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Synergistic inhibition of tumor cell proliferation by metformin and mito-metformin in the presence of iron chelators.

Cheng G, Zielonka J, Hardy M, Ouari O, Chitambar CR, Dwinell MB, Kalyanaraman B.

Oncotarget. 2019 May 28;10(37):3518-3532. doi: 10.18632/oncotarget.26943. eCollection 2019 May 28.


Irradiation of pediatric glioblastoma cells promotes radioresistance and enhances glioma malignancy via genome-wide transcriptome changes.

Alhajala HS, Nguyen HS, Shabani S, Best B, Kaushal M, Al-Gizawiy MM, Erin Ahn EY, Knipstein JA, Mirza S, Schmainda KM, Chitambar CR, Doan NB.

Oncotarget. 2018 Sep 25;9(75):34122-34131. doi: 10.18632/oncotarget.26137. eCollection 2018 Sep 25.


Methotrexate-induced Leukoencephalopathy without Typical Restricted Diffusion on Diffusion-weighted Imaging and the Utility of Magnetic Resonance Spectroscopy to Support the Diagnosis.

Doan N, Patel M, Nguyen HS, Doan H, Shabani S, Gelsomino M, Mountoure A, Janich K, Chitambar CR.

Asian J Neurosurg. 2018 Jul-Sep;13(3):848-850. doi: 10.4103/ajns.AJNS_324_16.


Does Progesterone Receptor Matter in the Risk of Recurrence for Patients With Ductal Carcinoma in Situ?

Chaudhary LN, Jawa Z, Hanif A, Szabo A, Kamaraju S, Cheng YC, Chitambar CR.

WMJ. 2018 Jun;117(2):62-67.


Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model.

Doan NB, Nguyen HS, Alhajala HS, Jaber B, Al-Gizawiy MM, Ahn EE, Mueller WM, Chitambar CR, Mirza SP, Schmainda KM.

Oncotarget. 2018 May 4;9(34):23532-23542. doi: 10.18632/oncotarget.25247. eCollection 2018 May 4.


Gallium Maltolate Disrupts Tumor Iron Metabolism and Retards the Growth of Glioblastoma by Inhibiting Mitochondrial Function and Ribonucleotide Reductase.

Chitambar CR, Al-Gizawiy MM, Alhajala HS, Pechman KR, Wereley JP, Wujek R, Clark PA, Kuo JS, Antholine WE, Schmainda KM.

Mol Cancer Ther. 2018 Jun;17(6):1240-1250. doi: 10.1158/1535-7163.MCT-17-1009. Epub 2018 Mar 28.


Gallium Complexes as Anticancer Drugs.

Chitambar CR.

Met Ions Life Sci. 2018 Feb 5;18. pii: /books/9783110470734/9783110470734-016/9783110470734-016.xml. doi: 10.1515/9783110470734-016. Review.


Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency.

Doan NB, Alhajala H, Al-Gizawiy MM, Mueller WM, Rand SD, Connelly JM, Cochran EJ, Chitambar CR, Clark P, Kuo J, Schmainda KM, Mirza SP.

Oncotarget. 2017 Nov 7;8(68):112662-112674. doi: 10.18632/oncotarget.22637. eCollection 2017 Dec 22.


Acid ceramidase confers radioresistance to glioblastoma cells.

Doan NB, Nguyen HS, Al-Gizawiy MM, Mueller WM, Sabbadini RA, Rand SD, Connelly JM, Chitambar CR, Schmainda KM, Mirza SP.

Oncol Rep. 2017 Oct;38(4):1932-1940. doi: 10.3892/or.2017.5855. Epub 2017 Jul 28.


Acid ceramidase is a novel drug target for pediatric brain tumors.

Doan NB, Nguyen HS, Montoure A, Al-Gizawiy MM, Mueller WM, Kurpad S, Rand SD, Connelly JM, Chitambar CR, Schmainda KM, Mirza SP.

Oncotarget. 2017 Apr 11;8(15):24753-24761. doi: 10.18632/oncotarget.15800.


The therapeutic potential of iron-targeting gallium compounds in human disease: From basic research to clinical application.

Chitambar CR.

Pharmacol Res. 2017 Jan;115:56-64. doi: 10.1016/j.phrs.2016.11.009. Epub 2016 Nov 14. Review.


Gallium and its competing roles with iron in biological systems.

Chitambar CR.

Biochim Biophys Acta. 2016 Aug;1863(8):2044-53. doi: 10.1016/j.bbamcr.2016.04.027. Epub 2016 May 3. Review.


Impact of obesity and exercise on chemotherapy-related fatigue.

Herath K, Peswani N, Chitambar CR.

