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Items: 1 to 50 of 92

1.

A fatal case of COQ7-associated primary coenzyme Q10 deficiency.

Kwong AK, Chiu AT, Tsang MH, Lun KS, Rodenburg RJT, Smeitink J, Chung BH, Fung CW.

JIMD Rep. 2019 Apr 3;47(1):23-29. doi: 10.1002/jmd2.12032. eCollection 2019 May.

2.

Healthcare burden of rare diseases in Hong Kong - adopting ORPHAcodes in ICD-10 based healthcare administrative datasets.

Chiu ATG, Chung CCY, Wong WHS, Lee SL, Chung BHY.

Orphanet J Rare Dis. 2018 Aug 28;13(1):147. doi: 10.1186/s13023-018-0892-5. Review.

3.

Spinal Muscular Atrophy With Respiratory Distress Type 1-A Child With Atypical Presentation.

Chiu ATG, Chan SHS, Wu SP, Ting SH, Chung BHY, Chan AOK, Wong VCN.

Child Neurol Open. 2018 Apr 19;5:2329048X18769811. doi: 10.1177/2329048X18769811. eCollection 2018.

4.

Okur-Chung neurodevelopmental syndrome: Eight additional cases with implications on phenotype and genotype expansion.

Chiu ATG, Pei SLC, Mak CCY, Leung GKC, Yu MHC, Lee SL, Vreeburg M, Pfundt R, van der Burgt I, Kleefstra T, Frederic TM, Nambot S, Faivre L, Bruel AL, Rossi M, Isidor B, Küry S, Cogne B, Besnard T, Willems M, Reijnders MRF, Chung BHY.

Clin Genet. 2018 Apr;93(4):880-890. doi: 10.1111/cge.13196. Epub 2018 Feb 13.

PMID:
29240241
5.

Use of clinical chromosomal microarray in Chinese patients with autism spectrum disorder-implications of a copy number variation involving DPP10.

Mak ASL, Chiu ATG, Leung GKC, Mak CCY, Chu YWY, Mok GTK, Tang WF, Chan KYK, Tang MHY, Lau Yim ET, So KW, Tao VQ, Fung CW, Wong VCN, Uddin M, Lee SL, Marshall CR, Scherer SW, Kan ASY, Chung BHY.

Mol Autism. 2017 Jun 26;8:31. doi: 10.1186/s13229-017-0136-x. eCollection 2017.

6.

A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146-Literature review and update.

Chiu AT, Leung GK, Chu YW, Gripp KW, Chung BH.

Am J Med Genet A. 2017 Apr;173(4):1109-1114. doi: 10.1002/ajmg.a.38118.

PMID:
28328122
7.

Before and after - Nutritional transformation of dysmorphism in a case of Costello syndrome.

Chiu AT, Zhu L, Mok GT, Leung GK, Chow CB, Chung BH.

Eur J Med Genet. 2016 Nov;59(11):573-576. doi: 10.1016/j.ejmg.2016.10.001. Epub 2016 Oct 2.

PMID:
27705751
8.

Gene therapy, gene targeting and induced pluripotent stem cells: applications in monogenic disease treatment.

Wong GK, Chiu AT.

Biotechnol Adv. 2011 Jan-Feb;29(1):1-10. doi: 10.1016/j.biotechadv.2010.07.005. Epub 2010 Jul 22.

PMID:
20656005
9.

Gene therapy, gene targeting and induced pluripotent stem cells: applications in monogenic disease treatment.

Wong GK, Chiu AT.

Biotechnol Adv. 2010 Nov-Dec;28(6):715-24. doi: 10.1016/j.biotechadv.2010.05.019. Epub 2010 May 17.

PMID:
20483370
10.

Combined spinal-epidural analgesia in the management of labouring parturients with mitral stenosis.

Ngan Kee WD, Shen J, Chiu AT, Lok I, Khaw KS.

