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A piperidinol-containing molecule is active against Mycobacterium tuberculosis by inhibiting the mycolic acid flippase activity of MmpL3.

Dupont C, Chen Y, Xu Z, Roquet-Banères F, Blaise M, Witt AK, Dubar F, Biot C, Guérardel Y, Maurer FP, Chng SS, Kremer L.

J Biol Chem. 2019 Nov 15;294(46):17512-17523. doi: 10.1074/jbc.RA119.010135. Epub 2019 Sep 27.


Maximally Disfiguring Surgery for Forefoot Osteomyelitis: Time for a Rethink?

Lee HJ, Chin KM, Lee S, Yap HY, Ch'ng JK, Chng SP, Tay HT.

Int J Low Extrem Wounds. 2019 Sep 26:1534734619876841. doi: 10.1177/1534734619876841. [Epub ahead of print]


Photochromic Materials by Postpolymerisation Surface Modification.

Chng S, Moloney MG, Wu LYL.

ACS Omega. 2018 Nov 15;3(11):15554-15565. doi: 10.1021/acsomega.8b02521. eCollection 2018 Nov 30.


Lipid trafficking across the Gram-negative cell envelope.

Shrivastava R, Chng SS.

J Biol Chem. 2019 Sep 27;294(39):14175-14184. doi: 10.1074/jbc.AW119.008139. Epub 2019 Aug 16. Review.


Novel Acetamide Indirectly Targets Mycobacterial Transporter MmpL3 by Proton Motive Force Disruption.

Shetty A, Xu Z, Lakshmanan U, Hill J, Choong ML, Chng SS, Yamada Y, Poulsen A, Dick T, Gengenbacher M.

Front Microbiol. 2018 Dec 4;9:2960. doi: 10.3389/fmicb.2018.02960. eCollection 2018.


Characterization of Interactions and Phospholipid Transfer between Substrate Binding Proteins of the OmpC-Mla System.

Ercan B, Low WY, Liu X, Chng SS.

Biochemistry. 2019 Jan 15;58(2):114-119. doi: 10.1021/acs.biochem.8b00897. Epub 2018 Oct 8.


Genetic mapping of a barley leaf rust resistance gene Rph26 introgressed from Hordeum bulbosum.

Yu X, Kong HY, Meiyalaghan V, Casonato S, Chng S, Jones EE, Butler RC, Pickering R, Johnston PA.

Theor Appl Genet. 2018 Dec;131(12):2567-2580. doi: 10.1007/s00122-018-3173-8. Epub 2018 Sep 3.


Hemodialysis Arteriovenous Fistula and Graft Stenoses: Randomized Trial Comparing Drug-eluting Balloon Angioplasty with Conventional Angioplasty.

Irani FG, Teo TKB, Tay KH, Yin WH, Win HH, Gogna A, Patel A, Too CW, Chan SXJM, Lo RHG, Toh LHW, Chng SP, Choong HL, Tan BS.

Radiology. 2018 Oct;289(1):238-247. doi: 10.1148/radiol.2018170806. Epub 2018 Jul 24.


The architecture of the OmpC-MlaA complex sheds light on the maintenance of outer membrane lipid asymmetry in Escherichia coli.

Yeow J, Tan KW, Holdbrook DA, Chong ZS, Marzinek JK, Bond PJ, Chng SS.

J Biol Chem. 2018 Jul 20;293(29):11325-11340. doi: 10.1074/jbc.RA118.002441. Epub 2018 May 30.


Pathogenomic Analysis of Wheat Yellow Rust Lineages Detects Seasonal Variation and Host Specificity.

Bueno-Sancho V, Persoons A, Hubbard A, Cabrera-Quio LE, Lewis CM, Corredor-Moreno P, Bunting DCE, Ali S, Chng S, Hodson DP, Madariaga Burrows R, Bryson R, Thomas J, Holdgate S, Saunders DGO.

Genome Biol Evol. 2017 Dec 1;9(12):3282-3296. doi: 10.1093/gbe/evx241.


MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis.

Isom GL, Davies NJ, Chong ZS, Bryant JA, Jamshad M, Sharif M, Cunningham AF, Knowles TJ, Chng SS, Cole JA, Henderson IR.

