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Items: 1 to 50 of 218

1.

Stiripentol for the treatment of seizures associated with Dravet syndrome.

Chiron C.

Expert Rev Neurother. 2019 Apr;19(4):301-310. doi: 10.1080/14737175.2019.1593142. Epub 2019 Apr 2.

PMID:
30900478
2.

Perception of impact of Dravet syndrome on children and caregivers in multiple countries: looking beyond seizures.

Nabbout R, Auvin S, Chiron C, Thiele E, Cross H, Scheffer IE, Schneider AL, Guerrini R, Williamson N; Zogenix and Adelphi Values study group.

Dev Med Child Neurol. 2019 Mar 4. doi: 10.1111/dmcn.14186. [Epub ahead of print]

PMID:
30828793
3.

Pharmacokinetic evaluation of vigabatrin dose for the treatment of refractory focal seizures in children using adult and pediatric data.

Rodrigues C, Chiron C, Ounissi M, Dulac O, Gaillard S, Nabbout R, Jullien V.

Epilepsy Res. 2019 Feb;150:38-45. doi: 10.1016/j.eplepsyres.2019.01.002. Epub 2019 Jan 7.

PMID:
30639958
4.

Early and long-term electroclinical features of patients with epilepsy and PCDH19 mutation.

Chemaly N, Losito E, Pinard JM, Gautier A, Villeneuve N, Arbues AS, An I, Desguerre I, Dulac O, Chiron C, Kaminska A, Nabbout R.

Epileptic Disord. 2018 Dec 1;20(6):457-467. doi: 10.1684/epd.2018.1009.

PMID:
30530412
5.

Three-Dimensional Probabilistic Maps of Mesial Temporal Lobe Structures in Children and Adolescents' Brains.

Bouyeure A, Germanaud D, Bekha D, Delattre V, Lefèvre J, Pinabiaux C, Mangin JF, Rivière D, Fischer C, Chiron C, Hertz-Pannier L, Noulhiane M.

Front Neuroanat. 2018 Nov 15;12:98. doi: 10.3389/fnana.2018.00098. eCollection 2018.

6.

Proposition of a Minimal Effective Dose of Vigabatrin for the Treatment of Infantile Spasms Using Pediatric and Adult Pharmacokinetic Data.

Ounissi M, Rodrigues C, Bienayme H, Duhamel P, Pons G, Dulac O, Nabbout R, Chiron C, Jullien V.

J Clin Pharmacol. 2019 Feb;59(2):177-188. doi: 10.1002/jcph.1309. Epub 2018 Sep 7.

PMID:
30192381
7.

Do children with Dravet syndrome continue to benefit from stiripentol for long through adulthood?

Chiron C, Helias M, Kaminska A, Laroche C, de Toffol B, Dulac O, Nabbout R, An I.

Epilepsia. 2018 Sep;59(9):1705-1717. doi: 10.1111/epi.14536. Epub 2018 Aug 22.

PMID:
30132836
8.

Which Protocol for Milrinone to Treat Cerebral Vasospasm Associated With Subarachnoid Hemorrhage?

Crespy T, Heintzelmann M, Chiron C, Vinclair M, Tahon F, Francony G, Payen JF.

J Neurosurg Anesthesiol. 2019 Jul;31(3):323-329. doi: 10.1097/ANA.0000000000000527.

PMID:
30015694
9.

Electrocorticographic telemetric recording in unrestrained mouse pups.

Chemaly N, Nehlig A, Chiron C, Nabbout R.

J Neurosci Methods. 2018 Jul 15;305:17-27. doi: 10.1016/j.jneumeth.2018.04.020. Epub 2018 May 1.

PMID:
29727612
10.

Correction to: 18F-FDG PET in drug-resistant epilepsy due to focal cortical dysplasia type 2: additional value of electroclinical data and coregistration with MRI.

Desarnaud S, Mellerio C, Semah F, Laurent A, Landre E, Devaux B, Chiron C, Lebon V, Chassoux F.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1465. doi: 10.1007/s00259-018-4022-3.

PMID:
29704039
11.

Off-label use and manipulations of antiepileptic drugs in children: Analysis of the outpatient prescriptions in a tertiary center.

Kuchenbuch M, Chemaly N, Henniene KM, Kaminska A, Chiron C, Nabbout R.