Anaesth Intensive Care. 1999 Oct;27(5):523-6.

11.

Discovery of losartan, the first angiotensin II receptor antagonist.

Timmermans PB, Duncia JV, Carini DJ, Chiu AT, Wong PC, Wexler RR, Smith RD.

J Hum Hypertens. 1995 Nov;9 Suppl 5:S3-18. Review.

PMID:
8583479
12.

Pharmacology and pharmacokinetics of a novel nonpeptide angiotensin II receptor antagonist--DMP 811.

Wong PC, Huang SM, Ardecky RJ, Carini DJ, Chiu AT, Price WA Jr, Agra AM, Wexler RR, Timmermans PB.

Clin Exp Hypertens. 1995 Nov;17(8):1233-56.

PMID:
8563699
13.

Balanced AT1/AT2 receptor antagonists. 4. XR510 and related 5-(3-amidopropanoyl)imidazoles possessing equal affinity for the AT1 and AT2 receptors.

Quan ML, Chiu AT, Ellis CD, Wong PC, Wexler RR, Timmermans PB.

J Med Chem. 1995 Jul 21;38(15):2938-45.

PMID:
7636854
14.

The preclinical basis of the therapeutic evaluation of losartan.

Timmermans PB, Wong PC, Chiu AT, Smith RD.

J Hypertens Suppl. 1995 Jul;13(1):S1-13. Review.

PMID:
18800450
15.

Proposed update of angiotensin receptor nomenclature.

de Gasparo M, Husain A, Alexander W, Catt KJ, Chiu AT, Drew M, Goodfriend T, Harding JW, Inagami T, Timmermans PB.

Hypertension. 1995 May;25(5):924-7. No abstract available.

PMID:
7737728
16.

Novel angiotensin receptor subtypes in fowl.

Nishimura H, Walker OE, Patton CM, Madison AB, Chiu AT, Keiser J.

Am J Physiol. 1994 Nov;267(5 Pt 2):R1174-81.

PMID:
7977843
17.

Properties of angiotensin II receptors of domestic turkey (Meleagris gallopavo) adrenal steroidogenic cells.

Kocsis JF, McIlroy PJ, Chiu AT, Schimmel RJ, Carsia RV.

Gen Comp Endocrinol. 1994 Oct;96(1):92-107.

PMID:
7843572
18.

EXP597, a nonpeptide angiotensin II receptor antagonist with high affinities for the angiotensin AT1 and AT2 receptor subtypes.

Wong PC, Duncia JV, Santella JB 3rd, Smith RD, Wexler RR, Timmermans PB, Chiu AT.

Eur J Pharmacol. 1994 Aug 1;260(2-3):261-4.

PMID:
7988654
19.

The ligand binding signatures of the rat AT1A, AT1B and the human AT1 receptors are essentially identical.

Chiu AT, Dunscomb J, Kosierowski J, Burton CR, Santomenna LD, Corjay MH, Benfield P.

Biochem Biophys Res Commun. 1993 Dec 15;197(2):440-9.

PMID:
8267579
20.

A novel series of selective, non-peptide inhibitors of angiotensin II binding to the AT2 site.

VanAtten MK, Ensinger CL, Chiu AT, McCall DE, Nguyen TT, Wexler RR, Timmermans PB.

J Med Chem. 1993 Dec 10;36(25):3985-92.

PMID:
8258820
21.

EXP063, a nonpeptide angiotensin II and beta adrenergic receptor antagonist.

Wong PC, Duncia JV, Chiu AT, Olson RE, Rominger DH, Tam SW, Timmermans PB.

J Pharmacol Exp Ther. 1993 Nov;267(2):641-7.

PMID:
7902431
22.

New perspectives in angiotensin system control.

Timmermans PB, Wong PC, Chiu AT, Herblin WF, Smith RD.

J Hum Hypertens. 1993 Aug;7 Suppl 2:S19-31. Review.