Support Care Cancer. 2016 Oct;24(10):4257-62. doi: 10.1007/s00520-016-3257-4. Epub 2016 May 5.


Relevance of progesterone receptor immunohistochemical staining to Oncotype DX recurrence score.

Chaudhary LN, Jawa Z, Szabo A, Visotcky A, Chitambar CR.

Hematol Oncol Stem Cell Ther. 2016 Jun;9(2):48-54. doi: 10.1016/j.hemonc.2015.12.001. Epub 2016 Jan 18.


p38γ MAPK Is a Therapeutic Target for Triple-Negative Breast Cancer by Stimulation of Cancer Stem-Like Cell Expansion.

Qi X, Yin N, Ma S, Lepp A, Tang J, Jing W, Johnson B, Dwinell MB, Chitambar CR, Chen G.

Stem Cells. 2015 Sep;33(9):2738-47. doi: 10.1002/stem.2068. Epub 2015 Jun 23.


Gallium maltolate inhibits human cutaneous T-cell lymphoma tumor development in mice.

Wu X, Wang TW, Lessmann GM, Saleh J, Liu X, Chitambar CR, Hwang ST.

J Invest Dermatol. 2015 Mar;135(3):877-884. doi: 10.1038/jid.2014.476. Epub 2014 Nov 5.


Iron-targeting antitumor activity of gallium compounds and novel insights into triapine(®)-metal complexes.

Chitambar CR, Antholine WE.

Antioxid Redox Signal. 2013 Mar 10;18(8):956-72. doi: 10.1089/ars.2012.4880. Epub 2012 Oct 3. Review.


Gallium-containing anticancer compounds.

Chitambar CR.

Future Med Chem. 2012 Jun;4(10):1257-72. doi: 10.4155/fmc.12.69. Review.


A Phase II Study of Concurrent Docetaxel, Epirubicin and Cyclophosphamide as a Neoadjuvant Chemotherapy Regimen in Patients with Locally Advanced Breast Cancer.

Yao X, Hosenpud J, Chitambar CR, Charlson J, Cheng YC.

J Cancer. 2012;3:145-51. doi: 10.7150/jca.3980. Epub 2012 Apr 1.


p38γ mitogen-activated protein kinase (MAPK) confers breast cancer hormone sensitivity by switching estrogen receptor (ER) signaling from classical to nonclassical pathway via stimulating ER phosphorylation and c-Jun transcription.

Qi X, Zhi H, Lepp A, Wang P, Huang J, Basir Z, Chitambar CR, Myers CR, Chen G.

J Biol Chem. 2012 Apr 27;287(18):14681-91. doi: 10.1074/jbc.M112.349357. Epub 2012 Mar 7.


Cytotoxic Evaluation of 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone, 3-AP, in Peripheral Blood Lymphocytes of Patients with Refractory Solid Tumors using Electron Paramagnetic Resonance.

Kolesar JM, Sachidanandam K, Schelman WR, Eickhoff J, Holen KD, Traynor AM, Alberti DB, Thomas JP, Chitambar CR, Wilding G, Antholine WE.

Exp Ther Med. 2011 Jan;2(1):119-123.


Medical applications and toxicities of gallium compounds.

Chitambar CR.

Int J Environ Res Public Health. 2010 May;7(5):2337-61. doi: 10.3390/ijerph7052337. Epub 2010 May 10. Review.


Intravascular large B-cell lymphoma, an exclusively small vessel disease? A case report and review of literature.

Yao X, Saad A, Chitambar CR.

Leuk Res. 2010 Oct;34(10):e275-7. doi: 10.1016/j.leukres.2010.05.016. Epub 2010 Jun 9. Review. No abstract available.


A novel gallium compound synergistically enhances bortezomib-induced apoptosis in mantle cell lymphoma cells.

Chitambar CR, Purpi DP.

Leuk Res. 2010 Jul;34(7):950-3. doi: 10.1016/j.leukres.2010.02.034. Epub 2010 Mar 24.


Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells.

Yang M, Chitambar CR.

Free Radic Biol Med. 2008 Sep 15;45(6):763-72. doi: 10.1016/j.freeradbiomed.2008.05.031. Epub 2008 Jun 14.


Electron paramagnetic resonance study of peripheral blood mononuclear cells from patients with refractory solid tumors treated with Triapine.

Kolesar JM, Schelman WR, Geiger PG, Holen KD, Traynor AM, Alberti DB, Thomas JP, Chitambar CR, Wilding G, Antholine WE.

J Inorg Biochem. 2008 Apr;102(4):693-8. Epub 2007 Oct 30.


Case reports: efalizumab-associated lymphoproliferative disease.

Bommakanti S, Patil A, Eshoa C, Chitambar CR.

