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Items: 1 to 50 of 121

1.

VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy.

Fonseca AM, González R, Bardají A, Jairoce C, Rupérez M, Jiménez A, Quintó L, Cisteró P, Vala A, Sacoor C, Gupta H, Hegewisch-Taylor J, Brew J, Ndam NT, Kariuki S, López M, Dobaño C, Chitnis CE, Ouma P, Ramharter M, Abdulla S, Aponte JJ, Massougbodji A, Briand V, Mombo-Ngoma G, Desai M, Cot M, Nhacolo A, Sevene E, Macete E, Menéndez C, Mayor A.

Emerg Infect Dis. 2019 Oct;25(10):1851-1860. doi: 10.3201/eid2510.181177.

2.

Blood cytokine, chemokine and growth factor profiling in a cohort of pregnant women from tropical countries.

Dobaño C, Bardají A, Kochar S, Kochar SK, Padilla N, López M, Unger HW, Ome-Kaius M, Castellanos ME, Arévalo-Herrera M, Hans D, Martínez-Espinosa FE, Bôtto-Menezes C, Malheiros A, Desai M, Casellas A, Chitnis CE, Rogerson S, Mueller I, Menéndez C, Requena P.

Cytokine. 2019 Sep 9;125:154818. doi: 10.1016/j.cyto.2019.154818. [Epub ahead of print]

PMID:
31514106
3.

Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission.

Singh P, Alaganan A, More KR, Lorthiois A, Thiberge S, Gorgette O, Guillotte Blisnick M, Guglielmini J, Aguilera SS, Touqui L, Singh S, Chitnis CE.

Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17498-17508. doi: 10.1073/pnas.1900266116. Epub 2019 Aug 14.

PMID:
31413195
4.

Development of Blood Stage Malaria Vaccines.

Vijayan A, Chitnis CE.

Methods Mol Biol. 2019;2013:199-218. doi: 10.1007/978-1-4939-9550-9_15.

PMID:
31267504
5.

Recombinant measles vaccine expressing malaria antigens induces long-term memory and protection in mice.

Mura M, Ruffié C, Combredet C, Aliprandini E, Formaglio P, Chitnis CE, Amino R, Tangy F.

NPJ Vaccines. 2019 Feb 27;4:12. doi: 10.1038/s41541-019-0106-8. eCollection 2019.

6.

Antibody responses to Plasmodium vivax Duffy binding and Erythrocyte binding proteins predict risk of infection and are associated with protection from clinical Malaria.

He WQ, Shakri AR, Bhardwaj R, França CT, Stanisic DI, Healer J, Kiniboro B, Robinson LJ, Guillotte-Blisnick M, Huon C, Siba P, Cowman A, King CL, Tham WH, Chitnis CE, Mueller I.

PLoS Negl Trop Dis. 2019 Feb 15;13(2):e0006987. doi: 10.1371/journal.pntd.0006987. eCollection 2019 Feb.

7.

Genetic diversity in two Plasmodium vivax protein ligands for reticulocyte invasion.

Roesch C, Popovici J, Bin S, Run V, Kim S, Ramboarina S, Rakotomalala E, Rakotoarison RL, Rasoloharimanana T, Andriamanantena Z, Kumar A, Guillotte-Blisnick M, Huon C, Serre D, Chitnis CE, Vigan-Womas I, Menard D.

PLoS Negl Trop Dis. 2018 Oct 22;12(10):e0006555. doi: 10.1371/journal.pntd.0006555. eCollection 2018 Oct.

8.

Malaria vaccine candidate based on Duffy-binding protein elicits strain transcending functional antibodies in a Phase I trial.

Singh K, Mukherjee P, Shakri AR, Singh A, Pandey G, Bakshi M, Uppal G, Jena R, Rawat A, Kumar P, Bhardwaj R, Yazdani SS, Hans D, Mehta S, Srinivasan A, Anil K, Madhusudhan RL, Patel J, Singh A, Rao R, Gangireddy S, Patil R, Kaviraj S, Singh S, Carter D, Reed S, Kaslow DC, Birkett A, Chauhan VS, Chitnis CE.

NPJ Vaccines. 2018 Sep 28;3:48. doi: 10.1038/s41541-018-0083-3. eCollection 2018.

9.

Targeting a Reticulocyte Binding Protein and Duffy Binding Protein to Inhibit Reticulocyte Invasion by Plasmodium vivax.

Gupta S, Singh S, Popovici J, Roesch C, Shakri AR, Guillotte-Blisnick M, Huon C, Menard D, Chitnis CE.