PMID:
8230085
23.

Angiotensin II receptors and angiotensin II receptor antagonists.

Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD.

Pharmacol Rev. 1993 Jun;45(2):205-51. Review. No abstract available.

PMID:
8372104
24.
25.

Characterization of angiotensin AT1A receptor isoform by its ligand binding signature.

Chiu AT, Dunscomb JH, McCall DE, Benfield P, Baubonis W, Sauer B.

Regul Pept. 1993 Mar 19;44(2):141-7.

PMID:
8469769
26.

Angiotensin II receptors and functional correlates.

Timmermans PB, Benfield P, Chiu AT, Herblin WF, Wong PC, Smith RD.

Am J Hypertens. 1992 Dec;5(12 Pt 2):221S-235S. Review.

PMID:
1290617
27.

Rationale for the chemical development of angiotensin II receptor antagonists.

Wexler RR, Carini DJ, Duncia JV, Johnson AL, Wells GJ, Chiu AT, Wong PC, Timmermans PB.

Am J Hypertens. 1992 Dec;5(12 Pt 2):209S-220S. Review.

PMID:
1290616
28.

[125I]EXP985: a highly potent and specific nonpeptide radioligand antagonist for the AT1 angiotensin receptor.

Chiu AT, McCall DE, Roscoe WA.

Biochem Biophys Res Commun. 1992 Nov 16;188(3):1030-9.

PMID:
1445340
29.

AT1 receptors mediate the release of prostaglandins in porcine smooth muscle cells and rat astrocytes.

Leung KH, Chang RS, Lotti VJ, Roscoe WA, Smith RD, Timmermans PB, Chiu AT.

Am J Hypertens. 1992 Sep;5(9):648-56.

PMID:
1418854
30.

Characterization of biochemical responses of angiotensin II (AT2) binding sites in the rat pheochromocytoma PC12W cells.

Leung KH, Roscoe WA, Smith RD, Timmermans PB, Chiu AT.

Eur J Pharmacol. 1992 Sep 1;227(1):63-70.

PMID:
1330640
31.

Angiotensin II receptor antagonists and receptor subtypes.

Wong PC, Chiu AT, Duncia JV, Herblin WF, Smith RD, Timmermans PB.

Trends Endocrinol Metab. 1992 Aug;3(6):211-7.

PMID:
18407102
32.

Angiotensin II receptor subtypes.

Timmermans PB, Chiu AT, Herblin WF, Wong PC, Smith RD.

Am J Hypertens. 1992 Jun;5(6 Pt 1):406-10. Review.

PMID:
1524767
33.

Angiotensin II exerts its effect on aldosterone production and potassium permeability through receptor subtype AT1 in rat adrenal glomerulosa cells.

Hajnóczky G, Csordás G, Bagó A, Chiu AT, Spät A.

Biochem Pharmacol. 1992 Mar 3;43(5):1009-12.

PMID:
1554376
34.

The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist.

Duncia JV, Carini DJ, Chiu AT, Johnson AL, Price WA, Wong PC, Wexler RR, Timmermans PB.

Med Res Rev. 1992 Mar;12(2):149-91. Review. No abstract available.

PMID:
1619965
35.

Pharmacology of nonpeptide angiotensin II receptor antagonists.

Smith RD, Chiu AT, Wong PC, Herblin WF, Timmermans PB.

Annu Rev Pharmacol Toxicol. 1992;32:135-65. Review. No abstract available.

PMID:
1605566
36.

Multiple angiotensin receptors: selective ligands and functional correlates.

Timmermans PB, Chiu AT, Herblin WF, Smith RD, Wong PC.

Jpn J Pharmacol. 1992;58 Suppl 2:135P-141P. Review. No abstract available.

37.

Novel non-peptide angiotensin II receptor antagonists.

Timmermans PB, Chiu AT, Smith RD, Wong PC.

Proc West Pharmacol Soc. 1992;35:65-71. Review. No abstract available.

