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Items: 1 to 50 of 136


Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction-induced memory enhancement.

Teng LL, Lu GL, Chiou LC, Lin WS, Cheng YY, Hsueh TE, Huang YC, Hwang NH, Yeh JW, Liao RM, Fan SZ, Yen JH, Fu TF, Tsai TF, Wu MS, Wang PY.

PLoS Biol. 2019 Mar 18;17(3):e2007097. doi: 10.1371/journal.pbio.2007097. eCollection 2019 Mar.


Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls.

Wang MH, Wu CH, Huang TY, Sung HW, Chiou LL, Lin SP, Lee HS.

Dev Biol. 2019 May 15;449(2):122-131. doi: 10.1016/j.ydbio.2019.02.011. Epub 2019 Feb 28.


Plasma Calcitonin Gene-Related Peptide: A Potential Biomarker for Diagnosis and Therapeutic Responses in Pediatric Migraine.

Fan PC, Kuo PH, Lee MT, Chang SH, Chiou LC.

Front Neurol. 2019 Jan 24;10:10. doi: 10.3389/fneur.2019.00010. eCollection 2019.


Randomized controlled clinical effectiveness of adjunct 660-nm light-emitting diode irradiation during non-surgical periodontal therapy.

Chen YW, Hsieh O, Chen YA, Chiou LL, Chang PC.

J Formos Med Assoc. 2019 Jan 29. pii: S0929-6646(18)30864-7. doi: 10.1016/j.jfma.2019.01.010. [Epub ahead of print]


Real-world cost-effectiveness of drug-eluting stents vs. bare-metal stents for coronary heart disease-A five-year follow-up study.

Cheng HM, Chiou LJ, Chen TC, Sung SH, Chen CH, Lang HC.

Health Policy. 2019 Feb;123(2):229-234. doi: 10.1016/j.healthpol.2018.11.010. Epub 2018 Nov 28.


Median nerve stimulation induces analgesia via orexin-initiated endocannabinoid disinhibition in the periaqueductal gray.

Chen YH, Lee HJ, Lee MT, Wu YT, Lee YH, Hwang LL, Hung MS, Zimmer A, Mackie K, Chiou LC.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10720-E10729. doi: 10.1073/pnas.1807991115. Epub 2018 Oct 22.


Age-Dependent Anti-migraine Effects of Valproic Acid and Topiramate in Rats.

Huang P, Kuo PH, Lee MT, Chiou LC, Fan PC.

Front Pharmacol. 2018 Sep 25;9:1095. doi: 10.3389/fphar.2018.01095. eCollection 2018.


Orexin-mediated restoration of hippocampal synaptic potentiation in mice with established cocaine-conditioned place preference.

Lu GL, Lee MT, Chiou LC.

Addict Biol. 2019 Nov;24(6):1153-1166. doi: 10.1111/adb.12672. Epub 2018 Oct 1.


The α6 subunit-containing GABAA receptor: A novel drug target for inhibition of trigeminal activation.

Fan PC, Lai TH, Hor CC, Lee MT, Huang P, Sieghart W, Ernst M, Knutson DE, Cook J, Chiou LC.

Neuropharmacology. 2018 Sep 15;140:1-13. doi: 10.1016/j.neuropharm.2018.07.017. Epub 2018 Jul 21.


Paeonol promotes hippocampal synaptic transmission: The role of the Kv2.1 potassium channel.

Yang CT, Lu GL, Hsu SF, MacDonald I, Chiou LC, Hung SY, Chen YH.

Eur J Pharmacol. 2018 May 15;827:227-237. doi: 10.1016/j.ejphar.2018.03.020. Epub 2018 Mar 15.


Cerebellar α6 -subunit-containing GABAA receptors: a novel therapeutic target for disrupted prepulse inhibition in neuropsychiatric disorders.

Chiou LC, Lee HJ, Ernst M, Huang WJ, Chou JF, Chen HL, Mouri A, Chen LC, Treven M, Mamiya T, Fan PC, Knutson DE, Witzigmann C, Cook J, Sieghart W, Nabeshima T.

Br J Pharmacol. 2018 Jun;175(12):2414-2427. doi: 10.1111/bph.14198. Epub 2018 May 10.


Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability.

Knutson DE, Kodali R, Divović B, Treven M, Stephen MR, Zahn NM, Dobričić V, Huber AT, Meirelles MA, Verma RS, Wimmer L, Witzigmann C, Arnold LA, Chiou LC, Ernst M, Mihovilovic MD, Savić MM, Sieghart W, Cook JM.

