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Items: 32


ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder.

Williams LB, Javed A, Sabri A, Morgan DJ, Huff CD, Grigg JR, Heng XT, Khng AJ, Hollink IHIM, Morrison MA, Owen LA, Anderson K, Kinard K, Greenlees R, Novacic D, Nida Sen H, Zein WM, Rodgers GM, Vitale AT, Haider NB, Hillmer AM, Ng PC, Shankaracharya, Cheng A, Zheng L, Gillies MC, van Slegtenhorst M, van Hagen PM, Missotten TOAR, Farley GL, Polo M, Malatack J, Curtin J, Martin F, Arbuckle S, Alexander SI, Chircop M, Davila S, Digre KB, Jamieson RV, DeAngelis MM.

Genet Med. 2019 Sep;21(9):2103-2115. doi: 10.1038/s41436-019-0476-3. Epub 2019 Apr 10.


Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.

Luwor R, Morokoff AP, Amiridis S, D'Abaco G, Paradiso L, Stylli SS, Nguyen HPT, Tarleton M, Young KA, O'Brien TJ, Robinson PJ, Chircop M, McCluskey A, Jones NC.

Cancer Invest. 2019;37(3):144-155. doi: 10.1080/07357907.2019.1582060. Epub 2019 Mar 25.


Automated classification and characterization of the mitotic spindle following knockdown of a mitosis-related protein.

Khushi M, Dean IM, Teber ET, Chircop M, Arthur JW, Flores-Rodriguez N.

BMC Bioinformatics. 2017 Dec 28;18(Suppl 16):566. doi: 10.1186/s12859-017-1966-4.


The Clathrin-dependent Spindle Proteome.

Rao SR, Flores-Rodriguez N, Page SL, Wong C, Robinson PJ, Chircop M.

Mol Cell Proteomics. 2016 Aug;15(8):2537-53. doi: 10.1074/mcp.M115.054809. Epub 2016 May 12.


Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling.

Tremblay CS, Brown FC, Collett M, Saw J, Chiu SK, Sonderegger SE, Lucas SE, Alserihi R, Chau N, Toribio ML, McCormack MP, Chircop M, Robinson PJ, Jane SM, Curtis DJ.

Leukemia. 2016 Oct;30(10):1993-2001. doi: 10.1038/leu.2016.100. Epub 2016 Apr 27.


Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling.

Phoa AF, Browne S, Gurgis FM, Åkerfeldt MC, Döbber A, Renn C, Peifer C, Stringer BW, Day BW, Wong C, Chircop M, Johns TG, Kassiou M, Munoz L.

Biochem Pharmacol. 2015 Dec 15;98(4):587-601. doi: 10.1016/j.bcp.2015.10.014. Epub 2015 Oct 28.


A Cholesterol-Dependent Endocytic Mechanism Generates Midbody Tubules During Cytokinesis.

Kettle E, Page SL, Morgan GP, Malladi CS, Wong CL, Boadle RA, Marsh BJ, Robinson PJ, Chircop M.

Traffic. 2015 Nov;16(11):1174-92. doi: 10.1111/tra.12328. Epub 2015 Sep 23.


IQGAP1 is associated with nuclear envelope reformation and completion of abscission.

Lian AT, Hains PG, Sarcevic B, Robinson PJ, Chircop M.

Cell Cycle. 2015;14(13):2058-74. doi: 10.1080/15384101.2015.1044168. Epub 2015 Apr 30.


Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2.

Gurgis F, Åkerfeldt MC, Heng B, Wong C, Adams S, Guillemin GJ, Johns TG, Chircop M, Munoz L.

Cell Death Discov. 2015 Sep 7;1:15028. doi: 10.1038/cddiscovery.2015.28. eCollection 2015.


Cellular stress responses in cancer and cancer therapy.

Chircop M, Speidel D.

Front Oncol. 2014 Oct 29;4:304. doi: 10.3389/fonc.2014.00304. eCollection 2014. No abstract available.


Rho GTPases as regulators of mitosis and cytokinesis in mammalian cells.

Chircop M.

Small GTPases. 2014;5. pii: e29770. doi: 10.4161/sgtp.29770. Epub 2014 Jul 2. Review.


Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.

McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ.

Traffic. 2013 Dec;14(12):1272-89. doi: 10.1111/tra.12119. Epub 2013 Oct 9.


Sorting nexin 9 recruits clathrin heavy chain to the mitotic spindle for chromosome alignment and segregation.

Ma MP, Robinson PJ, Chircop M.

PLoS One. 2013 Jul 5;8(7):e68387. doi: 10.1371/journal.pone.0068387. Print 2013.


CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci.

Boutros R, Mondesert O, Lorenzo C, Astuti P, McArthur G, Chircop M, Ducommun B, Gabrielli B.

PLoS One. 2013 Jul 1;8(7):e67822. doi: 10.1371/journal.pone.0067822. Print 2013.


Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.

McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, Gorgani NN, Keating DJ, Cousin MA, van Dam EM, Mariana A, Whiting A, Perera S, Novelle A, Young KA, Deane FM, Gilbert J, Sakoff JA, Chircop M, McCluskey A, Robinson PJ.

ACS Chem Biol. 2013 Jul 19;8(7):1507-18. doi: 10.1021/cb400137p. Epub 2013 May 30.


Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells.

Smith CM, Haucke V, McCluskey A, Robinson PJ, Chircop M.

Mol Cancer. 2013 Jan 17;12:4. doi: 10.1186/1476-4598-12-4.


Development of second-generation indole-based dynamin GTPase inhibitors.

Gordon CP, Venn-Brown B, Robertson MJ, Young KA, Chau N, Mariana A, Whiting A, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2013 Jan 10;56(1):46-59. doi: 10.1021/jm300844m. Epub 2012 Dec 18.


Clathrin-mediated endocytic proteins are involved in regulating mitotic progression and completion.

Smith CM, Chircop M.

Traffic. 2012 Dec;13(12):1628-41. doi: 10.1111/tra.12001. Epub 2012 Sep 7.


SNX9, SNX18 and SNX33 are required for progression through and completion of mitosis.

Ma MP, Chircop M.

J Cell Sci. 2012 Sep 15;125(Pt 18):4372-82. doi: 10.1242/jcs.105981. Epub 2012 Jun 20.


Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, MacGregor KA, Tomilin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Kräusslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V.

Cell. 2011 Aug 5;146(3):471-84. doi: 10.1016/j.cell.2011.06.025. Erratum in: Cell. 2011 Sep 2;146(5):841. Tomlin, Nikolay [corrected to Tomilin, Nikolay].


Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.

Chircop M, Perera S, Mariana A, Lau H, Ma MP, Gilbert J, Jones NC, Gordon CP, Young KA, Morokoff A, Sakoff J, O'Brien TJ, McCluskey A, Robinson PJ.

Mol Cancer Ther. 2011 Sep;10(9):1553-62. doi: 10.1158/1535-7163.MCT-11-0067. Epub 2011 Jul 12.


Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression.

Joshi S, Braithwaite AW, Robinson PJ, Chircop M.

Mol Cancer. 2011 Jun 28;10:78. doi: 10.1186/1476-4598-10-78.


Phosphorylation of dynamin II at serine-764 is associated with cytokinesis.

Chircop M, Sarcevic B, Larsen MR, Malladi CS, Chau N, Zavortink M, Smith CM, Quan A, Anggono V, Hains PG, Graham ME, Robinson PJ.

Biochim Biophys Acta. 2011 Oct;1813(10):1689-99. doi: 10.1016/j.bbamcr.2010.12.018. Epub 2010 Dec 29.


The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.

Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M.

Mol Cancer Ther. 2010 Jul;9(7):1995-2006. doi: 10.1158/1535-7163.MCT-10-0161. Epub 2010 Jun 22.


Calcineurin activity is required for the completion of cytokinesis.

Chircop M, Malladi CS, Lian AT, Page SL, Zavortink M, Gordon CP, McCluskey A, Robinson PJ.

Cell Mol Life Sci. 2010 Nov;67(21):3725-37. doi: 10.1007/s00018-010-0401-z. Epub 2010 May 23.


Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.

Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2009 Jun 25;52(12):3762-73. doi: 10.1021/jm900036m.


The actin-binding and bundling protein, EPLIN, is required for cytokinesis.

Chircop M, Oakes V, Graham ME, Ma MP, Smith CM, Robinson PJ, Khanna KK.

Cell Cycle. 2009 Mar 1;8(5):757-64. Epub 2009 Mar 18.


Significant thresholds for the 75-g oral glucose tolerance test in pregnancy.

Savona-Ventura C, Chircop M.

J Diabetes Complications. 2008 May-Jun;22(3):178-80. doi: 10.1016/j.jdiacomp.2006.10.001. Epub 2008 Apr 16.


The outcome of diabetic pregnancies in Malta.

Savona-Ventura C, Ellul A, Chircop M.

Int J Gynaecol Obstet. 2003 Aug;82(2):217-8. No abstract available.


Birth weight influence on the subsequent development of gestational diabetes mellitus.

Savona-Ventura C, Chircop M.

Acta Diabetol. 2003 Jun;40(2):101-4.


Risk factors for gestational impaired glucose tolerance in the Maltese population: a cross-sectional study.

Savona-Ventura C, Schranz AG, Chircop M.

J Obstet Gynaecol. 2001 Nov;21(6):591-4.


Wound healing and growth factor expression in T lymphocyte deficiency.

Chircop MP, Yu Y, Berney CR, Yang JL, Crowe PJ, Walsh WR.

ANZ J Surg. 2002 Jul;72(7):491-5.


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