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Items: 1 to 50 of 54

1.

Food-grade titanium dioxide (E171) by solid or liquid matrix administration induces inflammation, germ cells sloughing in seminiferous tubules and blood-testis barrier disruption in mice.

Rodríguez-Escamilla JC, Medina-Reyes EI, Rodríguez-Ibarra C, Déciga-Alcaraz A, Flores-Flores JO, Ganem-Rondero A, Rodríguez-Sosa M, Terrazas LI, Delgado-Buenrostro NL, Chirino YI.

J Appl Toxicol. 2019 Aug 15. doi: 10.1002/jat.3842. [Epub ahead of print]

PMID:
31415109
2.

Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation.

Callejas BE, Mendoza-Rodríguez MG, Villamar-Cruz O, Reyes-Martínez S, Sánchez-Barrera CA, Rodríguez-Sosa M, Delgado-Buenrostro NL, Martínez-Saucedo D, Chirino YI, León-Cabrera SA, Pérez-Plasencia C, Vaca-Paniagua F, Arias-Romero LE, Terrazas LI.

Int J Cancer. 2019 Dec 1;145(11):3126-3139. doi: 10.1002/ijc.32626. Epub 2019 Aug 30.

PMID:
31407335
3.

Macrophage Migration Inhibitory Factor Promotes the Interaction between the Tumor, Macrophages, and T Cells to Regulate the Progression of Chemically Induced Colitis-Associated Colorectal Cancer.

Pacheco-Fernández T, Juárez-Avelar I, Illescas O, Terrazas LI, Hernández-Pando R, Pérez-Plasencia C, Gutiérrez-Cirlos EB, Ávila-Moreno F, Chirino YI, Reyes JL, Maldonado V, Rodriguez-Sosa M.

Mediators Inflamm. 2019 Jul 10;2019:2056085. doi: 10.1155/2019/2056085. eCollection 2019.

4.

Airborne particulate matter induces mitotic slippage and chromosomal missegregation through disruption of the spindle assembly checkpoint (SAC).

Santibáñez-Andrade M, Sánchez-Pérez Y, Chirino YI, Morales-Bárcenas R, Herrera LA, García-Cuellar CM.

Chemosphere. 2019 Nov;235:794-804. doi: 10.1016/j.chemosphere.2019.06.232. Epub 2019 Jul 1.

PMID:
31280048
5.

Novel thiosemicarbazones induce high toxicity in estrogen-receptor-positive breast cancer cells (MCF7) and exacerbate cisplatin effectiveness in triple-negative breast (MDA-MB231) and lung adenocarcinoma (A549) cells.

Medina-Reyes EI, Mancera-Rodríguez MA, Delgado-Buenrostro NL, Moreno-Rodríguez A, Bautista-Martínez JL, Díaz-Velásquez CE, Martínez-Alarcón SA, Torrens H, de Los Ángeles Godínez-Rodríguez M, Terrazas-Valdés LI, Chirino YI, Vaca-Paniagua F.

Invest New Drugs. 2019 Jun 8. doi: 10.1007/s10637-019-00789-1. [Epub ahead of print]

PMID:
31177399
6.

Comprehensive Analysis of Germline Variants in Mexican Patients with Hereditary Breast and Ovarian Cancer Susceptibility.

Quezada Urban R, Díaz Velásquez CE, Gitler R, Rojo Castillo MP, Sirota Toporek M, Figueroa Morales A, Moreno García O, García Esquivel L, Torres Mejía G, Dean M, Delgado Enciso I, Ochoa Díaz López H, Rodríguez León F, Jan V, Garzón Barrientos VH, Ruiz Flores P, Espino Silva PK, Haro Santa Cruz J, Martínez Gregorio H, Rojas Jiménez EA, Romero Cruz LE, Méndez Catalá CF, Álvarez Gómez RM, Fragoso Ontiveros V, Herrera LA, Romieu I, Terrazas LI, Chirino YI, Frecha C, Oliver J, Perdomo S, Vaca Paniagua F.

Cancers (Basel). 2018 Sep 27;10(10). pii: E361. doi: 10.3390/cancers10100361.

