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Advancements in Life Cycle Human Exposure and Toxicity Characterization.

Fantke P, Aylward L, Bare J, Chiu WA, Dodson R, Dwyer R, Ernstoff A, Howard B, Jantunen M, Jolliet O, Judson R, Kirchhübel N, Li D, Miller A, Paoli G, Price P, Rhomberg L, Shen B, Shin HM, Teeguarden J, Vallero D, Wambaugh J, Wetmore BA, Zaleski R, McKone TE.

Environ Health Perspect. 2018 Dec;126(12):125001. doi: 10.1289/EHP3871.


Key Characteristics Approach to Carcinogenic Hazard Identification.

Guyton KZ, Rieswijk L, Wang A, Chiu WA, Smith MT.

Chem Res Toxicol. 2018 Dec 6. doi: 10.1021/acs.chemrestox.8b00321. [Epub ahead of print]


Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships.

Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Rusyn I, Chiu WA.

Clin Pharmacol Ther. 2018 Oct 22. doi: 10.1002/cpt.1259. [Epub ahead of print]


Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip.

Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I.

Sci Rep. 2018 Oct 5;8(1):14882. doi: 10.1038/s41598-018-33099-2.


Modulation of Tetrachloroethylene-Associated Kidney Effects by Nonalcoholic Fatty Liver or Steatohepatitis in Male C57BL/6J Mice.

Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2019 Jan 1;167(1):126-137. doi: 10.1093/toxsci/kfy223.


Comparative analysis of metabolism of trichloroethylene and tetrachloroethylene among mouse tissues and strains.

Luo YS, Hsieh NH, Soldatow VY, Chiu WA, Rusyn I.

Toxicology. 2018 Nov 1;409:33-43. doi: 10.1016/j.tox.2018.07.012. Epub 2018 Jul 24.


Determinants for asthma control, quality of life and use of complementary and alternative medicine in asthmatic pediatric patients in four cities.

Hon KL, Bao YM, Chan KC, Chau KW, Chen RS, Cheok KTG, Chiu WK, Deng L, He CH, Ieong KM, Kung JSC, Lam P, Lam SYD, Lee QU, Lee SL, Leung TF, Leung TNH, Shi L, Siu KK, Tan WP, Wang MH, Wong TW, Wu BJ, Yip AYF, Zheng YJ, Ng DK.

World J Pediatr. 2018 Oct;14(5):482-491. doi: 10.1007/s12519-018-0167-1. Epub 2018 Jul 25.


A human population-based organotypic in vitro model for cardiotoxicity screening.

Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I.

ALTEX. 2018;35(4):441-452. doi: 10.14573/altex.1805301. Epub 2018 Jul 8.


Re: 'Application of the key characteristics of carcinogens in cancer hazard evaluation': response to Goodman, Lynch and Rhomberg.

Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT.

Carcinogenesis. 2018 Jul 3. doi: 10.1093/carcin/bgy082. [Epub ahead of print] No abstract available.


Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects.

Chiu WA, Axelrad DA, Dalaijamts C, Dockins C, Shao K, Shapiro AJ, Paoli G.

Environ Health Perspect. 2018 Jun 28;126(6):067009. doi: 10.1289/EHP3368. eCollection 2018 Jun.


Applying a Global Sensitivity Analysis Workflow to Improve the Computational Efficiencies in Physiologically-Based Pharmacokinetic Modeling.

Hsieh NH, Reisfeld B, Bois FY, Chiu WA.

Front Pharmacol. 2018 Jun 8;9:588. doi: 10.3389/fphar.2018.00588. eCollection 2018.


Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice.

Dalaijamts C, Cichocki JA, Luo YS, Rusyn I, Chiu WA.

Toxicol Appl Pharmacol. 2018 Aug 1;352:142-152. doi: 10.1016/j.taap.2018.05.033. Epub 2018 May 29.