Sci Rep. 2018 Jul 12;8(1):10511. doi: 10.1038/s41598-018-28757-4.

10.

Analysis of factors affecting the variability of a quantitative suspension bead array assay measuring IgG to multiple Plasmodium antigens.

Ubillos I, Aguilar R, Sanz H, Jiménez A, Vidal M, Valmaseda A, Dong Y, Gaur D, Chitnis CE, Dutta S, Angov E, Aponte JJ, Campo JJ, Valim C, Harezlak J, Dobaño C.

PLoS One. 2018 Jul 2;13(7):e0199278. doi: 10.1371/journal.pone.0199278. eCollection 2018.

11.

IgM and IgG against Plasmodium falciparum lysate as surrogates of malaria exposure and protection during pregnancy.

Mayor A, Dobaño C, Nhabomba A, Guinovart C, Jiménez A, Manaca MN, Aguilar R, Barbosa A, Rodríguez MH, Cisteró P, Quimice LM, Menéndez C, Aponte JJ, Ordi J, Chitnis CE, Alonso PL.

Malar J. 2018 May 10;17(1):182. doi: 10.1186/s12936-018-2331-4.

12.

Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress.

Iyer GR, Singh S, Kaur I, Agarwal S, Siddiqui MA, Bansal A, Kumar G, Saini E, Paul G, Mohmmed A, Chitnis CE, Malhotra P.

J Biol Chem. 2018 Jun 22;293(25):9736-9746. doi: 10.1074/jbc.RA117.001540. Epub 2018 May 1.

13.

Identifying Immune Correlates of Protection Against Plasmodium falciparum Through a Novel Approach to Account for Heterogeneity in Malaria Exposure.

Valmaseda A, Macete E, Nhabomba A, Guinovart C, Aide P, Bardají A, Bassat Q, Nhampossa T, Maculuve S, Casellas A, Quintó L, Sanz S, Jiménez A, Feng G, Langer C, Reiling L, Reddy KS, Pandey A, Chitnis CE, Chauhan VS, Aguilar R, Aponte JJ, Dobaño C, Beeson JG, Gaur D, Menéndez C, Alonso PL, Mayor A.

Clin Infect Dis. 2018 Feb 1;66(4):586-593. doi: 10.1093/cid/cix837.

PMID:
29401272
14.

Assessment of the Combined Effect of Epstein-Barr Virus and Plasmodium falciparum Infections on Endemic Burkitt Lymphoma Using a Multiplex Serological Approach.

Aguilar R, Casabonne D, O'Callaghan-Gordo C, Vidal M, Campo JJ, Mutalima N, Angov E, Dutta S, Gaur D, Chitnis CE, Chauhan V, Michel A, de Sanjosé S, Waterboer T, Kogevinas M, Newton R, Dobaño C.

Front Immunol. 2017 Oct 26;8:1284. doi: 10.3389/fimmu.2017.01284. eCollection 2017.

15.

Human vaccination against Plasmodium vivax Duffy-binding protein induces strain-transcending antibodies.

Payne RO, Silk SE, Elias SC, Milne KH, Rawlinson TA, Llewellyn D, Shakri AR, Jin J, Labbé GM, Edwards NJ, Poulton ID, Roberts R, Farid R, Jørgensen T, Alanine DG, de Cassan SC, Higgins MK, Otto TD, McCarthy JS, de Jongh WA, Nicosia A, Moyle S, Hill AV, Berrie E, Chitnis CE, Lawrie AM, Draper SJ.

JCI Insight. 2017 Jun 15;2(12). pii: 93683. doi: 10.1172/jci.insight.93683. eCollection 2017 Jun 15.

16.

Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes.

Singh S, Chitnis CE.

Cold Spring Harb Perspect Med. 2017 Oct 3;7(10). pii: a026815. doi: 10.1101/cshperspect.a026815. Review.

17.

Molecular mechanisms that mediate invasion and egress of malaria parasites from red blood cells.

Alaganan A, Singh P, Chitnis CE.

Curr Opin Hematol. 2017 May;24(3):208-214. doi: 10.1097/MOH.0000000000000334. Review.

PMID:
28306665
18.

Cytoadhesion to gC1qR through Plasmodium falciparum Erythrocyte Membrane Protein 1 in Severe Malaria.