7.

Deficiency in STAT1 Signaling Predisposes Gut Inflammation and Prompts Colorectal Cancer Development.

Leon-Cabrera S, Vázquez-Sandoval A, Molina-Guzman E, Delgado-Ramirez Y, Delgado-Buenrostro NL, Callejas BE, Chirino YI, Pérez-Plasencia C, Rodríguez-Sosa M, Olguín JE, Salinas C, Satoskar AR, Terrazas LI.

Cancers (Basel). 2018 Sep 19;10(9). pii: E341. doi: 10.3390/cancers10090341.

8.

Transcriptomics analysis reveals new insights in E171-induced molecular alterations in a mouse model of colon cancer.

Proquin H, Jetten MJ, Jonkhout MCM, Garduño-Balderas LG, Briedé JJ, de Kok TM, van Loveren H, Chirino YI.

Sci Rep. 2018 Jun 27;8(1):9738. doi: 10.1038/s41598-018-28063-z.

9.

miRNAs deregulation in lung cells exposed to airborne particulate matter (PM10) is associated with pathways deregulated in lung tumors.

Quezada-Maldonado EM, Sánchez-Pérez Y, Chirino YI, Vaca-Paniagua F, García-Cuellar CM.

Environ Pollut. 2018 Oct;241:351-358. doi: 10.1016/j.envpol.2018.05.073. Epub 2018 May 22.

PMID:
29852438
10.

Early and Partial Reduction in CD4+Foxp3+ Regulatory T Cells during Colitis-Associated Colon Cancer Induces CD4+ and CD8+ T Cell Activation Inhibiting Tumorigenesis.

Olguín JE, Medina-Andrade I, Molina E, Vázquez A, Pacheco-Fernández T, Saavedra R, Pérez-Plasencia C, Chirino YI, Vaca-Paniagua F, Arias-Romero LE, Gutierrez-Cirlos EB, León-Cabrera SA, Rodriguez-Sosa M, Terrazas LI.

J Cancer. 2018 Jan 1;9(2):239-249. doi: 10.7150/jca.21336. eCollection 2018.

11.

Time course gene expression data in colon of mice after exposure to food-grade E171.

Proquin H, Jetten MJ, Jonkhout MCM, Garduño-Balderas LG, Briedé JJ, de Kok TM, Chirino YI, van Loveren H.

Data Brief. 2017 Nov 22;16:531-600. doi: 10.1016/j.dib.2017.11.067. eCollection 2018 Feb.

12.

Influence of shape and dispersion media of titanium dioxide nanostructures on microvessel network and ossification.

Freyre-Fonseca V, Medina-Reyes EI, Téllez-Medina DI, Paniagua-Contreras GL, Monroy-Pérez E, Vaca-Paniagua F, Delgado-Buenrostro NL, Flores-Flores JO, López-Villegas EO, Gutiérrez-López GF, Chirino YI.

Colloids Surf B Biointerfaces. 2018 Feb 1;162:193-201. doi: 10.1016/j.colsurfb.2017.11.049. Epub 2017 Nov 23.

PMID:
29190471
13.

Renal damage in the metabolic syndrome (MetSx): Disorders implicated.

Joyce T, Chirino YI, Natalia MT, Jose PC.

Eur J Pharmacol. 2018 Jan 5;818:554-568. doi: 10.1016/j.ejphar.2017.11.032. Epub 2017 Nov 21. Review.

PMID:
29162432
14.

Gene expression profiling in colon of mice exposed to food additive titanium dioxide (E171).

Proquin H, Jetten MJ, Jonkhout MCM, Garduño-Balderas LG, Briedé JJ, de Kok TM, Chirino YI, van Loveren H.

Food Chem Toxicol. 2018 Jan;111:153-165. doi: 10.1016/j.fct.2017.11.011. Epub 2017 Nov 8.

PMID:
29128614
15.

Lack of STAT6 Attenuates Inflammation and Drives Protection against Early Steps of Colitis-Associated Colon Cancer.

