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Items: 20


Endothelial ERK1/2 signaling maintains integrity of the quiescent endothelium.

Ricard N, Scott RP, Booth CJ, Velazquez H, Cilfone NA, Baylon JL, Gulcher JR, Quaggin SE, Chittenden TW, Simons M.

J Exp Med. 2019 Aug 5;216(8):1874-1890. doi: 10.1084/jem.20182151. Epub 2019 Jun 13.


Enhancing Retrosynthetic Reaction Prediction with Deep Learning Using Multiscale Reaction Classification.

Baylon JL, Cilfone NA, Gulcher JR, Chittenden TW.

J Chem Inf Model. 2019 Feb 25;59(2):673-688. doi: 10.1021/acs.jcim.8b00801. Epub 2019 Feb 1.


Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.

Ayers KL, Glicksberg BS, Garfield AS, Longerich S, White JA, Yang P, Du L, Chittenden TW, Gulcher JR, Roy S, Fiedorek F, Gottesdiener K, Cohen S, North KE, Schadt EE, Li SD, Chen R, Van der Ploeg LHT.

J Clin Endocrinol Metab. 2018 Jul 1;103(7):2601-2612. doi: 10.1210/jc.2018-00258.


Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification.

Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK.

Nat Commun. 2018 Feb 14;9(1):720. doi: 10.1038/s41467-018-03076-4. No abstract available.


Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification.

Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK.

Nat Commun. 2017 Dec 15;8(1):2149. doi: 10.1038/s41467-017-01742-7.


Aging and neurodegeneration are associated with increased mutations in single human neurons.

Lodato MA, Rodin RE, Bohrson CL, Coulter ME, Barton AR, Kwon M, Sherman MA, Vitzthum CM, Luquette LJ, Yandava CN, Yang P, Chittenden TW, Hatem NE, Ryu SC, Woodworth MB, Park PJ, Walsh CA.

Science. 2018 Feb 2;359(6375):555-559. doi: 10.1126/science.aao4426. Epub 2017 Dec 7. Erratum in: Science. 2018 Jul 6;361(6397):.


FGF-dependent metabolic control of vascular development.

Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M.

Nature. 2017 May 11;545(7653):224-228. doi: 10.1038/nature22322. Epub 2017 May 3.


Cell types differ in global coordination of splicing and proportion of highly expressed genes.

Trakhtenberg EF, Pho N, Holton KM, Chittenden TW, Goldberg JL, Dong L.

Sci Rep. 2016 Aug 31;6:32249. doi: 10.1038/srep32249.


Somatic mutation in single human neurons tracks developmental and transcriptional history.

Lodato MA, Woodworth MB, Lee S, Evrony GD, Mehta BK, Karger A, Lee S, Chittenden TW, D'Gama AM, Cai X, Luquette LJ, Lee E, Park PJ, Walsh CA.

Science. 2015 Oct 2;350(6256):94-98. doi: 10.1126/science.aab1785.


Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase HERC2.

Galligan JT, Martinez-Noël G, Arndt V, Hayes S, Chittenden TW, Harper JW, Howley PM.

J Proteome Res. 2015 Feb 6;14(2):953-66. doi: 10.1021/pr501005v. Epub 2014 Dec 15.


Science and technology consortia in U.S. biomedical research: a paradigm shift in response to unsustainable academic growth.

Balch C, Arias-Pulido H, Banerjee S, Lancaster AK, Clark KB, Perilstein M, Hawkins B, Rhodes J, Sliz P, Wilkins J, Chittenden TW.

Bioessays. 2015 Feb;37(2):119-22. doi: 10.1002/bies.201400167. Epub 2014 Nov 12. No abstract available.


nEASE: a method for gene ontology subclassification of high-throughput gene expression data.

Chittenden TW, Howe EA, Taylor JM, Mar JC, Aryee MJ, Gómez H, Sultana R, Braisted J, Nair SJ, Quackenbush J, Holmes C.

Bioinformatics. 2012 Mar 1;28(5):726-8. doi: 10.1093/bioinformatics/bts011. Epub 2012 Jan 13.


Therapeutic implications of GIPC1 silencing in cancer.

Chittenden TW, Pak J, Rubio R, Cheng H, Holton K, Prendergast N, Glinskii V, Cai Y, Culhane A, Bentink S, Schwede M, Mar JC, Howe EA, Aryee M, Sultana R, Lanahan AA, Taylor JM, Holmes C, Hahn WC, Zhao JJ, Iglehart JD, Quackenbush J.

PLoS One. 2010 Dec 30;5(12):e15581. doi: 10.1371/journal.pone.0015581.


Functional classification analysis of somatically mutated genes in human breast and colorectal cancers.

Chittenden TW, Howe EA, Culhane AC, Sultana R, Taylor JM, Holmes C, Quackenbush J.

Genomics. 2008 Jun;91(6):508-11. doi: 10.1016/j.ygeno.2008.03.002. Epub 2008 Apr 22.


Synectin/syndecan-4 regulate coronary arteriolar growth during development.

Dedkov EI, Thomas MT, Sonka M, Yang F, Chittenden TW, Rhodes JM, Simons M, Ritman EL, Tomanek RJ.

Dev Dyn. 2007 Jul;236(7):2004-10.


Unique cardiopulmonary exercise test responses in overweight middle-aged adults with obstructive sleep apnea.

Kaleth AS, Chittenden TW, Hawkins BJ, Hargens TA, Guill SG, Zedalis D, Gregg JM, Herbert WG.

Sleep Med. 2007 Mar;8(2):160-8. Epub 2007 Feb 1.


Transcriptional profiling in coronary artery disease: indications for novel markers of coronary collateralization.

Chittenden TW, Sherman JA, Xiong F, Hall AE, Lanahan AA, Taylor JM, Duan H, Pearlman JD, Moore JH, Schwartz SM, Simons M.

Circulation. 2006 Oct 24;114(17):1811-20. Epub 2006 Oct 16.


Synectin-dependent gene expression in endothelial cells.

Lanahan AA, Chittenden TW, Mulvihill E, Smith K, Schwartz S, Simons M.

Physiol Genomics. 2006 Nov 27;27(3):380-90. Epub 2006 Aug 29.


Selective regulation of arterial branching morphogenesis by synectin.

Chittenden TW, Claes F, Lanahan AA, Autiero M, Palac RT, Tkachenko EV, Elfenbein A, Ruiz de Almodovar C, Dedkov E, Tomanek R, Li W, Westmore M, Singh JP, Horowitz A, Mulligan-Kehoe MJ, Moodie KL, Zhuang ZW, Carmeliet P, Simons M.

Dev Cell. 2006 Jun;10(6):783-95.


Automated migration analysis based on cell texture: method & reliability.

Qin J, Chittenden TW, Gao L, Pearlman JD.

BMC Cell Biol. 2005 Mar 3;6(1):9.

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