Magallón-Tejada A, Machevo S, Cisteró P, Lavstsen T, Aide P, Rubio M, Jiménez A, Turner L, Valmaseda A, Gupta H, De Las Salas B, Mandomando I, Wang CW, Petersen JE, Muñoz J, Gascón J, Macete E, Alonso PL, Chitnis CE, Bassat Q, Mayor A.

PLoS Pathog. 2016 Nov 11;12(11):e1006011. doi: 10.1371/journal.ppat.1006011. eCollection 2016 Nov.

19.

Production of recombinant PvDBPII, receptor binding domain of Plasmodium vivax Duffy binding protein, and evaluation of immunogenicity to identify an adjuvant formulation for vaccine development.

Bhardwaj R, Shakri AR, Hans D, Gupta P, Fernandez-Becerra C, Del Portillo HA, Pandey G, Chitnis CE.

Protein Expr Purif. 2017 Aug;136:52-57. doi: 10.1016/j.pep.2015.06.011. Epub 2015 Nov 11.

PMID:
26578115
20.

Workshop report: Malaria vaccine development in Europe--preparing for the future.

Viebig NK, D'Alessio F, Draper SJ, Sim BK, Mordmüller B, Bowyer PW, Luty AJ, Jungbluth S, Chitnis CE, Hill AV, Kremsner P, Craig AG, Kocken CH, Leroy O.

Vaccine. 2015 Nov 17;33(46):6137-44. doi: 10.1016/j.vaccine.2015.09.074. Epub 2015 Oct 1. Review.

PMID:
26431986
21.

Development of vaccines for Plasmodium vivax malaria.

Mueller I, Shakri AR, Chitnis CE.

Vaccine. 2015 Dec 22;33(52):7489-95. doi: 10.1016/j.vaccine.2015.09.060. Epub 2015 Oct 1. Review.

22.

Correction: Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175.

Chitnis CE, Mukherjee P, Mehta S, Yazdani SS, Dhawan S, Shakri AR, Bhardwaj R, Gupta PK, Hans D, Mazumdar S, Singh B, Kumar S, Pandey G, Parulekar V, Imbault N, Shivyogi P, Godbole G, Mohan K, Leroy O, Singh K, Chauhan VS.

PLoS One. 2015 Sep 2;10(9):e0137816. doi: 10.1371/journal.pone.0137816. eCollection 2015.

23.

Preclinical Assessment of Viral Vectored and Protein Vaccines Targeting the Duffy-Binding Protein Region II of Plasmodium Vivax.

de Cassan SC, Shakri AR, Llewellyn D, Elias SC, Cho JS, Goodman AL, Jin J, Douglas AD, Suwanarusk R, Nosten FH, Rénia L, Russell B, Chitnis CE, Draper SJ.

Front Immunol. 2015 Jul 8;6:348. doi: 10.3389/fimmu.2015.00348. eCollection 2015.

24.

Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.

Alam MM, Solyakov L, Bottrill AR, Flueck C, Siddiqui FA, Singh S, Mistry S, Viskaduraki M, Lee K, Hopp CS, Chitnis CE, Doerig C, Moon RW, Green JL, Holder AA, Baker DA, Tobin AB.

Nat Commun. 2015 Jul 7;6:7285. doi: 10.1038/ncomms8285.

25.

Phase I Clinical Trial of a Recombinant Blood Stage Vaccine Candidate for Plasmodium falciparum Malaria Based on MSP1 and EBA175.

Chitnis CE, Mukherjee P, Mehta S, Yazdani SS, Dhawan S, Shakri AR, Bhardwaj R, Gupta PK, Hans D, Mazumdar S, Singh B, Kumar S, Pandey G, Parulekar V, Imbault N, Shivyogi P, Godbole G, Mohan K, Leroy O, Singh K, Chauhan VS.

PLoS One. 2015 Apr 30;10(4):e0117820. doi: 10.1371/journal.pone.0117820. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0137816. Bharadwaj, Rukmini [corrected to Bhardwaj, Rukmini].

26.

Proinflammatory responses and higher IL-10 production by T cells correlate with protection against malaria during pregnancy and delivery outcomes.

Requena P, Barrios D, Robinson LJ, Samol P, Umbers AJ, Wangnapi R, Ome-Kaius M, Rosanas-Urgell A, Mayor A, López M, de Lazzari E, Arévalo-Herrera M, Fernández-Becerra C, del Portillo H, Chitnis CE, Siba PM, Rogerson S, Mueller I, Bardají A, Menéndez C, Dobaño C.

J Immunol. 2015 Apr 1;194(7):3275-85. doi: 10.4049/jimmunol.1401038. Epub 2015 Feb 27.

