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Items: 1 to 50 of 165

1.

Preferred end coordinates and somatic variants as signatures of circulating tumor DNA associated with hepatocellular carcinoma.

Jiang P, Sun K, Tong YK, Cheng SH, Cheng THT, Heung MMS, Wong J, Wong VWS, Chan HLY, Chan KCA, Lo YMD, Chiu RWK.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10925-E10933. doi: 10.1073/pnas.1814616115. Epub 2018 Oct 29.

2.

Sequencing of Circulating Cell-free DNA during Pregnancy.

Bianchi DW, Chiu RWK.

N Engl J Med. 2018 Aug 2;379(5):464-473. doi: 10.1056/NEJMra1705345. Review. No abstract available.

PMID:
30067923
3.

Liver- and Colon-Specific DNA Methylation Markers in Plasma for Investigation of Colorectal Cancers with or without Liver Metastases.

Gai W, Ji L, Lam WKJ, Sun K, Jiang P, Chan AWH, Wong J, Lai PBS, Ng SSM, Ma BBY, Wong GLH, Wong VWS, Chan HLY, Chiu RWK, Lo YMD, Chan KCA.

Clin Chem. 2018 Aug;64(8):1239-1249. doi: 10.1373/clinchem.2018.290304. Epub 2018 Jun 14.

PMID:
29903871
4.

Sequencing-based counting and size profiling of plasma Epstein-Barr virus DNA enhance population screening of nasopharyngeal carcinoma.

Lam WKJ, Jiang P, Chan KCA, Cheng SH, Zhang H, Peng W, Tse OYO, Tong YK, Gai W, Zee BCY, Ma BBY, Hui EP, Chan ATC, Woo JKS, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5115-E5124. doi: 10.1073/pnas.1804184115. Epub 2018 May 14.

5.

Size-tagged preferred ends in maternal plasma DNA shed light on the production mechanism and show utility in noninvasive prenatal testing.

Sun K, Jiang P, Wong AIC, Cheng YKY, Cheng SH, Zhang H, Chan KCA, Leung TY, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5106-E5114. doi: 10.1073/pnas.1804134115. Epub 2018 May 14.

6.

Noninvasive reconstruction of placental methylome from maternal plasma DNA: Potential for prenatal testing and monitoring.

Sun K, Lun FMF, Leung TY, Chiu RWK, Lo YMD, Sun H.

Prenat Diagn. 2018 Feb;38(3):196-203. doi: 10.1002/pd.5214. Epub 2018 Jan 31.

PMID:
29334402
7.

cfDNA screening and diagnosis of monogenic disorders - where are we heading?

Chiu EKL, Hui WWI, Chiu RWK.

Prenat Diagn. 2018 Jan;38(1):52-58. doi: 10.1002/pd.5207. Epub 2018 Jan 24.

8.

DNase1 Does Not Appear to Play a Major Role in the Fragmentation of Plasma DNA in a Knockout Mouse Model.

Cheng THT, Lui KO, Peng XL, Cheng SH, Jiang P, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2018 Feb;64(2):406-408. doi: 10.1373/clinchem.2017.280446. Epub 2017 Nov 2. No abstract available. Erratum in: Clin Chem. 2018 May;64(5):869.

PMID:
29097509
9.

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics.

Tsang JCH, Vong JSL, Ji L, Poon LCY, Jiang P, Lui KO, Ni YB, To KF, Cheng YKY, Chiu RWK, Lo YMD.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7786-E7795. doi: 10.1073/pnas.1710470114. Epub 2017 Aug 22.

10.

Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.

Chan KCA, Woo JKS, King A, Zee BCY, Lam WKJ, Chan SL, Chu SWI, Mak C, Tse IOL, Leung SYM, Chan G, Hui EP, Ma BBY, Chiu RWK, Leung SF, van Hasselt AC, Chan ATC, Lo YMD.

N Engl J Med. 2017 Aug 10;377(6):513-522. doi: 10.1056/NEJMoa1701717. Erratum in: N Engl J Med. 2018 Mar 8;378(10 ):973.

PMID:
28792880
11.

DNA of Erythroid Origin Is Present in Human Plasma and Informs the Types of Anemia.

Lam WKJ, Gai W, Sun K, Wong RSM, Chan RWY, Jiang P, Chan NPH, Hui WWI, Chan AWH, Szeto CC, Ng SC, Law MF, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2017 Oct;63(10):1614-1623. doi: 10.1373/clinchem.2017.272401. Epub 2017 Aug 7.

12.

Liquid biopsy of PIK3CA mutations in cervical cancer in Hong Kong Chinese women.

Chung TKH, Cheung TH, Yim SF, Yu MY, Chiu RWK, Lo KWK, Lee IPC, Wong RRY, Lau KKM, Wang VW, Worley MJ Jr, Elias KM, Fiascone SJ, Smith DI, Berkowitz RS, Wong YF.