J Med Chem. 2018 Mar 22;61(6):2422-2446. doi: 10.1021/acs.jmedchem.7b01664. Epub 2018 Mar 6.


Prognostic role of initial pan-endoscopic tumor length at diagnosis in operable esophageal squamous cell carcinoma undergoing esophagectomy with or without neoadjuvant concurrent chemoradiotherapy.

Lin CS, Liu CY, Cheng CT, Tsai YC, Chiou LW, Lee MY, Liu CC, Shih CH.

J Thorac Dis. 2017 Sep;9(9):3193-3207. doi: 10.21037/jtd.2017.08.108.


Total Synthesis and Metabolic Stability of Hispidulin and Its d-Labelled Derivative.

Chen LC, Hsu KC, Chiou LC, Tseng HJ, Huang WJ.

Molecules. 2017 Nov 4;22(11). pii: E1897. doi: 10.3390/molecules22111897.


Conditioned place preference training prevents hippocampal depotentiation in an orexin-dependent manner.

Lu GL, Yau HJ, Chiou LC.

J Biomed Sci. 2017 Sep 6;24(1):69. doi: 10.1186/s12929-017-0378-0.


Diffusion tensor tractography reveals muscle reconnection during axolotl limb regeneration.

Wu CH, Chen YJ, Wang MH, Chiou LL, Tseng WI, Lee HS.

PLoS One. 2017 Mar 2;12(3):e0173425. doi: 10.1371/journal.pone.0173425. eCollection 2017.


Re-epithelialization of large wound in paedomorphic and metamorphic axolotls.

Huang TY, Chang CC, Cheng NC, Wang MH, Chiou LL, Lee KL, Lee HS.

J Morphol. 2017 Feb;278(2):228-235. doi: 10.1002/jmor.20631. Epub 2016 Nov 17.


Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons.

Tung LW, Lu GL, Lee YH, Yu L, Lee HJ, Leishman E, Bradshaw H, Hwang LL, Hung MS, Mackie K, Zimmer A, Chiou LC.

Nat Commun. 2016 Jul 22;7:12199. doi: 10.1038/ncomms12199.


Hispidulin alleviated methamphetamine-induced hyperlocomotion by acting at α6 subunit-containing GABAA receptors in the cerebellum.

Liao YH, Lee HJ, Huang WJ, Fan PC, Chiou LC.

Psychopharmacology (Berl). 2016 Sep;233(17):3187-99. doi: 10.1007/s00213-016-4365-z. Epub 2016 Jul 6.


Orexin A induces bidirectional modulation of synaptic plasticity: Inhibiting long-term potentiation and preventing depotentiation.

Lu GL, Lee CH, Chiou LC.

Neuropharmacology. 2016 Aug;107:168-180. doi: 10.1016/j.neuropharm.2016.03.005. Epub 2016 Mar 7.


Stress induces analgesia via orexin 1 receptor-initiated endocannabinoid/CB1 signaling in the mouse periaqueductal gray.

Lee HJ, Chang LY, Ho YC, Teng SF, Hwang LL, Mackie K, Chiou LC.

Neuropharmacology. 2016 Jun;105:577-586. doi: 10.1016/j.neuropharm.2016.02.018. Epub 2016 Feb 18.


Antitumor Activity of Garcinol in Human Prostate Cancer Cells and Xenograft Mice.

Wang Y, Tsai ML, Chiou LY, Ho CT, Pan MH.

J Agric Food Chem. 2015 Oct 21;63(41):9047-52. doi: 10.1021/acs.jafc.5b03851. Epub 2015 Oct 13.


Cortical Auditory Evoked Potentials Recorded From Nucleus Hybrid Cochlear Implant Users.

Brown CJ, Jeon EK, Chiou LK, Kirby B, Karsten SA, Turner CW, Abbas PJ.

Ear Hear. 2015 Nov-Dec;36(6):723-32. doi: 10.1097/AUD.0000000000000206.


Total Synthesis of Hispidulin and the Structural Basis for Its Inhibition of Proto-oncogene Kinase Pim-1.

Chao SW, Su MY, Chiou LC, Chen LC, Chang CI, Huang WJ.

J Nat Prod. 2015 Aug 28;78(8):1969-76. doi: 10.1021/acs.jnatprod.5b00324. Epub 2015 Aug 14.


