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Items: 1 to 50 of 196

1.

Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague-Dawley rats.

Guo C, Robertson S, Weber RJM, Buckley A, Warren J, Hodgson A, Rappoport JZ, Ignatyev K, Meldrum K, Römer I, Macchiarulo S, Chipman JK, Marczylo T, Leonard MO, Gant TW, Viant MR, Smith R.

Nanotoxicology. 2019 Feb 1:1-18. doi: 10.1080/17435390.2018.1554751. [Epub ahead of print]

PMID:
30704321
2.

Use of 5-azacytidine in a proof-of-concept study to evaluate the impact of pre-natal and post-natal exposures, as well as within generation persistent DNA methylation changes in Daphnia.

Athanasio CG, Sommer U, Viant MR, Chipman JK, Mirbahai L.

Ecotoxicology. 2018 Jul;27(5):556-568. doi: 10.1007/s10646-018-1927-3. Epub 2018 Apr 5.

3.

The percutaneous toxicokinetics of VX in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant.

Lydon H, Hall C, Matar H, Dalton C, Chipman JK, Graham JS, Chilcott RP.

J Appl Toxicol. 2018 Mar;38(3):318-328. doi: 10.1002/jat.3542. Epub 2017 Oct 10.

PMID:
29023806
4.

The percutaneous absorption of soman in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant.

Dalton C, Hall C, Lydon H, Jenner J, Chipman JK, Graham JS, Chilcott RP.

Cutan Ocul Toxicol. 2018 Jun;37(2):172-179. doi: 10.1080/15569527.2017.1365883. Epub 2017 Aug 30.

PMID:
28853336
5.

Mutagenic activities of biochars from pyrolysis.

Piterina AV, Chipman JK, Pembroke JT, Hayes MHB.

Sci Total Environ. 2017 Aug 15;592:674-679. doi: 10.1016/j.scitotenv.2017.02.198. Epub 2017 Mar 15.

PMID:
28314607
6.

The percutaneous toxicokinetics of Sulphur mustard in a damaged skin porcine model and the evaluation of WoundStat™ as a topical decontaminant.

Hall CA, Lydon HL, Dalton CH, Chipman JK, Graham JS, Chilcott RP.

J Appl Toxicol. 2017 Sep;37(9):1036-1045. doi: 10.1002/jat.3453. Epub 2017 Mar 17.

PMID:
28304107
7.

Development of haemostatic decontaminants for treatment of wounds contaminated with chemical warfare agents. 3: Evaluation of in vitro topical decontamination efficacy using damaged skin.

Lydon HL, Hall CA, Dalton CH, Chipman JK, Graham JS, Chilcott RP.

J Appl Toxicol. 2017 Aug;37(8):976-984. doi: 10.1002/jat.3446. Epub 2017 Feb 20.

PMID:
28218409
8.

Protein Corona Modulates Uptake and Toxicity of Nanoceria via Clathrin-Mediated Endocytosis.

Mazzolini J, Weber RJ, Chen HS, Khan A, Guggenheim E, Shaw RK, Chipman JK, Viant MR, Rappoport JZ.

Biol Bull. 2016 Aug;231(1):40-60.

PMID:
27638694
9.

Optimisation of DNA extraction from the crustacean Daphnia.

Athanasio CG, Chipman JK, Viant MR, Mirbahai L.

PeerJ. 2016 May 10;4:e2004. doi: 10.7717/peerj.2004. eCollection 2016.

10.

Gene expression and metabolic responses of HepG2/C3A cells exposed to flame retardants and dust extracts at concentrations relevant to indoor environmental exposures.

Zhang J, Abdallah MA, Williams TD, Harrad S, Chipman JK, Viant MR.

Chemosphere. 2016 Feb;144:1996-2003. doi: 10.1016/j.chemosphere.2015.10.014. Epub 2015 Nov 11.

PMID:
26551197
11.

Assessment of global and gene-specific DNA methylation in rat liver and kidney in response to non-genotoxic carcinogen exposure.

Ozden S, Turgut Kara N, Sezerman OU, Durasi İM, Chen T, Demirel G, Alpertunga B, Chipman JK, Mally A.

Toxicol Appl Pharmacol. 2015 Dec 1;289(2):203-12. doi: 10.1016/j.taap.2015.09.023. Epub 2015 Sep 30.

PMID:
26431795
12.

Transcriptomic and metabolomic approaches to investigate the molecular responses of human cell lines exposed to the flame retardant hexabromocyclododecane (HBCD).

Zhang J, Williams TD, Abdallah MA, Harrad S, Chipman JK, Viant MR.

Toxicol In Vitro. 2015 Dec;29(8):2116-23. doi: 10.1016/j.tiv.2015.08.017. Epub 2015 Aug 28.

PMID:
26320833
13.