Epilepsy Behav. 2018 May;82:133-139. doi: 10.1016/j.yebeh.2018.03.013. Epub 2018 Apr 3.

PMID:
29625363
12.

18F-FDG PET in drug-resistant epilepsy due to focal cortical dysplasia type 2: additional value of electroclinical data and coregistration with MRI.

Desarnaud S, Mellerio C, Semah F, Laurent A, Landre E, Devaux B, Chiron C, Lebon V, Chassoux F.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1449-1460. doi: 10.1007/s00259-018-3994-3. Epub 2018 Mar 29. Erratum in: Eur J Nucl Med Mol Imaging. 2018 Apr 28;:.

PMID:
29594410
13.

A population pharmacokinetic model taking into account protein binding for the sustained-release granule formulation of valproic acid in children with epilepsy.

Rodrigues C, Chhun S, Chiron C, Dulac O, Rey E, Pons G, Jullien V.

Eur J Clin Pharmacol. 2018 Jun;74(6):793-803. doi: 10.1007/s00228-018-2444-2. Epub 2018 Mar 21.

PMID:
29564480
14.

Long-term pragmatic use of stiripentol for Dravet syndrome.

Chiron C.

Dev Med Child Neurol. 2018 Jun;60(6):535. doi: 10.1111/dmcn.13720. Epub 2018 Mar 7. No abstract available.

15.

Flow cytometry: a versatile technology for specific quantification and viability assessment of micro-organisms in multistrain probiotic products.

Chiron C, Tompkins TA, Burguière P.

J Appl Microbiol. 2018 Feb;124(2):572-584. doi: 10.1111/jam.13666. Epub 2018 Jan 15.

PMID:
29236340
16.

Cortical Auditory-Evoked Responses in Preterm Neonates: Revisited by Spectral and Temporal Analyses.

Kaminska A, Delattre V, Laschet J, Dubois J, Labidurie M, Duval A, Manresa A, Magny JF, Hovhannisyan S, Mokhtari M, Ouss L, Boissel A, Hertz-Pannier L, Sintsov M, Minlebaev M, Khazipov R, Chiron C.

Cereb Cortex. 2018 Oct 1;28(10):3429-3444. doi: 10.1093/cercor/bhx206.

PMID:
29194486
17.

Development and content validation of a preliminary core set of patient- and caregiver-relevant outcomes for inclusion in a potential composite endpoint for Dravet Syndrome.

Nabbout R, Auvin S, Chiron C, Irwin J, Mistry A, Bonner N, Williamson N, Bennett B.

Epilepsy Behav. 2018 Jan;78:232-242. doi: 10.1016/j.yebeh.2017.08.029. Epub 2017 Nov 4.

18.

Determination of the R(-) and S(+)-enantiomers of vigabatrin in human plasma by ultra-high-performance liquid chromatography and tandem mass-spectrometry.

Duhamel P, Ounissi M, Le Saux T, Bienayme H, Chiron C, Jullien V.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Dec 1;1070:31-36. doi: 10.1016/j.jchromb.2017.10.037. Epub 2017 Oct 20.

PMID:
29107733
19.

Relationships between Regional Radiation Doses and Cognitive Decline in Children Treated with Cranio-Spinal Irradiation for Posterior Fossa Tumors.

Doger de Speville E, Robert C, Perez-Guevara M, Grigis A, Bolle S, Pinaud C, Dufour C, Beaudré A, Kieffer V, Longaud A, Grill J, Valteau-Couanet D, Deutsch E, Lefkopoulos D, Chiron C, Hertz-Pannier L, Noulhiane M.

Front Oncol. 2017 Aug 18;7:166. doi: 10.3389/fonc.2017.00166. eCollection 2017.

20.

Population Pharmacokinetics of Stiripentol in Paediatric Patients with Dravet Syndrome Treated with Stiripentol, Valproate and Clobazam Combination Therapy.

Peigné S, Chhun S, Tod M, Rey E, Rodrigues C, Chiron C, Pons G, Jullien V.

Clin Pharmacokinet. 2018 Jun;57(6):739-748. doi: 10.1007/s40262-017-0592-7.

PMID:
28819726
21.

Population pharmacokinetics of oxcarbazepine and its monohydroxy derivative in epileptic children.

Rodrigues C, Chiron C, Rey E, Dulac O, Comets E, Pons G, Jullien V.

