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Items: 1 to 50 of 85

1.

Towards a combinatorial approach for the prediction of immunoglobulin G half-life and clearance.

Goulet DR, Watson MJ, Tam SH, Zwolak A, Chiu ML, Atkins WM, Nath A.

Drug Metab Dispos. 2018 Sep 19. pii: dmd.118.081893. doi: 10.1124/dmd.118.081893. [Epub ahead of print]

PMID:
30232177
2.

Human IgG subclass cross-species reactivity to mouse and cynomolgus monkey Fcγ receptors.

Derebe MG, Nanjunda RK, Gilliland GL, Lacy ER, Chiu ML.

Immunol Lett. 2018 May;197:1-8. doi: 10.1016/j.imlet.2018.02.006. Epub 2018 Feb 21.

PMID:
29476755
3.

Unique pharmacology of a novel allosteric agonist/sensitizer insulin receptor monoclonal antibody.

Hinke SA, Cieniewicz AM, Kirchner T, D'Aquino K, Nanjunda R, Aligo J, Perkinson R, Cooper P, Boayke K, Chiu ML, Jarantow S, Lacy ER, Liang Y, Johnson DL, Whaley JM, Lingham RB, Kihm AJ.

Mol Metab. 2018 Apr;10:87-99. doi: 10.1016/j.molmet.2018.01.014. Epub 2018 Feb 3.

4.

FcγRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody.

Zhang D, Whitaker B, Derebe MG, Chiu ML.

MAbs. 2018 Apr;10(3):463-475. doi: 10.1080/19420862.2018.1424611. Epub 2018 Jan 29.

5.

Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies.

Goulet DR, Orcutt SJ, Zwolak A, Rispens T, Labrijn AF, de Jong RN, Atkins WM, Chiu ML.

J Biol Chem. 2018 Jan 12;293(2):651-661. doi: 10.1074/jbc.RA117.000303. Epub 2017 Nov 17.

6.

Rapid Purification of Human Bispecific Antibodies via Selective Modulation of Protein A Binding.

Zwolak A, Leettola CN, Tam SH, Goulet DR, Derebe MG, Pardinas JR, Zheng S, Decker R, Emmell E, Chiu ML.

Sci Rep. 2017 Nov 14;7(1):15521. doi: 10.1038/s41598-017-15748-0.

7.

Modulation of protein A binding allows single-step purification of mouse bispecific antibodies that retain FcRn binding.

Zwolak A, Armstrong AA, Tam SH, Pardinas JR, Goulet DR, Zheng S, Brosnan K, Emmell E, Luo J, Gilliland GL, Chiu ML.

MAbs. 2017 Nov/Dec;9(8):1306-1316. doi: 10.1080/19420862.2017.1375639. Epub 2017 Sep 12.

8.

Functional optimization of agonistic antibodies to OX40 receptor with novel Fc mutations to promote antibody multimerization.

Zhang D, Armstrong AA, Tam SH, McCarthy SG, Luo J, Gilliland GL, Chiu ML.

MAbs. 2017 Oct;9(7):1129-1142. doi: 10.1080/19420862.2017.1358838. Epub 2017 Jul 31.

9.

Efficient Generation of Bispecific Murine Antibodies for Pre-Clinical Investigations in Syngeneic Rodent Models.

Labrijn AF, Meesters JI, Bunce M, Armstrong AA, Somani S, Nesspor TC, Chiu ML, Altintaş I, Verploegen S, Schuurman J, Parren PWHI.

Sci Rep. 2017 May 30;7(1):2476. doi: 10.1038/s41598-017-02823-9.

10.

Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum.

Goulet DR, Zwolak A, Chiu ML, Nath A, Atkins WM.

Biochemistry. 2017 May 2;56(17):2251-2260. doi: 10.1021/acs.biochem.6b01097. Epub 2017 Apr 14.

11.

Cohort Profile: The Taiwan MJ Cohort: half a million Chinese with repeated health surveillance data.

Wu X, Tsai SP, Tsao CK, Chiu ML, Tsai MK, Lu PJ, Lee JH, Chen CH, Wen C, Chang SS, Hsu CY, Wen CP.

Int J Epidemiol. 2017 Dec 1;46(6):1744-1744g. doi: 10.1093/ije/dyw282. No abstract available.

PMID:
28204597
12.

Fc Engineering Approaches to Enhance the Agonism and Effector Functions of an Anti-OX40 Antibody.

Zhang D, Goldberg MV, Chiu ML.

