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Items: 46

1.

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases.

Hashimoto M, Bacman SR, Peralta S, Falk MJ, Chomyn A, Chan DC, Williams SL, Moraes CT.

Mol Ther. 2015 Oct;23(10):1592-9. doi: 10.1038/mt.2015.126. Epub 2015 Jul 10.

2.

Decreased reactive oxygen species production in cells with mitochondrial haplogroups associated with longevity.

Chen A, Raule N, Chomyn A, Attardi G.

PLoS One. 2012;7(10):e46473. doi: 10.1371/journal.pone.0046473. Epub 2012 Oct 29.

3.

Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations.

Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC.

Cell. 2010 Apr 16;141(2):280-9. doi: 10.1016/j.cell.2010.02.026.

4.

Aging-related occurrence in Ashkenazi Jews of leukocyte heteroplasmic mtDNA mutation adjacent to replication origin frequently remodeled in Italian centenarians.

Iwata N, Zhang J, Atzmon G, Leanza S, Cho J, Chomyn A, Burk RD, Barzilai N, Attardi G.

Mitochondrion. 2007 Jul;7(4):267-72. Epub 2007 Mar 12.

PMID:
17452024
5.

Identification of a novel mitochondrial complex containing mitofusin 2 and stomatin-like protein 2.

Hájek P, Chomyn A, Attardi G.

J Biol Chem. 2007 Feb 23;282(8):5670-81. Epub 2006 Nov 22.

6.

Proteolytic processing of OPA1 links mitochondrial dysfunction to alterations in mitochondrial morphology.

Duvezin-Caubet S, Jagasia R, Wagener J, Hofmann S, Trifunovic A, Hansson A, Chomyn A, Bauer MF, Attardi G, Larsson NG, Neupert W, Reichert AS.

J Biol Chem. 2006 Dec 8;281(49):37972-9. Epub 2006 Sep 26.

7.

Disruption of fusion results in mitochondrial heterogeneity and dysfunction.

Chen H, Chomyn A, Chan DC.

J Biol Chem. 2005 Jul 15;280(28):26185-92. Epub 2005 May 17.

8.

Genetic and functional analysis of mitochondrial DNA-encoded complex I genes.

Bai Y, Hu P, Park JS, Deng JH, Song X, Chomyn A, Yagi T, Attardi G.

Ann N Y Acad Sci. 2004 Apr;1011:272-83.

PMID:
15126303
9.

MtDNA mutations in aging and apoptosis.

Chomyn A, Attardi G.

Biochem Biophys Res Commun. 2003 May 9;304(3):519-29. Review.

PMID:
12729587
10.

Mitochondrial outer membrane permeability change and hypersensitivity to digitonin early in staurosporine-induced apoptosis.

Duan S, Hajek P, Lin C, Shin SK, Attardi G, Chomyn A.

J Biol Chem. 2003 Jan 10;278(2):1346-53. Epub 2002 Oct 25.

11.

Mitochondrial genetic control of assembly and function of complex I in mammalian cells.

Chomyn A.

J Bioenerg Biomembr. 2001 Jun;33(3):251-7. Review.

PMID:
11695835
12.

Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene.

Bai Y, Hájek P, Chomyn A, Chan E, Seo BB, Matsuno-Yagi A, Yagi T, Attardi G.

J Biol Chem. 2001 Oct 19;276(42):38808-13. Epub 2001 Jul 30.

15.
17.

The mutation rate of the human mtDNA deletion mtDNA4977.

Shenkar R, Navidi W, Tavaré S, Dang MH, Chomyn A, Attardi G, Cortopassi G, Arnheim N.

Am J Hum Genet. 1996 Oct;59(4):772-80.

18.
19.

Platelet-mediated transformation of human mitochondrial DNA-less cells.

Chomyn A.

Methods Enzymol. 1996;264:334-9. No abstract available.

PMID:
8965706
20.

Immunoprecipitation of human mitochondrial translation products with peptide-specific antibodies.

Bentlage HA, Chomyn A.

Methods Enzymol. 1996;264:218-28. No abstract available.

PMID:
8965695
21.

In vivo labeling and analysis of human mitochondrial translation products.

Chomyn A.

Methods Enzymol. 1996;264:197-211. No abstract available.

PMID:
8965693
22.

Purification of mitochondrial DNA from human cell cultures and placenta.

Ausenda C, Chomyn A.

Methods Enzymol. 1996;264:122-8. No abstract available.

PMID:
8965686
23.

Complementation and segregation behavior of disease-causing mitochondrial DNA mutations in cellular model systems.

Attardi G, Yoneda M, Chomyn A.

Biochim Biophys Acta. 1995 May 24;1271(1):241-8. Review.

24.
25.

Multiple deficiencies of mitochondrial DNA- and nuclear-encoded subunits of respiratory NADH dehydrogenase detected with peptide- and subunit-specific antibodies in mitochondrial myopathies.