Key metabolic pathways involved in xenobiotic biotransformation and stress responses revealed by transcriptomics of the mangrove oyster Crassostrea brasiliana.

Lüchmann KH, Clark MS, Bainy AC, Gilbert JA, Craft JA, Chipman JK, Thorne MA, Mattos JJ, Siebert MN, Schroeder DC.

Aquat Toxicol. 2015 Sep;166:10-20. doi: 10.1016/j.aquatox.2015.06.012. Epub 2015 Jul 2.

PMID:
26186662
14.

Defensive and adverse energy-related molecular responses precede tris (1, 3-dichloro-2-propyl) phosphate cytotoxicity.

Zhang J, Williams TD, Chipman JK, Viant MR.

J Appl Toxicol. 2016 May;36(5):649-58. doi: 10.1002/jat.3194. Epub 2015 Jul 15.

PMID:
26179874
15.

Adverse Outcome Pathways can drive non-animal approaches for safety assessment.

Burden N, Sewell F, Andersen ME, Boobis A, Chipman JK, Cronin MT, Hutchinson TH, Kimber I, Whelan M.

J Appl Toxicol. 2015 Sep;35(9):971-5. doi: 10.1002/jat.3165. Epub 2015 May 5.

16.

Functional xenobiotic metabolism and efflux transporters in trout hepatocyte spheroid cultures.

Uchea C, Owen SF, Chipman JK.

Toxicol Res (Camb). 2015 Mar 23;4(2):494-507. Epub 2015 Feb 9.

17.

Molecular toxicity of cerium oxide nanoparticles to the freshwater alga Chlamydomonas reinhardtii is associated with supra-environmental exposure concentrations.

Taylor NS, Merrifield R, Williams TD, Chipman JK, Lead JR, Viant MR.

Nanotoxicology. 2016;10(1):32-41. doi: 10.3109/17435390.2014.1002868. Epub 2015 Mar 5.

18.

High-resolution mass spectrometry provides novel insights into products of human metabolism of organophosphate and brominated flame retardants.

Abdallah MA, Zhang J, Pawar G, Viant MR, Chipman JK, D'Silva K, Bromirski M, Harrad S.

Anal Bioanal Chem. 2015 Mar;407(7):1871-83. doi: 10.1007/s00216-015-8466-z. Epub 2015 Jan 21.

PMID:
25600687
19.

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: II. A focus on growth impairment in fish.

Groh KJ, Carvalho RN, Chipman JK, Denslow ND, Halder M, Murphy CA, Roelofs D, Rolaki A, Schirmer K, Watanabe KH.

Chemosphere. 2015 Feb;120:778-92. doi: 10.1016/j.chemosphere.2014.10.006. Epub 2014 Oct 30. Review.

20.

Development and application of the adverse outcome pathway framework for understanding and predicting chronic toxicity: I. Challenges and research needs in ecotoxicology.

Groh KJ, Carvalho RN, Chipman JK, Denslow ND, Halder M, Murphy CA, Roelofs D, Rolaki A, Schirmer K, Watanabe KH.

Chemosphere. 2015 Feb;120:764-77. doi: 10.1016/j.chemosphere.2014.09.068. Epub 2014 Nov 11. Review.

21.

Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 2: evaluation of in vitro topical decontamination efficacy using undamaged skin.

Dalton CH, Hall CA, Lydon HL, Chipman JK, Graham JS, Jenner J, Chilcott RP.

J Appl Toxicol. 2015 May;35(5):543-50. doi: 10.1002/jat.3060. Epub 2014 Sep 12.

PMID:
25219755
22.

Development of haemostatic decontaminants for the treatment of wounds contaminated with chemical warfare agents. 1: evaluation of in vitro clotting efficacy in the presence of certain contaminants.

Hall CA, Lydon HL, Dalton CH, Chipman JK, Graham JS, Chilcott RP.

J Appl Toxicol. 2015 May;35(5):536-42. doi: 10.1002/jat.3019. Epub 2014 Aug 15.

PMID:
25131713
23.

Molecular responses of European flounder (Platichthys flesus) chronically exposed to contaminated estuarine sediments.

Williams TD, Davies IM, Wu H, Diab AM, Webster L, Viant MR, Chipman JK, Leaver MJ, George SG, Moffat CF, Robinson CD.

Chemosphere. 2014 Aug;108:152-8. doi: 10.1016/j.chemosphere.2014.01.028. Epub 2014 Feb 15.

24.

Enantioselective biotransformation of hexabromocyclododecane by in vitro rat and trout hepatic sub-cellular fractions.

Abdallah MA, Uchea C, Chipman JK, Harrad S.

Environ Sci Technol. 2014;48(5):2732-40. doi: 10.1021/es404644s. Epub 2014 Feb 12.