Br J Clin Pharmacol. 2017 Dec;83(12):2695-2708. doi: 10.1111/bcp.13392. Epub 2017 Sep 20.

22.

Age-related "Sleep/nocturnal" tonic and tonic clonic seizure clusters are underdiagnosed in patients with Dravet Syndrome.

Losito E, Kuchenbuch M, Chemaly N, Laschet J, Chiron C, Kaminska A, Nabbout R.

Epilepsy Behav. 2017 Sep;74:33-40. doi: 10.1016/j.yebeh.2017.05.037. Epub 2017 Jul 3.

PMID:
28683344
23.

Language plasticity after hemispherotomy of the dominant hemisphere in 3 patients: Implication of non-linguistic networks.

Bulteau C, Jambaqué I, Chiron C, Rodrigo S, Dorfmüller G, Dulac O, Hertz-Pannier L, Noulhiane M.

Epilepsy Behav. 2017 Apr;69:86-94. doi: 10.1016/j.yebeh.2017.01.004. Epub 2017 Feb 23.

PMID:
28236728
24.

Treatment issues for children with epilepsy transitioning to adult care.

Nabbout R, Camfield CS, Andrade DM, Arzimanoglou A, Chiron C, Cramer JA, French JA, Kossoff E, Mula M, Camfield PR.

Epilepsy Behav. 2017 Apr;69:153-160. doi: 10.1016/j.yebeh.2016.11.008. Epub 2017 Feb 8. Review.

PMID:
28188045
25.

Patients with dravet syndrome in the era of stiripentol: A French cohort cross-sectional study.

De Liso P, Chemaly N, Laschet J, Barnerias C, Hully M, Leunen D, Desguerre I, Chiron C, Dulac O, Nabbout R.

Epilepsy Res. 2016 Sep;125:42-6. doi: 10.1016/j.eplepsyres.2016.05.012. Epub 2016 May 28.

PMID:
27389706
26.

Motor neuropathy contributes to crouching in patients with Dravet syndrome.

Gitiaux C, Chemaly N, Quijano-Roy S, Barnerias C, Desguerre I, Hully M, Chiron C, Dulac O, Nabbout R.

Neurology. 2016 Jul 19;87(3):277-81. doi: 10.1212/WNL.0000000000002859. Epub 2016 Jun 17.

PMID:
27316242
27.

No evidence of thalamic metabolic abnormality associated with continuous spike-and-wave during sleep.

Trotta N, Ligot N, Archambaud F, Goldman S, Van Bogaert P, Chiron C, De Tiège X.

Epilepsia. 2016 Jun;57(6):1007-8. doi: 10.1111/epi.13382. No abstract available.

28.

Dynamic changes of depolarizing GABA in a computational model of epileptogenic brain: Insight for Dravet syndrome.

Kurbatova P, Wendling F, Kaminska A, Rosati A, Nabbout R, Guerrini R, Dulac O, Pons G, Cornu C, Nony P; CRESIM/EpiCRESIM Study Group, Chiron C, Benquet P.

Exp Neurol. 2016 Sep;283(Pt A):57-72. doi: 10.1016/j.expneurol.2016.05.037. Epub 2016 May 28.

29.

Functional integration changes in regional brain glucose metabolism from childhood to adulthood.

Trotta N, Archambaud F, Goldman S, Baete K, Van Laere K, Wens V, Van Bogaert P, Chiron C, De Tiège X.

Hum Brain Mapp. 2016 Aug;37(8):3017-30. doi: 10.1002/hbm.23223. Epub 2016 May 2.

PMID:
27133021
30.

Stiripentol and vigabatrin current roles in the treatment of epilepsy.

Chiron C.

Expert Opin Pharmacother. 2016 Jun;17(8):1091-101. doi: 10.1517/14656566.2016.1161026. Epub 2016 Mar 17. Review.

PMID:
26933940
31.

Epilepsy in young Tsc1(+/-) mice exhibits age-dependent expression that mimics that of human tuberous sclerosis complex.

Gataullina S, Lemaire E, Wendling F, Kaminska A, Watrin F, Riquet A, Ville D, Moutard ML, de Saint Martin A, Napuri S, Pedespan JM, Eisermann M, Bahi-Buisson N, Nabbout R, Chiron C, Dulac O, Huberfeld G.