Leon-Cabrera SA, Molina-Guzman E, Delgado-Ramirez YG, Vázquez-Sandoval A, Ledesma-Soto Y, Pérez-Plasencia CG, Chirino YI, Delgado-Buenrostro NL, Rodríguez-Sosa M, Vaca-Paniagua F, Ávila-Moreno F, Gutierrez-Cirlos EB, Arias-Romero LE, Terrazas LI.

Cancer Immunol Res. 2017 May;5(5):385-396. doi: 10.1158/2326-6066.CIR-16-0168. Epub 2017 Apr 6.

16.

Current FDA-approved treatments for non-small cell lung cancer and potential biomarkers for its detection.

Ruiz-Ceja KA, Chirino YI.

Biomed Pharmacother. 2017 Jun;90:24-37. doi: 10.1016/j.biopha.2017.03.018. Epub 2017 Mar 21. Review.

PMID:
28340378
17.

Applications and Risks of Nanomaterials Used in Regenerative Medicine, Delivery Systems, Theranostics, and Therapy.

Medina-Reyes EI, Garcia-Viacobo D, Carrero-Martinez FA, Chirino YI.

Crit Rev Ther Drug Carrier Syst. 2017;34(1):35-61. doi: 10.1615/CritRevTherDrugCarrierSyst.2017016983. Review.

PMID:
28322140
18.

Airborne particulate matter in vitro exposure induces cytoskeleton remodeling through activation of the ROCK-MYPT1-MLC pathway in A549 epithelial lung cells.

Chirino YI, García-Cuellar CM, García-García C, Soto-Reyes E, Osornio-Vargas ÁR, Herrera LA, López-Saavedra A, Miranda J, Quintana-Belmares R, Pérez IR, Sánchez-Pérez Y.

Toxicol Lett. 2017 Apr 15;272:29-37. doi: 10.1016/j.toxlet.2017.03.002. Epub 2017 Mar 6.

PMID:
28279687
19.

Titanium dioxide food additive (E171) induces ROS formation and genotoxicity: contribution of micro and nano-sized fractions.

Proquin H, Rodríguez-Ibarra C, Moonen CG, Urrutia Ortega IM, Briedé JJ, de Kok TM, van Loveren H, Chirino YI.

Mutagenesis. 2017 Jan;32(1):139-149. doi: 10.1093/mutage/gew051. Epub 2016 Oct 27. Erratum in: Mutagenesis. 2018 Sep 17;33(3):267-268.

PMID:
27789654
20.

Role of Wasp and the small GTPases RhoA, RhoB, and Cdc42 during capacitation and acrosome reaction in spermatozoa of English guinea pigs.

Delgado-Buenrostro NL, Mújica A, Chiquete-Felix N, Déciga-Alcaraz A, Medina-Reyes EI, Uribe-Carvajal S, Chirino YI.

Mol Reprod Dev. 2016 Oct;83(10):927-937. doi: 10.1002/mrd.22657. Epub 2016 Jun 6.

PMID:
27182927
21.

Secretome derived from breast tumor cell lines alters the morphology of human umbilical vein endothelial cells.

Gómez EO, Chirino YI, Delgado-Buenrostro NL, López-Saavedra A, Meraz-Cruz N, López-Marure R.

Mol Membr Biol. 2016 Mar;33(1-2):29-37. Epub 2016 Sep 30.

PMID:
27690154
22.

Atmospheric particulate matter (PM10) exposure-induced cell cycle arrest and apoptosis evasion through STAT3 activation via PKCζ and Src kinases in lung cells.

Reyes-Zárate E, Sánchez-Pérez Y, Gutiérrez-Ruiz MC, Chirino YI, Osornio-Vargas ÁR, Morales-Bárcenas R, Souza-Arroyo V, García-Cuellar CM.

Environ Pollut. 2016 Jul;214:646-656. doi: 10.1016/j.envpol.2016.04.072. Epub 2016 Apr 29.

PMID:
27131825
23.

Food-grade titanium dioxide exposure exacerbates tumor formation in colitis associated cancer model.

