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Items: 1 to 50 of 358

1.

Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes.

Casanova N, Zhou T, Gonzalez-Garay ML, Rosas IO, Goldberg HJ, Ryter SW, Collard HR, El-Chemaly S, Flaherty KR, Hunninghake GM, Lasky JA, Lederer DJ, Machado RF, Martinez FJ, Noth I, Raghu G, Choi AMK, Garcia JGN.

Sci Rep. 2019 Oct 15;9(1):14802. doi: 10.1038/s41598-019-50585-3.

2.

Heteroplasmy concordance between mitochondrial DNA and RNA.

Zhang R, Nakahira K, Choi AMK, Gu Z.

Sci Rep. 2019 Sep 10;9(1):12942. doi: 10.1038/s41598-019-49279-7.

3.

DROSHA-Dependent AIM2 Inflammasome Activation Contributes to Lung Inflammation during Idiopathic Pulmonary Fibrosis.

Cho SJ, Hong KS, Jeong JH, Lee M, Choi AMK, Stout-Delgado HW, Moon JS.

Cells. 2019 Aug 20;8(8). pii: E938. doi: 10.3390/cells8080938.

4.

Necroptosis: a crucial pathogenic mediator of human disease.

Choi ME, Price DR, Ryter SW, Choi AMK.

JCI Insight. 2019 Aug 8;4(15). pii: 128834. doi: 10.1172/jci.insight.128834. eCollection 2019 Aug 8. Review.

5.

Circulating Mitochondrial DNA as Predictor of Mortality in Critically Ill Patients: A Systematic Review of Clinical Studies.

Harrington JS, Huh JW, Schenck EJ, Nakahira K, Siempos II, Choi AMK.

Chest. 2019 Aug 2. pii: S0012-3692(19)31389-3. doi: 10.1016/j.chest.2019.07.014. [Epub ahead of print]

PMID:
31381882
6.

Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis.

Chung KP, Hsu CL, Fan LC, Huang Z, Bhatia D, Chen YJ, Hisata S, Cho SJ, Nakahira K, Imamura M, Choi ME, Yu CJ, Cloonan SM, Choi AMK.

Nat Commun. 2019 Jul 29;10(1):3390. doi: 10.1038/s41467-019-11327-1.

7.

Fatty acid synthase downregulation contributes to acute lung injury in murine diet-induced obesity.

Plataki M, Fan L, Sanchez E, Huang Z, Torres LK, Imamura M, Zhu Y, Cohen DE, Cloonan SM, Choi AM.

JCI Insight. 2019 Jul 9;5. pii: 127823. doi: 10.1172/jci.insight.127823.

8.

Objectively Measured Chronic Lung Injury on Chest CT.

Harmouche R, Ash SY, Putman RK, Hunninghake GM, San Jose Estepar R, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Han MK, Bowler RP, Kalhan R, Rosas IO, Washko GR, San Jose Estepar R; COPDGene Investigators.

Chest. 2019 Jun 22. pii: S0012-3692(19)31197-3. doi: 10.1016/j.chest.2019.05.020. [Epub ahead of print]

PMID:
31233744
9.

Association of Elevated Plasma Interleukin-18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome.

Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM.

Crit Care Med. 2019 Aug;47(8):1089-1096. doi: 10.1097/CCM.0000000000003816.

PMID:
31206358
10.

Apolipoprotein E and periostin are potential biomarkers of nasal mucosal inflammation: a parallel approach of in vitro and in vivo secretomes.

Chung YW, Cha J, Han S, Chen Y, Gucek M, Cho HJ, Nakahira K, Choi AMK, Ryu JH, Yoon JH.

Am J Respir Cell Mol Biol. 2019 Jun 13. doi: 10.1165/rcmb.2018-0248OC. [Epub ahead of print]

PMID:
31194918
11.

Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3.

Lee CM, He CH, Park JW, Lee JH, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Elias JA, Lee CG.

Life Sci Alliance. 2019 May 13;2(3). pii: e201900350. doi: 10.26508/lsa.201900350. Print 2019 Jun.

12.

Shaping the Path for a Global Oncology Academic Career.

Balogun OD, Choi AMK, Formenti SC.

JAMA Oncol. 2019 Jul 1;5(7):931-932. doi: 10.1001/jamaoncol.2019.0555. No abstract available.

PMID:
31046103
13.

Circulating cell death biomarker TRAIL is associated with increased organ dysfunction in sepsis.

Schenck EJ, Ma KC, Price DR, Nicholson T, Oromendia C, Gentzler ER, Sanchez E, Baron RM, Fredenburgh LE, Huh JW, Siempos II, Choi AM.

JCI Insight. 2019 May 2;4(9). pii: 127143. doi: 10.1172/jci.insight.127143. eCollection 2019 May 2.

14.