Sci Rep. 2017 Aug 17;7(1):8608. doi: 10.1038/s41598-017-09111-6.


Outer membrane lipid homeostasis via retrograde phospholipid transport in Escherichia coli.

Shrivastava R, Jiang X, Chng SS.

Mol Microbiol. 2017 Nov;106(3):395-408. doi: 10.1111/mmi.13772. Epub 2017 Sep 6.


A case report of an anterior tibial artery pseudo-aneurysm open surgical management: A rare complication post total knee arthroplasty.

Darius Aw KL, Tan CC, Ch'ng JK, Chng SP.

Int J Surg Case Rep. 2017;37:196-199. doi: 10.1016/j.ijscr.2017.06.037. Epub 2017 Jun 28.


MmpL3 is the flippase for mycolic acids in mycobacteria.

Xu Z, Meshcheryakov VA, Poce G, Chng SS.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):7993-7998. doi: 10.1073/pnas.1700062114. Epub 2017 Jul 11.


Biological parameters used in setting captive-breeding quotas for Indonesia's breeding facilities.

Janssen J, Chng SCL.

Conserv Biol. 2018 Feb;32(1):18-25. doi: 10.1111/cobi.12978. Epub 2017 Sep 26.


ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.

Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B.

Science. 2017 Aug 18;357(6352):707-713. doi: 10.1126/science.aam6607. Epub 2017 Jun 29.


Percutaneous Endovascular Treatment to Salvage Non-Maturing Arteriovenous Fistulas in a Multiethnic Asian Population.

Tham WP, Burgmans MC, Tan BS, Tay KH, Irani FG, Gogna A, Patel A, Lo RH, Chng SP, Choong HL, Chan SX.

Ann Acad Med Singapore. 2017 Feb;46(2):64-71.


Quantitative imaging reveals real-time Pou5f3-Nanog complexes driving dorsoventral mesendoderm patterning in zebrafish.

Perez-Camps M, Tian J, Chng SC, Sem KP, Sudhaharan T, Teh C, Wachsmuth M, Korzh V, Ahmed S, Reversade B.

Elife. 2016 Sep 29;5. pii: e11475. doi: 10.7554/eLife.11475.


A Two-Layer Gene Circuit for Decoupling Cell Growth from Metabolite Production.

Lo TM, Chng SH, Teo WS, Cho HS, Chang MW.

Cell Syst. 2016 Aug;3(2):133-143. doi: 10.1016/j.cels.2016.07.012.


Defining key roles for auxiliary proteins in an ABC transporter that maintains bacterial outer membrane lipid asymmetry.

Thong S, Ercan B, Torta F, Fong ZY, Wong HY, Wenk MR, Chng SS.

Elife. 2016 Aug 16;5. pii: e19042. doi: 10.7554/eLife.19042.


Role of Vfr in the regulation of antifungal compound production by Pseudomonas fluorescens FD6.

Zhang Q, Ji Y, Xiao Q, Chng S, Tong Y, Chen X, Liu F.

Microbiol Res. 2016 Jul-Aug;188-189:106-112. doi: 10.1016/j.micres.2016.04.013. Epub 2016 May 2.


Commuting and wellbeing in London: The roles of commute mode and local public transport connectivity.

Chng S, White M, Abraham C, Skippon S.

Prev Med. 2016 Jul;88:182-8. doi: 10.1016/j.ypmed.2016.04.014. Epub 2016 Apr 16.


The Apelin receptor enhances Nodal/TGFβ signaling to ensure proper cardiac development.

Deshwar AR, Chng SC, Ho L, Reversade B, Scott IC.

Elife. 2016 Apr 14;5. pii: e13758. doi: 10.7554/eLife.13758.


Ablating the aryl hydrocarbon receptor (AhR) in CD11c+ cells perturbs intestinal epithelium development and intestinal immunity.

Chng SH, Kundu P, Dominguez-Brauer C, Teo WL, Kawajiri K, Fujii-Kuriyama Y, Mak TW, Pettersson S.

Sci Rep. 2016 Apr 12;6:23820. doi: 10.1038/srep23820.


Parental comments: Relationship with gender, body dissatisfaction, and disordered eating in Asian young adults.

Chng SC, Fassnacht DB.