Conditional Toxicity Value (CTV) Predictor: An In Silico Approach for Generating Quantitative Risk Estimates for Chemicals.

Wignall JA, Muratov E, Sedykh A, Guyton KZ, Tropsha A, Rusyn I, Chiu WA.

Environ Health Perspect. 2018 May 29;126(5):057008. doi: 10.1289/EHP2998. eCollection 2018 May.


Influenza vaccine effectiveness in hospitalised Hong Kong children: Feasibility of estimates from routine surveillance data.

Yeung KHT, Chan KCC, Chan PKS, Lam DSY, Sham PCO, Yau YS, Chan WH, Chiu WK, Ng KL, Ng DKK, Chan IMC, Nelson EAS.

Vaccine. 2018 Jun 7;36(24):3477-3485. doi: 10.1016/j.vaccine.2018.04.081. Epub 2018 May 5.


Application of the key characteristics of carcinogens in cancer hazard identification.

Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT.

Carcinogenesis. 2018 Apr 5;39(4):614-622. doi: 10.1093/carcin/bgy031.


Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse.

Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I.

Mamm Genome. 2018 Feb;29(1-2):168-181. doi: 10.1007/s00335-018-9734-y. Epub 2018 Jan 20.


Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities.

Chiu WA, Rusyn I.

Mamm Genome. 2018 Feb;29(1-2):182-189. doi: 10.1007/s00335-017-9731-6. Epub 2018 Jan 3.


APROBA-Plus: A probabilistic tool to evaluate and express uncertainty in hazard characterization and exposure assessment of substances.

Bokkers BGH, Mengelers MJ, Bakker MI, Chiu WA, Slob W.

Food Chem Toxicol. 2017 Dec;110:408-417. doi: 10.1016/j.fct.2017.10.038. Epub 2017 Oct 23.


Editor's Highlight: Comparative Dose-Response Analysis of Liver and Kidney Transcriptomic Effects of Trichloroethylene and Tetrachloroethylene in B6C3F1 Mouse.

Zhou YH, Cichocki JA, Soldatow VY, Scholl EH, Gallins PJ, Jima D, Yoo HS, Chiu WA, Wright FA, Rusyn I.

Toxicol Sci. 2017 Nov 1;160(1):95-110. doi: 10.1093/toxsci/kfx165.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Oct 1;159(2):481. doi: 10.1093/toxsci/kfx158. No abstract available.


Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice.

Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

Toxicol Sci. 2017 Sep 1;159(1):102-113. doi: 10.1093/toxsci/kfx120. Erratum in: Toxicol Sci. 2017 Oct 1;159(2):481.


Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I.

ALTEX. 2018;35(1):51-64. doi: 10.14573/altex.1703231. Epub 2017 Jul 24.


Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population.

Cichocki JA, Furuya S, Venkatratnam A, McDonald TJ, Knap AH, Wade T, Sweet S, Chiu WA, Threadgill DW, Rusyn I.

Environ Health Perspect. 2017 May 30;125(5):057006. doi: 10.1289/EHP788.


Grouping of Petroleum Substances as Example UVCBs by Ion Mobility-Mass Spectrometry to Enable Chemical Composition-Based Read-Across.

Grimm FA, Russell WK, Luo YS, Iwata Y, Chiu WA, Roy T, Boogaard PJ, Ketelslegers HB, Rusyn I.

Environ Sci Technol. 2017 Jun 20;51(12):7197-7207. doi: 10.1021/acs.est.6b06413. Epub 2017 May 26.


Editor's Highlight: Collaborative Cross Mouse Population Enables Refinements to Characterization of the Variability in Toxicokinetics of Trichloroethylene and Provides Genetic Evidence for the Role of PPAR Pathway in Its Oxidative Metabolism.

Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I.

Toxicol Sci. 2017 Jul 1;158(1):48-62. doi: 10.1093/toxsci/kfx065.


In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model.

Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR.

Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1.


Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice.

Cichocki JA, Furuya S, Konganti K, Luo YS, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I.

J Pharmacol Exp Ther. 2017 Apr;361(1):17-28. doi: 10.1124/jpet.116.238790. Epub 2017 Feb 1.


A tiered, Bayesian approach to estimating of population variability for regulatory decision-making.

Chiu WA, Wright FA, Rusyn I.

ALTEX. 2017;34(3):377-388. doi: 10.14573/altex.1608251. Epub 2016 Dec 13.


The Next Generation of Risk Assessment Multi-Year Study-Highlights of Findings, Applications to Risk Assessment, and Future Directions.

Cote I, Andersen ME, Ankley GT, Barone S, Birnbaum LS, Boekelheide K, Bois FY, Burgoon LD, Chiu WA, Crawford-Brown D, Crofton KM, DeVito M, Devlin RB, Edwards SW, Guyton KZ, Hattis D, Judson RS, Knight D, Krewski D, Lambert J, Maull EA, Mendrick D, Paoli GM, Patel CJ, Perkins EJ, Poje G, Portier CJ, Rusyn I, Schulte PA, Simeonov A, Smith MT, Thayer KA, Thomas RS, Thomas R, Tice RR, Vandenberg JJ, Villeneuve DL, Wesselkamper S, Whelan M, Whittaker C, White R, Xia M, Yauk C, Zeise L, Zhao J, DeWoskin RS.

Environ Health Perspect. 2016 Nov;124(11):1671-1682. Epub 2016 Apr 19. Review.


Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps.

Cichocki JA, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH.

J Pharmacol Exp Ther. 2016 Oct;359(1):110-23. doi: 10.1124/jpet.116.232629. Epub 2016 Aug 10. Review.


Development and application of a rat PBPK model to elucidate kidney and liver effects induced by ETBE and tert-butanol.

Salazar KD, Brinkerhoff CJ, Lee JS, Chiu WA.

Toxicol Appl Pharmacol. 2015 Nov 1;288(3):439-52. doi: 10.1016/j.taap.2015.08.015. Epub 2015 Sep 2.


The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.

Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I.

Toxicol Sci. 2015 Oct;147(2):339-49. doi: 10.1093/toxsci/kfv134. Epub 2015 Jul 1.


A Unified Probabilistic Framework for Dose-Response Assessment of Human Health Effects.

Chiu WA, Slob W.

Environ Health Perspect. 2015 Dec;123(12):1241-54. doi: 10.1289/ehp.1409385. Epub 2015 May 22. Review.


Benchmark Dose for Urinary Cadmium based on a Marker of Renal Dysfunction: A Meta-Analysis.

Woo HD, Chiu WA, Jo S, Kim J.

PLoS One. 2015 May 13;10(5):e0126680. doi: 10.1371/journal.pone.0126680. eCollection 2015.


Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.

Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA.

Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.


Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity.

Lash LH, Chiu WA, Guyton KZ, Rusyn I.

Mutat Res Rev Mutat Res. 2014 Oct-Dec;762:22-36. Review.


A framework for the next generation of risk science.

Krewski D, Westphal M, Andersen ME, Paoli GM, Chiu WA, Al-Zoughool M, Croteau MC, Burgoon LD, Cote I.

Environ Health Perspect. 2014 Aug;122(8):796-805. doi: 10.1289/ehp.1307260. Epub 2014 Apr 11.


Standardizing benchmark dose calculations to improve science-based decisions in human health assessments.

Wignall JA, Shapiro AJ, Wright FA, Woodruff TJ, Chiu WA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):499-505. doi: 10.1289/ehp.1307539. Epub 2014 Feb 25.


Human health effects of tetrachloroethylene: key findings and scientific issues.

Guyton KZ, Hogan KA, Scott CS, Cooper GS, Bale AS, Kopylev L, Barone S, Makris SL, Glenn B, Subramaniam RP, Gwinn MR, Dzubow RC, Chiu WA.