J Biol Chem. 2016 Dec 30;291(53):27134-27146. doi: 10.1074/jbc.M116.757773. Epub 2016 Nov 17.

13.

Novel Monoclonal Antibody Is an Allosteric Insulin Receptor Antagonist That Induces Insulin Resistance.

Cieniewicz AM, Kirchner T, Hinke SA, Nanjunda R, D'Aquino K, Boayke K, Cooper PR, Perkinson R, Chiu ML, Jarantow S, Johnson DL, Whaley JM, Lacy ER, Lingham RB, Liang Y, Kihm AJ.

Diabetes. 2017 Jan;66(1):206-217. doi: 10.2337/db16-0633. Epub 2016 Oct 26.

14.

Fc-mediated activity of EGFR x c-Met bispecific antibody JNJ-61186372 enhanced killing of lung cancer cells.

Grugan KD, Dorn K, Jarantow SW, Bushey BS, Pardinas JR, Laquerre S, Moores SL, Chiu ML.

MAbs. 2017 Jan;9(1):114-126. doi: 10.1080/19420862.2016.1249079. Epub 2016 Oct 27.

15.

Engineering antibody therapeutics.

Chiu ML, Gilliland GL.

Curr Opin Struct Biol. 2016 Jun;38:163-73. doi: 10.1016/j.sbi.2016.07.012. Epub 2016 Aug 12. Review.

16.

Physical activity to overcome the adversity of widowhood: Benefits beyond physical health.

Li CS, Lee JH, Chang LY, Liu CC, Chan YL, Wen C, Chiu ML, Tsai MK, Tsai SP, Wai JP, Tsao CK, Wu X, Wen CP.

Medicine (Baltimore). 2016 Aug;95(32):e4413. doi: 10.1097/MD.0000000000004413.

17.

A Novel Bispecific Antibody Targeting EGFR and cMet Is Effective against EGFR Inhibitor-Resistant Lung Tumors.

Moores SL, Chiu ML, Bushey BS, Chevalier K, Luistro L, Dorn K, Brezski RJ, Haytko P, Kelly T, Wu SJ, Martin PL, Neijssen J, Parren PW, Schuurman J, Attar RM, Laquerre S, Lorenzi MV, Anderson GM.

Cancer Res. 2016 Jul 1;76(13):3942-53. doi: 10.1158/0008-5472.CAN-15-2833. Epub 2016 May 23.

18.

An efficient process of generating bispecific antibodies via controlled Fab-arm exchange using culture supernatants.

Paul S, Connor J, Nesspor T, Haytko P, Boakye K, Chiu ML, Jiang H.

Protein Expr Purif. 2016 May;121:133-40. doi: 10.1016/j.pep.2016.01.014. Epub 2016 Jan 27.

PMID:
26826313
19.

Impact of Cell-surface Antigen Expression on Target Engagement and Function of an Epidermal Growth Factor Receptor × c-MET Bispecific Antibody.

Jarantow SW, Bushey BS, Pardinas JR, Boakye K, Lacy ER, Sanders R, Sepulveda MA, Moores SL, Chiu ML.

J Biol Chem. 2015 Oct 9;290(41):24689-704. doi: 10.1074/jbc.M115.651653. Epub 2015 Aug 10.

20.

Prompt Oseltamivir Therapy Reduces Medical Care and Mortality for Patients With Influenza Infection: An Asian Population Cohort Study.

Wang CB, Chiu ML, Lin PC, Liang WM, Chen CY, Chang YJ, Wu TN, Wang JH, Sung FC.

Medicine (Baltimore). 2015 Jul;94(27):e1070. doi: 10.1097/MD.0000000000001070.

21.

High-throughput assay for measuring monoclonal antibody self-association and aggregation in serum.

Li X, Geng SB, Chiu ML, Saro D, Tessier PM.

Bioconjug Chem. 2015 Mar 18;26(3):520-8. doi: 10.1021/acs.bioconjchem.5b00010. Epub 2015 Mar 6.

PMID:
25714504
22.

Raman spectroscopy characterization of antibody phases in serum.

Baker AE, Mantz AR, Chiu ML.

MAbs. 2014;6(6):1509-17. doi: 10.4161/19420862.2014.975100.

23.

Is conization once following by simple hysterectomy sufficient for all clinical stage IA1 cervical squamous cell carcinoma?

Chen JR, Chiu ML, Wang TY, Chen TC, Wang KG, Su TH, Chang CL, Yang YC, Wang KL.