Body Image. 2016 Mar;16:93-9. doi: 10.1016/j.bodyim.2015.12.001. Epub 2016 Jan 12.


The gut microbiota keeps enteric glial cells on the move; prospective roles of the gut epithelium and immune system.

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V.

Gut Microbes. 2015;6(6):398-403. doi: 10.1080/19490976.2015.1109767.


ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Ho L, Tan SY, Wee S, Wu Y, Tan SJ, Ramakrishna NB, Chng SC, Nama S, Szczerbinska I, Chan YS, Avery S, Tsuneyoshi N, Ng HH, Gunaratne J, Dunn NR, Reversade B.

Cell Stem Cell. 2015 Oct 1;17(4):435-47. doi: 10.1016/j.stem.2015.08.010. Epub 2015 Sep 17. Erratum in: Cell Stem Cell. 2015 Nov 5;17(5):635. Sczerbinska, Iwona [corrected to Szczerbinska, Iwona].


Osmoporin OmpC forms a complex with MlaA to maintain outer membrane lipid asymmetry in Escherichia coli.

Chong ZS, Woo WF, Chng SS.

Mol Microbiol. 2015 Dec;98(6):1133-46. doi: 10.1111/mmi.13202. Epub 2015 Sep 25.


The hormonal peptide Elabela guides angioblasts to the midline during vasculogenesis.

Helker CS, Schuermann A, Pollmann C, Chng SC, Kiefer F, Reversade B, Herzog W.

Elife. 2015 May 27;4. doi: 10.7554/eLife.06726.


Microbiota controls the homeostasis of glial cells in the gut lamina propria.

Kabouridis PS, Lasrado R, McCallum S, Chng SH, Snippert HJ, Clevers H, Pettersson S, Pachnis V.

Neuron. 2015 Jan 21;85(2):289-95. doi: 10.1016/j.neuron.2014.12.037. Epub 2015 Jan 8.


Evaluation of a Multidisciplinary Home-Based Medication Review Program for Elderly Singaporeans.

Ong KY, Chng SG, Chen LL, Cheen HH, Lim SH, Lim PS, Ng SM, Chang WT.

Value Health. 2014 Nov;17(7):A791. doi: 10.1016/j.jval.2014.08.435. Epub 2014 Oct 26. No abstract available.


Effects of A Multidisciplinary Home-Based Medication Review Program On Hospital Admissions In Older Adult Singaporeans.

Cheen HH, Ong KY, Lim SH, Chng SG, Chen LL, Lim PS, Ng SM, Chang WT.

Value Health. 2014 Nov;17(7):A506. doi: 10.1016/j.jval.2014.08.1538. Epub 2014 Oct 26. No abstract available.


ELABELA: a hormone essential for heart development signals via the apelin receptor.

Chng SC, Ho L, Tian J, Reversade B.

Dev Cell. 2013 Dec 23;27(6):672-80. doi: 10.1016/j.devcel.2013.11.002. Epub 2013 Dec 5.


Randomized clinical trial of cutting balloon angioplasty versus high-pressure balloon angioplasty in hemodialysis arteriovenous fistula stenoses resistant to conventional balloon angioplasty.

Aftab SA, Tay KH, Irani FG, Gong Lo RH, Gogna A, Haaland B, Tan SG, Chng SP, Pasupathy S, Choong HL, Tan BS.

J Vasc Interv Radiol. 2014 Feb;25(2):190-8. doi: 10.1016/j.jvir.2013.10.020. Epub 2013 Dec 5.


Disulfide rearrangement triggered by translocon assembly controls lipopolysaccharide export.

Chng SS, Xue M, Garner RA, Kadokura H, Boyd D, Beckwith J, Kahne D.

Science. 2012 Sep 28;337(6102):1665-8. Epub 2012 Aug 30.


Overexpression of the rhodanese PspE, a single cysteine-containing protein, restores disulphide bond formation to an Escherichia coli strain lacking DsbA.

Chng SS, Dutton RJ, Denoncin K, Vertommen D, Collet JF, Kadokura H, Beckwith J.

Mol Microbiol. 2012 Sep;85(5):996-1006. doi: 10.1111/j.1365-2958.2012.08157.x. Epub 2012 Jul 19.


Postgraduate family medicine training in Singapore--a new way forward.