Epilepsia. 2016 Apr;57(4):648-59. doi: 10.1111/epi.13325. Epub 2016 Feb 13.

32.

Bumetanide for neonatal seizures-back from the cotside.

Pressler RM, Boylan GB, Marlow N, de Vries LS, Blennow M, Chiron C, Cross JH, Hallberg B, Hellström-Westas L, Jullien V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Toet MC, Zohar S; NEMO consortium (NEonatal seizure treatment with Medication Off-patent).

Nat Rev Neurol. 2015 Dec;11(12):724. doi: 10.1038/nrneurol.2015.116. Epub 2015 Nov 3. No abstract available.

PMID:
26526530
33.

Pilot evaluation of the population pharmacokinetics of bumetanide in term newborn infants with seizures.

Jullien V, Pressler RM, Boylan G, Blennow M, Marlow N, Chiron C, Pons G; NEMO Consortium Neonatal Seizure Treatment With Medication Off-Patent.

J Clin Pharmacol. 2016 Mar;56(3):284-90. doi: 10.1002/jcph.596. Epub 2015 Sep 14.

PMID:
26189501
34.

The ketogenic diet can be used successfully in combination with corticosteroids for epileptic encephalopathies.

Ville D, Chiron C, Laschet J, Dulac O.

Epilepsy Behav. 2015 Jul;48:61-5. doi: 10.1016/j.yebeh.2015.03.003. Epub 2015 Jun 8.

PMID:
26057351
35.

Bumetanide for the treatment of seizures in newborn babies with hypoxic ischaemic encephalopathy (NEMO): an open-label, dose finding, and feasibility phase 1/2 trial.

Pressler RM, Boylan GB, Marlow N, Blennow M, Chiron C, Cross JH, de Vries LS, Hallberg B, Hellström-Westas L, Jullien V, Livingstone V, Mangum B, Murphy B, Murray D, Pons G, Rennie J, Swarte R, Toet MC, Vanhatalo S, Zohar S; NEonatal seizure treatment with Medication Off-patent (NEMO) consortium.

Lancet Neurol. 2015 May;14(5):469-77. doi: 10.1016/S1474-4422(14)70303-5. Epub 2015 Mar 10.

PMID:
25765333
36.

Associative episodic memory and recollective processes in childhood temporal lobe epilepsy.

Martins S, Guillery-Girard B, Clochon P, Bulteau C, Hertz-Pannier L, Chiron C, Eustache F, Jambaqué I.

Epilepsy Behav. 2015 Mar;44:86-9. doi: 10.1016/j.yebeh.2015.01.008. Epub 2015 Feb 4.

PMID:
25659044
37.

Pharmacokinetics of clobazam and N-desmethylclobazam in children with dravet syndrome receiving concomitant stiripentol and valproic Acid.

Jullien V, Chhun S, Rey E, Dulac O, Tod M, Chiron C, Pons G.

Clin Pharmacokinet. 2015 May;54(5):527-36. doi: 10.1007/s40262-014-0223-5.

PMID:
25503589
38.

Arterial Spin Labeling MRI: a step forward in non-invasive delineation of focal cortical dysplasia in children.

Blauwblomme T, Boddaert N, Chémaly N, Chiron C, Pages M, Varlet P, Bourgeois M, Bahi-Buisson N, Kaminska A, Grevent D, Brunelle F, Sainte-Rose C, Archambaud F, Nabbout R.

Epilepsy Res. 2014 Dec;108(10):1932-9. doi: 10.1016/j.eplepsyres.2014.09.029. Epub 2014 Oct 13.

PMID:
25454505
39.

Pretherapeutic functional magnetic resonance imaging in children.

Hertz-Pannier L, Noulhiane M, Rodrigo S, Chiron C.

Neuroimaging Clin N Am. 2014 Nov;24(4):639-53. doi: 10.1016/j.nic.2014.07.002. Epub 2014 Nov 1. Review.

PMID:
25441505
40.

Successful private-public funding of paediatric medicines research: lessons from the EU programme to fund research into off-patent medicines.

Ruggieri L, Giannuzzi V, Baiardi P, Bonifazi F, Davies EH, Giaquinto C, Bonifazi D, Felisi M, Chiron C, Pressler R, Rabe H, Whitaker MJ, Neubert A, Jacqz-Aigrain E, Eichler I, Turner MA, Ceci A; GRiP Consortium.