27.

The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes.

Dawn A, Singh S, More KR, Siddiqui FA, Pachikara N, Ramdani G, Langsley G, Chitnis CE.

PLoS Pathog. 2014 Dec 18;10(12):e1004520. doi: 10.1371/journal.ppat.1004520. eCollection 2014 Dec.

28.

Malaria and HIV infection in Mozambican pregnant women are associated with reduced transfer of antimalarial antibodies to their newborns.

Moro L, Bardají A, Nhampossa T, Mandomando I, Serra-Casas E, Sigaúque B, Cisteró P, Chauhan VS, Chitnis CE, Ordi J, Dobaño C, Alonso PL, Menéndez C, Mayor A.

J Infect Dis. 2015 Mar 15;211(6):1004-14. doi: 10.1093/infdis/jiu547. Epub 2014 Sep 30.

29.

Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels.

Requena P, Campo JJ, Umbers AJ, Ome M, Wangnapi R, Barrios D, Robinson LJ, Samol P, Rosanas-Urgell A, Ubillos I, Mayor A, López M, de Lazzari E, Arévalo-Herrera M, Fernández-Becerra C, del Portillo H, Chitnis CE, Siba PM, Bardají A, Mueller I, Rogerson S, Menéndez C, Dobaño C.

J Immunol. 2014 Sep 15;193(6):2971-83. doi: 10.4049/jimmunol.1401037. Epub 2014 Aug 18.

30.

Impact of age of first exposure to Plasmodium falciparum on antibody responses to malaria in children: a randomized, controlled trial in Mozambique.

Nhabomba AJ, Guinovart C, Jiménez A, Manaca MN, Quintó L, Cisteró P, Aguilar R, Barbosa A, Rodríguez MH, Bassat Q, Aponte JJ, Mayor A, Chitnis CE, Alonso PL, Dobaño C.

Malar J. 2014 Mar 27;13:121. doi: 10.1186/1475-2875-13-121.

31.

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes.

Wirth CC, Glushakova S, Scheuermayer M, Repnik U, Garg S, Schaack D, Kachman MM, Weißbach T, Zimmerberg J, Dandekar T, Griffiths G, Chitnis CE, Singh S, Fischer R, Pradel G.

Cell Microbiol. 2014 May;16(5):709-33. doi: 10.1111/cmi.12288. Epub 2014 Apr 4.

32.

Reticulocytes from cryopreserved erythroblasts support Plasmodium vivax infection in vitro.

Furuya T, Sá JM, Chitnis CE, Wellems TE, Stedman TT.

Parasitol Int. 2014 Apr;63(2):278-84. doi: 10.1016/j.parint.2013.11.011. Epub 2013 Dec 1.

33.

Bacterially expressed full-length recombinant Plasmodium falciparum RH5 protein binds erythrocytes and elicits potent strain-transcending parasite-neutralizing antibodies.

Reddy KS, Pandey AK, Singh H, Sahar T, Emmanuel A, Chitnis CE, Chauhan VS, Gaur D.

Infect Immun. 2014 Jan;82(1):152-64. doi: 10.1128/IAI.00970-13. Epub 2013 Oct 14.

34.

High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria.

Moncunill G, Mayor A, Jiménez A, Nhabomba A, Casas-Vila N, Puyol L, Campo JJ, Manaca MN, Aguilar R, Pinazo MJ, Almirall M, Soler C, Muñoz J, Bardají A, Angov E, Dutta S, Chitnis CE, Alonso PL, Gascón J, Dobaño C.

PLoS One. 2013 Aug 14;8(8):e73624. doi: 10.1371/journal.pone.0073624. eCollection 2013.

35.

Role of calcineurin and actin dynamics in regulated secretion of microneme proteins in Plasmodium falciparum merozoites during erythrocyte invasion.

Singh S, More KR, Chitnis CE.

Cell Microbiol. 2014 Jan;16(1):50-63. doi: 10.1111/cmi.12177. Epub 2013 Aug 21.

PMID:
23910910
36.

Key molecular events during host cell invasion by Apicomplexan pathogens.

Sharma P, Chitnis CE.

Curr Opin Microbiol. 2013 Aug;16(4):432-7. doi: 10.1016/j.mib.2013.07.004. Epub 2013 Jul 27. Review.

PMID:
23895827
37.

Glycan masking of Plasmodium vivax Duffy Binding Protein for probing protein binding function and vaccine development.

Sampath S, Carrico C, Janes J, Gurumoorthy S, Gibson C, Melcher M, Chitnis CE, Wang R, Schief WR, Smith JD.