Developing a Culture of Mentorship to Strengthen Academic Medical Centers.

Choi AMK, Moon JE, Steinecke A, Prescott JE.

Acad Med. 2019 May;94(5):630-633. doi: 10.1097/ACM.0000000000002498.

15.

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight.

Garrett-Bakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW.

Science. 2019 Apr 12;364(6436). pii: eaau8650. doi: 10.1126/science.aau8650.

PMID:
30975860
16.

Diurnal Rhythms Spatially and Temporally Organize Autophagy.

Ryzhikov M, Ehlers A, Steinberg D, Xie W, Oberlander E, Brown S, Gilmore PE, Townsend RR, Lane WS, Dolinay T, Nakahira K, Choi AMK, Haspel JA.

Cell Rep. 2019 Feb 12;26(7):1880-1892.e6. doi: 10.1016/j.celrep.2019.01.072.

17.

Mitochondrial Dysfunction as a Pathogenic Mediator of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis.

Ryter SW, Rosas IO, Owen CA, Martinez FJ, Choi ME, Lee CG, Elias JA, Choi AMK.

Ann Am Thorac Soc. 2018 Dec;15(Suppl 4):S266-S272. doi: 10.1513/AnnalsATS.201808-585MG.

PMID:
30759019
18.

Plasma mitochondrial DNA and metabolomic alterations in severe critical illness.

Johansson PI, Nakahira K, Rogers AJ, McGeachie MJ, Baron RM, Fredenburgh LE, Harrington J, Choi AMK, Christopher KB.

Crit Care. 2018 Dec 29;22(1):360. doi: 10.1186/s13054-018-2275-7.

19.

A phase I trial of low-dose inhaled carbon monoxide in sepsis-induced ARDS.

Fredenburgh LE, Perrella MA, Barragan-Bradford D, Hess DR, Peters E, Welty-Wolf KE, Kraft BD, Harris RS, Maurer R, Nakahira K, Oromendia C, Davies JD, Higuera A, Schiffer KT, Englert JA, Dieffenbach PB, Berlin DA, Lagambina S, Bouthot M, Sullivan AI, Nuccio PF, Kone MT, Malik MJ, Porras MAP, Finkelsztein E, Winkler T, Hurwitz S, Serhan CN, Piantadosi CA, Baron RM, Thompson BT, Choi AM.

JCI Insight. 2018 Dec 6;3(23). pii: 124039. doi: 10.1172/jci.insight.124039.

20.

Rapidly Improving ARDS in Therapeutic Randomized Controlled Trials.

Schenck EJ, Oromendia C, Torres LK, Berlin DA, Choi AMK, Siempos II.

Chest. 2019 Mar;155(3):474-482. doi: 10.1016/j.chest.2018.09.031. Epub 2018 Oct 22.

21.

Integrins αvβ5 and αvβ6 Mediate IL-4-induced Collective Migration in Human Airway Epithelial Cells.

Lee SN, Ahn JS, Lee SG, Lee HS, Choi AMK, Yoon JH.

Am J Respir Cell Mol Biol. 2019 Apr;60(4):420-433. doi: 10.1165/rcmb.2018-0081OC.

PMID:
30359079
22.

Beclin-1 regulates cigarette smoke-induced kidney injury in a murine model of chronic obstructive pulmonary disease.

Pabón MA, Patino E, Bhatia D, Rojas-Quintero J, Ma KC, Finkelsztein EJ, Osorio JC, Malick F, Polverino F, Owen CA, Ryter SW, Choi AM, Cloonan SM, Choi ME.

JCI Insight. 2018 Sep 20;3(18). pii: 99592. doi: 10.1172/jci.insight.99592. eCollection 2018 Sep 20.

23.

Laminin α1 is a genetic modifier of TGF-β1-stimulated pulmonary fibrosis.

Lee CM, Cho SJ, Cho WK, Park JW, Lee JH, Choi AM, Rosas IO, Zheng M, Peltz G, Lee CG, Elias JA.

JCI Insight. 2018 Sep 20;3(18). pii: 99574. doi: 10.1172/jci.insight.99574. eCollection 2018 Sep 20.

24.

Circulating RIPK3 levels are associated with mortality and organ failure during critical illness.

Ma KC, Schenck EJ, Siempos II, Cloonan SM, Finkelsztein EJ, Pabon MA, Oromendia C, Ballman KV, Baron RM, Fredenburgh LE, Higuera A, Lee JY, Chung CR, Jeon K, Yang JH, Howrylak JA, Huh JW, Suh GY, Choi AM.

JCI Insight. 2018 Jul 12;3(13). pii: 99692. doi: 10.1172/jci.insight.99692.

25.

Acute respiratory distress syndrome without identifiable risk factors: A secondary analysis of the ARDS network trials.