Wong TY, Chong PN, Chng SK, Tay EG.

Ann Acad Med Singapore. 2012 May;41(5):221-6.


Scope and mechanistic studies of electrophilic alkoxyetherification.

Chen J, Chng S, Zhou L, Yeung YY.

Org Lett. 2011 Dec 16;13(24):6456-9. doi: 10.1021/ol202751s. Epub 2011 Nov 16.


Lipoprotein LptE is required for the assembly of LptD by the beta-barrel assembly machine in the outer membrane of Escherichia coli.

Chimalakonda G, Ruiz N, Chng SS, Garner RA, Kahne D, Silhavy TJ.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2492-7. doi: 10.1073/pnas.1019089108. Epub 2011 Jan 21.


The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel.

Freinkman E, Chng SS, Kahne D.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2486-91. doi: 10.1073/pnas.1015617108. Epub 2011 Jan 21.


Compliance with topical nasal medication--an evaluation in children with rhinitis.

Wong IY, Soh SE, Chng SY, Shek LP, Goh DY, Van Bever HP, Lee BW.

Pediatr Allergy Immunol. 2010 Dec;21(8):1146-50. doi: 10.1111/j.1399-3038.2010.01015.x. Epub 2010 Aug 16.


Nonconsecutive disulfide bond formation in an essential integral outer membrane protein.

Ruiz N, Chng SS, Hiniker A, Kahne D, Silhavy TJ.

Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12245-50. doi: 10.1073/pnas.1007319107. Epub 2010 Jun 21.


Proteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex.

Chng SS, Gronenberg LS, Kahne D.

Biochemistry. 2010 Jun 8;49(22):4565-7. doi: 10.1021/bi100493e.


Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane.

Chng SS, Ruiz N, Chimalakonda G, Silhavy TJ, Kahne D.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5363-8. doi: 10.1073/pnas.0912872107. Epub 2010 Mar 4.


Distribution of cerebral blood flow in the nucleus caudatus, nucleus lentiformis, and thalamus: a study of territorial arterial spin-labeling MR imaging.

Hendrikse J, Petersen ET, Chng SM, Venketasubramanian N, Golay X.

Radiology. 2010 Mar;254(3):867-75. doi: 10.1148/radiol.09090284. Epub 2010 Jan 20.


Self-expanding nitinol stents in recanalisation of long-length superficial femoral artery occlusions in patients with critical limb ischaemia.

Taneja M, Tay KH, Sebastian M, Pasupathy S, Lin SE, Teo T, Low R, Irani FG, Chng SP, Dewan A, Tan BS.

Singapore Med J. 2009 Dec;50(12):1184-8.


Magnetic resonance imaging in acute optic neuritis in Singapore.

Lim SA, Sitoh YY, Chng SM, Boey PY, Goh KY.

Ann Acad Med Singapore. 2009 Sep;38(9):821-6.


Cerebral venous infarction during a high altitude expedition.

Cheng S, Chng SM, Singh R.

Singapore Med J. 2009 Aug;50(8):e306-8.


A cross-sectional study on reference ranges of normal oral temperatures among students in Singapore.

Kwang YP, Ma S, Chng SY, Chia FM, Leong KK.

Ann Acad Med Singapore. 2009 Jul;38(7):613-8.


Mutations in PYCR1 cause cutis laxa with progeroid features.

Reversade B, Escande-Beillard N, Dimopoulou A, Fischer B, Chng SC, Li Y, Shboul M, Tham PY, Kayserili H, Al-Gazali L, Shahwan M, Brancati F, Lee H, O'Connor BD, Schmidt-von Kegler M, Merriman B, Nelson SF, Masri A, Alkazaleh F, Guerra D, Ferrari P, Nanda A, Rajab A, Markie D, Gray M, Nelson J, Grix A, Sommer A, Savarirayan R, Janecke AR, Steichen E, Sillence D, Hausser I, Budde B, Nürnberg G, Nürnberg P, Seemann P, Kunkel D, Zambruno G, Dallapiccola B, Schuelke M, Robertson S, Hamamy H, Wollnik B, Van Maldergem L, Mundlos S, Kornak U.

Nat Genet. 2009 Sep;41(9):1016-21. doi: 10.1038/ng.413. Epub 2009 Aug 2.


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