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Items: 39

1.

Author Correction: Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.

Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T.

Nat Immunol. 2019 Nov;20(11):1555. doi: 10.1038/s41590-019-0517-8.

PMID:
31551573
2.

Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses.

Langston PK, Nambu A, Jung J, Shibata M, Aksoylar HI, Lei J, Xu P, Doan MT, Jiang H, MacArthur MR, Gao X, Kong Y, Chouchani ET, Locasale JW, Snyder NW, Horng T.

Nat Immunol. 2019 Sep;20(9):1186-1195. doi: 10.1038/s41590-019-0453-7. Epub 2019 Aug 5. Erratum in: Nat Immunol. 2019 Sep 24;:.

PMID:
31384058
3.

H+ transport is an integral function of the mitochondrial ADP/ATP carrier.

Bertholet AM, Chouchani ET, Kazak L, Angelin A, Fedorenko A, Long JZ, Vidoni S, Garrity R, Cho J, Terada N, Wallace DC, Spiegelman BM, Kirichok Y.

Nature. 2019 Jul;571(7766):515-520. doi: 10.1038/s41586-019-1400-3. Epub 2019 Jul 24.

PMID:
31341297
4.

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity.

Kazak L, Rahbani JF, Samborska B, Lu GZ, Jedrychowski MP, Lajoie M, Zhang S, Ramsay LC, Dou FY, Tenen D, Chouchani ET, Dzeja P, Watson IR, Tsai L, Rosen ED, Spiegelman BM.

Nat Metab. 2019;1(3):360-370. doi: 10.1038/s42255-019-0035-x. Epub 2019 Feb 25. No abstract available.

5.

Coupling Krebs cycle metabolites to signalling in immunity and cancer.

Ryan DG, Murphy MP, Frezza C, Prag HA, Chouchani ET, O'Neill LA, Mills EL.

Nat Metab. 2019 Jan;1:16-33. doi: 10.1038/s42255-018-0014-7.

6.

New Advances in Adaptive Thermogenesis: UCP1 and Beyond.

Chouchani ET, Kazak L, Spiegelman BM.

Cell Metab. 2019 Jan 8;29(1):27-37. doi: 10.1016/j.cmet.2018.11.002. Epub 2018 Nov 29. Review.

PMID:
30503034
7.

Mechanisms of Mitochondria Assembly, Dynamics and Turnover in Health and Disease.

Chouchani ET, Liesa M, Trifunovic A.

J Mol Biol. 2018 Dec 7;430(24):4821-4822. doi: 10.1016/j.jmb.2018.11.009. Epub 2018 Nov 11. No abstract available.

PMID:
30428302
8.

Accumulation of succinate controls activation of adipose tissue thermogenesis.

Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET.

Nature. 2018 Aug;560(7716):102-106. doi: 10.1038/s41586-018-0353-2. Epub 2018 Jul 18.

PMID:
30022159
9.

Multiplexed Isobaric Tag-Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy.

Paulo JA, Jedrychowski MP, Chouchani ET, Kazak L, Gygi SP.

Proteomics. 2018 May;18(10):e1700326. doi: 10.1002/pmic.201700326. Epub 2018 May 2.

10.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Mills EL, Ryan DG, Prag HA, Dikovskaya D, Menon D, Zaslona Z, Jedrychowski MP, Costa ASH, Higgins M, Hams E, Szpyt J, Runtsch MC, King MS, McGouran JF, Fischer R, Kessler BM, McGettrick AF, Hughes MM, Carroll RG, Booty LM, Knatko EV, Meakin PJ, Ashford MLJ, Modis LK, Brunori G, Sévin DC, Fallon PG, Caldwell ST, Kunji ERS, Chouchani ET, Frezza C, Dinkova-Kostova AT, Hartley RC, Murphy MP, O'Neill LA.

Nature. 2018 Apr 5;556(7699):113-117. doi: 10.1038/nature25986. Epub 2018 Mar 28.

11.

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM.

Cell Metab. 2017 Oct 3;26(4):693. doi: 10.1016/j.cmet.2017.09.007. No abstract available.

12.

Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity.

Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM.

Cell Metab. 2017 Oct 3;26(4):660-671.e3. doi: 10.1016/j.cmet.2017.08.009. Epub 2017 Aug 24. Erratum in: Cell Metab. 2017 Oct 3;26(4):693.

13.

Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.

Chouchani ET, Kazak L, Spiegelman BM.

J Biol Chem. 2017 Oct 13;292(41):16810-16816. doi: 10.1074/jbc.R117.789628. Epub 2017 Aug 24. Review.