Harrington JS, Schenck EJ, Oromendia C, Choi AMK, Siempos II.

J Crit Care. 2018 Oct;47:49-54. doi: 10.1016/j.jcrc.2018.06.002. Epub 2018 Jun 2.

26.

RIPK3 promotes sepsis-induced acute kidney injury via mitochondrial dysfunction.

Sureshbabu A, Patino E, Ma KC, Laursen K, Finkelsztein EJ, Akchurin O, Muthukumar T, Ryter SW, Gudas L, Choi AMK, Choi ME.

JCI Insight. 2018 Jun 7;3(11). pii: 98411. doi: 10.1172/jci.insight.98411. eCollection 2018 Jun 7.

27.

Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort.

Ash SY, Harmouche R, Ross JC, Diaz AA, Rahaghi FN, Vegas Sanchez-Ferrero G, Putman RK, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Bowler RP, Lynch DA, Hatabu H, Bhatt SP, Dransfield MT, Wells JM, Rosas IO, San Jose Estepar R, Washko GR; COPDGene Investigators.

Radiology. 2018 Aug;288(2):600-609. doi: 10.1148/radiol.2018172688. Epub 2018 Jun 5.

28.

RIPK3 mediates pathogenesis of experimental ventilator-induced lung injury.

Siempos II, Ma KC, Imamura M, Baron RM, Fredenburgh LE, Huh JW, Moon JS, Finkelsztein EJ, Jones DS, Lizardi MT, Schenck EJ, Ryter SW, Nakahira K, Choi AM.

JCI Insight. 2018 May 3;3(9). pii: 97102. doi: 10.1172/jci.insight.97102.

29.

Determination of Early Immune Function in Sepsis and Its Influence on Organ Dysfunction. Is a More Pragmatic Outcome on the Horizon?

Torres LK, Choi AMK.

Am J Respir Crit Care Med. 2018 Aug 1;198(3):298-300. doi: 10.1164/rccm.201803-0470ED. No abstract available.

PMID:
29558169
30.

Lipid Synthesis Is Required to Resolve Endoplasmic Reticulum Stress and Limit Fibrotic Responses in the Lung.

Romero F, Hong X, Shah D, Kallen CB, Rosas I, Guo Z, Schriner D, Barta J, Shaghaghi H, Hoek JB, Mesaros C, Choi AM, Snyder NW, Summer R.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):225-236. doi: 10.1165/rcmb.2017-0340OC.

31.

A community approach to mortality prediction in sepsis via gene expression analysis.

Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA, Choi AM, Bermejo-Martin JF, Almansa R, Tamayo E, Davenport EE, Burnham KL, Hinds CJ, Knight JC, Woods CW, Kingsmore SF, Ginsburg GS, Wong HR, Parnell GP, Tang B, Moldawer LL, Moore FE, Omberg L, Khatri P, Tsalik EL, Mangravite LM, Langley RJ.

Nat Commun. 2018 Feb 15;9(1):694. doi: 10.1038/s41467-018-03078-2.

32.

Danger Signals in the ICU.

Schenck EJ, Ma KC, Murthy SB, Choi AMK.

Crit Care Med. 2018 May;46(5):791-798. doi: 10.1097/CCM.0000000000003007. Review.

33.

Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers.

Ash SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, Hunninghake GM, San Jose Estepar R, Washko GR; COPDGene Investigators.

Thorax. 2018 Nov;73(11):1071-1074. doi: 10.1136/thoraxjnl-2017-211208. Epub 2018 Feb 13.

PMID:
29440587
34.

Dysbiosis of Inferior Turbinate Microbiota Is Associated with High Total IgE Levels in Patients with Allergic Rhinitis.

Hyun DW, Min HJ, Kim MS, Whon TW, Shin NR, Kim PS, Kim HS, Lee JY, Kang W, Choi AMK, Yoon JH, Bae JW.

Infect Immun. 2018 Mar 22;86(4). pii: e00934-17. doi: 10.1128/IAI.00934-17. Print 2018 Apr.

35.

RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase.

Imamura M, Moon JS, Chung KP, Nakahira K, Muthukumar T, Shingarev R, Ryter SW, Choi AM, Choi ME.

JCI Insight. 2018 Feb 8;3(3). pii: 94979. doi: 10.1172/jci.insight.94979. eCollection 2018 Feb 8.

36.

Human Lung DNA Methylation Quantitative Trait Loci Colocalize with Chronic Obstructive Pulmonary Disease Genome-Wide Association Loci.

Morrow JD, Glass K, Cho MH, Hersh CP, Pinto-Plata V, Celli B, Marchetti N, Criner G, Bueno R, Washko G, Choi AMK, Quackenbush J, Silverman EK, DeMeo DL.

Am J Respir Crit Care Med. 2018 May 15;197(10):1275-1284. doi: 10.1164/rccm.201707-1434OC.