Urrutia-Ortega IM, Garduño-Balderas LG, Delgado-Buenrostro NL, Freyre-Fonseca V, Flores-Flores JO, González-Robles A, Pedraza-Chaverri J, Hernández-Pando R, Rodríguez-Sosa M, León-Cabrera S, Terrazas LI, van Loveren H, Chirino YI.

Food Chem Toxicol. 2016 Jul;93:20-31. doi: 10.1016/j.fct.2016.04.014. Epub 2016 Apr 23.

PMID:
27117919
24.

Sampling and composition of airborne particulate matter (PM10) from two locations of Mexico City.

Chirino YI, Sánchez-Pérez Y, Osornio-Vargas ÁR, Rosas I, García-Cuellar CM.

Data Brief. 2015 Jul 2;4:353-6. doi: 10.1016/j.dib.2015.06.017. eCollection 2015 Sep.

25.

Particulate matter (PM₁₀) induces metalloprotease activity and invasion in airway epithelial cells.

Morales-Bárcenas R, Chirino YI, Sánchez-Pérez Y, Osornio-Vargas ÁR, Melendez-Zajgla J, Rosas I, García-Cuellar CM.

Toxicol Lett. 2015 Sep 17;237(3):167-73. doi: 10.1016/j.toxlet.2015.06.001. Epub 2015 Jun 3.

PMID:
26047787
26.

Difficulties in establishing regulations for engineered nanomaterials and considerations for policy makers: avoiding an unbalance between benefits and risks.

Garduño-Balderas LG, Urrutia-Ortega IM, Medina-Reyes EI, Chirino YI.

J Appl Toxicol. 2015 Oct;35(10):1073-85. doi: 10.1002/jat.3180. Epub 2015 Jun 5. Review.

PMID:
26046543
27.

Titanium dioxide nanoparticles induce an adaptive inflammatory response and invasion and proliferation of lung epithelial cells in chorioallantoic membrane.

Medina-Reyes EI, Déciga-Alcaraz A, Freyre-Fonseca V, Delgado-Buenrostro NL, Flores-Flores JO, Gutiérrez-López GF, Sánchez-Pérez Y, García-Cuéllar CM, Pedraza-Chaverri J, Chirino YI.

Environ Res. 2015 Jan;136:424-34. doi: 10.1016/j.envres.2014.10.016. Epub 2014 Nov 25.

PMID:
25460664
28.

Cell cycle synchronization reveals greater G2/M-phase accumulation of lung epithelial cells exposed to titanium dioxide nanoparticles.

Medina-Reyes EI, Bucio-López L, Freyre-Fonseca V, Sánchez-Pérez Y, García-Cuéllar CM, Morales-Bárcenas R, Pedraza-Chaverri J, Chirino YI.

Environ Sci Pollut Res Int. 2015 Mar;22(5):3976-82. doi: 10.1007/s11356-014-3871-y. Epub 2014 Nov 26.

PMID:
25422119
29.

Mitochondria as a target in the therapeutic properties of curcumin.

Trujillo J, Granados-Castro LF, Zazueta C, Andérica-Romero AC, Chirino YI, Pedraza-Chaverrí J.

Arch Pharm (Weinheim). 2014 Dec;347(12):873-84. doi: 10.1002/ardp.201400266. Epub 2014 Sep 22. Review.

PMID:
25243820
30.

Extraintestinal helminth infection reduces the development of colitis-associated tumorigenesis.

León-Cabrera S, Callejas BE, Ledesma-Soto Y, Coronel J, Pérez-Plasencia C, Gutiérrez-Cirlos EB, Ávila-Moreno F, Rodríguez-Sosa M, Hernández-Pando R, Marquina-Castillo B, Chirino YI, Terrazas LI.

Int J Biol Sci. 2014 Aug 24;10(9):948-56. doi: 10.7150/ijbs.9033. eCollection 2014.

31.

Titanium dioxide nanoparticles induce strong oxidative stress and mitochondrial damage in glial cells.

Huerta-García E, Pérez-Arizti JA, Márquez-Ramírez SG, Delgado-Buenrostro NL, Chirino YI, Iglesias GG, López-Marure R.

Free Radic Biol Med. 2014 Aug;73:84-94. doi: 10.1016/j.freeradbiomed.2014.04.026. Epub 2014 May 10.

