui SL, Ng CK, Yim A, Ma MK, Lo KY, Chow CC, Chu KH, Chak WL, Lam MF, Yung CY, Yip TP, Wong S, Tang CS, Ng FS, Chan TM.

Perit Dial Int. 2015 Mar-Apr;35(2):147-58. doi: 10.3747/pdi.2014.00125.


Path integral methods for stochastic differential equations.

Chow CC, Buice MA.

J Math Neurosci. 2015 Mar 24;5:8. doi: 10.1186/s13408-015-0018-5. eCollection 2015.


Kinetically-defined component actions in gene repression.

Chow CC, Finn KK, Storchan GB, Lu X, Sheng X, Simons SS Jr.

PLoS Comput Biol. 2015 Mar 27;11(3):e1004122. doi: 10.1371/journal.pcbi.1004122. eCollection 2015 Mar.


Second-generation PLINK: rising to the challenge of larger and richer datasets.

Chang CC, Chow CC, Tellier LC, Vattikuti S, Purcell SM, Lee JJ.

Gigascience. 2015 Feb 25;4:7. doi: 10.1186/s13742-015-0047-8. eCollection 2015.


Dynamics of chromatin accessibility and long-range interactions in response to glucocorticoid pulsing.

Stavreva DA, Coulon A, Baek S, Sung MH, John S, Stixova L, Tesikova M, Hakim O, Miranda T, Hawkins M, Stamatoyannopoulos JA, Chow CC, Hager GL.

Genome Res. 2015 Jun;25(6):845-57. doi: 10.1101/gr.184168.114. Epub 2015 Feb 12.


Treatment of recalcitrant radiation maculopathy using intravitreal dexamethasone (Ozurdex) implant.

Bui KM, Chow CC, Mieler WF.

Retin Cases Brief Rep. 2014 Summer;8(3):167-70. doi: 10.1097/ICB.0000000000000032.


Vitamin A deficiency and xerophthalmic fundus in autoimmune hepatitis and cirrhosis.

Chow CC, Mieler WF.

Retin Cases Brief Rep. 2014 Summer;8(3):164-6. doi: 10.1097/ICB.0000000000000031.


Kinetic competition during the transcription cycle results in stochastic RNA processing.

Coulon A, Ferguson ML, de Turris V, Palangat M, Chow CC, Larson DR.

Elife. 2014 Oct 1;3. doi: 10.7554/eLife.03939.


Metabolic profiles and treatment gaps in young-onset type 2 diabetes in Asia (the JADE programme): a cross-sectional study of a prospective cohort.

Yeung RO, Zhang Y, Luk A, Yang W, Sobrepena L, Yoon KH, Aravind SR, Sheu W, Nguyen TK, Ozaki R, Deerochanawong C, Tsang CC, Chan WB, Hong EG, Do TQ, Cheung Y, Brown N, Goh SY, Ma RC, Mukhopadhyay M, Ojha AK, Chakraborty S, Kong AP, Lau W, Jia W, Li W, Guo X, Bian R, Weng J, Ji L, Reyes-dela Rosa M, Toledo RM, Himathongkam T, Yoo SJ, Chow CC, Ho LL, Chuang LM, Tutino G, Tong PC, So WY, Wolthers T, Ko G, Lyubomirsky G, Chan JC.

Lancet Diabetes Endocrinol. 2014 Dec;2(12):935-43. doi: 10.1016/S2213-8587(14)70137-8. Epub 2014 Jul 28. Erratum in: Lancet Diabetes Endocrinol. 2014 Dec;2(12):e17.


Applying compressed sensing to genome-wide association studies.

Vattikuti S, Lee JJ, Chang CC, Hsu SD, Chow CC.

Gigascience. 2014 Jun 16;3:10. doi: 10.1186/2047-217X-3-10. eCollection 2014.


Hypoglycaemia, chronic kidney disease and death in type 2 diabetes: the Hong Kong diabetes registry.

Kong AP, Yang X, Luk A, Cheung KK, Ma RC, So WY, Ho CS, Chan MH, Ozaki R, Chow CC, Brown N, Chan JC.

BMC Endocr Disord. 2014 Jun 13;14:48. doi: 10.1186/1472-6823-14-48.


Additive effects of blood glucose lowering drugs, statins and renin-angiotensin system blockers on all-site cancer risk in patients with type 2 diabetes.

Kong AP, Yang X, So WY, Luk A, Ma RC, Ozaki R, Cheung KK, Lee HM, Yu L, Xu G, Chow CC, Chan JC.

BMC Med. 2014 May 13;12:76. doi: 10.1186/1741-7015-12-76.


Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.

Blackford JA Jr, Brimacombe KR, Dougherty EJ, Pradhan M, Shen M, Li Z, Auld DS, Chow CC, Austin CP, Simons SS Jr.

Mol Endocrinol. 2014 Jul;28(7):1194-206. doi: 10.1210/me.2014-1069. Epub 2014 May 21.


Effects of telephone-based peer support in patients with type 2 diabetes mellitus receiving integrated care: a randomized clinical trial.

Chan JC, Sui Y, Oldenburg B, Zhang Y, Chung HH, Goggins W, Au S, Brown N, Ozaki R, Wong RY, Ko GT, Fisher E; JADE and PEARL Project Team.

JAMA Intern Med. 2014 Jun;174(6):972-81. doi: 10.1001/jamainternmed.2014.655.


Conditions for the validity of SNP-based heritability estimation.

Lee JJ, Chow CC.

Hum Genet. 2014 Aug;133(8):1011-22. doi: 10.1007/s00439-014-1441-5. Epub 2014 Apr 18.


Short and long-term energy intake patterns and their implications for human body weight regulation.

Chow CC, Hall KD.

Physiol Behav. 2014 Jul;134:60-5. doi: 10.1016/j.physbeh.2014.02.044. Epub 2014 Feb 28.


A kinase-independent activity of Cdk9 modulates glucocorticoid receptor-mediated gene induction.

Zhu R, Lu X, Pradhan M, Armstrong SP, Storchan GB, Chow CC, Simons SS Jr.

Biochemistry. 2014 Mar 25;53(11):1753-67. doi: 10.1021/bi5000178. Epub 2014 Mar 11.


Severe hypoglycemia identifies vulnerable patients with type 2 diabetes at risk for premature death and all-site cancer: the Hong Kong diabetes registry.

Kong AP, Yang X, Luk A, Ma RC, So WY, Ozaki R, Ting R, Cheung K, Ho CS, Chan MH, Chow CC, Chan JC.

Diabetes Care. 2014 Apr;37(4):1024-31. doi: 10.2337/dc13-2507. Epub 2014 Feb 10.


Genetic variants for type 2 diabetes and new-onset cancer in Chinese with type 2 diabetes.

Ma RC, So WY, Tam CH, Luk AO, Ho JS, Wang Y, Lam VK, Lee HM, Kong AP, Tong PC, Xu G, Chow CC, Ng MC, Yang XL, Chan JC.

Diabetes Res Clin Pract. 2014 Feb;103(2):328-37. doi: 10.1016/j.diabres.2013.12.016. Epub 2013 Dec 27.


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