PLoS Pathog. 2013;9(6):e1003420. doi: 10.1371/journal.ppat.1003420. Epub 2013 Jun 13.

38.

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.

Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG.

J Immunol. 2013 Jul 15;191(2):795-809. doi: 10.4049/jimmunol.1300778. Epub 2013 Jun 17.

39.

Talking to each other to initiate sexual differentiation.

Del Portillo HA, Chitnis CE.

Cell. 2013 May 23;153(5):945-7. doi: 10.1016/j.cell.2013.05.013.

40.

Malaria vaccine R&D in the Decade of Vaccines: breakthroughs, challenges and opportunities.

Birkett AJ, Moorthy VS, Loucq C, Chitnis CE, Kaslow DC.

Vaccine. 2013 Apr 18;31 Suppl 2:B233-43. doi: 10.1016/j.vaccine.2013.02.040. Review.

PMID:
23598488
41.

Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites.

Garg S, Agarwal S, Kumar S, Yazdani SS, Chitnis CE, Singh S.

Nat Commun. 2013;4:1736. doi: 10.1038/ncomms2725.

PMID:
23591903
42.

Improved pregnancy outcomes in women exposed to malaria with high antibody levels against Plasmodium falciparum.

Mayor A, Kumar U, Bardají A, Gupta P, Jiménez A, Hamad A, Sigaúque B, Singh B, Quintó L, Kumar S, Gupta PK, Chauhan VS, Dobaño C, Alonso PL, Menéndez C, Chitnis CE.

J Infect Dis. 2013 Jun 1;207(11):1664-74. doi: 10.1093/infdis/jit083. Epub 2013 Feb 28.

PMID:
23448726
43.

Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure.

Moncunill G, Mayor A, Jiménez A, Nhabomba A, Puyol L, Manaca MN, Barrios D, Cisteró P, Guinovart C, Aguilar R, Bardají A, Pinazo MJ, Angov E, Dutta S, Chitnis CE, Muñoz J, Gascón J, Dobaño C.

PLoS One. 2013;8(2):e55756. doi: 10.1371/journal.pone.0055756. Epub 2013 Feb 21.

44.

Dealing with change: the different microenvironments faced by the malarial parasite.

Chitnis CE, Staines HM.

Mol Microbiol. 2013 Apr;88(1):1-4. doi: 10.1111/mmi.12179. Epub 2013 Mar 11.

45.

A thrombospondin structural repeat containing rhoptry protein from Plasmodium falciparum mediates erythrocyte invasion.

Siddiqui FA, Dhawan S, Singh S, Singh B, Gupta P, Pandey A, Mohmmed A, Gaur D, Chitnis CE.

Cell Microbiol. 2013 Aug;15(8):1341-56. doi: 10.1111/cmi.12118. Epub 2013 Mar 6.

PMID:
23387921
46.

Ca(2+) -mediated exocytosis of subtilisin-like protease 1: a key step in egress of Plasmodium falciparum merozoites.

Agarwal S, Singh MK, Garg S, Chitnis CE, Singh S.

Cell Microbiol. 2013 Jun;15(6):910-21. doi: 10.1111/cmi.12086. Epub 2012 Dec 28.

PMID:
23217145
47.

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion.

Bansal A, Singh S, More KR, Hans D, Nangalia K, Yogavel M, Sharma A, Chitnis CE.

J Biol Chem. 2013 Jan 18;288(3):1590-602. doi: 10.1074/jbc.M112.411934. Epub 2012 Nov 30. Erratum in: J Biol Chem. 2013 Jul 5;288(27):19643.

48.

Identification of a potent combination of key Plasmodium falciparum merozoite antigens that elicit strain-transcending parasite-neutralizing antibodies.

Pandey AK, Reddy KS, Sahar T, Gupta S, Singh H, Reddy EJ, Asad M, Siddiqui FA, Gupta P, Singh B, More KR, Mohmmed A, Chitnis CE, Chauhan VS, Gaur D.

Infect Immun. 2013 Feb;81(2):441-51. doi: 10.1128/IAI.01107-12. Epub 2012 Nov 26.

50.

Development of quantitative receptor-ligand binding assay for use as a tool to estimate immune responses against Plasmodium vivax Duffy binding protein Region II.

Shakri AR, Rizvi MM, Chitnis CE.

J Immunoassay Immunochem. 2012;33(4):403-13. doi: 10.1080/15321819.2012.659781.

PMID:
22963489

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