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Items: 13


MAP3K11/GDF15 axis is a critical driver of cancer cachexia.

Lerner L, Tao J, Liu Q, Nicoletti R, Feng B, Krieger B, Mazsa E, Siddiquee Z, Wang R, Huang L, Shen L, Lin J, Vigano A, Chiu MI, Weng Z, Winston W, Weiler S, Gyuris J.

J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):467-82. doi: 10.1002/jcsm.12077. Epub 2015 Oct 29.


Plasma growth differentiation factor 15 is associated with weight loss and mortality in cancer patients.

Lerner L, Hayes TG, Tao N, Krieger B, Feng B, Wu Z, Nicoletti R, Chiu MI, Gyuris J, Garcia JM.

J Cachexia Sarcopenia Muscle. 2015 Dec;6(4):317-24. doi: 10.1002/jcsm.12033. Epub 2015 Apr 30.


Spontaneous genomic alterations in a chimeric model of colorectal cancer enable metastasis and guide effective combinatorial therapy.

Zhou Y, Rideout WM 3rd, Bressel A, Yalavarthi S, Zi T, Potz D, Farlow S, Brodeur J, Monti A, Reddipalli S, Xiao Q, Bottega S, Feng B, Chiu MI, Bosenberg M, Heyer J.

PLoS One. 2014 Aug 27;9(8):e105886. doi: 10.1371/journal.pone.0105886. eCollection 2014.


Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer.

Buck E, Gokhale PC, Koujak S, Brown E, Eyzaguirre A, Tao N, Rosenfeld-Franklin M, Lerner L, Chiu MI, Wild R, Epstein D, Pachter JA, Miglarese MR.

Mol Cancer Ther. 2010 Oct;9(10):2652-64. doi: 10.1158/1535-7163.MCT-10-0318. Epub 2010 Oct 5.


Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas.

Zhou Y, Rideout WM 3rd, Zi T, Bressel A, Reddypalli S, Rancourt R, Woo JK, Horner JW, Chin L, Chiu MI, Bosenberg M, Jacks T, Clark SC, Depinho RA, Robinson MO, Heyer J.

Nat Biotechnol. 2010 Jan;28(1):71-8. doi: 10.1038/nbt.1595. Epub 2009 Dec 20.


De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model.

Watters JW, Cheng C, Majumder PK, Wang R, Yalavarthi S, Meeske C, Kong L, Sun W, Lin J, Heyer J, Ware C, Winter C, Reilly JF, Demuth T, Clark S, Chiu MI, Robinson MO, Kohl N, Kannan K.

Cancer Res. 2009 Dec 1;69(23):8949-57. doi: 10.1158/0008-5472.CAN-09-1544. Epub 2009 Nov 10.


The ubiquitin-mediated proteolytic pathway as a therapeutic area.

Rolfe M, Chiu MI, Pagano M.

J Mol Med (Berl). 1997 Jan;75(1):5-17. Review.


RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

Chiu MI, Katz H, Berlin V.

Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12574-8.


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