Environ Health Perspect. 2014 Apr;122(4):325-34. doi: 10.1289/ehp.1307359. Epub 2014 Feb 14.


Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse.

Chiu WA, Campbell JL Jr, Clewell HJ 3rd, Zhou YH, Wright FA, Guyton KZ, Rusyn I.

Environ Health Perspect. 2014 May;122(5):456-63. doi: 10.1289/ehp.1307623. Epub 2014 Feb 11.


Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.

Rusyn I, Chiu WA, Lash LH, Kromhout H, Hansen J, Guyton KZ.

Pharmacol Ther. 2014 Jan;141(1):55-68. doi: 10.1016/j.pharmthera.2013.08.004. Epub 2013 Aug 23. Review.


A systematic approach for identifying and presenting mechanistic evidence in human health assessments.

Kushman ME, Kraft AD, Guyton KZ, Chiu WA, Makris SL, Rusyn I.

Regul Toxicol Pharmacol. 2013 Nov;67(2):266-77. doi: 10.1016/j.yrtph.2013.08.005. Epub 2013 Aug 16.


An approach for integrating toxicogenomic data in risk assessment: the dibutyl phthalate case study.

Euling SY, Thompson CM, Chiu WA, Benson R.

Toxicol Appl Pharmacol. 2013 Sep 15;271(3):324-35. doi: 10.1016/j.taap.2013.03.013. Epub 2013 Mar 26.


Human health effects of trichloroethylene: key findings and scientific issues.

Chiu WA, Jinot J, Scott CS, Makris SL, Cooper GS, Dzubow RC, Bale AS, Evans MV, Guyton KZ, Keshava N, Lipscomb JC, Barone S Jr, Fox JF, Gwinn MR, Schaum J, Caldwell JC.

Environ Health Perspect. 2013 Mar;121(3):303-11. doi: 10.1289/ehp.1205879. Epub 2012 Dec 18. Review.


Addressing human variability in next-generation human health risk assessments of environmental chemicals.

Zeise L, Bois FY, Chiu WA, Hattis D, Rusyn I, Guyton KZ.

Environ Health Perspect. 2013 Jan;121(1):23-31. doi: 10.1289/ehp.1205687. Epub 2012 Oct 19.


Approaches to human health risk assessment based on the signal-to-noise crossover dose.

Chiu WA, Guyton KZ, Hogan K, Jinot J.

Environ Health Perspect. 2012 Jul;120(7):a264; author reply a264-5. doi: 10.1289/ehp.1205212. No abstract available.


Follow up of aerobic capacity in children affected by severe acute respiratory syndrome.

Yu CC, Li AM, Au CT, McManus AM, So RC, Lam HS, Chu WC, So HK, Chiu WK, Leung CW, Yau YS, Fok TF, Sung RY.

Respirology. 2012 Apr;17(3):513-8. doi: 10.1111/j.1440-1843.2011.02125.x.


Trichloroacetic acid: updated estimates of its bioavailability and its contribution to trichloroethylene-induced mouse hepatomegaly.

Chiu WA.

Toxicology. 2011 Jul 29;285(3):114-25. doi: 10.1016/j.tox.2011.04.009. Epub 2011 Apr 28.


Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans.

Chiu WA, Ginsberg GL.

Toxicol Appl Pharmacol. 2011 Jun 15;253(3):203-34. doi: 10.1016/j.taap.2011.03.020. Epub 2011 Apr 3.


Approaches to advancing quantitative human health risk assessment of environmental chemicals in the post-genomic era.

Chiu WA, Euling SY, Scott CS, Subramaniam RP.

Toxicol Appl Pharmacol. 2013 Sep 15;271(3):309-23. doi: 10.1016/j.taap.2010.03.019. Epub 2010 Mar 29. Review.


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