Gynecol Oncol. 2017 Aug;146(2):334-339. doi: 10.1016/j.ygyno.2017.05.038. Epub 2017 Jun 3.

PMID:
28587748
13.

Noninvasive detection of F8 int22h-related inversions and sequence variants in maternal plasma of hemophilia carriers.

Hudecova I, Jiang P, Davies J, Lo YMD, Kadir RA, Chiu RWK.

Blood. 2017 Jul 20;130(3):340-347. doi: 10.1182/blood-2016-12-755017. Epub 2017 May 10.

14.

Emerging Considerations for Noninvasive Prenatal Testing.

Korpi-Steiner N, Chiu RWK, Chandrasekharan S, Chitty LS, Evans MI, Jackson JA, Palomaki GE.

Clin Chem. 2017 May;63(5):946-953. doi: 10.1373/clinchem.2016.266544. Epub 2017 Mar 15. No abstract available.

15.

Single-Stranded DNA Library Preparation Preferentially Enriches Short Maternal DNA in Maternal Plasma.

Vong JSL, Tsang JCH, Jiang P, Lee WS, Leung TY, Chan KCA, Chiu RWK, Lo YMD.

Clin Chem. 2017 May;63(5):1031-1037. doi: 10.1373/clinchem.2016.268656. Epub 2017 Mar 9.

16.

Genomewide bisulfite sequencing reveals the origin and time-dependent fragmentation of urinary cfDNA.

Cheng THT, Jiang P, Tam JCW, Sun X, Lee WS, Yu SCY, Teoh JYC, Chiu PKF, Ng CF, Chow KM, Szeto CC, Chan KCA, Chiu RWK, Lo YMD.

Clin Biochem. 2017 Jun;50(9):496-501. doi: 10.1016/j.clinbiochem.2017.02.017. Epub 2017 Feb 24.

17.

COFFEE: control-free noninvasive fetal chromosomal examination using maternal plasma DNA.

Sun K, Chan KC, Hudecova I, Chiu RW, Lo YM, Jiang P.

Prenat Diagn. 2017 Apr;37(4):336-340. doi: 10.1002/pd.5016. Epub 2017 Feb 17.

PMID:
28165140
18.

Gestational Age Assessment by Methylation and Size Profiling of Maternal Plasma DNA: A Feasibility Study.

Jiang P, Tong YK, Sun K, Cheng SH, Leung TY, Chan KC, Chiu RW, Lo YM.

Clin Chem. 2017 Feb;63(2):606-608. doi: 10.1373/clinchem.2016.265702. Epub 2016 Dec 15. No abstract available.

19.

Combined Count- and Size-Based Analysis of Maternal Plasma DNA for Noninvasive Prenatal Detection of Fetal Subchromosomal Aberrations Facilitates Elucidation of the Fetal and/or Maternal Origin of the Aberrations.

Yu SC, Jiang P, Chan KC, Faas BH, Choy KW, Leung WC, Leung TY, Lo YM, Chiu RW.

Clin Chem. 2017 Feb;63(2):495-502. doi: 10.1373/clinchem.2016.254813. Epub 2016 Dec 14.

20.

Universal Haplotype-Based Noninvasive Prenatal Testing for Single Gene Diseases.

Hui WW, Jiang P, Tong YK, Lee WS, Cheng YK, New MI, Kadir RA, Chan KC, Leung TY, Lo YM, Chiu RW.

Clin Chem. 2017 Feb;63(2):513-524. doi: 10.1373/clinchem.2016.268375. Epub 2016 Dec 8.

21.

Non-invasive prenatal diagnosis of thalassemias using maternal plasma cell free DNA.

Hudecova I, Chiu RW.

Best Pract Res Clin Obstet Gynaecol. 2017 Feb;39:63-73. doi: 10.1016/j.bpobgyn.2016.10.016. Epub 2016 Oct 26. Review.

PMID:
27887921
22.

Second generation noninvasive fetal genome analysis reveals de novo mutations, single-base parental inheritance, and preferred DNA ends.

Chan KC, Jiang P, Sun K, Cheng YK, Tong YK, Cheng SH, Wong AI, Hudecova I, Leung TY, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8159-E8168. Epub 2016 Oct 31.

23.

Cell-free DNA in maternal plasma and serum: A comparison of quantity, quality and tissue origin using genomic and epigenomic approaches.

Wong FC, Sun K, Jiang P, Cheng YK, Chan KC, Leung TY, Chiu RW, Lo YM.

Clin Biochem. 2016 Dec;49(18):1379-1386. doi: 10.1016/j.clinbiochem.2016.09.009. Epub 2016 Sep 9.