37.

Plasma surfactant protein-D as a diagnostic biomarker for acute respiratory distress syndrome: validation in US and Korean cohorts.

Park J, Pabon M, Choi AMK, Siempos II, Fredenburgh LE, Baron RM, Jeon K, Chung CR, Yang JH, Park CM, Suh GY.

BMC Pulm Med. 2017 Dec 15;17(1):204. doi: 10.1186/s12890-017-0532-1.

38.

Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure.

Mizumura K, Justice MJ, Schweitzer KS, Krishnan S, Bronova I, Berdyshev EV, Hubbard WC, Pewzner-Jung Y, Futerman AH, Choi AMK, Petrache I.

FASEB J. 2018 Apr;32(4):1880-1890. doi: 10.1096/fj.201700571R. Epub 2018 Jan 5.

39.

Autophagy and inflammation in chronic respiratory disease.

Racanelli AC, Kikkers SA, Choi AMK, Cloonan SM.

Autophagy. 2018;14(2):221-232. doi: 10.1080/15548627.2017.1389823. Epub 2018 Feb 8. Review.

40.

Carbon monoxide in lung cell physiology and disease.

Ryter SW, Ma KC, Choi AMK.

Am J Physiol Cell Physiol. 2018 Feb 1;314(2):C211-C227. doi: 10.1152/ajpcell.00022.2017. Epub 2017 Nov 8. Review.

41.

A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis.

Rosas IO, Goldberg HJ, Collard HR, El-Chemaly S, Flaherty K, Hunninghake GM, Lasky JA, Lederer DJ, Machado R, Martinez FJ, Maurer R, Teller D, Noth I, Peters E, Raghu G, Garcia JGN, Choi AMK.

Chest. 2018 Jan;153(1):94-104. doi: 10.1016/j.chest.2017.09.052. Epub 2017 Oct 31.

42.

NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection.

Cho SJ, Rooney K, Choi AMK, Stout-Delgado HW.

Am J Physiol Lung Cell Mol Physiol. 2018 Mar 1;314(3):L372-L387. doi: 10.1152/ajplung.00393.2017. Epub 2017 Nov 2.

43.

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria.

Mebratu YA, Leyva-Baca I, Wathelet MG, Lacey N, Chand HS, Choi AMK, Tesfaigzi Y.

Nat Commun. 2017 Oct 6;8(1):803. doi: 10.1038/s41467-017-00975-w.

44.

The Role of Danger Signals in the Pathogenesis and Perpetuation of Critical Illness.

Ma KC, Schenck EJ, Pabon MA, Choi AMK.

Am J Respir Crit Care Med. 2018 Feb 1;197(3):300-309. doi: 10.1164/rccm.201612-2460PP. Review. No abstract available.

45.

Metabolome alterations in severe critical illness and vitamin D status.

Lasky-Su J, Dahlin A, Litonjua AA, Rogers AJ, McGeachie MJ, Baron RM, Gazourian L, Barragan-Bradford D, Fredenburgh LE, Choi AMK, Mogensen KM, Quraishi SA, Amrein K, Christopher KB.

Crit Care. 2017 Jul 28;21(1):193. doi: 10.1186/s13054-017-1794-y.

46.

Macrolides protect against Pseudomonas aeruginosa infection via inhibition of inflammasomes.

Fan LC, Lin JL, Yang JW, Mao B, Lu HW, Ge BX, Choi AMK, Xu JF.

Am J Physiol Lung Cell Mol Physiol. 2017 Oct 1;313(4):L677-L686. doi: 10.1152/ajplung.00123.2017. Epub 2017 Jul 6.

47.

Molecular definitions of autophagy and related processes.

Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G.

EMBO J. 2017 Jul 3;36(13):1811-1836. doi: 10.15252/embj.201796697. Epub 2017 Jun 8. Review.

48.

Mitochondrial DNA in Sepsis.

Harrington JS, Choi AMK, Nakahira K.

Curr Opin Crit Care. 2017 Aug;23(4):284-290. doi: 10.1097/MCC.0000000000000427. Review.

49.

Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers.

Ash SY, Harmouche R, Putman RK, Ross JC, Diaz AA, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Rosas IO, San Jose Estepar R, Washko GR; COPDGene Investigators.

Chest. 2017 Oct;152(4):780-791. doi: 10.1016/j.chest.2017.04.185. Epub 2017 May 12.

50.

The "Iron"-y of Iron Overload and Iron Deficiency in Chronic Obstructive Pulmonary Disease.

Cloonan SM, Mumby S, Adcock IM, Choi AMK, Chung KF, Quinlan GJ.

Am J Respir Crit Care Med. 2017 Nov 1;196(9):1103-1112. doi: 10.1164/rccm.201702-0311PP. No abstract available.

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