Eur J Pediatr. 2015 Apr;174(4):481-91. doi: 10.1007/s00431-014-2398-z. Epub 2014 Sep 23.

41.

Pharmacology aspects during transition and at transfer in patients with epilepsy.

Chiron C, An I.

Epilepsia. 2014 Aug;55 Suppl 3:8-11. doi: 10.1111/epi.12708. Review.

42.

Seizures and epilepsy in hypoglycaemia caused by inborn errors of metabolism.

Gataullina S, Delonlay P, Lemaire E, Boddaert N, Bulteau C, Soufflet C, Laín GA, Nabbout R, Chiron C, Dulac O.

Dev Med Child Neurol. 2015 Feb;57(2):194-9. doi: 10.1111/dmcn.12574. Epub 2014 Aug 22.

43.

Analysis of vigabatrin treatment causing visual field defects in infantile spasms.

Chiron C, Dulac O.

Dev Med Child Neurol. 2015 Jan;57(1):9-10. doi: 10.1111/dmcn.12558. Epub 2014 Aug 11. No abstract available.

44.

Default mode network hypometabolism in epileptic encephalopathies with CSWS.

Ligot N, Archambaud F, Trotta N, Goldman S, Van Bogaert P, Chiron C, De Tiège X.

Epilepsy Res. 2014 Jul;108(5):861-71. doi: 10.1016/j.eplepsyres.2014.03.014. Epub 2014 Mar 27.

PMID:
24746674
45.

Reassessment of stiripentol pharmacokinetics in healthy adult volunteers.

Peigné S, Rey E, Le Guern ME, Dulac O, Chiron C, Pons G, Jullien V.

Epilepsy Res. 2014 Jul;108(5):909-16. doi: 10.1016/j.eplepsyres.2014.03.009. Epub 2014 Mar 26.

PMID:
24725808
46.

Treatment of dilute methylene blue-containing wastewater by coupling sawdust adsorption and electrochemical regeneration.

Bouaziz I, Chiron C, Abdelhedi R, Savall A, Groenen Serrano K.

Environ Sci Pollut Res Int. 2014;21(14):8565-72. Epub 2014 Mar 25.

PMID:
24659458
47.

The c.429_452 duplication of the ARX gene: a unique developmental-model of limb kinetic apraxia.

Curie A, Nazir T, Brun A, Paulignan Y, Reboul A, Delange K, Cheylus A, Bertrand S, Rochefort F, Bussy G, Marignier S, Lacombe D, Chiron C, Cossée M, Leheup B, Philippe C, Laugel V, De Saint Martin A, Sacco S, Poirier K, Bienvenu T, Souville I, Gilbert-Dussardier B, Bieth E, Kauffmann D, Briot P, de Fréminville B, Prieur F, Till M, Rooryck-Thambo C, Mortemousque I, Bobillier-Chaumont I, Toutain A, Touraine R, Sanlaville D, Chelly J, Freeman S, Kong J, Hadjikhani N, Gollub RL, Roy A, des Portes V.

Orphanet J Rare Dis. 2014 Feb 14;9:25. doi: 10.1186/1750-1172-9-25.

48.

Memory for fearful faces across development: specialization of amygdala nuclei and medial temporal lobe structures.

Pinabiaux C, Hertz-Pannier L, Chiron C, Rodrigo S, Jambaqué I, Noulhiane M.

Front Hum Neurosci. 2013 Dec 25;7:901. doi: 10.3389/fnhum.2013.00901. eCollection 2013.

49.

Auditory stimuli mimicking ambient sounds drive temporal "delta-brushes" in premature infants.

Chipaux M, Colonnese MT, Mauguen A, Fellous L, Mokhtari M, Lezcano O, Milh M, Dulac O, Chiron C, Khazipov R, Kaminska A.

PLoS One. 2013 Nov 11;8(11):e79028. doi: 10.1371/journal.pone.0079028. eCollection 2013.

50.

Encephalopathy in children with Dravet syndrome is not a pure consequence of epilepsy.

Nabbout R, Chemaly N, Chipaux M, Barcia G, Bouis C, Dubouch C, Leunen D, Jambaqué I, Dulac O, Dellatolas G, Chiron C.

Orphanet J Rare Dis. 2013 Nov 13;8:176. doi: 10.1186/1750-1172-8-176.

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