Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 191

1.

New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties.

Zhang Q, Du R, Reis Monteiro Dos Santos GR, Yefidoff-Freedman R, Bohm A, Halperin J, Chorev M, Aktas BH.

Eur J Med Chem. 2020 Feb 1;187:111973. doi: 10.1016/j.ejmech.2019.111973. Epub 2019 Dec 16.

PMID:
31881453
2.

Predicting Breast Cancer by Applying Deep Learning to Linked Health Records and Mammograms.

Akselrod-Ballin A, Chorev M, Shoshan Y, Spiro A, Hazan A, Melamed R, Barkan E, Herzel E, Naor S, Karavani E, Koren G, Goldschmidt Y, Shalev V, Rosen-Zvi M, Guindy M.

Radiology. 2019 Aug;292(2):331-342. doi: 10.1148/radiol.2019182622. Epub 2019 Jun 18.

PMID:
31210611
3.

Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC)-Mediated Macrocyclization of Peptides: Impact on Conformation and Biological Activity.

Testa C, Papini AM, Chorev M, Rovero P.

Curr Top Med Chem. 2018;18(7):591-610. doi: 10.2174/1568026618666180518095755. Review.

PMID:
29773065
4.

A Data-Driven Decision-Support Tool for Population Health Policies.

Chorev M, Shpigelman L, Bak P, Yaeli A, Michael E, Goldschmidt Y.

Stud Health Technol Inform. 2017;245:332-336.

PMID:
29295110
5.
6.

Identification of introns harboring functional sequence elements through positional conservation.

Chorev M, Joseph Bekker A, Goldberger J, Carmel L.

Sci Rep. 2017 Jun 23;7(1):4201. doi: 10.1038/s41598-017-04476-0.

7.

Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response.

Yefidoff-Freedman R, Fan J, Yan L, Zhang Q, Dos Santos GRR, Rana S, Contreras JI, Sahoo R, Wan D, Young J, Dias Teixeira KL, Morisseau C, Halperin J, Hammock B, Natarajan A, Wang P, Chorev M, Aktas BH.

J Med Chem. 2017 Jul 13;60(13):5392-5406. doi: 10.1021/acs.jmedchem.7b00059. Epub 2017 Jun 19.

8.

Plasma Glycated CD59, a Novel Biomarker for Detection of Pregnancy-Induced Glucose Intolerance.

Ghosh P, Luque-Fernandez MA, Vaidya A, Ma D, Sahoo R, Chorev M, Zera C, McElrath TF, Williams MA, Seely EW, Halperin JA.

Diabetes Care. 2017 Jul;40(7):981-984. doi: 10.2337/dc16-2598. Epub 2017 Apr 27.

9.

Epidemiological Models Lacking Process Noise Can Be Overconfident.

Shpigelman L, Chorev M, Waks Z, Goldschmidt Y, Michael E.

Stud Health Technol Inform. 2017;235:136-140.

PMID:
28423770
10.

LEMONS - A Tool for the Identification of Splice Junctions in Transcriptomes of Organisms Lacking Reference Genomes.

Levin L, Bar-Yaacov D, Bouskila A, Chorev M, Carmel L, Mishmar D.

PLoS One. 2015 Nov 25;10(11):e0143329. doi: 10.1371/journal.pone.0143329. eCollection 2015.

11.

JuncDB: an exon-exon junction database.

Chorev M, Guy L, Carmel L.

Nucleic Acids Res. 2016 Jan 4;44(D1):D101-9. doi: 10.1093/nar/gkv1142. Epub 2015 Oct 30.

12.

Role of complement and complement regulatory proteins in the complications of diabetes.

Ghosh P, Sahoo R, Vaidya A, Chorev M, Halperin JA.

Endocr Rev. 2015 Jun;36(3):272-88. doi: 10.1210/er.2014-1099. Epub 2015 Apr 10. Review.

13.

1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.

Testa C, Scrima M, Grimaldi M, D'Ursi AM, Dirain ML, Lubin-Germain N, Singh A, Haskell-Luevano C, Chorev M, Rovero P, Papini AM.

J Med Chem. 2014 Nov 26;57(22):9424-34. doi: 10.1021/jm501027w. Epub 2014 Nov 13.

14.

Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.

Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):E3187-95. doi: 10.1073/pnas.1410250111. Epub 2014 Jul 21.

15.

Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction.

Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M.

J Med Chem. 2014 Jun 26;57(12):5094-111. doi: 10.1021/jm401733v. Epub 2014 Jun 4.

16.

Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors.

Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M.

Eur J Med Chem. 2014 Apr 22;77:361-77. doi: 10.1016/j.ejmech.2014.03.034. Epub 2014 Mar 13.

17.

Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans.

Ghosh P, Vaidya A, Sahoo R, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA.

J Clin Endocrinol Metab. 2014 Jun;99(6):E999-E1006. doi: 10.1210/jc.2013-4232. Epub 2014 Mar 14.

18.

3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction.

Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M.

Chembiochem. 2014 Mar 3;15(4):595-611. doi: 10.1002/cbic.201300723. Epub 2014 Jan 23.