PMID:
27620950
24.

FetalQuantSD: accurate quantification of fetal DNA fraction by shallow-depth sequencing of maternal plasma DNA.

Jiang P, Peng X, Su X, Sun K, Yu SCY, Chu WI, Leung TY, Sun H, Chiu RWK, Lo YMD, Chan KCA.

NPJ Genom Med. 2016 May 11;1:16013. doi: 10.1038/npjgenmed.2016.13. eCollection 2016.

25.

Noninvasive prenatal testing beyond genomic analysis: what the future holds.

Hui WW, Chiu RW.

Curr Opin Obstet Gynecol. 2016 Apr;28(2):105-10. doi: 10.1097/GCO.0000000000000252. Review.

PMID:
26866842
26.

Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

Sun K, Jiang P, Chan KC, Wong J, Cheng YK, Liang RH, Chan WK, Ma ES, Chan SL, Cheng SH, Chan RW, Tong YK, Ng SS, Wong RS, Hui DS, Leung TN, Leung TY, Lai PB, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):E5503-12. doi: 10.1073/pnas.1508736112. Epub 2015 Sep 21.

27.

Circulating Nucleic Acids Special Issue.

Chiu RW, Oudejans CB.

Clin Biochem. 2015 Oct;48(15):931. doi: 10.1016/j.clinbiochem.2015.08.021. Epub 2015 Aug 24. No abstract available.

PMID:
26315671
28.

Noninvasive prenatal testing by nanopore sequencing of maternal plasma DNA: feasibility assessment.

Cheng SH, Jiang P, Sun K, Cheng YK, Chan KC, Leung TY, Chiu RW, Lo YM.

Clin Chem. 2015 Oct;61(10):1305-6. doi: 10.1373/clinchem.2015.245076. Epub 2015 Aug 18. No abstract available.

29.

Position statement from the Chromosome Abnormality Screening Committee on behalf of the Board of the International Society for Prenatal Diagnosis.

Benn P, Borrell A, Chiu RW, Cuckle H, Dugoff L, Faas B, Gross S, Huang T, Johnson J, Maymon R, Norton M, Odibo A, Schielen P, Spencer K, Wright D, Yaron Y.

Prenat Diagn. 2015 Aug;35(8):725-34. doi: 10.1002/pd.4608. Epub 2015 Jun 4. No abstract available.

PMID:
25970088
30.

Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients.

Jiang P, Chan CW, Chan KC, Cheng SH, Wong J, Wong VW, Wong GL, Chan SL, Mok TS, Chan HL, Lai PB, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2015 Mar 17;112(11):E1317-25. doi: 10.1073/pnas.1500076112. Epub 2015 Feb 2.

31.

Molecular diagnostics: a revolution in progress.

Chiu RW, Lo YM, Wittwer CT.

Clin Chem. 2015 Jan;61(1):1-3. doi: 10.1373/clinchem.2014.233361. No abstract available.

32.

Plasma DNA aberrations in systemic lupus erythematosus revealed by genomic and methylomic sequencing.

Chan RW, Jiang P, Peng X, Tam LS, Liao GJ, Li EK, Wong PC, Sun H, Chan KC, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):E5302-11. doi: 10.1073/pnas.1421126111. Epub 2014 Nov 26.

33.
34.

Noninvasive prenatal testing by maternal plasma DNA analysis: current practice and future applications.

Chiu RW.

Scand J Clin Lab Invest Suppl. 2014;244:48-53; discussion 51-2. doi: 10.3109/00365513.2014.936681.

PMID:
25083893
35.

Methy-Pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis.

Jiang P, Sun K, Lun FM, Guo AM, Wang H, Chan KC, Chiu RW, Lo YM, Sun H.

PLoS One. 2014 Jun 19;9(6):e100360. doi: 10.1371/journal.pone.0100360. eCollection 2014.

36.

Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing.

Yu SC, Chan KC, Zheng YW, Jiang P, Liao GJ, Sun H, Akolekar R, Leung TY, Go AT, van Vugt JM, Minekawa R, Oudejans CB, Nicolaides KH, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8583-8. doi: 10.1073/pnas.1406103111. Epub 2014 May 19.

37.

Maternal plasma RNA sequencing for genome-wide transcriptomic profiling and identification of pregnancy-associated transcripts.

Tsui NB, Jiang P, Wong YF, Leung TY, Chan KC, Chiu RW, Sun H, Lo YM.

Clin Chem. 2014 Jul;60(7):954-62. doi: 10.1373/clinchem.2014.221648. Epub 2014 Apr 16.

38.

Noninvasive prenatal diagnosis of congenital adrenal hyperplasia using cell-free fetal DNA in maternal plasma.