14.

Identification and quantification of protein S-nitrosation by nitrite in the mouse heart during ischemia.

Chouchani ET, James AM, Methner C, Pell VR, Prime TA, Erickson BK, Forkink M, Lau GY, Bright TP, Menger KE, Fearnley IM, Krieg T, Murphy MP.

J Biol Chem. 2017 Sep 1;292(35):14486-14495. doi: 10.1074/jbc.M117.798744. Epub 2017 Jul 14.

15.

UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.

Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7981-7986. doi: 10.1073/pnas.1705406114. Epub 2017 Jun 19.

16.

Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes.

Ortega SP, Chouchani ET, Boudina S.

Adipocyte. 2017 Jan 2;6(1):56-61. doi: 10.1080/21623945.2016.1273298. Epub 2016 Dec 16. Review.

17.

Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling.

Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y.

Cell Metab. 2017 Apr 4;25(4):811-822.e4. doi: 10.1016/j.cmet.2017.03.002.

18.

Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.

Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM.

Nature. 2016 Aug 18;536(7616):360. doi: 10.1038/nature18279. Epub 2016 May 18. No abstract available.

PMID:
27281219
19.

Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.

Pell VR, Chouchani ET, Frezza C, Murphy MP, Krieg T.

Cardiovasc Res. 2016 Jul 15;111(2):134-41. doi: 10.1093/cvr/cvw100. Epub 2016 May 18. Review.

PMID:
27194563
20.

Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.

Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM.

Nature. 2016 Apr 7;532(7597):112-6. doi: 10.1038/nature17399. Epub 2016 Mar 30. Erratum in: Nature. 2016 Aug 18;536(7616):360.

21.

Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy.

Pell VR, Chouchani ET, Murphy MP, Brookes PS, Krieg T.

Circ Res. 2016 Mar 4;118(5):898-906. doi: 10.1161/CIRCRESAHA.115.306569. Review.

22.

A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury.

Chouchani ET, Pell VR, James AM, Work LM, Saeb-Parsy K, Frezza C, Krieg T, Murphy MP.

Cell Metab. 2016 Feb 9;23(2):254-63. doi: 10.1016/j.cmet.2015.12.009. Epub 2016 Jan 14. Review.

23.

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry.

Logan A, Pell VR, Shaffer KJ, Evans C, Stanley NJ, Robb EL, Prime TA, Chouchani ET, Cochemé HM, Fearnley IM, Vidoni S, James AM, Porteous CM, Partridge L, Krieg T, Smith RA, Murphy MP.

Cell Metab. 2016 Feb 9;23(2):379-85. doi: 10.1016/j.cmet.2015.11.014. Epub 2015 Dec 17.

24.

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster.

Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP.

Cell Rep. 2015 Nov 10;13(6):1285. doi: 10.1016/j.celrep.2015.10.048. Epub 2015 Nov 10. No abstract available.

25.

A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat.

Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM.

Cell. 2015 Oct 22;163(3):643-55. doi: 10.1016/j.cell.2015.09.035. Epub 2015 Oct 22.

26.

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster.

Menger KE, James AM, Cochemé HM, Harbour ME, Chouchani ET, Ding S, Fearnley IM, Partridge L, Murphy MP.

Cell Rep. 2015 Jun 30;11(12):1856-65. doi: 10.1016/j.celrep.2015.05.033. Epub 2015 Jun 18. Erratum in: Cell Rep. 2015 Nov 10;13(6):1285.

27.

Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma.

Cunniff B, Newick K, Nelson KJ, Wozniak AN, Beuschel S, Leavitt B, Bhave A, Butnor K, Koenig A, Chouchani ET, James AM, Haynes AC, Lowther WT, Murphy MP, Shukla A, Heintz NH.

PLoS One. 2015 May 26;10(5):e0127310. doi: 10.1371/journal.pone.0127310. eCollection 2015.

28.

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.

Chouchani ET, Pell VR, Gaude E, Aksentijević D, Sundier SY, Robb EL, Logan A, Nadtochiy SM, Ord ENJ, Smith AC, Eyassu F, Shirley R, Hu CH, Dare AJ, James AM, Rogatti S, Hartley RC, Eaton S, Costa ASH, Brookes PS, Davidson SM, Duchen MR, Saeb-Parsy K, Shattock MJ, Robinson AJ, Work LM, Frezza C, Krieg T, Murphy MP.

Nature. 2014 Nov 20;515(7527):431-435. doi: 10.1038/nature13909. Epub 2014 Nov 5.