Taiwan J Obstet Gynecol. 2013 Sep;52(3):385-8. doi: 10.1016/j.tjog.2012.12.004.

24.

Quantification of TRPV1 protein levels in rat tissues to understand its physiological roles.

Han P, Korepanova AV, Vos MH, Moreland RB, Chiu ML, Faltynek CR.

J Mol Neurosci. 2013 May;50(1):23-32. doi: 10.1007/s12031-012-9849-7. Epub 2012 Jul 14.

PMID:
22798269
25.

Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong.

Chiu ML, Hu M, Ng MH, Yeung CK, Chan JC, Chang MM, Cheng SH, Li L, Tomlinson B.

Br J Dermatol. 2012 Jul;167(1):44-9. doi: 10.1111/j.1365-2133.2012.10894.x. Epub 2012 May 8.

PMID:
22348415
26.

Introduction to membrane proteins.

Chiu ML.

Curr Protoc Protein Sci. 2012 Feb;Chapter 29:Unit 29.1. doi: 10.1002/0471140864.ps2901s67. Review.

PMID:
22294326
27.

Development of ELISA to measure TRPV1 protein in rat tissues.

Han P, Korepanova AV, Vos MH, Pereda-Lopez A, Lake MR, Bianchi BR, Moreland RB, Faltynek CR, Chiu ML.

J Neurosci Methods. 2011 Sep 15;200(2):144-52. doi: 10.1016/j.jneumeth.2011.06.029. Epub 2011 Jul 6.

PMID:
21762727
28.

Characterization of morphine-glucose-6-phosphate dehydrogenase conjugates by mass spectrometry.

Chiu ML, Ytterberg AJ, Ogorzalek Loo RR, Loo JA, Monbouquette HG.

Bioconjug Chem. 2011 Aug 17;22(8):1595-604. doi: 10.1021/bc2001352. Epub 2011 Jul 7.

29.

A convenient homogeneous enzyme immunoassay for estradiol detection.

Chiu ML, Tseng TT, Monbouquette HG.

Biotechnol Appl Biochem. 2011 Jan-Feb;58(1):75-82. doi: 10.1002/bab.5.

PMID:
21446962
30.

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

Wertz IE, Kusam S, Lam C, Okamoto T, Sandoval W, Anderson DJ, Helgason E, Ernst JA, Eby M, Liu J, Belmont LD, Kaminker JS, O'Rourke KM, Pujara K, Kohli PB, Johnson AR, Chiu ML, Lill JR, Jackson PK, Fairbrother WJ, Seshagiri S, Ludlam MJ, Leong KG, Dueber EC, Maecker H, Huang DC, Dixit VM.

Nature. 2011 Mar 3;471(7336):110-4. doi: 10.1038/nature09779. Erratum in: Nature. 2011 Jul 7;475(7354):122.

PMID:
21368834
31.

An influenza hemagglutinin A peptide assay based on the enzyme-multiplied immunoassay technique.

Chiu ML, Lai D, Monbouquette HG.

J Immunoassay Immunochem. 2011;32(1):1-17. doi: 10.1080/15321819.2011.538623.

PMID:
21253966
32.

Cerebral metabolic changes in neurologically presymptomatic patients undergoing haemodialysis: in vivo proton MR spectroscopic findings.

Chiu ML, Li CW, Chang JM, Chiang IC, Ko CH, Chuang HY, Sheu RS, Lee CC, Hsieh TJ.

Eur Radiol. 2010 Jun;20(6):1502-7. doi: 10.1007/s00330-009-1673-2. Epub 2009 Dec 8.

PMID:
19997847
33.

Distinction between pyogenic brain abscess and necrotic brain tumour using 3-tesla MR spectroscopy, diffusion and perfusion imaging.

Chiang IC, Hsieh TJ, Chiu ML, Liu GC, Kuo YT, Lin WC.

Br J Radiol. 2009 Oct;82(982):813-20. doi: 10.1259/bjr/90100265. Epub 2009 May 26.

PMID:
19470568
34.

Expression and purification of human TRPV1 in baculovirus-infected insect cells for structural studies.

Korepanova A, Pereda-Lopez A, Solomon LR, Walter KA, Lake MR, Bianchi BR, McDonald HA, Neelands TR, Shen J, Matayoshi ED, Moreland RB, Chiu ML.

Protein Expr Purif. 2009 May;65(1):38-50. doi: 10.1016/j.pep.2008.12.006. Epub 2008 Dec 13.