Impairment of adenylyl cyclase-mediated glutamatergic synaptic plasticity in the periaqueductal grey in a rat model of neuropathic pain.

Ho YC, Cheng JK, Chiou LC.

J Physiol. 2015 Jul 1;593(13):2955-73. doi: 10.1113/JP270384. Epub 2015 May 14.


Cooperative regulation of substrate stiffness and extracellular matrix proteins in skin wound healing of axolotls.

Huang TY, Wu CH, Wang MH, Chen BS, Chiou LL, Lee HS.

Biomed Res Int. 2015;2015:712546. doi: 10.1155/2015/712546. Epub 2015 Mar 8.


Brain isoform glycogen phosphorylase as a novel hepatic progenitor cell marker.

Huang YW, Chiu CC, Liang JD, Chiou LL, Huang GT, Yu MJ, Lee HS.

PLoS One. 2015 Mar 31;10(3):e0122528. doi: 10.1371/journal.pone.0122528. eCollection 2015.


Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice.

Huang WJ, Lee HJ, Chen HL, Fan PC, Ku YL, Chiou LC.

J Ethnopharmacol. 2015 May 26;166:18-22. doi: 10.1016/j.jep.2015.03.001. Epub 2015 Mar 9.


Long-duration muscle dedifferentiation during limb regeneration in axolotls.

Wu CH, Huang TY, Chen BS, Chiou LL, Lee HS.

PLoS One. 2015 Feb 11;10(2):e0116068. doi: 10.1371/journal.pone.0116068. eCollection 2015.


Elevated plasma orexin A levels in a subgroup of patients with schizophrenia associated with fewer negative and disorganized symptoms.

Chien YL, Liu CM, Shan JC, Lee HJ, Hsieh MH, Hwu HG, Chiou LC.

Psychoneuroendocrinology. 2015 Mar;53:1-9. doi: 10.1016/j.psyneuen.2014.12.012. Epub 2014 Dec 20.


Garcinol suppresses inflammation-associated colon carcinogenesis in mice.

Tsai ML, Chiou YS, Chiou LY, Ho CT, Pan MH.

Mol Nutr Food Res. 2014 Sep;58(9):1820-9. doi: 10.1002/mnfr.201400149. Epub 2014 Jul 1.


Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells.

Lin CW, Sun MS, Liao MY, Chung CH, Chi YH, Chiou LT, Yu J, Lou KL, Wu HC.

Carcinogenesis. 2014 Nov;35(11):2425-35. doi: 10.1093/carcin/bgu139. Epub 2014 Jun 26.


Multipotent adult hippocampal progenitor cells maintained as neurospheres favor differentiation toward glial lineages.

Oh J, Daniels GJ, Chiou LS, Ye EA, Jeong YS, Sakaguchi DS.

Biotechnol J. 2014 Jul;9(7):921-33. doi: 10.1002/biot.201400019. Epub 2014 Jun 23.


Enhancement of CYP3A4 activity in Hep G2 cells by lentiviral transfection of hepatocyte nuclear factor-1 alpha.

Chiang TS, Yang KC, Chiou LL, Huang GT, Lee HS.

PLoS One. 2014 Apr 14;9(4):e94885. doi: 10.1371/journal.pone.0094885. eCollection 2014.


Orexin/hypocretin role in reward: implications for opioid and other addictions.

Baimel C, Bartlett SE, Chiou LC, Lawrence AJ, Muschamp JW, Patkar O, Tung LW, Borgland SL.

Br J Pharmacol. 2015 Jan;172(2):334-48. doi: 10.1111/bph.12639. Epub 2014 Jul 1. Review.


Targeting the cannabinoid system for pain relief?

Chiou LC, Hu SS, Ho YC.

Acta Anaesthesiol Taiwan. 2013 Dec;51(4):161-70. doi: 10.1016/j.aat.2013.10.004. Epub 2013 Dec 25. Review.


No more pain upon Gq-protein-coupled receptor activation: role of endocannabinoids.

Hu SS, Ho YC, Chiou LC.

Eur J Neurosci. 2014 Feb;39(3):467-84. doi: 10.1111/ejn.12475. Review. Retraction in: Eur J Neurosci. 2016 Apr;43(7):991.


A novel titanium dioxide-polydimethylsiloxane plate for phosphopeptide enrichment and mass spectrometry analysis.