New MI, Tong YK, Yuen T, Jiang P, Pina C, Chan KC, Khattab A, Liao GJ, Yau M, Kim SM, Chiu RW, Sun L, Zaidi M, Lo YM.

J Clin Endocrinol Metab. 2014 Jun;99(6):E1022-30. doi: 10.1210/jc.2014-1118. Epub 2014 Feb 28.

39.

Maternal plasma fetal DNA fractions in pregnancies with low and high risks for fetal chromosomal aneuploidies.

Hudecova I, Sahota D, Heung MM, Jin Y, Lee WS, Leung TY, Lo YM, Chiu RW.

PLoS One. 2014 Feb 28;9(2):e88484. doi: 10.1371/journal.pone.0088484. eCollection 2014.

40.

Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing.

Chan KC, Jiang P, Chan CW, Sun K, Wong J, Hui EP, Chan SL, Chan WC, Hui DS, Ng SS, Chan HL, Wong CS, Ma BB, Chan AT, Lai PB, Sun H, Chiu RW, Lo YM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18761-8. doi: 10.1073/pnas.1313995110. Epub 2013 Nov 4.

41.

Noninvasive prenatal methylomic analysis by genomewide bisulfite sequencing of maternal plasma DNA.

Lun FM, Chiu RW, Sun K, Leung TY, Jiang P, Chan KC, Sun H, Lo YM.

Clin Chem. 2013 Nov;59(11):1583-94. doi: 10.1373/clinchem.2013.212274. Epub 2013 Jul 15.

42.

The potential clinical utility of serial plasma albumin mRNA monitoring for the post-liver transplantation management.

Chan RW, Wong J, Lai PB, Lo YM, Chiu RW.

Clin Biochem. 2013 Oct;46(15):1313-9. doi: 10.1016/j.clinbiochem.2013.04.022. Epub 2013 Apr 30.

PMID:
23643885
43.

Noninvasive prenatal molecular karyotyping from maternal plasma.

Yu SC, Jiang P, Choy KW, Chan KC, Won HS, Leung WC, Lau ET, Tang MH, Leung TY, Lo YM, Chiu RW.

PLoS One. 2013 Apr 17;8(4):e60968. doi: 10.1371/journal.pone.0060968. Print 2013.

44.

High-resolution profiling of fetal DNA clearance from maternal plasma by massively parallel sequencing.

Yu SC, Lee SW, Jiang P, Leung TY, Chan KC, Chiu RW, Lo YM.

Clin Chem. 2013 Aug;59(8):1228-37. doi: 10.1373/clinchem.2013.203679. Epub 2013 Apr 19.

45.

Noninvasive twin zygosity assessment and aneuploidy detection by maternal plasma DNA sequencing.

Leung TY, Qu JZ, Liao GJ, Jiang P, Cheng YK, Chan KC, Chiu RW, Lo YM.

Prenat Diagn. 2013 Jul;33(7):675-81. doi: 10.1002/pd.4132. Epub 2013 Apr 29.

PMID:
23595772
46.

High resolution size analysis of fetal DNA in the urine of pregnant women by paired-end massively parallel sequencing.

Tsui NB, Jiang P, Chow KC, Su X, Leung TY, Sun H, Chan KC, Chiu RW, Lo YM.

PLoS One. 2012;7(10):e48319. doi: 10.1371/journal.pone.0048319. Epub 2012 Oct 31.

47.

Noninvasive prenatal determination of twin zygosity by maternal plasma DNA analysis.

Qu JZ, Leung TY, Jiang P, Liao GJ, Cheng YK, Sun H, Chiu RW, Chan KC, Lo YM.

Clin Chem. 2013 Feb;59(2):427-35. doi: 10.1373/clinchem.2012.194068. Epub 2012 Oct 31.

48.

Clinical applications of maternal plasma fetal DNA analysis: translating the fruits of 15 years of research.

Chiu RW, Lo YM.

Clin Chem Lab Med. 2013 Jan;51(1):197-204. doi: 10.1515/cclm-2012-0601. Review.

PMID:
23072857
49.

Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing.

Chan KC, Jiang P, Zheng YW, Liao GJ, Sun H, Wong J, Siu SS, Chan WC, Chan SL, Chan AT, Lai PB, Chiu RW, Lo YM.

Clin Chem. 2013 Jan;59(1):211-24. doi: 10.1373/clinchem.2012.196014. Epub 2012 Oct 11.

50.

FetalQuant: deducing fractional fetal DNA concentration from massively parallel sequencing of DNA in maternal plasma.

Jiang P, Chan KC, Liao GJ, Zheng YW, Leung TY, Chiu RW, Lo YM, Sun H.

Bioinformatics. 2012 Nov 15;28(22):2883-90. doi: 10.1093/bioinformatics/bts549. Epub 2012 Sep 8.

PMID:
22962347

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