PMID:
24824983
32.

Nrf2 protects the lung against inflammation induced by titanium dioxide nanoparticles: A positive regulator role of Nrf2 on cytokine release.

Delgado-Buenrostro NL, Medina-Reyes EI, Lastres-Becker I, Freyre-Fonseca V, Ji Z, Hernández-Pando R, Marquina B, Pedraza-Chaverri J, Espada S, Cuadrado A, Chirino YI.

Environ Toxicol. 2015 Jul;30(7):782-92. doi: 10.1002/tox.21957. Epub 2014 Feb 26.

PMID:
24615891
33.

Toxins from the Caribbean sea anemone Bunodeopsis globulifera increase cisplatin-induced cytotoxicity of lung adenocarcinoma cells.

Monroy-Estrada HI, Chirino YI, Soria-Mercado IE, Sánchez-Rodríguez J.

J Venom Anim Toxins Incl Trop Dis. 2013 May 7;19(1):12. doi: 10.1186/1678-9199-19-12.

34.

Cytoplasmic p21(CIP1/WAF1), ERK1/2 activation, and cytoskeletal remodeling are associated with the senescence-like phenotype after airborne particulate matter (PM(10)) exposure in lung cells.

Sánchez-Pérez Y, Chirino YI, Osornio-Vargas ÁR, Herrera LA, Morales-Bárcenas R, López-Saavedra A, González-Ramírez I, Miranda J, García-Cuellar CM.

Toxicol Lett. 2014 Feb 10;225(1):12-9. doi: 10.1016/j.toxlet.2013.11.018. Epub 2013 Nov 26.

PMID:
24291038
35.

Renoprotective effect of the antioxidant curcumin: Recent findings.

Trujillo J, Chirino YI, Molina-Jijón E, Andérica-Romero AC, Tapia E, Pedraza-Chaverrí J.

Redox Biol. 2013 Sep 17;1:448-56. doi: 10.1016/j.redox.2013.09.003. Review.

36.

Decrease in respiratory function and electron transport chain induced by airborne particulate matter (PM10) exposure in lung mitochondria.

Delgado-Buenrostro NL, Freyre-Fonseca V, Cuéllar CM, Sánchez-Pérez Y, Gutierrez-Cirlos EB, Cabellos-Avelar T, Orozco-Ibarra M, Pedraza-Chaverri J, Chirino YI.

Toxicol Pathol. 2013;41(4):628-38. doi: 10.1177/0192623312463784. Epub 2012 Oct 26.

PMID:
23104767
37.

Titanium dioxide nanoparticles inhibit proliferation and induce morphological changes and apoptosis in glial cells.

Márquez-Ramírez SG, Delgado-Buenrostro NL, Chirino YI, Iglesias GG, López-Marure R.

Toxicology. 2012 Dec 16;302(2-3):146-56. doi: 10.1016/j.tox.2012.09.005. Epub 2012 Oct 5.

PMID:
23044362
38.

Titanium dioxide nanoparticles impair lung mitochondrial function.

Freyre-Fonseca V, Delgado-Buenrostro NL, Gutiérrez-Cirlos EB, Calderón-Torres CM, Cabellos-Avelar T, Sánchez-Pérez Y, Pinzón E, Torres I, Molina-Jijón E, Zazueta C, Pedraza-Chaverri J, García-Cuéllar CM, Chirino YI.

Toxicol Lett. 2011 Apr 25;202(2):111-9. doi: 10.1016/j.toxlet.2011.01.025. Epub 2011 Feb 15.

PMID:
21315139
39.

Protective effect of sulforaphane against oxidative stress: recent advances.

Guerrero-Beltrán CE, Calderón-Oliver M, Pedraza-Chaverri J, Chirino YI.

Exp Toxicol Pathol. 2012 Jul;64(5):503-8. doi: 10.1016/j.etp.2010.11.005. Epub 2010 Dec 3. Review.

PMID:
21129940
40.

The alpha-mangostin prevention on cisplatin-induced apoptotic death in LLC-PK1 cells is associated to an inhibition of ROS production and p53 induction.