Chen CJ, Lai CC, Tseng MC, Liu YC, Liu YH, Chiou LW, Tsai FJ.

Anal Chim Acta. 2014 Feb 17;812:105-13. doi: 10.1016/j.aca.2014.01.010. Epub 2014 Jan 15.


Functional ginger extracts from supercritical fluid carbon dioxide extraction via in vitro and in vivo assays: antioxidation, antimicroorganism, and mice xenografts models.

Lee CC, Chiou LY, Wang JY, Chou SY, Lan JC, Huang TS, Huang KC, Wang HM.

ScientificWorldJournal. 2013 Jul 29;2013:210845. doi: 10.1155/2013/210845. eCollection 2013.


Hypofunction of glutamatergic neurotransmission in the periaqueductal gray contributes to nerve-injury-induced neuropathic pain.

Ho YC, Cheng JK, Chiou LC.

J Neurosci. 2013 May 1;33(18):7825-36. doi: 10.1523/JNEUROSCI.5583-12.2013.


Clerodendrum inerme Leaf Extract Alleviates Animal Behaviors, Hyperlocomotion, and Prepulse Inhibition Disruptions, Mimicking Tourette Syndrome and Schizophrenia.

Chen HL, Lee HJ, Huang WJ, Chou JF, Fan PC, Du JC, Ku YL, Chiou LC.

Evid Based Complement Alternat Med. 2012;2012:284301. doi: 10.1155/2012/284301. Epub 2012 Jul 15.


Different trigemino-vascular responsiveness between adolescent and adult rats in a migraine model.

Fan PC, Kuo PH, Hu JW, Chang SH, Hsieh ST, Chiou LC.

Cephalalgia. 2012 Oct;32(13):979-90. Epub 2012 Jul 26.


Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation.

Kanda J, Chiou LW, Szabolcs P, Sempowski GD, Rizzieri DA, Long GD, Sullivan KM, Gasparetto C, Chute JP, Morris A, McPherson J, Hale J, Livingston JA, Broadwater G, Niedzwiecki D, Chao NJ, Horwitz ME.

Biol Blood Marrow Transplant. 2012 Nov;18(11):1664-1676.e1. doi: 10.1016/j.bbmt.2012.06.005. Epub 2012 Jun 12.


The prediction of drug metabolism using scaffold-mediated enhancement of the induced cytochrome P450 activities in fibroblasts by hepatic transcriptional regulators.

Chiang TS, Yang KC, Zheng SK, Chiou LL, Hsu WM, Lin FH, Huang GT, Lee HS.

Biomaterials. 2012 Jul;33(21):5187-97. doi: 10.1016/j.biomaterials.2012.04.014. Epub 2012 Apr 26.


Calcitonin gene-related peptide and size of the atrial septal defect in new-onset migraine after transcatheter closure: results of a preliminary study.

Wei SH, Fan PC, Kuo PH, Chiou LC, Wang JK.

Headache. 2012 Jun;52(6):985-92. doi: 10.1111/j.1526-4610.2012.02152.x. Epub 2012 Apr 5.


Quantitative study of [Tyr10]nociceptin/orphanin FQ (1-11) at NOP receptors in rat periaqueductal gray and expressed NOP receptors in HEK293 cells.

Liao YY, Lee CW, Ho IK, Chiou LC.

Life Sci. 2012 Feb 13;90(7-8):306-12. doi: 10.1016/j.lfs.2011.12.004. Epub 2011 Dec 22.


Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition.

Ho YC, Lee HJ, Tung LW, Liao YY, Fu SY, Teng SF, Liao HT, Mackie K, Chiou LC.

J Neurosci. 2011 Oct 12;31(41):14600-10. doi: 10.1523/JNEUROSCI.2671-11.2011.


Apical membrane rupture and backward bile flooding in acetaminophen-induced hepatocyte necrosis.

Li FC, Huang GT, Lin CJ, Wang SS, Sun TL, Lo SY, Lo W, Chiou LL, Dong CY, Lee HS.

Cell Death Dis. 2011 Jul 21;2:e183. doi: 10.1038/cddis.2011.68.


Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.

Lee CW, Yan JY, Chiang YC, Hung TW, Wang HL, Chiou LC, Ho IK.

Neurochem Res. 2011 Nov;36(11):2008-21. doi: 10.1007/s11064-011-0525-z. Epub 2011 Jun 14.

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