J Drugs Dermatol. 2007 Jun;6(6):646-8.


Expression of the hemochromatosis gene modulates the cytotoxicity of doxorubicin in breast cancer cells.

Chitambar CR, Kotamraju S, Wereley JP.

Int J Cancer. 2006 Nov 1;119(9):2200-4.


Resistance to the antineoplastic agent gallium nitrate results in marked alterations in intracellular iron and gallium trafficking: identification of novel intermediates.

Davies NP, Suryo Rahmanto Y, Chitambar CR, Richardson DR.

J Pharmacol Exp Ther. 2006 Apr;317(1):153-62. Epub 2005 Dec 22.


Cellular iron metabolism: mitochondria in the spotlight.

Chitambar CR.

Blood. 2005 Mar 1;105(5):1844-5. Review.


Apoptotic mechanisms of gallium nitrate: basic and clinical investigations.

Chitambar CR.

Oncology (Williston Park). 2004 Nov;18(13 Suppl 10):39-44. Review.


Gallium compounds as antineoplastic agents.

Chitambar CR.

Curr Opin Oncol. 2004 Nov;16(6):547-52. Review.


Gallium nitrate for the treatment of non-Hodgkin's lymphoma.

Chitambar CR.

Expert Opin Investig Drugs. 2004 May;13(5):531-41. Review.


Mantle cell lymphoma in lymph nodes with metastatic small cell carcinoma of lung: a diagnostic and treatment dilemma.

Kampalath B, Abed N, Chitambar CR, Vantuinen P, Chakrabarty G, Hanson G, Rao RN, Shidham VB, Chang CC.

Leuk Lymphoma. 2004 Feb;45(2):409-14.


Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis.

Kotamraju S, Kalivendi SV, Konorev E, Chitambar CR, Joseph J, Kalyanaraman B.

Methods Enzymol. 2004;378:362-82. Review. No abstract available.


Nitric oxide mitigates peroxide-induced iron-signaling, oxidative damage, and apoptosis in endothelial cells: role of proteasomal function?

Kotamraju S, Tampo Y, Kalivendi SV, Joseph J, Chitambar CR, Kalyanaraman B.

Arch Biochem Biophys. 2004 Mar 1;423(1):74-80. Review.


Nitric oxide inhibits H2O2-induced transferrin receptor-dependent apoptosis in endothelial cells: Role of ubiquitin-proteasome pathway.

Kotamraju S, Tampo Y, Keszler A, Chitambar CR, Joseph J, Haas AL, Kalyanaraman B.

Proc Natl Acad Sci U S A. 2003 Sep 16;100(19):10653-8. Epub 2003 Sep 4.


Analysis of single nucleotide polymorphism C3435T of the multidrug resistance gene MDR1 in acute lymphoblastic leukemia.

Efferth T, Sauerbrey A, Steinbach D, Gebhart E, Drexler HG, Miyachi H, Chitambar CR, Becker CM, Zintl F, Humeny A.

Int J Oncol. 2003 Aug;23(2):509-17.


Expression of the hemochromatosis (HFE) gene modulates the cellular uptake of 67Ga.

Chitambar CR, Wereley JP.

J Nucl Med. 2003 Jun;44(6):943-6.


Gallium nitrate revisited.

Chitambar CR.

Semin Oncol. 2003 Apr;30(2 Suppl 5):1-4. Review.


Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.

Efferth T, Verdorfer I, Miyachi H, Sauerbrey A, Drexler HG, Chitambar CR, Haber M, Gebhart E.

Blood Cells Mol Dis. 2002 Jul-Aug;29(1):1-13.


Expression of MUM1/IRF4 correlates with clinical outcome in patients with B-cell chronic lymphocytic leukemia.

Chang CC, Lorek J, Sabath DE, Li Y, Chitambar CR, Logan B, Kampalath B, Cleveland RP.

Blood. 2002 Dec 15;100(13):4671-5. Epub 2002 Aug 1.


CD5+ T-cell/histiocyte-rich large B-cell lymphoma.

Chang CC, Bunyi-Teopengco E, Eshoa C, Chitambar CR, Kampalath B.

Mod Pathol. 2002 Oct;15(10):1051-7.


Diagnosis, workup, and prognosis of cutaneous metastases of unknown primary origin.

Carroll MC, Fleming M, Chitambar CR, Neuburg M.

Dermatol Surg. 2002 Jun;28(6):533-5.


Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells: role of oxidant-induced iron signaling in apoptosis.

Kotamraju S, Chitambar CR, Kalivendi SV, Joseph J, Kalyanaraman B.

J Biol Chem. 2002 May 10;277(19):17179-87. Epub 2002 Feb 20.


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