29.

Mitochondria selective S-nitrosation by mitochondria-targeted S-nitrosothiol protects against post-infarct heart failure in mouse hearts.

Methner C, Chouchani ET, Buonincontri G, Pell VR, Sawiak SJ, Murphy MP, Krieg T.

Eur J Heart Fail. 2014 Jul;16(7):712-7. doi: 10.1002/ejhf.100. Epub 2014 May 31.

30.

Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy.

Chouchani ET, Methner C, Buonincontri G, Hu CH, Logan A, Sawiak SJ, Murphy MP, Krieg T.

PLoS One. 2014 Apr 4;9(4):e94157. doi: 10.1371/journal.pone.0094157. eCollection 2014.

31.

Using exomarkers to assess mitochondrial reactive species in vivo.

Logan A, Cochemé HM, Li Pun PB, Apostolova N, Smith RA, Larsen L, Larsen DS, James AM, Fearnley IM, Rogatti S, Prime TA, Finichiu PG, Dare A, Chouchani ET, Pell VR, Methner C, Quin C, McQuaker SJ, Krieg T, Hartley RC, Murphy MP.

Biochim Biophys Acta. 2014 Feb;1840(2):923-30. doi: 10.1016/j.bbagen.2013.05.026. Epub 2013 May 30. Review.

32.

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I.

Chouchani ET, Methner C, Nadtochiy SM, Logan A, Pell VR, Ding S, James AM, Cochemé HM, Reinhold J, Lilley KS, Partridge L, Fearnley IM, Robinson AJ, Hartley RC, Smith RA, Krieg T, Brookes PS, Murphy MP.

Nat Med. 2013 Jun;19(6):753-9. doi: 10.1038/nm.3212. Epub 2013 May 26.

33.

Inactivation of pyruvate dehydrogenase kinase 2 by mitochondrial reactive oxygen species.

Hurd TR, Collins Y, Abakumova I, Chouchani ET, Baranowski B, Fearnley IM, Prime TA, Murphy MP, James AM.

J Biol Chem. 2012 Oct 12;287(42):35153-60. doi: 10.1074/jbc.M112.400002. Epub 2012 Aug 21.

34.

Mitochondrial redox signalling at a glance.

Collins Y, Chouchani ET, James AM, Menger KE, Cochemé HM, Murphy MP.

J Cell Sci. 2012 Feb 15;125(Pt 4):801-6. doi: 10.1242/jcs.098475. No abstract available. Erratum in: J Cell Sci. 2012 Apr 1;125(Pt 7):1837.

35.

Proteomic approaches to the characterization of protein thiol modification.

Chouchani ET, James AM, Fearnley IM, Lilley KS, Murphy MP.

Curr Opin Chem Biol. 2011 Feb;15(1):120-8. doi: 10.1016/j.cbpa.2010.11.003. Epub 2010 Dec 2. Review.

36.

Quantification and identification of mitochondrial proteins containing vicinal dithiols.

Requejo R, Chouchani ET, James AM, Prime TA, Lilley KS, Fearnley IM, Murphy MP.

Arch Biochem Biophys. 2010 Dec 15;504(2):228-35. doi: 10.1016/j.abb.2010.09.003. Epub 2010 Sep 15.

PMID:
20836988
37.

Measuring mitochondrial protein thiol redox state.

Requejo R, Chouchani ET, Hurd TR, Menger KE, Hampton MB, Murphy MP.

Methods Enzymol. 2010;474:123-47. doi: 10.1016/S0076-6879(10)74008-8. Epub 2010 Jun 20.

PMID:
20609908
38.

Identification of S-nitrosated mitochondrial proteins by S-nitrosothiol difference in gel electrophoresis (SNO-DIGE): implications for the regulation of mitochondrial function by reversible S-nitrosation.

Chouchani ET, Hurd TR, Nadtochiy SM, Brookes PS, Fearnley IM, Lilley KS, Smith RA, Murphy MP.

Biochem J. 2010 Aug 15;430(1):49-59. doi: 10.1042/BJ20100633.

39.

A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury.

Prime TA, Blaikie FH, Evans C, Nadtochiy SM, James AM, Dahm CC, Vitturi DA, Patel RP, Hiley CR, Abakumova I, Requejo R, Chouchani ET, Hurd TR, Garvey JF, Taylor CT, Brookes PS, Smith RA, Murphy MP.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10764-9. doi: 10.1073/pnas.0903250106. Epub 2009 Jun 15.

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