19.

Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinase.

Chen T, Takrouri K, Hee-Hwang S, Rana S, Yefidoff-Freedman R, Halperin J, Natarajan A, Morisseau C, Hammock B, Chorev M, Aktas BH.

J Med Chem. 2013 Dec 12;56(23):9457-70. doi: 10.1021/jm400793v. Epub 2013 Nov 27.

20.

Synthesis and SAR study of novel 3,3-diphenyl-1,3-dihydroindol-2-one derivatives as potent eIF2·GTP·Met-tRNAiMet ternary complex inhibitors.

Denoyelle S, Chen T, Yang H, Chen L, Zhang Y, Halperin JA, Aktas BH, Chorev M.

Eur J Med Chem. 2013 Nov;69:537-53. doi: 10.1016/j.ejmech.2013.08.030. Epub 2013 Sep 17.

PMID:
24095748
21.

Dual activators of protein kinase R (PKR) and protein kinase R-like kinase PERK identify common and divergent catalytic targets.

Bai H, Chen T, Ming J, Sun H, Cao P, Fusco DN, Chung RT, Chorev M, Jin Q, Aktas BH.

Chembiochem. 2013 Jul 8;14(10):1255-62. doi: 10.1002/cbic.201300177. Epub 2013 Jun 19.

22.

A specific and sensitive assay for blood levels of glycated CD59: a novel biomarker for diabetes.

Ghosh P, Sahoo R, Vaidya A, Cantel S, Kavishwar A, Goldfine A, Herring N, Bry L, Chorev M, Halperin JA.

Am J Hematol. 2013 Aug;88(8):670-6. doi: 10.1002/ajh.23478. Epub 2013 Jun 20.

23.

Computational identification of functional introns: high positional conservation of introns that harbor RNA genes.

Chorev M, Carmel L.

Nucleic Acids Res. 2013 Jun;41(11):5604-13. doi: 10.1093/nar/gkt244. Epub 2013 Apr 19.

24.

Solvent independent conformational propensities of [1,2,3]triazolyl-bridged parathyroid hormone-related peptide-derived cyclo-nonapeptide analogues.

Scrima M, Grimaldi M, Di Marino S, Testa C, Rovero P, Papini AM, Chorev M, D'Ursi AM.

Biopolymers. 2012;98(6):535-45. doi: 10.1002/bip.22139.

PMID:
23203759
25.

Tumor suppression by small molecule inhibitors of translation initiation.

Chen L, Aktas BH, Wang Y, He X, Sahoo R, Zhang N, Denoyelle S, Kabha E, Yang H, Freedman RY, Supko JG, Chorev M, Wagner G, Halperin JA.

Oncotarget. 2012 Aug;3(8):869-81.

26.

Removal of the tag from His-tagged ILYd4, a human CD59 inhibitor, significantly improves its physical properties and its activity.

Wu L, Su S, Liu F, Xu T, Wang X, Huang Y, Sun X, Ge X, Chen T, Liu H, Wang C, Chorev M, Xu T, Qin X.

Curr Pharm Des. 2012;18(27):4187-96.

27.

The function of introns.

Chorev M, Carmel L.

Front Genet. 2012 Apr 13;3:55. doi: 10.3389/fgene.2012.00055. eCollection 2012.

28.

In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.

Denoyelle S, Chen T, Chen L, Wang Y, Klosi E, Halperin JA, Aktas BH, Chorev M.

Bioorg Med Chem Lett. 2012 Jan 1;22(1):402-9. doi: 10.1016/j.bmcl.2011.10.126. Epub 2011 Nov 16.

29.

Conventional and microwave-assisted SPPS approach: a comparative synthesis of PTHrP(1-34)NH(2).

Rizzolo F, Testa C, Lambardi D, Chorev M, Chelli M, Rovero P, Papini AM.

J Pept Sci. 2011 Oct;17(10):708-14. doi: 10.1002/psc.1395. Epub 2011 Aug 1.

PMID:
21805540
30.

Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer target.

Chen T, Ozel D, Qiao Y, Harbinski F, Chen L, Denoyelle S, He X, Zvereva N, Supko JG, Chorev M, Halperin JA, Aktas BH.

Nat Chem Biol. 2011 Jul 17;7(9):610-6. doi: 10.1038/nchembio.613.

31.

Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation.

Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E.

Proc Natl Acad Sci U S A. 2011 Feb 22;108(8):3383-8. doi: 10.1073/pnas.1013063108. Epub 2011 Feb 2.

32.

Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis.

Hu W, Ge X, You T, Xu T, Zhang J, Wu G, Peng Z, Chorev M, Aktas BH, Halperin JA, Brown JR, Qin X.

Cancer Res. 2011 Mar 15;71(6):2298-307. doi: 10.1158/0008-5472.CAN-10-3016. Epub 2011 Jan 20.

33.

Side chain-to-side chain cyclization by click reaction.

Le Chevalier Isaad A, Papini AM, Chorev M, Rovero P.