Sánchez-Pérez Y, Morales-Bárcenas R, García-Cuellar CM, López-Marure R, Calderon-Oliver M, Pedraza-Chaverri J, Chirino YI.

Chem Biol Interact. 2010 Oct 6;188(1):144-50. doi: 10.1016/j.cbi.2010.06.014.

PMID:
20603111
41.

PM(10) impairs the antioxidant defense system and exacerbates oxidative stress driven cell death.

Chirino YI, Sánchez-Pérez Y, Osornio-Vargas AR, Morales-Bárcenas R, Gutiérrez-Ruíz MC, Segura-García Y, Rosas I, Pedraza-Chaverri J, García-Cuellar CM.

Toxicol Lett. 2010 Apr 1;193(3):209-16. doi: 10.1016/j.toxlet.2010.01.009. Epub 2010 Jan 22.

PMID:
20096756
42.

DNA damage response of A549 cells treated with particulate matter (PM10) of urban air pollutants.

Sánchez-Pérez Y, Chirino YI, Osornio-Vargas ÁR, Morales-Bárcenas R, Gutiérrez-Ruíz C, Vázquez-López I, García-Cuellar CM.

Cancer Lett. 2009 Jun 18;278(2):192-200. doi: 10.1016/j.canlet.2009.01.010. Epub 2009 Feb 13.

PMID:
19217710
43.

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity.

Chirino YI, Pedraza-Chaverri J.

Exp Toxicol Pathol. 2009 May;61(3):223-42. doi: 10.1016/j.etp.2008.09.003. Epub 2008 Nov 4. Review.

PMID:
18986801
44.

Garlic powder ameliorates cisplatin-induced nephrotoxicity and oxidative stress.

Razo-Rodríguez AC, Chirino YI, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Pedraza-Chaverri J.

J Med Food. 2008 Sep;11(3):582-6. doi: 10.1089/jmf.2008.0033.

PMID:
18800910
45.

PJ34, a poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity.

Yam-Canul P, Chirino YI, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Pedraza-Chaverri J.

Basic Clin Pharmacol Toxicol. 2008 May;102(5):483-8. doi: 10.1111/j.1742-7843.2008.00224.x. Epub 2008 Mar 6.

46.

Protective effects of apocynin against cisplatin-induced oxidative stress and nephrotoxicity.

Chirino YI, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Pedraza-Chaverri J.

Toxicology. 2008 Mar 12;245(1-2):18-23. doi: 10.1016/j.tox.2007.12.007. Epub 2007 Dec 23.

PMID:
18243469
47.

Nordihydroguaiaretic acid attenuates potassium dichromate-induced oxidative stress and nephrotoxicity.

Yam-Canul P, Chirino YI, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Villanueva C, Pedraza-Chaverri J.

Food Chem Toxicol. 2008 Mar;46(3):1089-96. Epub 2007 Nov 17.

PMID:
18155343
48.

Selective iNOS inhibition reduces renal damage induced by cisplatin.

Chirino YI, Trujillo J, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Bobadilla NA, Pedraza-Chaverri J.

Toxicol Lett. 2008 Jan 4;176(1):48-57. Epub 2007 Oct 24.

PMID:
18063323
49.

Protective effects of garlic powder against potassium dichromate-induced oxidative stress and nephrotoxicity.

Pedraza-Chaverri J, Yam-Canul P, Chirino YI, Sánchez-González DJ, Martínez-Martínez CM, Cruz C, Medina-Campos ON.

Food Chem Toxicol. 2008 Feb;46(2):619-27. Epub 2007 Sep 18.

PMID:
17950512
50.

Renoprotective and antihypertensive effects of S-allylcysteine in 5/6 nephrectomized rats.

Cruz C, Correa-Rotter R, Sánchez-González DJ, Hernández-Pando R, Maldonado PD, Martínez-Martínez CM, Medina-Campos ON, Tapia E, Aguilar D, Chirino YI, Pedraza-Chaverri J.

Am J Physiol Renal Physiol. 2007 Nov;293(5):F1691-8. Epub 2007 Aug 8.

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