Bentlage HA, Janssen AJ, Chomyn A, Attardi G, Walker JE, Schägger H, Sengers RC, Trijbels FJ.

Biochim Biophys Acta. 1995 Mar 8;1234(1):63-73.

26.

Immunoprecipitation of human NADH: ubiquinone oxidoreductase and cytochrome-c oxidase with single subunit-specific antibodies.

Mariottini P, Chomyn A.

Methods Enzymol. 1995;260:202-10. No abstract available.

PMID:
8592445
28.

Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse.

Valberg SJ, Carlson GP, Cardinet GH 3rd, Birks EK, Jones JH, Chomyn A, DiMauro S.

Muscle Nerve. 1994 Mar;17(3):305-12.

PMID:
8107707
29.

Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy.

Yoneda M, Chomyn A, Martinuzzi A, Hurko O, Attardi G.

Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11164-8.

30.

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

Chomyn A, Martinuzzi A, Yoneda M, Daga A, Hurko O, Johns D, Lai ST, Nonaka I, Angelini C, Attardi G.

Proc Natl Acad Sci U S A. 1992 May 15;89(10):4221-5.

31.

Zidovudine induces molecular, biochemical, and ultrastructural changes in rat skeletal muscle mitochondria.

Lewis W, Gonzalez B, Chomyn A, Papoian T.

J Clin Invest. 1992 Apr;89(4):1354-60.

32.

In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria.

Chomyn A, Meola G, Bresolin N, Lai ST, Scarlato G, Attardi G.

Mol Cell Biol. 1991 Apr;11(4):2236-44.

33.

A case of mitochondrial myopathy, lactic acidosis and complex I deficiency.

Bet L, Bresolin N, Moggio M, Meola G, Prelle A, Schapira AH, Binzoni T, Chomyn A, Fortunato F, Cerretelli P, et al.

J Neurol. 1990 Nov;237(7):399-404.

PMID:
2125637
34.

Regulation of mitochondrial gene expression in mammalian cells.

Attardi G, Chomyn A, King MP, Kruse B, Polosa PL, Murdter NN.

Biochem Soc Trans. 1990 Aug;18(4):509-13. No abstract available.

PMID:
2276421
36.

The site of synthesis of the iron-sulfur subunits of the flavoprotein and iron-protein fractions of human NADH dehydrogenase.

Chomyn A, Patel SD, Cleeter MW, Ragan CI, Attardi G.

J Biol Chem. 1988 Nov 5;263(31):16395-400.

37.

URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit.

Chomyn A, Cleeter MW, Ragan CI, Riley M, Doolittle RF, Attardi G.

Science. 1986 Oct 31;234(4776):614-8.

PMID:
3764430
39.

Identification of the polypeptides encoded in the unassigned reading frames 2, 4, 4L, and 5 of human mitochondrial DNA.

Mariottini P, Chomyn A, Riley M, Cottrell B, Doolittle RF, Attardi G.

Proc Natl Acad Sci U S A. 1986 Mar;83(6):1563-7.

40.

Seven unidentified reading frames of human mitochondrial DNA encode subunits of the respiratory chain NADH dehydrogenase.

Attardi G, Chomyn A, Doolittle RF, Mariottini P, Ragan CI.

Cold Spring Harb Symp Quant Biol. 1986;51 Pt 1:103-14. No abstract available.

PMID:
3472707
41.

Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

Chomyn A, Mariottini P, Cleeter MW, Ragan CI, Matsuno-Yagi A, Hatefi Y, Doolittle RF, Attardi G.

Nature. 1985 Apr 18-24;314(6012):592-7.

PMID:
3921850
42.

Identification of the polypeptides encoded in the ATPase 6 gene and in the unassigned reading frames 1 and 3 of human mtDNA.

Chomyn A, Mariottini P, Gonzalez-Cadavid N, Attardi G, Strong DD, Trovato D, Riley M, Doolittle RF.

Proc Natl Acad Sci U S A. 1983 Sep;80(18):5535-9.

43.

Antibodies against synthetic peptides reveal that the unidentified reading frame A6L, overlapping the ATPase 6 gene, is expressed in human mitochondria.

Mariottini P, Chomyn A, Attardi G, Trovato D, Strong DD, Doolittle RF.

Cell. 1983 Apr;32(4):1269-77.

PMID:
6301689
44.

Identification and mapping of human mitochondrial genes.

Attardi G, Chomyn A, Montoya J, Ojala D.

Birth Defects Orig Artic Ser. 1982;18(2):85-98. No abstract available.

PMID:
7159712
45.

Identification and mapping of human mitochondrial genes.

Attardi G, Chomyn A, Montoya J, Ojala D.

Cytogenet Cell Genet. 1982;32(1-4):85-98. No abstract available.

PMID:
7140372
46.

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