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Items: 23


Oxidative Inhibition of Pbp1 Phase Separation.

Chong PA, Forman-Kay JD.

Biochemistry. 2019 Jul 16;58(28):3057-3059. doi: 10.1021/acs.biochem.9b00511. Epub 2019 Jul 8. No abstract available.


RGG/RG Motif Regions in RNA Binding and Phase Separation.

Chong PA, Vernon RM, Forman-Kay JD.

J Mol Biol. 2018 Nov 2;430(23):4650-4665. doi: 10.1016/j.jmb.2018.06.014. Epub 2018 Jun 15. Review.


Pi-Pi contacts are an overlooked protein feature relevant to phase separation.

Vernon RM, Chong PA, Tsang B, Kim TH, Bah A, Farber P, Lin H, Forman-Kay JD.

Elife. 2018 Feb 9;7. pii: e31486. doi: 10.7554/eLife.31486.


CFTR structure.

Callebaut I, Chong PA, Forman-Kay JD.

J Cyst Fibros. 2018 Mar;17(2S):S5-S8. doi: 10.1016/j.jcf.2017.08.008. Epub 2017 Aug 31. Review.


Stabilization of a nucleotide-binding domain of the cystic fibrosis transmembrane conductance regulator yields insight into disease-causing mutations.

Vernon RM, Chong PA, Lin H, Yang Z, Zhou Q, Aleksandrov AA, Dawson JE, Riordan JR, Brouillette CG, Thibodeau PH, Forman-Kay JD.

J Biol Chem. 2017 Aug 25;292(34):14147-14164. doi: 10.1074/jbc.M116.772335. Epub 2017 Jun 27.


Direct Binding of the Corrector VX-809 to Human CFTR NBD1: Evidence of an Allosteric Coupling between the Binding Site and the NBD1:CL4 Interface.

Hudson RP, Dawson JE, Chong PA, Yang Z, Millen L, Thomas PJ, Brouillette CG, Forman-Kay JD.

Mol Pharmacol. 2017 Aug;92(2):124-135. doi: 10.1124/mol.117.108373. Epub 2017 May 25.


Interplay of buried histidine protonation and protein stability in prion misfolding.

Malevanets A, Chong PA, Hansen DF, Rizk P, Sun Y, Lin H, Muhandiram R, Chakrabartty A, Kay LE, Forman-Kay JD, Wodak SJ.

Sci Rep. 2017 Apr 13;7(1):882. doi: 10.1038/s41598-017-00954-7.


Molecular biology: A hidden competitive advantage of disorder.

Chong PA, Forman-Kay JD.

Nature. 2017 Mar 16;543(7645):325-326. doi: 10.1038/nature21893. Epub 2017 Mar 8. No abstract available.


A New Phase in ALS Research.

Chong PA, Forman-Kay JD.

Structure. 2016 Sep 6;24(9):1435-6. doi: 10.1016/j.str.2016.08.003.


Liquid-liquid phase separation in cellular signaling systems.

Chong PA, Forman-Kay JD.

Curr Opin Struct Biol. 2016 Dec;41:180-186. doi: 10.1016/ Epub 2016 Aug 20. Review.


Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.

Hall JD, Wang H, Byrnes LJ, Shanker S, Wang K, Efremov IV, Chong PA, Forman-Kay JD, Aulabaugh AE.

Protein Sci. 2016 Feb;25(2):360-73. doi: 10.1002/pro.2821. Epub 2016 Jan 12.


Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.

Chong PA, Farber PJ, Vernon RM, Hudson RP, Mittermaier AK, Forman-Kay JD.

J Biol Chem. 2015 Sep 18;290(38):22862-78. doi: 10.1074/jbc.M115.641134. Epub 2015 Jul 6.


Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions.

Bozoky Z, Krzeminski M, Chong PA, Forman-Kay JD.

FEBS J. 2013 Sep;280(18):4407-16. doi: 10.1111/febs.12422. Epub 2013 Jul 25. Review.


Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stability.

Chong PA, Kota P, Dokholyan NV, Forman-Kay JD.

Cold Spring Harb Perspect Med. 2013 Mar 1;3(3):a009522. doi: 10.1101/cshperspect.a009522. Review.


Conformational changes relevant to channel activity and folding within the first nucleotide binding domain of the cystic fibrosis transmembrane conductance regulator.

Hudson RP, Chong PA, Protasevich II, Vernon R, Noy E, Bihler H, An JL, Kalid O, Sela-Culang I, Mense M, Senderowitz H, Brouillette CG, Forman-Kay JD.

J Biol Chem. 2012 Aug 17;287(34):28480-94. doi: 10.1074/jbc.M112.371138. Epub 2012 Jun 21.


Characterization of the PilN, PilO and PilP type IVa pilus subcomplex.

Tammam S, Sampaleanu LM, Koo J, Sundaram P, Ayers M, Chong PA, Forman-Kay JD, Burrows LL, Howell PL.

Mol Microbiol. 2011 Dec;82(6):1496-514. doi: 10.1111/j.1365-2958.2011.07903.x. Epub 2011 Nov 18.


NMR spectroscopy to study the dynamics and interactions of CFTR.

Kanelis V, Chong PA, Forman-Kay JD.

Methods Mol Biol. 2011;741:377-403. doi: 10.1007/978-1-61779-117-8_25.


Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity.

Chong PA, Lin H, Wrana JL, Forman-Kay JD.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18404-9. doi: 10.1073/pnas.1003023107. Epub 2010 Oct 11.


Structural, functional, and bioinformatic studies demonstrate the crucial role of an extended peptide binding site for the SH3 domain of yeast Abp1p.

Stollar EJ, Garcia B, Chong PA, Rath A, Lin H, Forman-Kay JD, Davidson AR.

J Biol Chem. 2009 Sep 25;284(39):26918-27. doi: 10.1074/jbc.M109.028431. Epub 2009 Jul 9.


A hybrid mobile-based patient location tracking system for personal healthcare applications.

Chew SH, Chong PA, Gunawan E, Goh KW, Kim Y, Soh CB.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:5188-91.


An expanded WW domain recognition motif revealed by the interaction between Smad7 and the E3 ubiquitin ligase Smurf2.

Chong PA, Lin H, Wrana JL, Forman-Kay JD.

J Biol Chem. 2006 Jun 23;281(25):17069-75. Epub 2006 Apr 26.


Disorder in a target for the smad2 mad homology 2 domain and its implications for binding and specificity.

Chong PA, Ozdamar B, Wrana JL, Forman-Kay JD.

J Biol Chem. 2004 Sep 24;279(39):40707-14. Epub 2004 Jul 1.


Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massagué J, Shi Y.

Science. 2000 Jan 7;287(5450):92-7.

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