J Pept Sci. 2009 Jul;15(7):451-4. doi: 10.1002/psc.1141.

PMID:
19455541
34.

Glycated-CD59 antigen: exploration of synthetic approaches.

Cantel S, Kavishwar A, Schlimme M, Khatri A, Halperin JA, Chorev M.

Adv Exp Med Biol. 2009;611:317-8. No abstract available.

PMID:
19400208
35.

Side chain-to-side chain cyclization by intramolecular click reaction--building blocks, solid phase synthesis and conformational characterization.

Cantel S, Halperin JA, Chorev M, Scrima M, D'Ursi AM, Levy JJ, DiMarchi RD, Le Chevalier A, Rovero P, Papini AM.

Adv Exp Med Biol. 2009;611:175-6. No abstract available.

PMID:
19400147
36.

Structure-function relationship study of parathyroid hormone (1-11) analogues containing D-AA.

Caporale A, Fiori N, Schievano E, Wittelsberger A, Mammi S, Chorev M, Peggion E.

Adv Exp Med Biol. 2009;611:113-4. No abstract available.

PMID:
19400117
37.

Building blocks for the synthesis of post-translationally modified glycated peptides and proteins.

Carganico S, Rovero P, Halperin JA, Papini AM, Chorev M.

J Pept Sci. 2009 Feb;15(2):67-71. doi: 10.1002/psc.1105.

PMID:
19090529
38.

Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition.

Cantel S, Isaad Ale C, Scrima M, Levy JJ, DiMarchi RD, Rovero P, Halperin JA, D'Ursi AM, Papini AM, Chorev M.

J Org Chem. 2008 Aug 1;73(15):5663-74. doi: 10.1021/jo800142s. Epub 2008 May 20.

PMID:
18489158
39.

Structure-function relationship studies of PTH(1-11) analogues containing sterically hindered dipeptide mimetics.

Fiori N, Caporale A, Schievano E, Mammi S, Geyer A, Tremmel P, Wittelsberger A, Woznica I, Chorev M, Peggion E.

J Pept Sci. 2007 Aug;13(8):504-12.

PMID:
17617795
40.

Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction.

Hyberts SG, Heffron GJ, Tarragona NG, Solanky K, Edmonds KA, Luithardt H, Fejzo J, Chorev M, Aktas H, Colson K, Falchuk KH, Halperin JA, Wagner G.

J Am Chem Soc. 2007 Apr 25;129(16):5108-16. Epub 2007 Mar 28.

41.

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G.

Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G.

Cell. 2007 Jan 26;128(2):257-67.

42.

Parathyroid hormone 1-34 enhances titanium implant anchorage in low-density trabecular bone: a correlative micro-computed tomographic and biomechanical analysis.

Gabet Y, Müller R, Levy J, Dimarchi R, Chorev M, Bab I, Kohavi D.

Bone. 2006 Aug;39(2):276-82. Epub 2006 Apr 17.

PMID:
16617039
43.

The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation.

Wittelsberger A, Corich M, Thomas BE, Lee BK, Barazza A, Czodrowski P, Mierke DF, Chorev M, Rosenblatt M.

Biochemistry. 2006 Feb 21;45(7):2027-34.

PMID:
16475791
44.

Backbone dynamics of human parathyroid hormone (1-34): flexibility of the central region under different environmental conditions.

Scian M, Marin M, Bellanda M, Tou L, Alexander JM, Rosenblatt M, Chorev M, Peggion E, Mammi S.

Biopolymers. 2006;84(2):147-60.

PMID:
16123988
45.

Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics.

Natarajan A, Guo Y, Arthanari H, Wagner G, Halperin JA, Chorev M.

J Org Chem. 2005 Aug 5;70(16):6362-8.

46.

Intermittently administered parathyroid hormone 1-34 reverses bone loss and structural impairment in orchiectomized adult rats.

Gabet Y, Kohavi D, Müller R, Chorev M, Bab I.

Osteoporos Int. 2005 Nov;16(11):1436-43. Epub 2005 Apr 6.

PMID:
15812598
47.

The partial retro-inverso modification: a road traveled together.

Chorev M.

Biopolymers. 2005;80(2-3):67-84.

PMID:
15729688
48.

Bioactive N-terminal undecapeptides derived from parathyroid hormone: the role of alpha-helicity.

Barazza A, Wittelsberger A, Fiori N, Schievano E, Mammi S, Toniolo C, Alexander JM, Rosenblatt M, Peggion E, Chorev M.

J Pept Res. 2005 Jan;65(1):23-35.

PMID:
15686531
49.

Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation.

Natarajan A, Guo Y, Harbinski F, Fan YH, Chen H, Luus L, Diercks J, Aktas H, Chorev M, Halperin JA.

J Med Chem. 2004 Oct 7;47(21):4979-82.

PMID:
15456240
50.

Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes.

Qin X, Goldfine A, Krumrei N, Grubissich L, Acosta J, Chorev M, Hays AP, Halperin JA.

Diabetes. 2004 Oct;53(10):2653-61.

Supplemental Content

Loading ...
Support Center