PMID:
19121396
35.

Over-expression, solubilization, and purification of G protein-coupled receptors for structural biology.

Chiu ML, Tsang C, Grihalde N, MacWilliams MP.

Comb Chem High Throughput Screen. 2008 Jul;11(6):439-62. Review.

PMID:
18673272
36.

Generalized granuloma annulare associated with gastrointestinal stromal tumour: case report and review of clinical features and management.

Chiu ML, Tang MB.

Clin Exp Dermatol. 2008 Jul;33(4):469-71. doi: 10.1111/j.1365-2230.2007.02681.x. Epub 2008 Feb 28.

PMID:
18312456
37.

Angiodysplasia mimicking colon cancer: colonoscopy, double contrast barium enema, and CT findings.

Chiu ML, Liu GC, Liu CS, Chen CY.

AJR Am J Roentgenol. 2007 May;188(5):W456-8. No abstract available.

PMID:
17449743
38.

Cardiovascular complications of severe acute respiratory syndrome.

Yu CM, Wong RS, Wu EB, Kong SL, Wong J, Yip GW, Soo YO, Chiu ML, Chan YS, Hui D, Lee N, Wu A, Leung CB, Sung JJ.

Postgrad Med J. 2006 Feb;82(964):140-4.

39.

Crystallization of bacteriorhodopsin solubilized by a tripod amphiphile.

Theisen MJ, Potocky TB, McQuade DT, Gellman SH, Chiu ML.

Biochim Biophys Acta. 2005 Aug 10;1751(2):213-6.

PMID:
15963773
40.

Prevalence of Cryptosporidium for foreign workers in Taiwan.

Lee JD, Chiu ML, Chung LY, Yen CM.

Trop Doct. 2004 Jul;34(3):185-6. No abstract available.

PMID:
15267060
41.

Rat cytochrome P450C24 (CYP24A1) and the role of F249 in substrate binding and catalytic activity.

Annalora A, Bobrovnikova-Marjon E, Serda R, Lansing L, Chiu ML, Pastuszyn A, Iyer S, Marcus CB, Omdahl JL.

Arch Biochem Biophys. 2004 May 15;425(2):133-46.

PMID:
15111121
42.

Epidermal growth factor receptor is a cellular receptor for human cytomegalovirus.

Wang X, Huong SM, Chiu ML, Raab-Traub N, Huang ES.

Nature. 2003 Jul 24;424(6947):456-61.

PMID:
12879076
43.

Ligand-induced changes in the Streptomyces lividans TipAL protein imply an alternative mechanism of transcriptional activation for MerR-like proteins.

Chiu ML, Viollier PH, Katoh T, Ramsden JJ, Thompson CJ.

Biochemistry. 2001 Oct 30;40(43):12950-8.

PMID:
11669632
44.

Crystallization in cubo: general applicability to membrane proteins.

Chiu ML, Nollert P, Loewen MC, Belrhali H, Pebay-Peyroula E, Rosenbusch JP, Landau EM.

Acta Crystallogr D Biol Crystallogr. 2000 Jun;56(Pt 6):781-4.

PMID:
10818364
46.

Broad spectrum thiopeptide recognition specificity of the Streptomyces lividans TipAL protein and its role in regulating gene expression.

Chiu ML, Folcher M, Katoh T, Puglia AM, Vohradsky J, Yun BS, Seto H, Thompson CJ.

J Biol Chem. 1999 Jul 16;274(29):20578-86.

47.

Lipidic Cubic Phases: New Matrices for the Three-Dimensional Crystallization of Membrane Proteins.

Rummel G, Hardmeyer A, Widmer C, Chiu ML, Nollert P, Locher KP, Pedruzzi I I, Landau EM, Rosenbusch JP.

J Struct Biol. 1998;121(2):82-91.

PMID:
9618339
48.
49.

Characterization of the covalent binding of thiostrepton to a thiostrepton-induced protein from Streptomyces lividans.

Chiu ML, Folcher M, Griffin P, Holt T, Klatt T, Thompson CJ.

Biochemistry. 1996 Feb 20;35(7):2332-41.

PMID:
8652574
50.

Influence of human serum on the postantifungal effect induced by therapeutic concentrations of ketoconazole and 5-fluorocytosine.

Lima JE, Minguez F, Chiu ML, Garcia MT, Guardiola L, Prieto J.

J Chemother. 1995 Nov;7 Suppl 4:38-9. No abstract available.

PMID:
8904100

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