PMID:
24483621
25.

The toxicological application of transcriptomics and epigenomics in zebrafish and other teleosts.

Williams TD, Mirbahai L, Chipman JK.

Brief Funct Genomics. 2014 Mar;13(2):157-71. doi: 10.1093/bfgp/elt053. Epub 2014 Jan 7. Review.

PMID:
24397978
26.

Epigenetic memory of environmental organisms: a reflection of lifetime stressor exposures.

Mirbahai L, Chipman JK.

Mutat Res Genet Toxicol Environ Mutagen. 2014 Apr;764-765:10-7. doi: 10.1016/j.mrgentox.2013.10.003. Epub 2013 Oct 17. Review.

27.

The critical importance of defined media conditions in Daphnia magna nanotoxicity studies.

Römer I, Gavin AJ, White TA, Merrifield RC, Chipman JK, Viant MR, Lead JR.

Toxicol Lett. 2013 Oct 23;223(1):103-8. doi: 10.1016/j.toxlet.2013.08.026. Epub 2013 Sep 8.

28.

Transcriptomic responses of European flounder (Platichthys flesus) liver to a brominated flame retardant mixture.

Williams TD, Diab AM, Gubbins M, Collins C, Matejusova I, Kerr R, Chipman JK, Kuiper R, Vethaak AD, George SG.

Aquat Toxicol. 2013 Oct 15;142-143:45-52. doi: 10.1016/j.aquatox.2013.07.013. Epub 2013 Jul 29.

PMID:
23948077
29.

Disruption of DNA methylation via S-adenosylhomocysteine is a key process in high incidence liver carcinogenesis in fish.

Mirbahai L, Southam AD, Sommer U, Williams TD, Bignell JP, Lyons BP, Viant MR, Chipman JK.

J Proteome Res. 2013 Jun 7;12(6):2895-904. doi: 10.1021/pr400195u. Epub 2013 May 6.

PMID:
23611792
30.

Furan in heat-treated foods: formation, exposure, toxicity, and aspects of risk assessment.

Moro S, Chipman JK, Wegener JW, Hamberger C, Dekant W, Mally A.

Mol Nutr Food Res. 2012 Aug;56(8):1197-211. doi: 10.1002/mnfr.201200093. Epub 2012 May 29. Review.

PMID:
22641279
31.

Metabolism of ibuprofen in zebrafish larvae.

Jones HS, Trollope HT, Hutchinson TH, Panter GH, Chipman JK.

Xenobiotica. 2012 Nov;42(11):1069-75. doi: 10.3109/00498254.2012.684410. Epub 2012 May 17.

PMID:
22594345
32.

Alternative splicing interference by xenobiotics.

Zaharieva E, Chipman JK, Soller M.

Toxicology. 2012 Jun 14;296(1-3):1-12. doi: 10.1016/j.tox.2012.01.014. Epub 2012 Feb 1. Review.

PMID:
22321775
33.

Identification and pathway mapping of furan target proteins reveal mitochondrial energy production and redox regulation as critical targets of furan toxicity.

Moro S, Chipman JK, Antczak P, Turan N, Dekant W, Falciani F, Mally A.

Toxicol Sci. 2012 Apr;126(2):336-52. doi: 10.1093/toxsci/kfs005. Epub 2012 Jan 12.

PMID:
22240984
34.

Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety.

Wilkinson LJ, White RJ, Chipman JK.

J Wound Care. 2011 Nov;20(11):543-9. Review.

PMID:
22240850
35.

Gene expression and epigenetic changes by furan in rat liver.

Chen T, Williams TD, Mally A, Hamberger C, Mirbahai L, Hickling K, Chipman JK.

Toxicology. 2012 Feb 26;292(2-3):63-70. doi: 10.1016/j.tox.2011.10.020. Epub 2011 Nov 3.

PMID:
22079235
36.

DNA methylation in liver tumorigenesis in fish from the environment.

Mirbahai L, Yin G, Bignell JP, Li N, Williams TD, Chipman JK.

Epigenetics. 2011 Nov;6(11):1319-33. doi: 10.4161/epi.6.11.17890. Epub 2011 Nov 1.

PMID:
22048251
37.

Transcriptional responses in neonate and adult Daphnia magna in relation to relative susceptibility to genotoxicants.

David RM, Dakic V, Williams TD, Winter MJ, Chipman JK.

Aquat Toxicol. 2011 Aug;104(3-4):192-204. doi: 10.1016/j.aquatox.2011.04.016. Epub 2011 Apr 30.

PMID:
21632023
38.

Comprehensive profiling of zebrafish hepatic proximal promoter CpG island methylation and its modification during chemical carcinogenesis.

Mirbahai L, Williams TD, Zhan H, Gong Z, Chipman JK.