PMID:
1502242
38.

Angiotensin II receptor antagonists. From discovery to antihypertensive drugs.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Wexler RR, Johnson AL.

Hypertension. 1991 Nov;18(5 Suppl):III136-42. Review.

PMID:
1937677
39.

Pharmacology of DuP 532, a selective and noncompetitive AT1 receptor antagonist.

Wong PC, Hart SD, Chiu AT, Herblin WF, Carini DJ, Smith RD, Wexler RR, Timmermans PB.

J Pharmacol Exp Ther. 1991 Nov;259(2):861-70.

PMID:
1941632
40.
41.

Inhibition of the thrombin-platelet reactions by DuP 714.

Chiu AT, Mousa SA, Pease LJ, Roscoe WA, Bozarth JM, Reilly TM, Smith RD, Timmermans PB.

Biochem Biophys Res Commun. 1991 Sep 30;179(3):1500-8.

PMID:
1930190
42.

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

Carini DJ, Duncia JV, Aldrich PE, Chiu AT, Johnson AL, Pierce ME, Price WA, Santella JB 3rd, Wells GJ, Wexler RR, et al.

J Med Chem. 1991 Aug;34(8):2525-47.

PMID:
1875348
43.

DuP 532: a second generation of nonpeptide angiotensin II receptor antagonists.

Chiu AT, Carini DJ, Duncia JV, Leung KH, McCall DE, Price WA Jr, Wong PC, Smith RD, Wexler RR, Timmermans PB.

Biochem Biophys Res Commun. 1991 May 31;177(1):209-17.

PMID:
2043107
44.

Nomenclature for angiotensin receptors. A report of the Nomenclature Committee of the Council for High Blood Pressure Research.

Bumpus FM, Catt KJ, Chiu AT, DeGasparo M, Goodfriend T, Husain A, Peach MJ, Taylor DG Jr, Timmermans PB.

Hypertension. 1991 May;17(5):720-1. No abstract available.

PMID:
2022414
45.

In vivo pharmacology of DuP 753.

Wong PC, Price WA Jr, Chiu AT, Duncia JV, Carini DJ, Wexler RR, Johnson AL, Timmermans PB.

Am J Hypertens. 1991 Apr;4(4 Pt 2):288S-298S. Review.

PMID:
1854454
46.

In vitro pharmacology of DuP 753.

Chiu AT, McCall DE, Price WA Jr, Wong PC, Carini DJ, Duncia JV, Wexler RR, Yoo SE, Johnson AL, Timmermans PB.

Am J Hypertens. 1991 Apr;4(4 Pt 2):282S-287S. Review.

PMID:
1854453
47.

The discovery of a new class of highly specific nonpeptide angiotensin II receptor antagonists.

Timmermans PB, Carini DJ, Chiu AT, Duncia JV, Price WA Jr, Wells GJ, Wong PC, Johnson AL, Wexler RR.

Am J Hypertens. 1991 Apr;4(4 Pt 2):275S-281S. Review.

PMID:
1854452
48.

DuP 753 can antagonize the effects of angiotensin II in rat liver.

Bauer PH, Chiu AT, Garrison JC.

Mol Pharmacol. 1991 Apr;39(4):579-85.

PMID:
2017158
49.

Angiotensin II receptor heterogeneity.

Herblin WF, Chiu AT, McCall DE, Ardecky RJ, Carini DJ, Duncia JV, Pease LJ, Wong PC, Wexler RR, Johnson AL, et al.

Am J Hypertens. 1991 Apr;4(4 Pt 2):299S-302S.

PMID:
1854455
50.

Regional distribution of the two subtypes of angiotensin II receptor in rat brain using selective nonpeptide antagonists.

Leung KH, Smith RD, Pieter, Timmermans BM, Chiu AT.

Neurosci Lett. 1991 Feb 11;123(1):95-8.

PMID:
2062460

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