BMC Genomics. 2011 Jan 4;12:3. doi: 10.1186/1471-2164-12-3.

39.

Reverse engineering adverse outcome pathways.

Perkins EJ, Chipman JK, Edwards S, Habib T, Falciani F, Taylor R, Van Aggelen G, Vulpe C, Antczak P, Loguinov A.

Environ Toxicol Chem. 2011 Jan;30(1):22-38. doi: 10.1002/etc.374.

PMID:
20963852
40.

Mapping drug physico-chemical features to pathway activity reveals molecular networks linked to toxicity outcome.

Antczak P, Ortega F, Chipman JK, Falciani F.

PLoS One. 2010 Aug 27;5(8):e12385. doi: 10.1371/journal.pone.0012385.

41.

Low doses of the carcinogen furan alter cell cycle and apoptosis gene expression in rat liver independent of DNA methylation.

Chen T, Mally A, Ozden S, Chipman JK.

Environ Health Perspect. 2010 Nov;118(11):1597-602. doi: 10.1289/ehp.1002153.

42.

Functional and proliferative effects of repeated low-dose oral administration of furan in rat liver.

Mally A, Graff C, Schmal O, Moro S, Hamberger C, Schauer UM, Brück J, Ozden S, Sieber M, Steger U, Schrenk D, Hard GC, Chipman JK, Dekant W.

Mol Nutr Food Res. 2010 Nov;54(11):1556-67. doi: 10.1002/mnfr.201000064.

PMID:
20540150
43.

Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo.

Jones HS, Panter GH, Hutchinson TH, Chipman JK.

Zebrafish. 2010 Mar;7(1):23-30. doi: 10.1089/zeb.2009.0630.

PMID:
20415643
44.

Induction and progression of cholangiofibrosis in rat liver injured by oral administration of furan.

Hickling KC, Hitchcock JM, Chipman JK, Hammond TG, Evans JG.

Toxicol Pathol. 2010 Feb;38(2):213-29. doi: 10.1177/0192623309357945.

PMID:
20231548
45.

Gene expression analyses of hepatocellular adenoma and hepatocellular carcinoma from the marine flatfish Limanda limanda.

Small HJ, Williams TD, Sturve J, Chipman JK, Southam AD, Bean TP, Lyons BP, Stentiford GD.

Dis Aquat Organ. 2010 Jan 25;88(2):127-41. doi: 10.3354/dao02148.

46.

Evidence of oxidative stress and associated DNA damage, increased proliferative drive, and altered gene expression in rat liver produced by the cholangiocarcinogenic agent furan.

Hickling KC, Hitchcock JM, Oreffo V, Mally A, Hammond TG, Evans JG, Chipman JK.

Toxicol Pathol. 2010 Feb;38(2):230-43. doi: 10.1177/0192623309357946. Epub 2010 Feb 2.

PMID:
20124500
47.

Pyrosequencing of Mytilus galloprovincialis cDNAs: tissue-specific expression patterns.

Craft JA, Gilbert JA, Temperton B, Dempsey KE, Ashelford K, Tiwari B, Hutchinson TH, Chipman JK.

PLoS One. 2010 Jan 25;5(1):e8875. doi: 10.1371/journal.pone.0008875.

48.

Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook.

Van Aggelen G, Ankley GT, Baldwin WS, Bearden DW, Benson WH, Chipman JK, Collette TW, Craft JA, Denslow ND, Embry MR, Falciani F, George SG, Helbing CC, Hoekstra PF, Iguchi T, Kagami Y, Katsiadaki I, Kille P, Liu L, Lord PG, McIntyre T, O'Neill A, Osachoff H, Perkins EJ, Santos EM, Skirrow RC, Snape JR, Tyler CR, Versteeg D, Viant MR, Volz DC, Williams TD, Yu L.

Environ Health Perspect. 2010 Jan;118(1):1-5. doi: 10.1289/ehp.0900985.

49.

Identifying health impacts of exposure to copper using transcriptomics and metabolomics in a fish model.

Santos EM, Ball JS, Williams TD, Wu H, Ortega F, van Aerle R, Katsiadaki I, Falciani F, Viant MR, Chipman JK, Tyler CR.

Environ Sci Technol. 2010 Jan 15;44(2):820-6. doi: 10.1021/es902558k.

PMID:
20020678
50.

Hepatic gene expression in flounder chronically exposed to multiply polluted estuarine sediment: Absence of classical exposure 'biomarker' signals and induction of inflammatory, innate immune and apoptotic pathways.

Leaver MJ, Diab A, Boukouvala E, Williams TD, Chipman JK, Moffat CF, Robinson CD, George SG.

Aquat Toxicol. 2010 Feb 18;96(3):234-45. doi: 10.1016/j.aquatox.2009.10.025. Epub 2009 Nov 10.

PMID:
19945177

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